The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy
Open accessAbstract
Unlabelled Although exercise can significantly reduce the prevalence and severity of diabetic complications, no studies have evaluated the impact of exercise on nerve function in people with diagnosed diabetic peripheral neuropathy (DPN). The purpose of this pilot study was to examine feasibility and effectiveness of a supervised, moderately intense aerobic and resistance exercise program in people with DPN. We hypothesized that the exercise intervention can improve neuropathic symptoms, nerve function, and cutaneous innervation.Methods A pre-test post-test design was used to assess change in outcome measures following participation in a 10-week aerobic and strengthening exercise program. Seventeen subjects with diagnosed DPN (8 males/9 females; age 58.4±5.98; duration of diabetes 12.4±12.2 years) completed the study. Outcome measures included pain measures (visual analog scale), Michigan Neuropathy Screening Instrument (MNSI) questionnaire of neuropathic symptoms, nerve function measures, and intraepidermal nerve fiber (IENF) density and branching in distal and proximal lower extremity skin biopsies.Results Significant reductions in pain (-18.1±35.5 mm on a 100 mm scale, P=.05), neuropathic symptoms (-1.24±1.8 on MNSI, P=.01), and increased intraepidermal nerve fiber branching (+0.11±0.15 branch nodes/fiber, P=.008) from a proximal skin biopsy were noted following the intervention.Conclusions This is the first study to describe improvements in neuropathic and cutaneous nerve fiber branching following supervised exercise in people with diabetic peripheral neuropathy. These findings are particularly promising given the short duration of the intervention, but need to be validated by comparison with a control group in future studies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Most foot ulcerations have a neuropathic component and can be prevented by foot care such as daily inspection, nail and skin care, deformity correction, and appropriate footwear.
“Most foot ulcerations have a neuropathic component577 and are preventable by foot care that includes daily inspection, nail and skin care, correction of foot deformities, and/or provision of appropriate footwear to accommodate structural changes.578”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [578]
The introductory passage says diabetic peripheral neuropathy increases susceptibility to lower-extremity injury and amputation, but does not say that most foot ulcers have a neuropathic component. The Methods and Outcomes passages do not address whether the listed foot-care measures prevent ulcers; searches for both parts of the claim found no supporting passage in our copy. (LLM, conf=0.74)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works
Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1047 · Cited by 15,297 · see citing works
Pharmacological interventions for somatoform disorders in adults
Kleinstäuber, M., Witthöft, M., Steffanowski, A., van Marwijk, H., Hiller, W., & Lambert, M. J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010628.pub2 · Cited by 11,361 · see citing works
Foundations of Clinical Research: Applications to Practice,
(2002) · Survey of Ophthalmology · doi:10.1016/s0039-6257(02)00362-4 · Cited by 9,485 · see citing works
(2014) · Medical Entomology and Zoology · Cited by 9,400 · see citing works
Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
(2005) · New England Journal of Medicine · doi:10.1056/nejmoa052187 · Cited by 5,138 · see citing works
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,012 · see citing works
Vinik, A. I., Maser, R. E., Mitchell, B. D., & Freeman, R. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1553 · Cited by 2,044 · see citing works
Boulton, A. J. M., Vinik, A. I., Arezzo, J. C., Bril, V., Feldman, E. L., Freeman, R., Malik, R. A., Maser, R. E., Sosenko, J. M., & Ziegler, D. (2005) · Diabetes Care · doi:10.2337/diacare.28.4.956 · Cited by 1,859 · see citing works
Orchard, T. J., Temprosa, M., Goldberg, R., Haffner, S., Ratner, R., Marcovina, S., Fowler, S., & for the Diabetes Prevention Program Research Group (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-8-200504190-00009 · Cited by 948 · see citing works
Foundations of clinical research : applications to practice, 2nd ed.
Portney, L. G. (2000) · Cited by 936 · see citing works
Exercise for type 2 diabetes mellitus
Thomas, D., Elliott, E. J., & Naughton, G. A. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002968.pub2 · Cited by 728 · see citing works
Lifestyle intervention for pre-diabetic neuropathy
Smith, A. G., Russell, J., Feldman, E. L., Goldstein, J., Peltier, A., Smith, S., Hamwi, J., Pollari, D., Bixby, B., Howard, J., et al. (2006) · Diabetes Care · doi:10.2337/dc06-0224 · Cited by 585 · see citing works
Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study
Lauria, G., Bakkers, M., Schmitz, C., Lombardi, R., Penza, P., Devigili, G., Smith, A. G., Hsieh, S., Mellgren, S. I., Umapathi, T., et al. (2010) · Journal of the Peripheral Nervous System · doi:10.1111/j.1529-8027.2010.00271.x · Cited by 518 · see citing works
Dyck, P. J., Albers, J. W., Andersen, H., Arezzo, J. C., Biessels, G. J., Bril, V., Feldman, E. L., Litchy, W. J., O’Brien, P. C., Russell, J. W., et al. (2011) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1226 · Cited by 502 · see citing works
Maiorana, A., O’Driscoll, G., Cheetham, C., Dembo, L. G., Stanton, K. G., Goodman, C., Taylor, R. R., & GREEN, D. J. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01439-5 · Cited by 481 · see citing works
Diet and Exercise Among Adults With Type 2 Diabetes
Nelson, K. M., Reiber, G., & Boyko, E. J. (2002) · Diabetes Care · doi:10.2337/diacare.25.10.1722 · Cited by 442 · see citing works
Exercise training can modify the natural history of diabetic peripheral neuropathy
Balducci, S., Iacobellis, G., Parisi, L., Di Biase, N., Calandriello, E., Leonetti, F., & Fallucca, F. (2006) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2005.07.005 · Cited by 427 · see citing works
The anti-inflammatory effects of exercise training in patients with type 2 diabetes mellitus
Kadoglou, N. P. E., Iliadis, F., Angelopoulou, N., Perrea, D., Ampatzidis, G., Liapis, C. D., & Alevizos, M. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3282efaf50 · Cited by 337 · see citing works
Mueller, M. J., Minor, S. D., Sahrmann, S. A., Schaaf, J. A., & Strube, M. (1994) · Physical Therapy · doi:10.1093/ptj/74.4.299 · Cited by 333 · see citing works
Davidson, L. E., Hudson, R., Kilpatrick, K., Kuk, J. L., McMillan, K., Janiszewski, P. M., Lee, S., Lam, M., & Ross, R. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2008.558 · Cited by 297 · see citing works
Neurotrophins and their receptors: roles in plasticity, neurodegeneration and neuroprotection
Hennigan, A., O'Callaghan, R., & Kelly, A. M. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350424 · Cited by 245 · see citing works
Sinnreich, M., Taylor, B. V., & Dyck, P. J. B. (2005) · The Neurologist · doi:10.1097/01.nrl.0000156314.24508.ed · Cited by 207 · see citing works
Thurman, D. J., Stevens, J. A., & Rao, J. K. (2008) · Neurology · doi:10.1212/01.wnl.0000299085.18976.20 · Cited by 201 · see citing works
Diabetes, Vestibular Dysfunction, and Falls
Agrawal, Y., Carey, J. P., Santina, C. C. D., Schubert, M. C., & Minor, L. B. (2010) · Otology & Neurotology · doi:10.1097/mao.0b013e3181f2f035 · Cited by 175 · see citing works
Song, C. H., PETROFSKY, J. S., Lee, S., Lee, K. J., & Yim, J. (2011) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2011.0036 · Cited by 157 · see citing works
Exercise for people with peripheral neuropathy
White, C. M., Pritchard, J., & Turner‐Stokes, L. F. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003904.pub2 · Cited by 146 · see citing works
New insights into the pathogenesis of diabetic neuropathy
Feldman, E. L., Russell, J. W., Sullivan, K. A., & Golovoy, D. (1999) · Current Opinion in Neurology · doi:10.1097/00019052-199910000-00009 · Cited by 114 · see citing works
daCosta DiBonaventura, M., Cappelleri, J. C., & Joshi, A. V. (2011) · Pain Medicine · doi:10.1111/j.1526-4637.2010.01012.x · Cited by 112 · see citing works
Effect of Exercise Training on Physical Fitness in Type II Diabetes Mellitus
Larose, J., Sigal, R. J., Boulé, N. G., Wells, G. A., Prud’homme, D., Fortier, M., Reid, R. D., Tulloch, H. E., Coyle, D., Phillips, P., et al. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181d322dd · Cited by 88 · see citing works
Novel exercise protocol suitable for use on a treadmill or a bicycle ergometer.
Northridge, D. B., Grant, S., Ford, I., Christie, J., McLenachan, J. M., Connelly, D. M., McMurray, J. J. V., Ray, S. G., Henderson, E., & Dargie, H. J. (1990) · Heart · doi:10.1136/hrt.64.5.313 · Cited by 78 · see citing works
Sigal, R. J., Kenny, G. P., Boulé, N. G., Wells, G. A., Prud'homme, D., Fortier, M., Reid, R. D., Tulloch, H., Coyle, D., Phillips, P., et al. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-6-200709180-00005 · Cited by 48 · see citing works
Kirtane, M. V., de Souza, C. E., Sanna, M., Devaiah, A. K., Kirtane, M. V., de Souza, C. E., Bantwal, A. R., Bewley, A. F., Beyea, J. A., Brackmann, D. E., et al. (2013) · Thieme eBooks · doi:10.1055/b-002-80414 · Cited by 36 · see citing works
Mandrekar, S. J., & Mandrekar, J. N. (2003) · Statistical Methods in Medical Research · doi:10.1191/0962280203sm346oa · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Colloca, L., Ludman, T., Bouhassira, D., Baron, R., Dickenson, A. H., Yarnitsky, D., Freeman, R. L., Truini, A., Attal, N., Finnerup, N. B., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.2 · Cited by 2,209 · see citing works
Feldman, E. L., Callaghan, B. C., Pop-Busui, R., Zochodne, D. W., Wright, D. E., Bennett, D. L., Bril, V., Russell, J. W., & Viswanathan, V. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0092-1 · Cited by 1,697 · see citing works
Self-citationSelvarajah, D., Kar, D., Khunti, K. K., Davies, M. J., Scott, A. R., Walker, J., & Tesfaye, S. H. (2019) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(19)30081-6 · Cited by 576 · see citing works
Blonde, L., Umpierrez, G. E., Reddy, S. S., McGill, J. B., Berga, S. L., Bush, M., Chandrasekaran, S., DeFronzo, R. A., Einhorn, D., Galindo, R. J., et al. (2022) · Endocrine Practice · doi:10.1016/j.eprac.2022.08.002 · Cited by 507 · see citing works
Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy
Sloan, G., Selvarajah, D., & Tesfaye, S. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00496-z · Cited by 534 · see citing works
Diabetic Neuropathy: Mechanisms, Emerging Treatments, and Subtypes
Albers, J. W., & Pop‐Busui, R. (2014) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-014-0473-5 · Cited by 365 · see citing works
A Mechanism-Based Approach to Physical Therapist Management of Pain
Chimenti, R. L., Frey-Law, L. A., & Sluka, K. A. (2018) · Physical Therapy · doi:10.1093/ptj/pzy030 · Cited by 300 · see citing works
Diabetic neuropathy: cutting-edge research and future directions
Yang, Y., Zhao, B. T., Wang, Y., Lan, H. H., Liu, X., Hu, Y., & Cao, P. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02175-1 · Cited by 285 · see citing works
Peltier, A., Goutman, S. A., & Callaghan, B. C. (2014) · BMJ · doi:10.1136/bmj.g1799 · Cited by 233 · see citing works
Hewston, P. A., & Deshpande, N. (2016) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2015.08.005 · Cited by 205 · see citing works
Advances in Screening, Early Diagnosis and Accurate Staging of Diabetic Neuropathy
Carmichael, J., Fadavi, H., Ishibashi, F., Shore, A. C., & Tavakoli, M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.671257 · Cited by 190 · see citing works
Molecular mechanisms of exercise contributing to tissue regeneration
Chen, J., Zhou, R. J., Ye, F., & Cheng, L. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01233-2 · Cited by 173 · see citing works
Metabolic syndrome and peripheral neuropathy
Kazamel, M., Stino, A. M., & Smith, A. G. (2020) · Muscle & Nerve · doi:10.1002/mus.27086 · Cited by 164 · see citing works
Diabetic neuropathy: what does the future hold?
Callaghan, B. C., Gallagher, G., Fridman, V., & Feldman, E. L. (2020) · Diabetologia · doi:10.1007/s00125-020-05085-9 · Cited by 170 · see citing works
Smith, S. M., Dworkin, R. H., Turk, D. C., Baron, R., Polydefkis, M. J., Tracey, I., Borsook, D., Edwards, R. R., Harris, R. E., Wager, T. D., et al. (2017) · Journal of Pain · doi:10.1016/j.jpain.2017.02.429 · Cited by 151 · see citing works
Impact of Diabetic Complications on Balance and Falls: Contribution of the Vestibular System
D’Silva, L. J., Lin, Y.-C., Staecker, H., Whitney, S. L., & Kluding, P. M. (2015) · Physical Therapy · doi:10.2522/ptj.20140604 · Cited by 149 · see citing works
Self-citationBobinski, F., Teixeira, J. M., Sluka, K. A., & Santos, A. R. S. (2017) · Pain · doi:10.1097/j.pain.0000000000001109 · Cited by 151 · see citing works
Khawaja, N. M., Abu-Shennar, J. A., Saleh, M., Dahbour, S. S., Khader, Y. S., & Ajlouni, K. M. (2018) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-018-0309-6 · Cited by 148 · see citing works
Early Detection of Diabetic Peripheral Neuropathy: A Focus on Small Nerve Fibres
Burgess, J., Frank, B., Marshall, A. G., Khalil, R. S., Ponirakis, G., Petropoulos, I. N., Cuthbertson, D. J., Malik, R. A., & Alam, U. (2021) · Diagnostics · doi:10.3390/diagnostics11020165 · Cited by 149 · see citing works
Treatment of diabetic peripheral neuropathy: a review
Khdour, M. R. (2020) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13241 · Cited by 143 · see citing works
BMI, Lifestyle Factors and Taxane-Induced Neuropathy in Breast Cancer Patients: The Pathways Study
Greenlee, H., Hershman, D. L., Shi, Z., Kwan, M. L., Ergas, I. J., Roh, J. M., & Kushi, L. H. (2016) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djw206 · Cited by 135 · see citing works
Benefits of exercise intervention in reducing neuropathic pain
Dobson, J. L., McMillan, J. L., & Li, L. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00102 · Cited by 131 · see citing works
Exercise increases cutaneous nerve density in diabetic patients without neuropathy
Singleton, J. R., Marcus, R. L., Jackson, J. E., K. Lessard, M., Graham, T. E., & Smith, A. G. (2014) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.125 · Cited by 127 · see citing works
de Almeida, C. A. S., Demaman, A. S., Kusuda, R., Cadetti, F., Ravanelli, M. I. B., Queiroz, A. L., Sousa, T. A. E., Zanon, S., Silveira, L. R., & Lucas, G. (2015) · Pain · doi:10.1097/01.j.pain.0000460339.23976.12 · Cited by 127 · see citing works
Dixit, S., Maiya, A. G., & Shastry, B. A. (2014) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.12.006 · Cited by 124 · see citing works
Supervised exercise improves cutaneous reinnervation capacity in metabolic syndrome patients
Singleton, J. R., Marcus, R. L., Lessard, M. K., Jackson, J. E., & Smith, A. G. (2014) · Annals of Neurology · doi:10.1002/ana.24310 · Cited by 120 · see citing works
Exercise improves cardiac autonomic function in obesity and diabetes
Voulgari, C., Pagoni, S., Vinik, A. I., & Poirier, P. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.005 · Cited by 118 · see citing works
Physical Training and Activity in People With Diabetic Peripheral Neuropathy: Paradigm Shift
Kluding, P. M., Bareiss, S. K., Hastings, M. K., Marcus, R. L., Sinacore, D. R., & Mueller, M. J. (2016) · Physical Therapy · doi:10.2522/ptj.20160124 · Cited by 117 · see citing works
Self-citationSedentary behaviour as a new behavioural target in the prevention and treatment of type 2 diabetes
Henson, J. J., Dunstan, D. W., Davies, M. J., & Yates, T. E. (2016) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2759 · Cited by 113 · see citing works
Morrison, S., Colberg, S. R., Parson, H. K., & Vinik, A. I. (2014) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2014.04.007 · Cited by 110 · see citing works
Emerging Relationships between Exercise, Sensory Nerves, and Neuropathic Pain
Cooper, M. A., Kluding, P. M., & Wright, D. E. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00372 · Cited by 105 · see citing works
Self-citationManagement of diabetic neuropathy
Cernea, S., & Raz, I. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154867 · Cited by 102 · see citing works
Pasnoor, M., Dimachkie, M. M., Kluding, P. M., & Barohn, R. J. (2013) · Neurologic Clinics · doi:10.1016/j.ncl.2013.02.004 · Cited by 101 · see citing works
Self-citationExercise-mediated improvements in painful neuropathy associated with prediabetes in mice
Groover, A. L., Ryals, J. M., Guilford, B. L., Wilson, N. M., Christianson, J. A., & Wright, D. E. (2013) · Pain · doi:10.1016/j.pain.2013.07.052 · Cited by 102 · see citing works
Self-citationDeclining Skeletal Muscle Function in Diabetic Peripheral Neuropathy
Parasoglou, P., Rao, S., & Slade, J. M. (2017) · Clinical Therapeutics · doi:10.1016/j.clinthera.2017.05.001 · Cited by 104 · see citing works
Physical activity and dietary interventions in diabetic neuropathy: a systematic review
Zilliox, L. A., & Russell, J. W. (2019) · Clinical Autonomic Research · doi:10.1007/s10286-019-00607-x · Cited by 92 · see citing works
Vinik, A. I., Camacho, P. M., Reddy, S. S. K., Valencia, W. M., Trence, D., Matsumoto, A. M., & Morley, J. E. (2017) · Endocrine Practice · doi:10.4158/ep171794.ra · Cited by 89 · see citing works
Diabetic Peripheral Neuropathy: Should a Chaperone Accompany Our Therapeutic Approach?
Farmer, K. L., Li, C., & Dobrowsky, R. T. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005314 · Cited by 88 · see citing works
Self-citationExercise and Neuropathic Pain: A General Overview of Preclinical and Clinical Research
Leitzelar, B. N., & Koltyn, K. F. (2021) · Sports Medicine - Open · doi:10.1186/s40798-021-00307-9 · Cited by 84 · see citing works
Venkataraman, K., Tai, B. C., Khoo, E. Y. H., Tavintharan, S., Chandran, K., Hwang, S. W., Phua, M. S. L. A., Wee, H. L., Koh, G. C. H., & Tai, E. S. (2019) · Diabetologia · doi:10.1007/s00125-019-04979-7 · Cited by 81 · see citing works
Hammond, E. A., Pitz, M. W., Steinfeld, K., Lambert, P. J., & Shay, B. L. (2020) · Neurorehabilitation and neural repair · doi:10.1177/1545968319899918 · Cited by 81 · see citing works
Falls Risk in Older Adults with Type 2 Diabetes
Vinik, A. I., Vinik, E. J., Colberg, S. R., & Morrison, S. (2014) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2014.09.002 · Cited by 81 · see citing works
Stino, A. M., Rumora, A. E., Kim, B., & Feldman, E. L. (2020) · Journal of the Peripheral Nervous System · doi:10.1111/jns.12387 · Cited by 78 · see citing works
Dietary reversal of neuropathy in a murine model of prediabetes and the metabolic syndrome
Hinder, L. M., O’Brien, P. D., Hayes, J. M., Backus, C., Solway, A. P., Sims‐Robinson, C., & Feldman, E. L. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.028530 · Cited by 75 · see citing works
Exercise-based rehabilitation for cancer survivors with chemotherapy-induced peripheral neuropathy
McCrary, J. M., Goldstein, D., Sandler, C. X., Barry, B. K., Marthick, M., Timmins, H. C., Li, T., Horvath, L. G., Grimison, P., & Park, S. B. (2019) · Supportive Care in Cancer · doi:10.1007/s00520-019-04680-w · Cited by 74 · see citing works
Pattern-Recognition Approach to Neuropathy and Neuronopathy
Barohn, R. J., & Amato, A. A. (2013) · Neurologic Clinics · doi:10.1016/j.ncl.2013.02.001 · Cited by 74 · see citing works
Huneif, M. A., Alshehri, D. B., Alshaibari, K. S., Dammaj, M. Z., Mahnashi, M. H., Majid, S. U., Javed, M. A., Ahmad, S., Rashid, U., & Sadiq, A. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113038 · Cited by 72 · see citing works
Gholami, F., Nikookheslat, S. D., Salekzamani, Y., Boulé, N. G., & Jafari, A. (2018) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2018.03.001 · Cited by 71 · see citing works
Crews, R. T., Schneider, K. L., Yalla, S. V., Reeves, N. D., & Vileikytė, L. (2016) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2817 · Cited by 70 · see citing works
Villafaina, S., Collado‐Mateo, D., García, J. P. F., Merellano-Navarro, E., & Gusi, N. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0941-9 · Cited by 70 · see citing works
Diagnosis and management of sensory polyneuropathy
Gwathmey, K. G., & Pearson, K. (2019) · BMJ · doi:10.1136/bmj.l1108 · Cited by 72 · see citing works
Advances About Immunoinflammatory Pathogenesis and Treatment in Diabetic Peripheral Neuropathy
Xue, T., Zhang, X., Xing, Y., Liu, S., Zhang, L., Wang, X., & Min, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.748193 · Cited by 68 · see citing works
Kanchanasamut, W., & Pensri, P. (2017) · Diabetic Foot & Ankle · doi:10.1080/2000625x.2017.1287239 · Cited by 66 · see citing works
Kluding, P. M., Pasnoor, M., Singh, R., D’Silva, L. J., Yoo, M., Billinger, S. A., LeMaster, J. W., Dimachkie, M. M., Herbelin, L. L., & Wright, D. E. (2014) · Physical Therapy · doi:10.2522/ptj.20140108 · Cited by 66 · see citing works
Self-citationExercise as Therapy for Diabetic and Prediabetic Neuropathy
Singleton, J. R., Smith, A. G., & Marcus, R. L. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0682-6 · Cited by 66 · see citing works
Physiology in Medicine: neuromuscular consequences of diabetic neuropathy
Allen, M. D., Doherty, T. J., Rice, C. L., & Kimpinski, K. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00733.2015 · Cited by 66 · see citing works
Francia, P., Gulisano, M., Anichini, R., & Seghieri, G. (2014) · Current Diabetes Reviews · doi:10.2174/1573399810666140507112536 · Cited by 64 · see citing works
Seyedizadeh, S. H., Cheragh-Birjandi, S., & Nia, M. R. H. (2020) · Journal of Diabetes Research · doi:10.1155/2020/6978128 · Cited by 64 · see citing works
Malik, R. A., Aldinc, E., Chan, S.-P., Deerochanawong, C., Hwu, C., Rosales, R. L., Yeung, C., Fujii, K., & Parsons, B. (2017) · Advances in Therapy · doi:10.1007/s12325-017-0536-5 · Cited by 59 · see citing works
The Application of Exercise Training for Diabetic Peripheral Neuropathy
Holmes, C. J., & Hastings, M. K. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10215042 · Cited by 62 · see citing works
Chung, K., Park, S. B., Streckmann, F., Wiskemann, J., Mohile, N. A., Kleckner, A. S., Colloca, L., Dorsey, S. G., & Kleckner, I. R. (2022) · Cancers · doi:10.3390/cancers14051224 · Cited by 95 · see citing works
Morrison, S., Simmons, R., Colberg, S. R., Parson, H. K., & Vinik, A. I. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.11.004 · Cited by 56 · see citing works
Low-Dose Pulsatile Interleukin-6 As a Treatment Option for Diabetic Peripheral Neuropathy
Cox, A., Sagot, Y., Hédou, G., Grek, C. L., Wilkes, T., Vinik, A. I., & Ghatnekar, G. S. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00089 · Cited by 53 · see citing works
Electrophysiological measurements of diabetic peripheral neuropathy: A systematic review
Shabeeb, D., Najafi, M., Hasanzadeh, G., Hadian, M. R., Musa, A., & Shirazi, A. (2018) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2018.03.026 · Cited by 53 · see citing works
Painful Diabetic Peripheral Neuropathy: Practical Guidance and Challenges for Clinical Management
Preston, F., Riley, D. R. J., Azmi, S., & Alam, U. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s370050 · Cited by 60 · see citing works
van Laake-Geelen, C. C. M., Smeets, R. J. E. M., Quadflieg, S. P. A. B., Kleijnen, J., & Verbunt, J. A. (2019) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2019-0001 · Cited by 51 · see citing works
Consensus on the diagnosis and management of chronic leg ulcers - Brazilian Society of Dermatology
Abbade, L. P. F., Frade, M. A. C., Pegas, J. R. P., Granja, P. D., Garcia, L. C., Filho, R. B., & Parenti, C. E. F. (2020) · Anais Brasileiros de Dermatologia · doi:10.1016/j.abd.2020.06.002 · Cited by 49 · see citing works
From treatment to preventive actions: improving function in patients with diabetic polyneuropathy
Sacco, I. D. C. N., & Sartor, C. D. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2737 · Cited by 48 · see citing works
Ahmad, I., Verma, S., Noohu, M. M., Shareef, M. Y., & Hussain, M. E. (2020) · PubMed Central · Cited by 46 · see citing works
Fernyhough, P., & McGavock, J. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53480-4.00027-8 · Cited by 47 · see citing works
Monteiro, R. L., Sartor, C. D., Ferreira, J. S. S. P., Dantas, M. G. B., Bus, S. A., & Sacco, I. D. C. N. (2018) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-018-2323-0 · Cited by 50 · see citing works
Mendlik, M. T., & Uritsky, T. J. (2015) · Current Treatment Options in Neurology · doi:10.1007/s11940-015-0381-2 · Cited by 44 · see citing works
Abdissa, D., Hamba, N., Kene, K., Bedane, D. A., Etana, G., Muleta, D., & Gerbi, A. (2020) · Journal of Diabetes Research · doi:10.1155/2020/9562920 · Cited by 45 · see citing works
An exercise regimen prevents development paclitaxel induced peripheral neuropathy in a mouse model
Park, J. S., Kim, S., & Höke, A. (2015) · Journal of the Peripheral Nervous System · doi:10.1111/jns.12109 · Cited by 41 · see citing works
Cox, E. R., Gajanand, T., Burton, N. W., Coombes, J. S., & Coombes, B. K. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108168 · Cited by 39 · see citing works
Alternative Quantitative Tools in the Assessment of Diabetic Peripheral and Autonomic Neuropathy
Vinik, A. I., CASELLINI, C. M., & Névoret, M. L. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.03.010 · Cited by 37 · see citing works
Neuropathic Pain in Taxane-Induced Peripheral Neuropathy: Evidence for Exercise in Treatment
Hammond, E. A., Pitz, M. W., & Shay, B. L. (2019) · Neurorehabilitation and neural repair · doi:10.1177/1545968319860486 · Cited by 38 · see citing works
Painful Diabetic Peripheral Neuropathy: Presentations, Mechanisms, and Exercise Therapy
Yoo, M. (2013) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.s10-005 · Cited by 39 · see citing works
Physical activity, glycemic control, and diabetic peripheral neuropathy: A national sample
Loprinzi, P. D., Hager, K. K., & Ramulu, P. Y. (2014) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.08.008 · Cited by 38 · see citing works
Dietary weight loss in people with severe obesity stabilizes neuropathy and improves symptomatology
Callaghan, B. C., Reynolds, E. L., Banerjee, M., Akıncı, G., Chant, E., Villegas‐Umana, E., Rothberg, A. E., Burant, C., & Feldman, E. L. (2021) · Obesity · doi:10.1002/oby.23246 · Cited by 38 · see citing works
Diabetes and Peripheral Nerve Disease
Zilliox, L. A. (2021) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2020.12.001 · Cited by 36 · see citing works
Chiaramonte, R., Pavone, V., Testa, G., Pesce, I., Scaturro, D., Musumeci, G., Mauro, G. L., & Vecchio, M. M. (2023) · Diagnostics · doi:10.3390/diagnostics13030364 · Cited by 36 · see citing works
Nabrdalik, K., Kwiendacz, H., Moos, J., Moos, Ł., Kulpa, J., Brzoza, Z., Stompór, T. P., Gumprecht, J., & Lip, G. Y. H. (2023) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2023.101726 · Cited by 37 · see citing works
Yaribeygi, H., Butler, A. E., & Sahebkar, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28110 · Cited by 34 · see citing works
Orlando, G., Balducci, S., Boulton, A. J. M., Degens, H., & Reeves, N. D. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.109183 · Cited by 34 · see citing works
Obesity-Associated Neuropathy: Recent Preclinical Studies and Proposed Mechanisms
Bonomo, R. R., Krämer, S., & Mansuy‐Aubert, V. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0278 · Cited by 35 · see citing works
Gu, Y., Dennis, S. M., Kiernan, M. C., & Harmer, A. R. (2018) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3099 · Cited by 34 · see citing works
Exercise-Induced Modulation of Pain in Adults With and Without Painful Diabetic Neuropathy
Knauf, M. T., & Koltyn, K. F. (2014) · Journal of Pain · doi:10.1016/j.jpain.2014.02.008 · Cited by 33 · see citing works
Al‐Maskari, F. (2014) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000346 · Cited by 32 · see citing works
Diabetic neuropathy in children and youth: New and emerging risk factors
Akıncı, G., Savelieff, M. G., Gallagher, G., Callaghan, B. C., & Feldman, E. L. (2020) · Pediatric Diabetes · doi:10.1111/pedi.13153 · Cited by 31 · see citing works
Vileikytė, L., Crews, R. T., & Reeves, N. D. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0945-5 · Cited by 31 · see citing works
Precision Medicine in Type 2 Diabetes Mellitus: Utility and Limitations
Galiero, R., Caturano, A., Vetrano, E., Monda, M., Marfella, R., Sardu, C., Salvatore, T., Rinaldi, L., & Sasso, F. C. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s390752 · Cited by 32 · see citing works
Yorek, M. S., Obrosov, A. A., Shevalye, H., Coppey, L. J., Kardon, R. H., & Yorek, M. A. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.12.022 · Cited by 30 · see citing works
Bibliometric Analysis of Exercise and Neuropathic Pain Research
Chen, Y., & Wang, X. (2020) · Journal of Pain Research · doi:10.2147/jpr.s258696 · Cited by 30 · see citing works
Diagnóstico e tratamento da neuropatia periférica diabética
Rolim, L. C., Thyssen, P. J., Flumignan, R. L., de Andrade, D. C., Dib, S. A., & Bertoluci, M. C. (2022) · Conectando Pessoas eBooks · doi:10.29327/557753.2022-14 · Cited by 30 · see citing works
The Diabetic Neuropathies: Practical and Rational Therapy
Singleton, J., & Smith, A. G. (2012) · Seminars in Neurology · doi:10.1055/s-0032-1329195 · Cited by 30 · see citing works
Moderate intensity exercise improves heart rate variability in obese adults with type 2 diabetes
Goit, R. K., Pant, B., & Shrewastwa, M. K. (2017) · Indian Heart Journal · doi:10.1016/j.ihj.2017.10.003 · Cited by 30 · see citing works
Tatikola, S. P., Natarajan, V., Desai, V. K., Asirvatham, A. R., & Rajsekhar, H. (2022) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2022.102603 · Cited by 29 · see citing works
Therapeutic Strategies for Cancer Treatment Related Peripheral Neuropathies
Pachman, D. R., Watson, J. C., & Loprinzi, C. L. (2014) · Current Treatment Options in Oncology · doi:10.1007/s11864-014-0303-7 · Cited by 29 · see citing works
Gravesande, J., & Richardson, J. A. (2016) · Disability and Rehabilitation · doi:10.1080/09638288.2016.1199741 · Cited by 29 · see citing works
- Authors
- Kluding, P. M., Pasnoor, M., Singh, R., Jernigan, S., Farmer, K., Rucker, J., Sharma, N. K., & Wright, D. E.
- Affiliations
- University of Kansas Medical Center (US)
- Corresponding author
- Kluding, Patricia M.
- ORCID
- Venue
- Journal of Diabetes and its Complications
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 26
- Issue
- 5
- Pages
- 424-429
- ISSN
- 0891-6632 (ISSN-L)
- 1056-8727
- PMC
- PMC3436981
- OpenAlex
- W2022830342
- Cited by
- 370
- References
- 34
- Citations by year
- 2026: 18 · 2025: 14 · 2024: 26 · 2023: 33 · 2022: 44 · 2021: 43 · 2020: 39 · 2019: 27 · 2018: 17 · 2017: 27 · 2016: 31 · 2015: 15 · 2014: 22 · 2013: 9 · 2012: 5
- FWCI
- 10.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Diabetes and its Complications (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Foundation for the National Institutes of Health
- Georgia Clinical and Translational Science Alliance
- National Institute of Neurological Disorders and Stroke (R01NS043314)
- National Center for Research Resources (UL1RR033179, M01RR023940, M01 RR 02394)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Keywords
- diabetic peripheral neuropathy, exercise intervention, aerobic exercise, resistance training, neuropathic pain, neuropathic symptoms, nerve function, intraepidermal nerve fibers, skin innervation, skin biopsy, supervised exercise
- MeSH terms
- Academic Medical Centers, Biopsy, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Feasibility Studies, Female, Humans, Kansas, Male, Middle Aged, Nerve Fibers, Oxygen Consumption, Pain Measurement, Peripheral Nerves, Pilot Projects, Severity of Illness Index, Skin, Exercise, Lower Extremity, Resistance Training
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
