Lower CSF amyloid-beta1–42 predicts a higher mortality rate in frontotemporal dementia
Open accessAbstract
Frontotemporal lobar degeneration, the neuropathological substrate of frontotemporal dementia (FTD), is characterized by the deposition of protein aggregates, including tau. Evidence has shown concomitant amyloid pathology in some of these patients, which seems to contribute to a more aggressive disease. Our aim was to evaluate cerebrospinal fluid (CSF) amyloid-beta as a predictor of the mortality of FTD patients. We included 99 patients diagnosed with FTD—both behavioral and language variants—with no associated motor neuron disease, from whom a CSF sample was collected. These patients were followed prospectively in our center, and demographic and clinical data were obtained. The survival analysis was carried through a Cox regression model. Patients who died during follow up had a significantly lower CSF amyloid-beta1–42 than those who did not. The survival analysis demonstrated that an increased death rate was associated with a lower CSF amyloid-beta1–42 (HR = 0.999, 95% CI = [0.997, 1.000], p = 0.049). Neither demographic nor clinical variables, nor CSF total tau or p-tau were significantly associated with this endpoint. These results suggest that amyloid deposition in FTD patients may be associated with a higher mortality.
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CSF amyloid-beta decrease has been associated with higher mortality in bvFTD.
“has been associated with higher mortality (Vieira et al., 2019)”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Vieira et al., 2019
CSF amyloid-beta decreased in both genetic and sporadic bvFTD over five year follow-up.
“CSF amyloid-beta, which is typically decreased in AD, showed to decrease in both genetic and sporadic bvFTD over five year follow-up”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Vieira et al., 2019
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- Authors
- Vieira, D., Durães, J., Baldeiras, I., Santiago, B., Duro, D., Lima, M., Leitão, M. J., Tábuas-Pereira, M., & Santana, I.
- Affiliations
- Unidade Local de Saúde de Coimbra (PT)
- Neurology Department, Centro Hospitalar e Universitário de Coimbra, 3000-045 Coimbra, Portugal
- ORCID
- Venue
- Diagnostics
- Publisher
- MDPI AG
- Published
- 2019-10-25
- Volume
- 9
- Issue
- 4
- Pages
- 162
- ISSN
- 2075-4418 (ISSN-L)
- PMC
- PMC6963225
- OpenAlex
- W2982269578
- Cited by
- 6
- References
- 23
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2021: 2 · 2019: 1
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Diagnostics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- frontotemporal dementia, mortality prediction, amyloid deposition, frontotemporal lobar degeneration, behavioral variant frontotemporal dementia, CSF tau, prognostic factors
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