Melatonin and (−)-Epigallocatechin-3-Gallate: Partners in Fighting Cancer
Open accessAbstract
We have demonstrated previously that melatonin attenuates hepatotoxicity triggered by high doses of (−)-epigallocatechin-3-gallate (EGCG) in mice. The current work investigated the influence of melatonin on the oncostatic activity of EGCG in two cancer cell lines, wherein melatonin induced an opposite response of p21. In human tongue cancer TCA8113 cells, melatonin-induced p21 and EGCG-mediated formation of quinoproteins were positively associated with the oncostatic effects of melatonin and EGCG. Melatonin-stimulated an increase in p21 which was correlated with a pronounced nuclear translocation of thioredoxin 1 and thioredoxin reductase 1, both of which are known to induce p21 via promoting p53 trans-activation. Melatonin did not influence the EGCG-mediated increase of quinoprotein formation nor did EGCG impair melatonin-induced p21 up-regulation. Co-treatment with both agents enhanced the cell-killing effect as well as the inhibitory activities against cell migration and colony formation. It is known that p21 also plays a powerful anti-apoptotic role in some cancer cells and confers these cells with a survival advantage, making it a target for therapeutic suppression. In human hepatocellular carcinoma HepG2 cells, melatonin suppressed p21 along with the induction of pro-survival proteins, PI3K and COX-2. However, EGCG prevented against melatonin-induced PI3K and COX-2, and melatonin probably sensitized HepG2 cells to EGCG cytotoxicity via down-regulating p21, Moreover, COX-2 and HO-1 were significantly reduced only by the co-treatment, and melatonin aided EGCG to achieve an increased inhibition on Bcl2 and NFκB. These events occurring in the co-treatment collectively resulted in an enhanced cytotoxicity. In addition, the co-treatment also enhanced the inhibitory activities against cell migration and colony formation. Overall, the results gathered from these two cancer cell lines with a divergent p21 response to melatonin show that the various oncostatic activities of melatonin and EGCG together are more robust than each agent alone, suggesting that they may be useful partners in fighting cancer.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There are initial indications that the antioxidant and anti-inflammatory actions of melatonin may work together with select polyphenols (e.g., resveratrol, epigallocatechin 3-gallate) for therapeutic indications.
“There are initial indications that the antioxidant and anti-inflammatory actions of melatonin may work together with select polyphenols (e.g., resveratrol, epigallocatechin 3-gallate) for therapeutic indications [48,49,50,51,52,53,54].”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [53]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2 retracted
RETRACTED: Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line
Martín‐Renedo, J., Mauriz, J. L., Jorquera, F., Ruiz‐Andrés, O., González, P., & González‐Gallego, J. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00641.x · Cited by 197 · see citing works
RetractedCarbajo‐Pescador, S., Martín‐Renedo, J., Palomo, A. G., Tuñón, M. J., Mauriz, J. L., & González‐Gallego, J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00719.x · Cited by 46 · see citing works
RetractedRegulation of antioxidant enzymes: a significant role for melatonin
Rodrı́guez, C., Mayo, J. C., Sainz, R. M., Antolı́n, I., Herrera, F., Martı́n, V., & Reiter, R. J. (2003) · Journal of Pineal Research · doi:10.1046/j.1600-079x.2003.00092.x · Cited by 1,990 · see citing works
Self-citationMelatonin as an antioxidant: under promises but over delivers
Reiter, R. J., Mayo, J. C., Tan, D. X., Sainz, R. M., Alatorre-Jiménez, M. A., & Qin, L. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12360 · Cited by 1,741 · see citing works
Self-citationTan, D., Manchester, L. C., Terron, M. P., Flores, L. J., & Reiter, R. J. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00407.x · Cited by 1,601 · see citing works
Self-citationThe emerging role of the Nrf2–Keap1 signaling pathway in cancerPreprint
Jaramillo, M. C., & Zhang, D. D. (2013) · Genes & Development · doi:10.1101/gad.225680.113 · Cited by 1,304 · see citing works
Cancer prevention by tea: animal studies, molecular mechanisms and human relevance
Yang, C. S., Wang, X., Lü, G., & Picinich, S. C. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2641 · Cited by 1,153 · see citing works
Self-citationTrachootham, D., Zhou, Y., Zhang, H., Demizu, Y., Chen, Z., Pelicano, H., Chiao, P. J., Achanta, G., Arlinghaus, R. B., Liu, J., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.009 · Cited by 1,080 · see citing works
Melatonin: an ancient molecule that makes oxygen metabolically tolerable
Manchester, L. C., Coto‐Montes, A. M., Boga, J. A., Andersen, L. P. H., Zhou, Z., Galano, A., Vriend, J. P., Tan, D. X., & Reiter, R. J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12267 · Cited by 954 · see citing works
Self-citationThe antioxidant and pro-oxidant activities of green tea polyphenols: A role in cancer prevention
Lambert, J. D., & Elias, R. J. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.06.013 · Cited by 865 · see citing works
Melatonin: a well‐documented antioxidant with conditional pro‐oxidant actions
Zhang, H., & Zhang, Y. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12162 · Cited by 816 · see citing works
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
Waldman, T., Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1996) · Nature · doi:10.1038/381713a0 · Cited by 728 · see citing works
Focus on mammalian thioredoxin reductases — Important selenoproteins with versatile functions
Arnér, E. S. J. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.01.014 · Cited by 675 · see citing works
Apoptosis inhibitory activity of cytoplasmic p21Cip1/WAF1 in monocytic differentiation
Asada, M., Yamada, T., Ichijo, H., Delia, D., Miyazono, K., Fukumuro, K., & Mizutani, S. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1223 · Cited by 586 · see citing works
The Safety of Melatonin in Humans
Andersen, L. P. H., Gögenür, I., Rosenberg, J., & Reiter, R. J. (2015) · Clinical Drug Investigation · doi:10.1007/s40261-015-0368-5 · Cited by 474 · see citing works
Self-citationLi, Y., Dowbenko, D. J., & Lasky, L. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109062200 · Cited by 442 · see citing works
Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis
Reiter, R. J., Rosales‐Corral, S., Tan, D., Acuña-Castroviejo, D., Qin, L., Yang, S., & Xu, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040843 · Cited by 437 · see citing works
Self-citationHepatotoxicity of high oral dose (−)-epigallocatechin-3-gallate in mice
Lambert, J. D., Kennett, M. J., Sang, S., Reuhl, K. R., Ju, J., & Yang, C. S. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.10.030 · Cited by 436 · see citing works
Self-citationThioredoxin-dependent Redox Regulation of p53-mediated p21 Activation
Ueno, M., Masutani, H., Arai, R. J., Yamauchi, A., Hirota, K., Sakai, T., Inamoto, T., Yamaoka, Y., Yodoi, J., & Nikaido, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.50.35809 · Cited by 428 · see citing works
Melatonin: reducing the toxicity and increasing the efficacy of drugs
Reiter, R. J., Tan, D., Sainz, R. M., Mayo, J. C., & López‐Burillo, S. (2002) · Journal of Pharmacy and Pharmacology · doi:10.1211/002235702760345374 · Cited by 418 · see citing works
Self-citationHepatotoxicity from green tea: a review of the literature and two unpublished cases
Mazzanti, G., Menniti‐Ippolito, F., Moro, P. A., Cassetti, F., Raschetti, R., Santuccio, C., & Mastrangelo, S. (2009) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-008-0610-7 · Cited by 412 · see citing works
The safety of green tea and green tea extract consumption in adults – Results of a systematic review
Hu, J., Webster, D., Cao, J., & Shao, A. E. (2018) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2018.03.019 · Cited by 406 · see citing works
Melatonin for the prevention and treatment of cancer
Li, Y., Li, S., Zhou, Y., Meng, X., Zhang, J., Xu, D.-P., & Li, H. (2017) · Oncotarget · doi:10.18632/oncotarget.16379 · Cited by 388 · see citing works
Self-citationProtective effect of green tea against prostate cancer: A case‐control study in southeast China
Jian, L., Xie, L., Lee, A. H., & Binns, C. W. (2003) · International Journal of Cancer · doi:10.1002/ijc.11550 · Cited by 369 · see citing works
The role of antioxidant versus pro‐oxidant effects of green tea polyphenols in cancer prevention
Forester, S. C., & Lambert, J. D. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000641 · Cited by 334 · see citing works
Green Tea Consumption and Prostate Cancer Risk in Japanese Men: A Prospective Study
Kurahashi, N., Sasazuki, S., Iwasaki, M., Inoue, M., & Shoichiro Tsugane for the JPHC Study Group (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm249 · Cited by 282 · see citing works
Systemic Therapy of Advanced Hepatocellular Carcinoma: How Hopeful Should We Be?
Zhu, A. X. (2006) · The Oncologist · doi:10.1634/theoncologist.11-7-790 · Cited by 260 · see citing works
Vriend, J., & Reiter, R. J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.12.013 · Cited by 246 · see citing works
Self-citationIshii, T., Mori, T., Tanaka, T., Mizuno, D., Yamaji, R., Kumazawa, S., Nakayama, T., & Akagawa, M. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.07.023 · Cited by 242 · see citing works
Protective effect of green tea on the risks of chronic gastritis and stomach cancer
Setiawan, V. W., Zhang, Z., Yu, G., Lu, Q., Li, Y.-L., Lu, M.-L., Wang, M., Guo, C. H., Yu, S., Kurtz, R. C., et al. (2001) · International Journal of Cancer · doi:10.1002/ijc.1231 · Cited by 239 · see citing works
p21Waf1/Cip1 as a therapeutic target in breast and other cancers
Weiss, R. H. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00308-8 · Cited by 237 · see citing works
Prevention of Chronic Diseases by Tea: Possible Mechanisms and Human Relevance
Yang, C. S., & Hong, J. (2013) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071811-150717 · Cited by 227 · see citing works
Self-citationMechanisms of cancer inhibition by melatonin
Reiter, R. J. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00165.x · Cited by 224 · see citing works
Self-citationNiu, L., Liu, L., Yang, S., Ren, J., Lai, P. B. S., & Chen, G. G. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.10.002 · Cited by 198 · see citing works
Hepatotoxicity of green tea: an update
Mazzanti, G., Di Sotto, A., & Vitalone, A. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1521-x · Cited by 189 · see citing works
Shanafelt, T. D., Call, T. G., Zent, C. S., LaPlant, B. R., Bowen, D. A., Roos, M., Secreto, C. R., Ghosh, A. K., Kabat, B., Lee, M., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.21.1284 · Cited by 181 · see citing works
Self-citationMelatonin: A pleiotropic molecule that modulates DNA damage response and repair pathways
Majidinia, M., Sadeghpour, A., Mehrzadi, S., Reiter, R. J., Khatami, N., & Yousefi, B. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12416 · Cited by 163 · see citing works
Self-citationGreen tea and the prevention of breast cancer: a case-control study in Southeast China
Zhang, M., Holman, C. D. J., Huang, J.-P., & Xie, X. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl252 · Cited by 159 · see citing works
Wang, D., Wang, Y., Wan, X., Yang, C. S., & Zhang, J. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.12.018 · Cited by 154 · see citing works
Self-citationCells lacking CIP1/WAF1 genes exhibit preferential sensitivity to cisplatin and nitrogen mustard
Fan, S., Chang, J. K., Smith, M. L., Duba, D. E., Fornace, A. J., & O'Connor, P. M. (1997) · Oncogene · doi:10.1038/sj.onc.1201052 · Cited by 150 · see citing works
Ortiz, F., Acuña-Castroviejo, D., Doerrier, C., Dayoub, J. C., López, L. C., Venegas, C., García, J. A. G., López, A., Volt, H., Luna‐Sánchez, M., et al. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12191 · Cited by 143 · see citing works
Pariente, R., Pariente, J. A., Rodríguez, A. B., & Espino, J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12288 · Cited by 137 · see citing works
Prieto‐Domínguez, N., Ordóñez, R., Fernández, A., Méndez‐Blanco, C., Baulies, A., García‐Ruiz, C., Fernández-Checa, J. C., Mauriz, J. L., & González‐Gallego, J. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12358 · Cited by 137 · see citing works
Zapico, S. C., Rodríguez‐Blanco, J., García‐Santos, G., Martı́n, V., Sánchez‐Sánchez, A. M., Antolı́n, I., & Rodrı́guez, C. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00727.x · Cited by 124 · see citing works
Prospective Cohort Study of Green Tea Consumption and Colorectal Cancer Risk in Women
Yang, G., Shu, X., Li, H., Chow, W., Ji, B., Zhang, X., Gao, Y.-T., & Zheng, W. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0097 · Cited by 124 · see citing works
Green tea drinking and multigenetic index on the risk of stomach cancer in a Chinese population
Mu, L., Lu, Q., Yu, S., Jiang, Q., Cao, W., You, N. Y., Setiawan, V. W., Zhou, X., Ding, B., Wang, R., et al. (2005) · International Journal of Cancer · doi:10.1002/ijc.21137 · Cited by 121 · see citing works
Dekant, W., Fujii, K., Shibata, E., Morita, O., & Shimotoyodome, A. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.06.008 · Cited by 117 · see citing works
Zhong, L., Goldberg, M. S., Gao, Y., Hanley, J. A., Parent, M., & Jin, F. (2001) · Epidemiology · doi:10.1097/00001648-200111000-00019 · Cited by 115 · see citing works
Mechanistic issues concerning cancer prevention by tea catechins
Yang, C. S., & Wang, H. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100036 · Cited by 109 · see citing works
Self-citationWei, Y., Chen, P., Ling, T.-J., Wang, Y., Dong, R., Zhang, C., Zhang, L., Han, M., Wang, D., Wan, X., et al. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.02.134 · Cited by 109 · see citing works
Self-citationGalley, H. F., McCormick, B., Wilson, K. L., Lowes, D. A., Colvin, L., & Torsney, C. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12444 · Cited by 106 · see citing works
Does melatonin induce apoptosis in MCF‐7 human breast cancer cells in vitro?
Cos, S., Mediavilla, M. D., Fernández, R., González‐Lamuño, D., & Sánchez‐Barceló, E. J. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2002.1821.x · Cited by 105 · see citing works
Green Tea Consumption and Subsequent Risk of Gastric Cancer by Subsite: The JPHC Study
Sasazuki, S., Inoue, M., Hanaoka, T., Yamamoto, S., Sobue, T., & Tsugane, S. (2004) · Cancer Causes & Control · doi:10.1023/b:caco.0000036449.68454.42 · Cited by 101 · see citing works
Stewart, Z. A., Mays, D. J., & Pietenpol, J. A. (1999) · PubMed · Cited by 101 · see citing works
Manda, K., Ueno, M., & Anzai, K. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00632.x · Cited by 97 · see citing works
Melatonin down‐regulates MDM 2 gene expression and enhances p53 acetylation in MCF ‐7 cells
Proietti, S., Cucina, A., Dobrowolny, G., D’Anselmi, F., Dinicola, S., Masiello, M. G., Pasqualato, A., Palombo, A., Morini, V., Reiter, R. J., et al. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12150 · Cited by 96 · see citing works
Self-citationLin, S., Hoffmann, K., Gao, C., Petrulionis, M., Herr, I., & Schemmer, P. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12398 · Cited by 96 · see citing works
Bitzer, Z. T., Elias, R. J., Vijay–Kumar, M., & Lambert, J. D. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201501042 · Cited by 85 · see citing works
Tao, L., Park, J., & Lambert, J. D. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400485 · Cited by 83 · see citing works
Bioactive nutrients - Time for tolerable upper intake levels to address safety
Yates, A. A., Erdman, J. W., Shao, A. E., Dolan, L. C., & Griffiths, J. C. (2017) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2017.01.002 · Cited by 81 · see citing works
Melatonin sensitizes human hepatoma cells to endoplasmic reticulum stress–induced apoptosis
Zha, L., Fan, L., Sun, G., Wang, H., Ma, T., Zhong, F., & Wei, W. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00946.x · Cited by 74 · see citing works
Human hepatocellular carcinoma: Protection by melatonin
Mortezaee, K. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26586 · Cited by 72 · see citing works
Fan, L., Sun, G., Ma, T., Zhong, F., Yu, L., Li, X., & Wei, W. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12061 · Cited by 71 · see citing works
Song, J., Ma, S., Luo, J., Zhang, H., Wang, R.-X., Liu, H., Li, L., Zhang, Z., & Zhou, R. (2018) · Oncology Reports · doi:10.3892/or.2018.6282 · Cited by 69 · see citing works
Zhang, J. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s29341 · Cited by 68 · see citing works
Self-citationAlonso‐González, C., González, A., Martínez‐Campa, C., Gómez‐Arozamena, J., & Cos, S. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12205 · Cited by 68 · see citing works
An antisense oligodeoxynucleotide to p21(Waf1/Cip1) causes apoptosis in human breast cancer cells.
Fan, Y., Borowsky, A. D., & Weiss, R. H. (2003) · PubMed · Cited by 68 · see citing works
Pae, M., Ren, Z., Meydani, M., Shang, F., Smith, D. E., Meydani, S. N., & Wu, D. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.02.006 · Cited by 67 · see citing works
Cross talk between two antioxidant systems, Thioredoxin and DJ-1: consequences for cancer
Raninga, P. V., Trapani, G. D., & Tonissen, K. F. (2014) · Oncoscience · doi:10.18632/oncoscience.12 · Cited by 63 · see citing works
Damdimopoulos, A. E., Miranda‐Vizuete, A., Treuter, E., Gustafsson, J.-Α., & Spyrou, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402753200 · Cited by 63 · see citing works
Safety and anti-hyperglycemic efficacy of various tea types in mice
Han, M., Zhao, G., Wang, Y., Wang, D., Sun, F., Ning, J., Wan, X., & Zhang, J. (2016) · Scientific Reports · doi:10.1038/srep31703 · Cited by 62 · see citing works
Self-citationInoue, H., Hwang, S. H., Wecksler, A. T., Hammock, B. D., & Weiss, R. H. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.12.9.17680 · Cited by 59 · see citing works
Wang, D., Wei, Y., Wang, T., Wan, X., Yang, C. S., Reiter, R. J., & Zhang, J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12281 · Cited by 57 · see citing works
Self-citationSorafenib induces growth suppression in mouse models of gastrointestinal stromal tumor
Huynh, H. T., Lee, J. W. J., Chow, P. K. H., Ngo, V. C., Lew, G. B., Lam, I., Ong, H. S., Chung, A. Y. F., & Soo, K. C. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0553 · Cited by 57 · see citing works
Alonso‐González, C., González, A., Martínez‐Campa, C., Menéndez-Menéndez, J., Gómez‐Arozamena, J., García-Vidal, A., & Cos, S. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.10.015 · Cited by 56 · see citing works
James, K. D., Forester, S. C., & Lambert, J. D. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.12.009 · Cited by 53 · see citing works
Weiss, R. H., Marshall, D., Howard, L. L., Corbacho, A. M., Cheung, A., & Sawai, E. T. (2002) · Cancer Letters · doi:10.1016/s0304-3835(02)00495-0 · Cited by 48 · see citing works
Dong, R., Wang, D., Wang, X., Zhang, K., Chen, P., Yang, C. S., & Zhang, J. (2016) · Redox Biology · doi:10.1016/j.redox.2016.10.009 · Cited by 47 · see citing works
Self-citationTransactivation of gene expression by NF-κB is dependent on thioredoxin reductase activity
Heilman, J. M., Burke, T. J., McClain, C. J., & Watson, W. H. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.028 · Cited by 41 · see citing works
Enhanced Antitumor Therapy by Inhibition of p21waf1 in Human Malignant Mesothelioma
Lazzarini, R., Moretti, S., Orecchia, S., Betta, P., Procopio, A. D., & Catalano, A. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0255 · Cited by 35 · see citing works
Melatonin and its anti-glioma functions: a comprehensive review
Maitra, S., Bhattacharya, D., Das, S., & Bhattacharya, S. (2019) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0041 · Cited by 34 · see citing works
Zhang, K., Dong, R., Sun, K., Wang, X., Wang, J., Yang, C. S., & Zhang, J. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.09.027 · Cited by 31 · see citing works
Self-citationPossible association of thioredoxin and p53 in breast cancer
Ueno, M., Matsutani, Y., Nakamura, H., Masutani, H., Yagi, M., Yamashiro, H., Kato, H., Inamoto, T., Yamauchi, A., Takahashi, R., et al. (2000) · Immunology Letters · doi:10.1016/s0165-2478(00)00284-4 · Cited by 30 · see citing works
Involvement of protein kinase C in melatonin’s oncostatic effect in C6 glioma cells
Martín, V., Herrera, F., García-Santos, G., Antolín, I., Rodríguez-Blanco, J., Medina, M., & Rodríguez, C. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00468.x · Cited by 28 · see citing works
Holmgren, A. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.05.024 · Cited by 26 · see citing works
Hao, J., Li, Z., Zhang, C., Yu, W., Tang, Z., Li, Y., Xu, F., Gao, Y., Liu, Q., Huang, W., et al. (2017) · PubMed Central · Cited by 26 · see citing works
Sun, K., Wu, S., Wang, Y., Wan, X., Thompson, H. J., & Zhang, J. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.10.038 · Cited by 10 · see citing works
Self-citation
Flagged first, then by citations
4 of the 91 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Yu, R., Chen, H., He, J., Zhang, Z., Zhou, J., Zheng, Q., Fu, Z., Lu, C., Lin, Z., Caruso, F., et al. (2023) · Advanced Materials · doi:10.1002/adma.202307680 · Cited by 223 · see citing works
Minich, D. M., Henning, M., Darley, C., Fahoum, M., Schuler, C. B., & Frame, J. (2022) · Nutrients · doi:10.3390/nu14193934 · Cited by 176 · see citing works
Wang, J., Wang, X., He, Y., Jia, L., Yang, C. S., Reiter, R. J., & Zhang, J. (2019) · Cells · doi:10.3390/cells8080903 · Cited by 70 · see citing works
Self-citationPTEN/AKT/mTOR signaling mediates anticancer effects of epigallocatechin‑3‑gallate in ovarian cancer
Qin, J., Fu, M., Wang, J., Huang, F., Liu, H., Huangfu, M., Yu, D. S., Liu, H., Li, X., Guan, X., et al. (2020) · Oncology Reports · doi:10.3892/or.2020.7571 · Cited by 59 · see citing works
Natural anti-cancer products: insights from herbal medicine
Cui, D., Zhang, C., Zhang, L., Zheng, J., Wang, J., He, L., Jin, H., Kang, Q., Zhang, Y., Li, N., et al. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01124-y · Cited by 59 · see citing works
Self-citationMelatonin as an Antitumor Agent against Liver Cancer: An Updated Systematic Review
Fernández‐Palanca, P., Méndez‐Blanco, C., Fondevila, F., Tuñón, M. J., Reiter, R. J., Mauriz, J. L., & González‐Gallego, J. (2021) · Antioxidants · doi:10.3390/antiox10010103 · Cited by 51 · see citing works
Self-citationExploring the Mechanical Perspective of a New Anti-Tumor Agent: Melatonin
Rohilla, S., Singh, M., Priya, S., Almalki, W. H., Haniffa, S. B. M., Subramaniyan, V., Fuloria, S., Fuloria, N. K., Sekar, M., Singh, S. K., et al. (2022) · Journal of Environmental Pathology Toxicology and Oncology · doi:10.1615/jenvironpatholtoxicoloncol.2022042088 · Cited by 49 · see citing works
Melatonin, Its Metabolites and Their Interference with Reactive Nitrogen Compounds
Hardeland, R. (2021) · Molecules · doi:10.3390/molecules26134105 · Cited by 45 · see citing works
Zhang, Z., Hao, M., Zhang, X.-C., He, Y.-F., Chen, X.-S., Taylor, E., & Zhang, J. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.12.012 · Cited by 26 · see citing works
Self-citationMetabolic Anti-Cancer Effects of Melatonin: Clinically Relevant Prospects
Samec, M., Líšková, A., Koklesová, L., Zhai, K., Varghese, E., Samuel, S. M., Šudomová, M., Lučanský, V., Kassayová, M., Péč, M. J., et al. (2021) · Cancers · doi:10.3390/cancers13123018 · Cited by 33 · see citing works
EGCG-derived polymeric oxidation products enhance insulin sensitivity in db/db mice
Wu, X., Yang, M., He, Y., Wang, F., Kong, Y.-S., Ling, T.-J., & Zhang, J. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102259 · Cited by 33 · see citing works
Self-citationYang, L., Jia, L., Li, X., Zhang, K., Wang, X., He, Y., Hao, M., Rayman, M. P., & Zhang, J. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.132812 · Cited by 33 · see citing works
Self-citationWu, X., Wang, Y., Wang, D., Wang, Z., Yang, M., Yang, L., Wang, F., Wang, W., & Zhang, X. (2024) · Food & Function · doi:10.1039/d3fo05309a · Cited by 27 · see citing works
Self-citationLi, D., Cao, D., Cui, Y., Sun, Y., Jiang, J., & Cao, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1201085 · Cited by 27 · see citing works
Fan, L., He, Y., Xu, Y., Li, P., Zhang, J., & Zhao, J. H. (2020) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2020.1798891 · Cited by 26 · see citing works
Self-citationAmmar, O. A.-A., El-Missiry, M. A., Othman, A. I., & Amer, M. E. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e08837 · Cited by 21 · see citing works
l -Theanine Inhibits (−)-Epigallocatechin-3-gallate Oxidation via Chelating Copper
Jia, L., Wang, F., Zhang, K., Wang, D., Wang, X., Li, X., & Zhang, J. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c01379 · Cited by 20 · see citing works
Self-citationProspective Selective Mechanism of Emerging Senolytic Agents Derived from Flavonoids
Wang, Y., He, Y., Rayman, M. P., & Zhang, J. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c04379 · Cited by 20 · see citing works
Self-citationChen, L., Guo, X., Hu, Y., Li, L., Liang, G., & Zhang, G. (2020) · FEBS Open Bio · doi:10.1002/2211-5463.12905 · Cited by 17 · see citing works
Preparation and anticancer actions of CuET-nanoparticles dispersed by bovine serum albumin
He, Y., Yang, M., Yang, L., Hao, M., Wang, F., Li, X., Taylor, E. W., Zhang, X., & Zhang, J. (2023) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2023.113329 · Cited by 12 · see citing works
Self-citationInfluence of EGCG oxidation on inhibitory activity against the SARS-CoV-2 main protease
He, Y., Hao, M., Yang, M., Guo, H., Rayman, M. P., Zhang, X., & Zhang, J. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133451 · Cited by 8 · see citing works
Self-citationHartung, E. E., Mukhtar, S. Z., Shah, S. M., & Niles, L. P. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05482-8 · Cited by 7 · see citing works
Dopamine and its precursor levodopa inactivate SARS-CoV-2 main protease by forming a quinoprotein
Hao, M., He, Y., Song, T., Guo, H., Rayman, M. P., & Zhang, J. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.05.008 · Cited by 5 · see citing works
Self-citationLi, S., Chen, L., Li, Y., Xu, L., Chen, Y., & Ma, Y. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27021089 · Cited by 2 · see citing works
Smorodin, E. P., Chuzmarov, V., & Veidebaum, T. (2024) · Current Oncology · doi:10.3390/curroncol31040149 · Cited by 2 · see citing works
Wu, D.-Q., Zhang, Y., Tang, H., Yang, J., Li, M., Liu, H., & Li, Q. (2022) · PubMed Central · doi:10.12122/j.issn.1673-4254.2022.02.16 · Cited by 2 · see citing works
Preclinical and Clinical Studies on the Efficacy of Phytochemicals in Cancer Treatment
Yadav, S. K., Sharma, P., Kumar, M., Bhat, B., & Das, M. (2024) · Springer eBooks · doi:10.1007/978-981-97-8005-1_8 · Cited by 1 · see citing works
The role and therapeutical potential of melatonin in oncology practice
Еременко, И. И., Пономарев, В. Е., Борисовна, П. С., Богуш, Е. А., Kirsanov, V. Y., Zisman, B. A., & Давыдов, М. М. (2022) · Patologiya krovoobrashcheniya i kardiokhirurgiya · doi:10.21688/1681-3472-2022-1-44-54
Mazlum, M. E., Chabuk, H. A.-H., & Al-Hassnawi, A. T. S. (2026) · Journal of Parasitic Diseases · doi:10.1007/s12639-026-01993-6
Wu, X., Wang, F., Huang, X., Yang, M., He, Y., Zhang, J., & Wang, H. (2026) · Molecules · doi:10.3390/molecules31193536
Self-citation
- Authors
- Zhang, L., He, Y., Wu, X., Zhao, G., Zhang, K., Yang, C. S., Reiter, R. J., & Zhang, J.
- Affiliations
- Anhui Agricultural University (CN)
- Rutgers, The State University of New Jersey (US)
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Zhang, Jinsong
- ORCID
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2019-07-19
- Volume
- 8
- Issue
- 7
- Pages
- 745
- ISSN
- 2073-4409 (ISSN-L)
- PMC
- PMC6678710
- OpenAlex
- W2963099938
- Cited by
- 30
- References
- 91
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 4 · 2020: 4 · 2019: 1
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Cells (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (31771971 and 31170648)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- melatonin, epigallocatechin gallate, p21, quinoproteins, thioredoxin-1, thioredoxin reductase 1, hepatocellular carcinoma, tongue cancer, phosphatidylinositol 3-kinase, cyclooxygenase-2, heme oxygenase-1, Bcl-2, NF-κB, synergistic antitumor effect, cell migration, colony formation, hepatotoxicity
- MeSH terms
- Catechin, Cell Cycle, Humans, Melatonin, Neoplasms, Anticarcinogenic Agents, Cyclin-Dependent Kinase Inhibitor p21, Hep G2 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
