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Cited by 14Skin Protection and AgingMedicinal Plant ResearchWound Healing and Treatments

The Potential of Sky Fruit as an Anti-Aging and Wound Healing Cosmeceutical Agent

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Mahendra, Camille Keisha, Tan, Loh Teng Hern, Mahendra, Cayvern Kishen, Ser, Hooi-Leng, Pusparajah, Priyia, Htar, Thet Thet, Chuah, Lay-Hong, Yap, Wei Hsum +4 more·2021·Cosmetics
DOI 10.3390/cosmetics8030079
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Abstract

There are many extrinsic factors that can contribute to the premature aging of the skin. In recent years, the demand for natural cosmetic from the general population has noticeable grow. Therefore, this research aimed to investigate the bioproperties of sky fruit (Swietenia macrophylla) seed extract that could help to inhibit premature skin aging. Firstly, the extract and its fractions were tested on HaCaT cells for their wound healing properties. The presence of sky fruit’s extract and its fractions on scratch wound significantly improved cellular proliferation, migration, and closure of the wound. These effects were distinctly observed following the treatment with S. macrophylla hexane fraction (SMHF) and S. macrophylla water fraction (SMWF). Our continuous research study revealed that SMWF had antioxidant properties, which might be one of the factors contributing to its emerging wound healing properties because antioxidants are known to act as suppressors of the inflammatory pathway and aid the transition towards cell proliferation. In addition, all samples had critical wavelengths that indicated that they were able to absorb the whole UVB range and some parts of the UVA wavelength. This suggested that S. macrophylla might contain potential photoprotective bioactive compounds, which could be developed into anti-UVB photoprotective sunscreens. Thus, this warrants further studies focusing on isolation and identifications of the bioactive compounds responsible for both its photoprotective and wound healing properties. A deeper study on mechanisms of the pathways that were affected by these compounds should be conducted as well to better understand this natural product and develop it into a potential cosmeceutical ingredient.

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  • Phytochemicals derived from plants showed skin beneficial properties related to UV protection, anti-oxidant action, matrix protection, and skin hydration.

    “In addition, phytochemicals derived from plants showed skin beneficial properties related to UV protection, anti-oxidant action, matrix protection, and skin hydration [31,32].”

    From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [32]

    The Abstract and §3.3 report UV absorption by sky-fruit seed extracts and antioxidant activity in one fraction, supporting those parts of the claim. The Introduction mentions pro-collagen properties of natural cosmetic ingredients, but the paper does not establish matrix protection or skin hydration for the extracts; its findings also concern a specific plant rather than plant phytochemicals generally. No page number is available in our copy. (LLM, conf=0.87)

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Authors
Mahendra, C. K., Tan, L. T. H., Mahendra, C. K., Ser, H.-L., Pusparajah, P., Htar, T. T., Chuah, L.-H., Yap, W. H., Tang, S. Y., Ming, L. C., Yow, Y.-Y., & Goh, B. H.
Affiliations
  • Monash University Malaysia (MY)
  • Taylor's University (MY)
  • Universiti Brunei Darussalam (BN)
  • Sunway University (MY)
Corresponding author
  • Yow, Yoon-Yen
  • Goh, Bey Hing
ORCID
Venue
Cosmetics
Publisher
MDPI AG
Published
2021-08-31
Volume
8
Issue
3
Pages
79
ISSN
2079-9284 (ISSN-L)
DOI
10.3390/cosmetics8030079
OpenAlex
W3196435762
Cited by
14
References
59
Citations by year
2026: 4 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 1
FWCI
2.00
Type
journal article
Language
en
Open access
Licence
Locations
  • Cosmetics (publishedVersion, cc-by)
  • Monash University Research Portal (Monash University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Taylor’s University Emerging Grant (TRGS/ERFS/2/2018/SBS/016)
  • External Industry Grants from Biotek Abadi Sdn Bhd (vote no. GBA-81811A)
  • Monash Global Asia in the 21st Century (GA21) research grant (GA-HW-19-L01 & GA-HW-19-S02)
  • Fundamental Research Grant Scheme (FRGS/1/2019/WAB09/MUSM/02/1 and FRGS/1/2019/SKK08/TAYLOR/02/2)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Keywords
Swietenia macrophylla, seed extract, anti-aging, wound healing, cosmeceuticals, skin aging, HaCaT keratinocytes, cell migration, cell proliferation, antioxidant activity, photoprotection, UVB absorption, sunscreen ingredients, natural cosmetics

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