The DOI matches its Crossref record; 173 of the 173 references it cites were found in a registry or an index.
Myelin Fat Facts: An Overview of Lipids and Fatty Acid Metabolism
Open accessAbstract
Myelin is critical for the proper function of the nervous system and one of the most complex cell–cell interactions of the body. Myelination allows for the rapid conduction of action potentials along axonal fibers and provides physical and trophic support to neurons. Myelin contains a high content of lipids, and the formation of the myelin sheath requires high levels of fatty acid and lipid synthesis, together with uptake of extracellular fatty acids. Recent studies have further advanced our understanding of the metabolism and functions of myelin fatty acids and lipids. In this review, we present an overview of the basic biology of myelin lipids and recent insights on the regulation of fatty acid metabolism and functions in myelinating cells. In addition, this review may serve to provide a foundation for future research characterizing the role of fatty acids and lipids in myelin biology and metabolic disorders affecting the central and peripheral nervous system.
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“Components of the myelin sheath (52) exhibited pronounced molecular dysregulation in Ts21 oligodendrocytes (fig. S12B).”
From Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortex (2026) · cites this paper as [52]
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Oligodendroglia metabolically support axons and contribute to neurodegeneration
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Metadata
- Authors
- Poitelon, Y., Kopec, A. M., & Belin, S.
- Affiliations
- Albany Medical College (US)
- Corresponding author
- Belin, Sophie
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2020-03-27
- Volume
- 9
- Issue
- 4
- Pages
- 812
- ISSN
- 2073-4409 (ISSN-L)
- PMC
- PMC7226731
- OpenAlex
- W3013269049
- Cited by
- 394
- References
- 173
- Citations by year
- 2026: 71 · 2025: 84 · 2024: 87 · 2023: 68 · 2022: 47 · 2021: 32 · 2020: 4
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Cells (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS110627)
- Albany Medical College (Start-up grant)
- AMC - Department of Neuroscience and Experimental Therapeutics (Developmental Fellowship)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- myelin lipids, fatty acid metabolism, myelination, myelinating cells, lipogenesis, myelin sheath, central nervous system, peripheral nervous system
- MeSH terms
- Animals, Fatty Acids, Humans, Models, Biological, Myelin Sheath, Oxidation-Reduction, Lipid Metabolism
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