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Cited by 17Gestational Diabetes Research and ManagementPregnancy and preeclampsia studiesPhysical Activity and Health

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The Effect of Physical Exercise on Oxidation Capacity and Utero-Placental Circulation in Pregnancies with Gestational Diabetes Mellitus and Uncomplicated Pregnancies, a Pilot Study

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Chatzakis, Christos, Sotiriadis, Alexandros, Fatouros, Ioannis G., Jamurtas, Athanasios Z., Deli, Chariklia K., Papagianni, Maria, Dinas, Konstantinos, Mastorakos, George·2022·Diagnostics
DOI 10.3390/diagnostics12071732PMC PMC9322693
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Abstract

Background: Gestational diabetes mellitus (GDM) is associated with aggravated oxidation capacity and utero-placental circulation, while aerobic exercise could improve both. The study aims to assess oxidation capacity and utero-placental circulation before and after a bout of aerobic exercise in GDM and uncomplicated pregnancies.; Methods: In this cross-sectional study, women with GDM (GDMs) and women with uncomplicated pregnancies(controls), underwent 30 min of moderate intensity cycling. Total antioxidant capacity (TAC), catalase activity (CAT), reduced glutathione (GSH), Uterine Arteries (UtA PI) and Umbilical Artery (UmA PI) pulsatility indexes were estimated prior-to, immediately after and one hour after exercise; Results: In each group, 25 pregnant women were included. In both groups, between prior-to and immediately after exercise, TAC and CAT increased, while GSH decreased, (p < 0.001). In GDMs, CAT was lower than controls at any time point (p < 0.05), while in GDMs delta(Δ) CAT (prior-to and immediately after exercise) was lower than controls (p = 0.003). In GDMs, UtA PI centiles decreased between prior-to and either immediately or one hour after exercise, while they did not change in controls. In GDMs, pre-conceptional BMI and weight gain predicted negatively ΔTAC (prior-to to one hour after exercise); Conclusions: Moderate intensity exercise bout improves oxidation capacity in GDM and uncomplicated pregnancies, although at a lesser extent in the former. Exercise leads to decreased UtA arteries resistance in women with GDM.

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  • Physical activity increases skeletal muscle glucose uptake, improves utero-placental oxidation capacity and complements MNT by preventing excessive weight gain.

    “Physical activity increases skeletal muscle glucose uptake, improves utero-placental oxidation capacity and complements MNT by preventing excessive weight gain [11,12,13].”

    From Medical Nutrition Therapy for Women with Gestational Diabetes: Current Practice and Future Perspectives (2025) · cites this paper as [12]

    The Discussion (§4.2; page unavailable) reports improved antioxidant markers after moderate exercise in both pregnancy groups and reduced uterine-artery resistance in women with GDM. It assesses oxidation capacity and utero-placental circulation separately, not utero-placental oxidation capacity specifically. Our copy does not establish increased skeletal-muscle glucose uptake or that exercise complements MNT by preventing excessive weight gain; it treats weight gain as a predictor of the antioxidant response. (LLM, conf=0.88)

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Cited by

Sorted by citations

Metadata

Authors
Chatzakis, C., Sotiriadis, A., Fatouros, I. G., Jamurtas, A. Z., Deli, C. K., Papagianni, M., Dinas, K., & Mastorakos, G.
Affiliations
  • Aristotle University of Thessaloniki (GR)
  • University of Thessaly (GR)
  • National and Kapodistrian University of Athens (GR)
Corresponding author
Mastorakos, George
ORCID
Venue
Diagnostics
Publisher
MDPI AG
Published
2022-07-16
Volume
12
Issue
7
Pages
1732
ISSN
2075-4418 (ISSN-L)
DOI
10.3390/diagnostics12071732
PMC
PMC9322693
OpenAlex
W4285732521
Cited by
17
References
1
Citations by year
2026: 3 · 2025: 8 · 2024: 1 · 2023: 5
FWCI
3.51
Type
journal article
Language
en
Open access
Licence
Locations
  • Diagnostics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • University of Thessaly Institutional Repository (University of Thessaly) (submittedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords
gestational diabetes mellitus, aerobic exercise, oxidative stress, antioxidant capacity, uteroplacental circulation, uterine artery pulsatility index, umbilical artery pulsatility index, catalase activity, reduced glutathione, cycling exercise, pregnancy, gestational weight gain

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