The DOI matches its Crossref record; 66 of the 68 references it cites were found in a registry or an index.
Curcumin: A Review of Its Effects on Human Health
Open accessAbstract
Turmeric, a spice that has long been recognized for its medicinal properties, has received interest from both the medical/scientific world and from culinary enthusiasts, as it is the major source of the polyphenol curcumin. It aids in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, and hyperlipidemia. It may also help in the management of exercise-induced inflammation and muscle soreness, thus enhancing recovery and performance in active people. In addition, a relatively low dose of the complex can provide health benefits for people that do not have diagnosed health conditions. Most of these benefits can be attributed to its antioxidant and anti-inflammatory effects. Ingesting curcumin by itself does not lead to the associated health benefits due to its poor bioavailability, which appears to be primarily due to poor absorption, rapid metabolism, and rapid elimination. There are several components that can increase bioavailability. For example, piperine is the major active component of black pepper and, when combined in a complex with curcumin, has been shown to increase bioavailability by 2000%. Curcumin combined with enhancing agents provides multiple health benefits. The purpose of this review is to provide a brief overview of the plethora of research regarding the health benefits of curcumin.
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“Regardless of the administration route, higher dosages have been determined to be more efficacious than lower dosages, and cognitive enhancement was more prominent when curcumin was administered with piperine, which has a plethora of pharmacological and positive health effects against chronic disorders [146].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [146]
In the citing paper
“Although research has demonstrated that curcumin in combination with vitamin C, B vitamins, piperine, and other dietary supplements has neuroprotective and synergistic effects, further research is necessary to conclusively state curcumin’s ability at ameliorating cognitive function in humans [146,162,169].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [146]
In the citing paper
“Regardless of the administration route, higher dosages have been determined to be more efficacious than lower dosages, and cognitive enhancement was more prominent when curcumin was administered with piperine, which has a plethora of pharmacological and positive health effects against chronic disorders [146].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [146]
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Vos, T., Barber, R. M., Bell, B., Bertozzi-Villa, A., Biryukov, S., Bolliger, I., Charlson, F., Davis, A., Degenhardt, L., Dicker, D., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60692-4 · Cited by 6,414
Bioavailability of curcumin: Problems and promises
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543
Anticancer potential of curcumin: preclinical and clinical studies.
Aggarwal, B. B., Kumar, A. J., & Bharti, A. C. (2003) · PubMed · Cited by 2,550
Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials
Gupta, S. C., Patchva, S., & Aggarwal, B. B. (2012) · The AAPS Journal · doi:10.1208/s12248-012-9432-8 · Cited by 2,224
Aggarwal, B. B., & Harikumar, K. B. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.06.010 · Cited by 2,139
Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
Guido, S., Joy, D. C., Joseph, T., Majeed, M. A., Rajendran, R., & Srinivas, P. (1998) · Planta Medica · doi:10.1055/s-2006-957450 · Cited by 1,976
Antioxidant and radical scavenging properties of curcumin
Ak, T. P., & Gülçın, İ. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.05.003 · Cited by 1,942
The Chemistry of Curcumin: From Extraction to Therapeutic Agent
Priyadarsini, K. I. (2014) · Molecules · doi:10.3390/molecules191220091 · Cited by 1,520
ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF CURCUMIN
Menon, V. P., & Sudheer, A. R. (2007) · Springer eBooks · doi:10.1007/978-0-387-46401-5_3 · Cited by 1,407
Dose escalation of a curcuminoid formulation
Lao, C. D., Ruffin, M. T., Normolle, D. P., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J. A., Rock, C. L., & Brenner, D. E. (2006) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-6-10 · Cited by 1,400
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Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects
Kotha, R. R., & Luthria, D. L. (2019) · Molecules · doi:10.3390/molecules24162930 · Cited by 960
Bioactivity of dietary polyphenols: The role of metabolites
Luca, S. V., Macovei, I., Bujor, A., Miron, A., Skalicka‐Woźniak, K., Aprotosoaie, A. C., & Trifan, A. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1546669 · Cited by 753
Plant-derived natural products for drug discovery: current approaches and prospects
Nasim, N., Sandeep, I. S., & Mohanty, S. (2022) · The Nucleus · doi:10.1007/s13237-022-00405-3 · Cited by 607
Najmi, A., Javed, S. A., Bratty, M. A., & Alhazmi, H. A. (2022) · Molecules · doi:10.3390/molecules27020349 · Cited by 668
Pateiro, M., Gómez, B., Munekata, P. E. S., Barba, F. J., Putnik, P., Kovačević, D. B., & Lorenzo, J. M. (2021) · Molecules · doi:10.3390/molecules26061547 · Cited by 603
Metadata
- Authors
- Hewlings, S., & Kalman, D.
- Affiliations
- Central Michigan University (US)
- Nova Southeastern University (US)
- Corresponding author
- Hewlings, Susan
- Venue
- Foods
- Publisher
- MDPI AG
- Published
- 2017-10-22
- Volume
- 6
- Issue
- 10
- Pages
- 92
- ISSN
- 2304-8158 (ISSN-L)
- PMC
- PMC5664031
- OpenAlex
- W2766083858
- Cited by
- 2,720
- References
- 68
- Citations by year
- 2026: 336 · 2025: 364 · 2024: 383 · 2023: 399 · 2022: 415 · 2021: 380 · 2020: 258 · 2019: 125 · 2018: 54 · 2017: 1
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Foods (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Saffron Plant Research Studies
- Keywords
- curcumin, turmeric, polyphenols, bioavailability, piperine, antioxidant activity, anti-inflammatory activity, oxidative stress, metabolic syndrome, arthritis, anxiety, hyperlipidemia, exercise-induced inflammation, muscle soreness, post-exercise recovery
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