The DOI matches its Crossref record; 170 of the 174 references it cites were found in a registry or an index.
Nitrites in Cured Meats, Health Risk Issues, Alternatives to Nitrites: A Review
Open accessAbstract
Nitrite is one of the most widely used curing ingredients in meat industries. Nitrites have numerous useful applications in cured meats and a vital component in giving cured meats their unique characteristics, such as their pink color and savory flavor. Nitrites are used to suppress the oxidation of lipid and protein in meat products and to limit the growth of pathogenic microorganisms such as Clostridium botulinum. Synthetic nitrite is frequently utilized for curing due to its low expenses and easier applications to meat. However, it is linked to the production of nitrosamines, which has raised several health concerns among consumers regarding its usage in meat products. Consumer desire for healthier meat products prepared with natural nitrite sources has increased due to a rising awareness regarding the application of synthetic nitrites. However, it is important to understand the various activities of nitrite in meat curing for developing novel substitutes of nitrites. This review emphasizes on the effects of nitrite usage in meat and highlights the role of nitrite in the production of carcinogenic nitrosamines as well as possible nitrite substitutes from natural resources explored also.
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“These compounds can be formed when nitrite reacts with amines in acidic conditions or during high-temperature processing, particularly in protein-rich foods such as processed meats [273,274,275].”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [275]
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Cites
A Comprehensive Review on Lipid Oxidation in Meat and Meat Products
Domínguez, R., Pateiro, M., Gagaoua, M., Barba, F. J., Zhang, W., & Lorenzo, J. M. (2019) · Antioxidants · doi:10.3390/antiox8100429 · Cited by 1,943
Carcinogenicity of consumption of red and processed meat
Bouvard, V., LOOMIS, D. P., Guyton, K. Z., Grosse, Y., Ghissassi, F. E., Benbrahim‐Tallaa, L., Guha, N., Mattock, H., & Straíf, K. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(15)00444-1 · Cited by 1,918
Protein oxidation in muscle foods: A review
Lund, M. N., Heinonen, M., Baron, C. P., & Estévez, M. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000453 · Cited by 1,065
Li, Y., Guo, C., Yang, J., Wei, J., Xu, J., & Cheng, S. (2005) · Food Chemistry · doi:10.1016/j.foodchem.2005.02.033 · Cited by 1,061
The use and control of nitrate and nitrite for the processing of meat products
Honikel, K. O. (2007) · Meat Science · doi:10.1016/j.meatsci.2007.05.030 · Cited by 959
Falowo, A. B., Fayemi, P. O., & Muchenje, V. (2014) · Food Research International · doi:10.1016/j.foodres.2014.06.022 · Cited by 892
Myoglobin Chemistry and Meat Color
Suman, S. P., & Joseph, P. (2012) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030212-182623 · Cited by 788
Formation of flavour compounds in the Maillard reaction
van Boekel, M. A. J. S. (2006) · Biotechnology Advances · doi:10.1016/j.biotechadv.2005.11.004 · Cited by 652
Antioxidant and antimutagenic activities of pomegranate peel extracts
Negi, P., Jayaprakasha, G., & Jena, B. (2003) · Food Chemistry · doi:10.1016/s0308-8146(02)00279-0 · Cited by 574
Food Processing by High Hydrostatic Pressure
Martin-Gonzalez, M. F. S., Barbosa‐Cánovas, G. V., & Swanson, B. G. (2002) · Critical Reviews in Food Science and Nutrition · doi:10.1080/20024091054274 · Cited by 559
Research works printed but not linked: 9
- Fidel, T. (2014). Principles of Curing. Handbook of Fermented Meat and Poultry, John Wiley & Sons, Ltd.
- Ahmed, M.M.A.A. (2017). Spectrophotometric Determination of Nitrite Content in Cured Meats. [Master’s Thesis, Sudan University of Science and Technology].
- Feiner, G. (2016). Salami: Practical Science and Processing Technology, Academic Press.
- Shahidi, F. (2012). The flavour of cured meat. Flavor of Meat and Meat Products, Springer.
- Zanardi, 2002, Comparative study on nitrite and nitrate ions determination, Ann. Fac. Med. Vet. Univ. Parma, 22, 70
- Fakhre, 2013, Flow-injection spectrophotometric determination of nitarate in wastewater samples using diazotization coupling reaction, App. Sci. Rep., 3, 125
- Thoa, 2017, Effects of partial replacement of nitrite by annatto (Bixa orellana, L.) seed powder on the properties of pork sausages, J. Sci. Technol., 55, 178
- Davidson, P.M. (2005). Organic acids. Antimicrobials in Food, CRC Press. [3rd ed.]. · DOI
- Sedghi, H., Mohammadi, T., Shariati, M.A., Atarod, S., and Branch, Q. (2022, June 26). The Effect of Substituting Sodium Nitrite, with Sodium Acetate on Microbial, Physiochemical and Sensory Characteristics of Meat Products. Available online: https://www.semanticscholar.org/paper/The-effect-of-substituting-sodium-nitrite%2C-with-on-Sedghi-Mohammadi/a689e9e16ff3660a1b90adc57a3d1cf1fc865db5.
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Dragoev, S. G. (2024) · Foods · doi:10.3390/foods13050797 · Cited by 148
Microbial interactions and ecology in fermented food ecosystems
Auchtung, J. M., Hallen‐Adams, H. E., & Hutkins, R. W. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01191-w · Cited by 110
New frontiers in the exploration of phenolic compounds and other bioactives as natural preservatives
de Oliveira, I., Santos‐Buelga, C., Aquino, Y., Barros, L., & Heleno, S. A. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106571 · Cited by 111
Trends of Nanoencapsulation Strategy for Natural Compounds in the Food Industry
Taouzinet, L., Djaoudene, O., Fatmi, S., Bouiche, C., Amrane‐Abider, M., Bougherra, H. H., Rezgui, F., & Madani, K. (2023) · Processes · doi:10.3390/pr11051459 · Cited by 86
Das, B., & Gupta, P. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215656 · Cited by 77
Metadata
- Authors
- Shakil, M. H., Trisha, A. T., Rahman, M., Talukdar, S., Kobun, R., Huda, N., & Zzaman, W.
- Affiliations
- Shahjalal University of Science and Technology (BD)
- Faculty of Food Science and Nutrition, Universiti Malaysia Sabah, Kota Kinabalu 88400, Sabah, Malaysia
- Universiti of Malaysia Sabah (MY)
- Corresponding author
- Huda, Nurul
- Zzaman, Wahidu
- Venue
- Foods
- Publisher
- MDPI AG
- Published
- 2022-10-25
- Volume
- 11
- Issue
- 21
- Pages
- 3355
- ISSN
- 2304-8158 (ISSN-L)
- PMC
- PMC9654915
- OpenAlex
- W4307550036
- Cited by
- 258
- References
- 174
- Citations by year
- 2026: 85 · 2025: 90 · 2024: 57 · 2023: 26
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Foods (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UMS Institutional Repository (Universiti Malaysia Sabah) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Universiti Malaysia Sabah
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Meat and Animal Product Quality
- Life Sciences › Agricultural and Biological Sciences › Food Science › Radiation Effects and Dosimetry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Keywords
- nitrite, cured meat, meat curing, nitrosamines, health risks, nitrite substitutes, Clostridium botulinum, lipid oxidation, pathogen control, carcinogenicity
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