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Cited by 209melanin and skin pigmentationBioactive natural compoundsMelanoma and MAPK Pathways

The DOI matches its Crossref record; 245 of the 245 references it cites were found in a registry or an index.

Natural and Bioinspired Phenolic Compounds as Tyrosinase Inhibitors for the Treatment of Skin Hyperpigmentation: Recent Advances

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Panzella, Lucia, Napolitano, Alessandra·2019·Cosmetics
DOI 10.3390/cosmetics6040057
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Abstract

One of the most common approaches for control of skin pigmentation involves the inhibition of tyrosinase, a copper-containing enzyme which catalyzes the key steps of melanogenesis. This review focuses on the tyrosinase inhibition properties of a series of natural and synthetic, bioinspired phenolic compounds that have appeared in the literature in the last five years. Both mushroom and human tyrosinase inhibitors have been considered. Among the first class, flavonoids, in particular chalcones, occupy a prominent role as natural inhibitors, followed by hydroxystilbenes (mainly resveratrol derivatives). A series of more complex phenolic compounds from a variety of sources, first of all belonging to the Moraceae family, have also been described as potent tyrosinase inhibitors. As to the synthetic compounds, hydroxycinnamic acids and chalcones again appear as the most exploited scaffolds. Several inhibition mechanisms have been reported for the described inhibitors, pointing to copper chelating and/or hydrophobic moieties as key structural requirements to achieve good inhibition properties. Emerging trends in the search for novel skin depigmenting agents, including the development of assays that could distinguish between inhibitors and potentially toxic substrates of the enzyme as well as of formulations aimed at improving the bioavailability and hence the effectiveness of well-known inhibitors, have also been addressed.

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Research works printed but not linked: 2

  1. Vanitha, 2017, Isolation and characterisation of mushroom tyrosinase and screening of herbal extracts for anti-tyrosinase activity, Int. J. ChemTech Res., 10, 1156
  2. Bourquelot, 1895, La laccase dans les champignons, Compt. Rendus., 121, 783

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Metadata

Authors
Panzella, L., & Napolitano, A.
Affiliations
University of Naples Federico II (IT)
Corresponding author
Panzella, Lucia
ORCID
Venue
Cosmetics
Publisher
MDPI AG
Published
2019-10-01
Volume
6
Issue
4
Pages
57
ISSN
2079-9284 (ISSN-L)
DOI
10.3390/cosmetics6040057
OpenAlex
W2977872445
Cited by
208
References
245
Citations by year
2026: 16 · 2025: 32 · 2024: 38 · 2023: 44 · 2022: 36 · 2021: 26 · 2020: 16
FWCI
10.32
Type
journal article
Language
en
Open access
Licence
Locations
  • Cosmetics (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Keywords
tyrosinase inhibitors, hyperpigmentation, melanogenesis, phenolic compounds, chalcones, flavonoids, hydroxystilbenes, resveratrol derivatives, Moraceae, hydroxycinnamic acids, copper chelation, enzyme inhibition mechanism, bioavailability

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