The DOI matches its Crossref record; 153 of the 153 references it cites were found in a registry or an index.
Physical Exercise Inhibits Inflammation and Microglial Activation
Open accessAbstract
Accumulating evidence indicates that exercise can enhance brain function and attenuate neurodegeneration. Besides improving neuroplasticity by altering the synaptic structure and function in various brain regions, exercise also modulates multiple systems that are known to regulate neuroinflammation and glial activation. Activated microglia and several pro-inflammatory cytokines play active roles in the pathogenesis of neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. The purpose of this review is to highlight the impacts of exercise on microglial activation. Possible mechanisms involved in exercise-modulated microglial activation are also discussed. Undoubtedly, more studies are needed in order to disclose the detailed mechanisms, but this approach offers therapeutic potential for improving the brain health of millions of aging people where pharmacological intervention has failed.
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1 retracted
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RetractedThe Physical Activity Guidelines for Americans
Piercy, K. L., Troiano, R. P., Ballard, R. M., Carlson, S. A., Fulton, J. E., Galuska, D. A., George, S. M., & Olson, R. D. (2018) · JAMA · doi:10.1001/jama.2018.14854 · Cited by 9,755 · cited 1×
“$ For human studies, we followed the criteria of Physical Activity Guidelines for Americans [54] to grade the intensity of exercise.”
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Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
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The Human Intestinal Microbiome in Health and Disease
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Cited by
Neuroinflammation in Alzheimer disease
Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., Jacobs, A. H., et al. (2025) · Nature Reviews Immunology · doi:10.1038/s41577-024-01104-7 · Cited by 638
Fernández-Calle, R., Konings, S. C., Frontiñán-Rubio, J., García-Revilla, J., Camprubí-Ferrer, L., Svensson, M., Martinson, I., Boza-Serrano, A., Venero, J. L., Nielsen, H. M., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00566-4 · Cited by 278
Exercise and Neuroinflammation in Health and Disease
Seo, D.-Y., Heo, J.-W., Ko, J. R., & Kwak, H.-B. (2019) · International Neurourology Journal · doi:10.5213/inj.1938214.107 · Cited by 88
Modulation of microRNAs through Lifestyle Changes in Alzheimer’s Disease
Pinto-Hernandez, P., Castilla-Silgado, J., Coto-Vilcapoma, A., Fernández-Sanjurjo, M., Fernández-García, B., Tomás-Zapico, C., & Iglesias-Gutiérrez, E. (2023) · Nutrients · doi:10.3390/nu15173688 · Cited by 22
de Souza, R. F., Augusto, R. L., de Moraes, S. R. A., de Souza, F. B., Gonçalves, L. V. D. P., Pereira, D. D., Moreno, G. M. M., de Souza, F. M. A., & Andrade-da-Costa, B. L. D. S. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00157 · Cited by 16
Metadata
- Authors
- Mee-inta, O., Zhao, Z.-W., & Kuo, Y.-M.
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2019-07-09
- Volume
- 8
- Issue
- 7
- Pages
- 691
- ISSN
- 2073-4409 (ISSN-L)
- OpenAlex
- W2959690091
- Cited by
- 268
- References
- 153
- FWCI
- 9.71
- Type
- journal article
- Language
- en
- Open access
- gold
- Funders
- Ministry of Science and Technology, Taiwan (107-2320-B-006-054-MY3)
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
