The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin
Open accessAbstract
Flavonoids are a class of natural substances present in plants, fruits, vegetables, wine, bulbs, bark, stems, roots, and tea. Several attempts are being made to isolate such natural products, which are popular for their health benefits. Flavonoids are now seen as an essential component in a number of cosmetic, pharmaceutical, and medicinal formulations. Quercetin is the major polyphenolic flavonoid found in food products, including berries, apples, cauliflower, tea, cabbage, nuts, and onions that have traditionally been treated as anticancer and antiviral, and used for the treatment of allergic, metabolic, and inflammatory disorders, eye and cardiovascular diseases, and arthritis. Pharmacologically, quercetin has been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium, Babesia, and Theileria parasites. Additionally, it has shown beneficial effects against Alzheimer’s disease (AD), and this activity is due to its inhibitory effect against acetylcholinesterase. It has also been documented to possess antioxidant, antifungal, anti-carcinogenic, hepatoprotective, and cytotoxic activity. Quercetin has been documented to accumulate in the lungs, liver, kidneys, and small intestines, with lower levels seen in the brain, heart, and spleen, and it is extracted through the renal, fecal, and respiratory systems. The current review examines the pharmacokinetics, as well as the toxic and biological activities of quercetin.
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Cites
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Cited by
Recent Advances in Potential Health Benefits of Quercetin
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Drug repurposing for cancer therapy
Xia, Y., Sun, M., Huang, H., & Jin, W.-L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01808-1 · Cited by 443
“235 Its anti-in fl ammatory and antioxidant properties, as well as its ability to modulate the TME, have led to its inclusion in functional foods as a commercial dietary supplement.”
BackgroundDi Pierro, F., Derosa, G., Maffioli, P., Bertuccioli, A., Togni, S., Riva, A., Allegrini, P., Khan, A., Khan, S., Khan, B. A., et al. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s318720 · Cited by 182
Rahman, M. H., Bajgai, J., Fadriquela, A., Sharma, S., Trinh, T. T., Akter, R., Jeong, Y. J., Goh, S. H., Kim, C.-S., & Lee, K.-J. (2021) · Molecules · doi:10.3390/molecules26175327 · Cited by 182
Rizvi, S. A. A., Einstein, G. P., Tulp, O. L., Sainvil, F., & Branly, R. (2022) · Biomolecules · doi:10.3390/biom12101442 · Cited by 181
Metadata
- Authors
- Batiha, G. E.-S., Beshbishy, A. M., Ikram, M., Mulla, Z. S., El-Hack, M. E. A., Taha, A. E., Algammal, A. M., & Elewa, Y. H. A.
- Venue
- Foods
- Publisher
- MDPI AG
- Published
- 2020-03-23
- Volume
- 9
- Issue
- 3
- Pages
- 374
- ISSN
- 2304-8158 (ISSN-L)
- OpenAlex
- W3012608664
- Cited by
- 709
- References
- 97
- FWCI
- 40.25
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- Batiha, G. E.-S., Beshbishy, A. M., Ikram, M., Mulla, Z. S., El-Hack, M. E. A., Taha, A. E., Algammal, A. M., & Elewa, Y. H. A. (2020). The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin. Foods. https://doi.org/10.3390/foods9030374
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