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Cited by 24Urinary Tract Infections ManagementAntibiotic Use and ResistanceAntibiotic Resistance in Bacteria

Urinary Tract Infections among Bladder Outlet Obstruction Patients in Accra, Ghana: Aetiology, Antibiotic Resistance, and Risk Factors

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Asafo-Adjei, Karikari, Mensah, James E., Labi, Appiah-Korang, Dayie, Nicholas T. K. D., Donkor, Eric S.·2018·Diseases
DOI 10.3390/diseases6030065PMC PMC6164110
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Abstract

The aim of this study was to investigate urinary tract infections among patients with Bladder Outlet Obstruction (BOO) at the Korle Bu Teaching Hospital (KBTH) in Accra, Ghana, including the prevalence, risk factors, aetiological agents and their antibiogram. Urine specimens were collected from 188 male patients presenting with BOO and cultured for bacteria. The bacterial isolates were identified using standard microbiological methods and tested against a spectrum of antimicrobial agents using the Kirby Bauer method. Demographic information and the clinical history of study participants were also recorded. The prevalence of urinary tract infection among the BOO patients was 76.6% and the main risk factor identified was catheterization (p < 0.0001). A wide range of bacterial organisms was isolated from urine specimens and they were predominantly, Enterobacteriaceae; Escherichia coli was the most frequent cause of bacteriuria (33.3%), followed by Klebsiella (17.3%). Bacterial isolates were most resistant to Augmentin (97.8%) followed by tetracycline (85.8%), nalidixic acid (82.8%) and ciprofloxacin (75%) while 93.6% were multi-drug resistant. The highest susceptibility was observed with amikacin, which had a resistance prevalence of 4.4% resistance. These findings have important implications in the treatment of urinary tract infections among the BOO patients in Ghana.

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Cited by

Sorted by citations

Authors
Asafo-Adjei, K., Mensah, J. E., Labi, A.-K., Dayie, N. T. K. D., & Donkor, E. S.
Affiliations
  • University of Ghana (GH)
  • Korle Bu Teaching Hospital (GH)
Corresponding author
Donkor, Eric S.
ORCID
Venue
Diseases
Publisher
MDPI AG
Published
2018-07-19
Volume
6
Issue
3
Pages
65
ISSN
2079-9721 (ISSN-L)
DOI
10.3390/diseases6030065
PMC
PMC6164110
OpenAlex
W2883514614
Cited by
24
References
1
Citations by year
2026: 3 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 1
FWCI
1.17
Type
journal article
Language
en
Open access
Licence
Locations
  • Diseases (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
University of Ghana
Topics
  • Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
Keywords
urinary tract infection, bladder outlet obstruction, bacteriuria, antibiotic resistance, multidrug resistance, Escherichia coli, Klebsiella, Enterobacteriaceae, urinary catheterization, risk factors, etiology, antimicrobial susceptibility, male patients

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