The DOI matches its Crossref record; 149 of the 149 references it cites were found in a registry or an index.
Immunotherapy, Inflammation and Colorectal Cancer
Open accessAbstract
Colorectal cancer (CRC) is the third most common cancer type, and third highest in mortality rates among cancer-related deaths in the United States. Originating from intestinal epithelial cells in the colon and rectum, that are impacted by numerous factors including genetics, environment and chronic, lingering inflammation, CRC can be a problematic malignancy to treat when detected at advanced stages. Chemotherapeutic agents serve as the historical first line of defense in the treatment of metastatic CRC. In recent years, however, combinational treatment with targeted therapies, such as vascular endothelial growth factor, or epidermal growth factor receptor inhibitors, has proven to be quite effective in patients with specific CRC subtypes. While scientific and clinical advances have uncovered promising new treatment options, the five-year survival rate for metastatic CRC is still low at about 14%. Current research into the efficacy of immunotherapy, particularly immune checkpoint inhibitor therapy (ICI) in mismatch repair deficient and microsatellite instability high (dMMR–MSI-H) CRC tumors have shown promising results, but its use in other CRC subtypes has been either unsuccessful, or not extensively explored. This Review will focus on the current status of immunotherapies, including ICI, vaccination and adoptive T cell therapy (ATC) in the treatment of CRC and its potential use, not only in dMMR–MSI-H CRC, but also in mismatch repair proficient and microsatellite instability low (pMMR-MSI-L).
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Cites
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Cited by
Hack, S. P., Zhu, A. X., & Wang, Y. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.598877 · Cited by 286
The Roles of Cloud-Based Systems on the Cancer-Related Studies: A Systematic Literature Review
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Identification of four novel hub genes as monitoring biomarkers for colorectal cancer
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Metadata
- Authors
- Lichtenstern, C. R., Ngu, R. K., Shalapour, S., & Karin, M.
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2020-03-04
- Volume
- 9
- Issue
- 3
- Pages
- 618
- ISSN
- 2073-4409 (ISSN-L)
- OpenAlex
- W3009619051
- Cited by
- 294
- References
- 149
- FWCI
- 14.03
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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