Type 1 Diabetes and Addison’s Disease: When the Diagnosis Is Suggested by the Continuous Glucose Monitoring System
Open accessAbstract
Our objective is to emphasize the important role of continuous glucose monitoring (CGM) in suggesting adrenal insufficiency in patients affected by type 1 diabetes. We describe an adolescent girl with type 1 diabetes and subsequent latent Addison’s disease diagnosed based on a recurrent hypoglycemic trend detected by CGM. In patients with type 1 diabetes, persistent unexplained hypoglycemic episodes at dawn together with reduced insulin requirement arouse souspicionof adrenal insufficiency. Adrenal insufficiency secondary to autoimmune Addison’s disease, even if rarely encountered among young patients, may be initially symptomless and characterized by slow progression up to acute adrenal crisis, which represents a potentially life-threatening condition. Besides glycometabolic assessment and adequate insulin dosage adjustment, type 1 diabetes needs prompt recognition of potentially associated autoimmune conditions. Among these, Addison’s disease can be suspected, although latent or paucisymptomatic, through periodic and careful evaluation of CGM data.
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A previously published case report described an adolescent girl with type 1 diabetes mellitus and subsequent latent Addison disease, diagnosed based on a recurrent hypoglycemic trend detected by continuous glucose monitoring.
“Recently, a case report described an adolescent girl with T1DM and subsequent latent AD, which was diagnosed based on a recurrent hypoglycemic trend detected by continuous glucose monitoring (CGM) [4].”
From Onset of Addison Disease in a Patient Using the Advanced Hybrid Closed-Loop MiniMed 780G: Diagnostic Challenges (2025) · cites this paper as [4]
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- Authors
- Vinci, F., d’Annunzio, G., Napoli, F., Bassi, M., Montobbio, C., Ferrando, G., & Minuto, N.
- Affiliations
- Istituto Giannina Gaslini (IT)
- Corresponding author
- Minuto, Nicola
- ORCID
- Venue
- Children
- Publisher
- MDPI AG
- Published
- 2021-08-14
- Volume
- 8
- Issue
- 8
- Pages
- 702
- ISSN
- 2227-9067 (ISSN-L)
- PMC
- PMC8391923
- OpenAlex
- W3193420991
- Cited by
- 9
- References
- 22
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 1
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Children (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion, other-oa)
- Funders
- Università degli Studi di Genova
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- type 1 diabetes, Addison's disease, adrenal insufficiency, continuous glucose monitoring, hypoglycemia, dawn phenomenon, autoimmune Addison's disease, adrenal crisis, adolescents
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