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Integrin Activation: Implications for Axon Regeneration

Cheah, Menghon, Andrews, Melissa·2018·Cells
DOI 10.3390/cells7030020PMC PMC5870352
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Abstract

Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by ‘inside–out’ and ‘outside–in’ signalling. This review will provide a detailed overview of integrin activation focusing on intracellular activation in neurons and discussing direct implications in the regulation of neurite outgrowth and axon regeneration.

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Crossref · 10.3390/cells7030020

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  • β1-integrin plays key roles in neurite outgrowth, axon guidance, and in the formation and maintenance of synapses.

    “β1-integrin plays key roles in neurite outgrowth, axon guidance, and in the formation and maintenance of synapses (Cheah and Andrews, 2018; Lilja and Ivaska, 2018; Park and Goda, 2016).”

    From Recruitment of the SNX17-Retriever recycling pathway regulates synaptic function and plasticity (2023) · cites this paper as Cheah and Andrews, 2018

    The ‘Outside–In’ Signalling section links β1-containing integrins to neurite growth, and the Introduction says integrins are required for synaptogenesis. The paper discusses guidance cues in axon regeneration, but does not establish a specific role for β1-integrin in axon guidance or synapse maintenance. No page numbers are available in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • β1-integrin is a well-characterized SNX17-Retriever cargo in non-neuronal cells.

    “We chose to test β1-integrin, which is a well-characterized SNX17-Retriever cargo in non-neuronal cells and plays several roles in regulating neuronal function and synaptic plasticity.”

    From Recruitment of the SNX17-Retriever recycling pathway regulates synaptic function and plasticity (2023) · cites this paper as Cheah and Andrews, 2018

    The ‘Outside–In’ Signalling section discusses β1-containing integrins and their ligands, while section 3 discusses integrin transport and activation. Neither passage identifies β1-integrin as an SNX17–Retriever cargo in non-neuronal cells; searches for SNX17, Retriever, and endosomal sorting found no passage addressing that relationship. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

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Metadata

Authors
Cheah, M., & Andrews, M.
Affiliations
  • John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UK
  • Department of Biological Sciences, University of Southampton, Life Sciences Bldg 85, Highfield Campus, Southampton SO17 1BJ, UK
ORCID
Cheah, Menghon
Venue
Cells
Publisher
MDPI AG
Published
2018-03-10
Volume
7
Issue
3
Pages
20
ISSN
2073-4409
DOI
10.3390/cells7030020
PMC
PMC5870352
Cited by
44
References
2
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
BBSRC (BB/N008189/1)

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