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Cited by 25Peripheral Neuropathies and DisordersPain Mechanisms and TreatmentsHereditary Neurological Disorders

A Systematic Review of the Diagnostic Methods of Small Fiber Neuropathies in Rehabilitation

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Chiaramonte, Rita, Romano, Marcello, Vecchio, Michele·2020·Diagnostics
DOI 10.3390/diagnostics10090613PMC PMC7554909
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Abstract

This systematic review describes the several methods to diagnose and measure the severity of small fiber neuropathies and aims to guide the physician to define all the diagnostic approaches for adopting the best strategies described in the current literature. The search was conducted in PubMed, EMBASE, Cochrane Library and Web of Science. Two reviewers independently reviewed and came to consensus on which articles met inclusion/exclusion criteria. The authors excluded all the duplicates, animals’ studies, and included the English articles in which the diagnostic measures were finalized to assess the effectiveness of rehabilitation and pharmacologic treatment of patients with small fiber neuropathies. The search identified a total of 975 articles with the keywords “small fiber neuropathy” AND “rehabilitation” OR “therapy” OR “treatment”. Seventy-eight selected full-text were analyzed by the reviewers. Forty-one publications met the inclusion criteria and were included in the systematic review. Despite the range of diagnostic tools for the assessment of small fiber neuropathy, other robust trials are needed. In addition, always different diagnostic approaches are used, a unique protocol could be important for the clinicians. More research is needed to build evidence for the best diagnostic methodologies and to delineate a definitive diagnostic protocol.

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  • Diversity in professional practice contributes to heterogeneity in the literature, as treatment outcomes are shaped by differences in clinical approach, underlying etiology, and involvement of structures such as joints, muscles, and neuropathic components.

    “This diversity contributes to heterogeneity in the literature, as treatment outcomes are shaped by differences in clinical approach [15,16], underlying etiology, and involvement of structures such as joints (TMJ or spine), muscles, and neuropathic components – factors that complicate differential diagnosis [17,18].”

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Authors
Chiaramonte, R., Romano, M., & Vecchio, M.
Affiliations
  • University of Catania (IT)
  • Ospedale Vincenzo Cervello (IT)
Corresponding author
  • Chiaramonte, Rita
  • Vecchio, Michele
ORCID
Venue
Diagnostics
Publisher
MDPI AG
Published
2020-08-20
Volume
10
Issue
9
Pages
613
ISSN
2075-4418 (ISSN-L)
DOI
10.3390/diagnostics10090613
PMC
PMC7554909
OpenAlex
W3051970228
Cited by
25
References
2
Citations by year
2026: 4 · 2025: 8 · 2024: 5 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2
FWCI
0.22
Type
journal article
Language
en
Open access
Licence
Locations
  • Diagnostics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Keywords
small fiber neuropathy, diagnostic methods, rehabilitation, pharmacotherapy, diagnostic protocol, peripheral neuropathy

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