Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges

Parkinson disease

Poewe, W., Seppi, K., Tanner, C. M., Halliday, G. M., Brundin, P., Volkmann, J., Schrag, A.-E., & Lang, A. E. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.13 · Cited by 5,415 · see citing works

DLS and zeta potential – What they are and what they are not?

Bhattacharjee, S. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.06.017 · Cited by 4,702 · see citing works

Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

Colovic, M. B., Krstic, D. Z., Lazarevic-Pasti, T. D., Bondzic, A. M., & Vasic, V. M. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311030006 · Cited by 2,611 · see citing works

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

Singh, A., Kukreti, R., Saso, L., & Kukreti, S. (2019) · Molecules · doi:10.3390/molecules24081583 · Cited by 2,305 · see citing works

The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age‐Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults

Nita, M., & Grzybowski, A. E. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3164734 · Cited by 1,451 · see citing works

The Role of Polyphenols in Human Health and Food Systems: A Mini-Review

Cory, H., Passarelli, S., Szeto, J., Tamez, M., & Mattei, J. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00087 · Cited by 1,297 · see citing works

Resveratrol: A Double-Edged Sword in Health Benefits

Salehi, B., Mishra, A. P., Nigam, M., Şener, B., Kılıç, M., Sharifi‐Rad, M., Fokou, P. V. T., Martins, N. A., & Sharifi‐Rad, J. (2018) · Biomedicines · doi:10.3390/biomedicines6030091 · Cited by 1,141 · see citing works

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

Shahmoradian, S. H., Lewis, A. J., Genoud, C., Hench, J., Moors, T. E., Navarro, P. P., Castaño‐Díez, D., Schweighauser, G., Graff-Meyer, A., Goldie, K. N., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0423-2 · Cited by 974 · see citing works

Inflammation in CNS neurodegenerative diseases

Stephenson, J., Nutma, E., van der Valk, P., & Amor, S. (2018) · Immunology · doi:10.1111/imm.12922 · Cited by 966 · see citing works

Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

Bhat, A. H., Dar, K. B., Anees, S., Zargar, M. A., Masood, A., Sofi, M. A., & Ganie, S. A. (2015) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.07.025 · Cited by 938 · see citing works

Proteostasis and aging

Kaushik, S., & Cuervo, A. M. (2015) · Nature Medicine · doi:10.1038/nm.4001 · Cited by 899 · see citing works

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

Obeso, J. A., Stamelou, M., Goetz, C. G., Poewe, W., Lang, A. E., Weintraub, D., Burn, D., Halliday, G. M., Bezard, E., Przedborski, S., et al. (2017) · Movement Disorders · doi:10.1002/mds.27115 · Cited by 859 · cited 1× · see citing works

LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms

Deane, R., Wu, Z., Sagare, A., Davis, J., Du Yan, S., Hamm, K., Xu, F., Parisi, M., LaRue, B., Hu, H. W., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.017 · Cited by 828 · see citing works

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Durazzo, A., Lucarini, M., Souto, E. B., Cicala, C., Caiazzo, E., Izzo, A. A., Novellino, E., & Santini, A. (2019) · Phytotherapy Research · doi:10.1002/ptr.6419 · Cited by 817 · see citing works

The basal ganglia and the cerebellum: nodes in an integrated network

Bostan, A. C., & Strick, P. L. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0002-7 · Cited by 786 · see citing works

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

Turner, R. S., Thomas, R. G., Craft, S., van Dyck, C. H., Mintzer, J. E., Reynolds, B., Brewer, J. B., Rissman, R. A., Raman, R., Aisen, P. S. S., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000002035 · Cited by 753 · see citing works

The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin

Batiha, G. E., Beshbishy, A. M., Ikram, M., Mulla, Z. S., El-Hack, M. E. A., Taha, A. E.-S., Algammal, A. M., & Elewa, Y. H. A. (2020) · Foods · doi:10.3390/foods9030374 · Cited by 716 · see citing works

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

Moussa, C., Hebron, M. L., Huang, X., Ahn, J., Rissman, R. A., Aisen, P. S. S., & Turner, R. S. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0779-0 · Cited by 712 · see citing works

Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases

Buendía, I., Michalska, P., Navarro, E., Gameiro‐Ros, I., Egea, J., & Leon, R. M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.11.003 · Cited by 683 · see citing works

Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications

Cunha, L., & Grenha, A. (2016) · Marine Drugs · doi:10.3390/md14030042 · Cited by 619 · see citing works

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

Williamson, G., Kay, C. D., & Crozier, A. (2018) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12351 · Cited by 607 · see citing works

Selective vulnerability in neurodegenerative diseases

Fu, H., Hardy, J., & Duff, K. E. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0221-2 · Cited by 585 · see citing works

Apigenin in cancer therapy: anti-cancer effects and mechanisms of action

Yan, X., Qi, M., Li, P., Zhan, Y., & Shao, H. (2017) · Cell & Bioscience · doi:10.1186/s13578-017-0179-x · Cited by 560 · see citing works

Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More

Costa, L. G., Garrick, J. M., Roqué, P. J., & Pellacani, C. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2986796 · Cited by 550 · see citing works

Neuroprotective Effects of Quercetin in Alzheimer’s Disease

Khan, H. Z., Ullah, H., Aschner, M., Cheang, W. S., & Akkol, E. K. (2019) · Biomolecules · doi:10.3390/biom10010059 · Cited by 541 · see citing works

The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease

Braak, H., & Del Tredici, K. (2015) · Brain · doi:10.1093/brain/awv236 · Cited by 540 · see citing works

Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment

Golpich, M., Amini, E., Mohamed, Z., Raymond, A. A., Ibrahim, N. M., & Ahmadiani, A. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12655 · Cited by 540 · see citing works

Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives

Park, J.-S., Davis, R. L., & Sue, C. M. (2018) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-018-0829-3 · Cited by 516 · see citing works

Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

Voet, S., Prinz, M., & van Loo, G. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.11.005 · Cited by 503 · see citing works

Luteolin as an anti-inflammatory and neuroprotective agent: A brief review

Nabavi, S. F., Braidy, N., Gortzi, O., Sobarzo‐Sánchez, E., Daglia, M., Skalicka‐Woźniak, K., & Nabavi, S. M. (2015) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.09.002 · Cited by 480 · see citing works

Mechanisms of neurodegeneration in Huntington’s disease

Gil‐Mohapel, J., & Rego, A. C. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06310.x · Cited by 480 · see citing works

Converging pathways in neurodegeneration, from genetics to mechanisms

Gan, L., Cookson, M. R., Petrucelli, L., & Spada, A. R. L. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0237-7 · Cited by 475 · see citing works

Mitochondrial Dysfunction in Parkinson’s Disease

Moon, H. E., & Paek, S. H. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.2.103 · Cited by 455 · see citing works

Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease

Gelders, G., Baekelandt, V., & Van der Perren, A. (2018) · Journal of Immunology Research · doi:10.1155/2018/4784268 · Cited by 430 · see citing works

Marine macroalgae as sources of protein and bioactive compounds in feed for monogastric animals

Øverland, M., Mydland, L. T., & Skrede, A. (2018) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9143 · Cited by 427 · see citing works

Neuroprotective action of resveratrol

Bastianetto, S., Ménard, C., & Quirion, R. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.09.011 · Cited by 411 · see citing works

Polyphenols: Multipotent Therapeutic Agents in Neurodegenerative Diseases

Bhullar, K. S., & Rupasinghe, H. P. V. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/891748 · Cited by 411 · see citing works

The amyloid precursor protein: beyond amyloid.

Zheng, H., & Koo, E. H. (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-5 · Cited by 403 · see citing works

Uncovering Potential Applications of Cyanobacteria and Algal Metabolites in Biology, Agriculture and Medicine: Current Status and Future Prospects

Singh, R., Parihar, P., Singh, M., Bajguz, A., Kumar, J., Singh, S., Singh, V. P., & Prasad, S. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00515 · Cited by 399 · see citing works

Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence

Hajialyani, M., Farzaei, M. H., Echeverría, J., Nabavi, S. M., Uriarte, E., & Sobarzo‐Sánchez, E. (2019) · Molecules · doi:10.3390/molecules24030648 · Cited by 385 · see citing works

Neuroinflammation: Microglia and T Cells Get Ready to Tango

Schetters, S. T. T., Gómez‐Nicola, D., García-Vallejo, J. J., & van Kooyk, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01905 · Cited by 378 · see citing works

Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebo-controlled trial

Akhondzadeh, S., Noroozıan, M., Mohammadi, M., Ohadinia, S., Jamshidi, A. H., & Khani, M. (2003) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1046/j.1365-2710.2003.00463.x · Cited by 345 · see citing works

Resveratrol encapsulation: Designing delivery systems to overcome solubility, stability and bioavailability issues

Davidov‐Pardo, G., & McClements, D. J. (2014) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2014.05.003 · Cited by 338 · see citing works

Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease

Osellame, L. D., Rahim, A. A., Hargreaves, I. P., Gegg, M. E., Richard-Loendt, A., Brandner, S., Waddington, S. N., Schapira, A. H. V., & Duchen, M. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.014 · Cited by 329 · see citing works

Mitochondrial permeability transition pore is a potential drug target for neurodegeneration

Rao, V. K., Carlson, E. A., & Yan, S. S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.09.003 · Cited by 325 · see citing works

Resveratrol: A miraculous natural compound for diseases treatment

Koushki, M., Dashatan, N. A., Ahmadi, N., Abbaszadeh, H., & Rezaei–Tavirani, M. (2018) · Food Science & Nutrition · doi:10.1002/fsn3.855 · Cited by 319 · see citing works

SIRT1 Activation by Natural Phytochemicals: An Overview

Iside, C., Scafuro, M., Nebbioso, A., & Altucci, L. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01225 · Cited by 318 · see citing works

Brown Rice Versus White Rice: Nutritional Quality, Potential Health Benefits, Development of Food Products, and Preservation Technologies

Saleh, A. S. M., Wang, P., Wang, N., et al. (2019) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12449 · Cited by 313 · see citing works

Resveratrol provides neuroprotection by regulating the JAK2/STAT3/PI3K/AKT/mTOR pathway after stroke in rats

Hou, Y., Wang, K., Wan, W., Yue, C., Pu, X., & Ye, X. (2018) · Genes & Diseases · doi:10.1016/j.gendis.2018.06.001 · Cited by 309 · see citing works

Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: A pilot double-blind randomized trial [ISRCTN45683816]

Akhondzadeh, S., Fallah-Pour, H., Afkham, K., Jamshidi, A.-H., & Khalighi-Cigaroudi, F. (2004) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-4-12 · Cited by 307 · see citing works

Beneficial Effects of Marine Algal Compounds in Cosmeceuticals

Thomas, N. V., & Kim, S. (2013) · Marine Drugs · doi:10.3390/md11010146 · Cited by 305 · see citing works

Diabetes mellitus and Alzheimer's disease: GSK-3β as a potential link

Zhang, Y., Huang, N.-Q., Yan, F., Jin, H., Zhou, S.-Y., Shi, J.-S., & Jin, F. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.11.015 · Cited by 301 · see citing works

Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats

Ishisaka, A., Ichikawa, S., Sakakibara, H., Piskula, M. K., Nakamura, T., Kato, Y., Ito, M., Miyamoto, K.-I., Tsuji, A., Kawai, Y., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.017 · Cited by 293 · see citing works

Manganese-Induced Neurotoxicity: New Insights Into the Triad of Protein Misfolding, Mitochondrial Impairment, and Neuroinflammation

Harischandra, D. S., Ghaisas, S., Zenitsky, G. D., Jin, H., Kanthasamy, A., Anantharam, V., & Kanthasamy, A. G. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00654 · Cited by 290 · see citing works

Nanolipidic particles improve the bioavailability and α-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease

Smith, A., Giunta, B., Bickford, P. C., Fountain, M., Tan, J., & Shytle, R. D. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.01.012 · Cited by 280 · see citing works

Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease

Balez, R., Steiner, N., Engel, M., Muñoz, S. S., Lum, J. S., Wu, Y., Wang, D., Vallotton, P., Sachdev, P. S., O’Connor, M. D., et al. (2016) · Scientific Reports · doi:10.1038/srep31450 · Cited by 278 · see citing works

Bioactivity of genistein: A review of in vitro and in vivo studies

Ganai, A. A., & Farooqi, H. (2015) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.10.026 · Cited by 274 · see citing works

Exploring Marine Resources for Bioactive Compounds

Kiuru, P. S., D’Auria, M. V., Muller, C. D., Tammela, P., Vuorela, H. J., & Yli‐Kauhaluoma, J. T. (2014) · Planta Medica · doi:10.1055/s-0034-1383001 · Cited by 252 · see citing works

Microglia: Housekeeper of the Central Nervous System

Kabba, J. A., Xu, Y., Christian, H., Ruan, W., Kitchen, C., Xiang, Y., Zhang, L., Saavedra, J. M., & Pang, T. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0504-2 · Cited by 251 · see citing works

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Sairazi, N. S. M., & Sirajudeen, K. N. S. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/6565396 · Cited by 250 · see citing works

Genistein ameliorates learning and memory deficits in amyloid β(1–40) rat model of Alzheimer’s disease

Bagheri, M., Joghataei, M. T., Mohseni, S., & Roghani, M. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.12.001 · Cited by 247 · see citing works

Naturally derived anti-inflammatory compounds from Chinese medicinal plants

Wang, Q., Kuang, H., Su, Y., Sun, Y., Feng, J., Guo, R., & Chan, K. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.12.013 · Cited by 241 · see citing works

Functional ingredients from microalgae

Buono, S., Langellotti, A. L., Martello, A., Rinna, F., & Fogliano, V. (2014) · Food & Function · doi:10.1039/c4fo00125g · Cited by 241 · see citing works

Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease

Zhang, K., Chen, M., Du, Z.-Y., Zheng, X., Li, D., & Zhou, R. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.230303 · Cited by 236 · see citing works

Bioaccessibility and bioavailability of phenolic compounds

Shahidi, F., & Peng, H. (2018) · Journal of Food Bioactives · doi:10.31665/jfb.2018.4162 · Cited by 234 · see citing works

An Update on Pharmacological Potential of Boswellic Acids against Chronic Diseases

Roy, N. K., Parama, D., Banik, K., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174101 · Cited by 233 · see citing works

Advances in the pharmacological treatment of Parkinson's disease: targeting neurotransmitter systems

Brichta, L., Greengard, P., & Flajolet, M. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.06.003 · Cited by 224 · see citing works

Apigenin as neuroprotective agent: Of mice and men

Nabavi, S. F., Khan, H. Z., D’Onofrio, G., Šamec, D., Shirooie, S., Dehpour, A. R., Argüelles, S., Habtemariam, S., & Sobarzo‐Sánchez, E. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.10.008 · Cited by 221 · see citing works

Glucagon-Like Peptide-1: A Focus on Neurodegenerative Diseases

Grieco, M., Giorgi, A., Gentile, M. C., d’Erme, M., Morano, S., Maras, B., & Filardi, T. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01112 · Cited by 218 · cited 1× · see citing works

Efficacy and Safety of Ashwagandha ( <i>Withania somnifera</i> (L.) <i>Dunal</i> ) Root Extract in Improving Memory and Cognitive Functions

Choudhary, D., Bhattacharyya, S., & Bose, S. (2017) · Journal of Dietary Supplements · doi:10.1080/19390211.2017.1284970 · Cited by 215 · see citing works

Inflammatory mechanisms and oxidative stress as key factors responsible for progression of neurodegeneration: role of brain innate immune system

Leszek, J., E. Barreto, G., G|siorowski, K., Koutsouraki, E., Ávila-Rodrigues, M., & Aliev, G. (2016) · CNS &amp; Neurological Disorders - Drug Targets · doi:10.2174/1871527315666160202125914 · Cited by 206 · cited 1× · see citing works

Dopamine and Levodopa Prodrugs for the Treatment of Parkinson’s Disease

Haddad, F., Sawalha, M., Khawaja, Y., Najjar, A., & Karaman, R. (2017) · Molecules · doi:10.3390/molecules23010040 · Cited by 206 · see citing works

Neuroprotective Strategies for Neurological Disorders by Natural 
Products: An update

Rehman, M., Wali, A., Ahmad, A., Shakeel, S., Rasool, S., Ali, R., Rashid, S. M., Madkhali, H. A., Ganaie, M., & Khan, R. (2019) · Current Neuropharmacology · doi:10.2174/1570159x16666180911124605 · Cited by 202 · see citing works

The Roles of Flavonols/Flavonoids in Neurodegeneration and Neuroinflammation

Çalış, Z., Moğulkoç, R., & Baltacı, A. K. (2019) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557519666190617150051 · Cited by 197 · see citing works

Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease

Rahman, M. H., Akter, R., Bhattacharya, T., Abdel‐Daim, M. M., Alkahtani, S. H., Arafah, M. W., AL–Johani, N. S., Alhoshani, N. M., Alkeraishan, N., Alhenaky, A., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.619024 · Cited by 194 · see citing works

Formulations of Curcumin Nanoparticles for Brain Diseases

Del Prado-Audelo, M. L., Caballero-Florán, I. H., Meza-Toledo, J. A., Mendoza-Muñoz, N., González-Torres, M., Florán, B., Cortés, H., & Leyva-Gómez, G. (2019) · Biomolecules · doi:10.3390/biom9020056 · Cited by 191 · see citing works

Impaired intracellular trafficking defines early Parkinson's disease

Hunn, B. H. M., Cragg, S. J., Bolam, J. P., Spillantini, M., & Wade‐Martins, R. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2014.12.009 · Cited by 185 · see citing works

Neuroprotective effects of the antiparkinson drug Mucuna pruriens

Manyam, B. V., Dhanasekaran, M., & Hare, T. A. (2004) · Phytotherapy Research · doi:10.1002/ptr.1514 · Cited by 185 · see citing works

Microglia in the Neurovascular Unit: Blood–Brain Barrier–microglia Interactions After Central Nervous System Disorders

Thurgur, H., & Pinteaux, E. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.06.046 · Cited by 181 · see citing works

Clinical development of curcumin in neurodegenerative disease

Hu, S., Maiti, P., Ma, Q., Zuo, X., Jones, M. R., Cole, G. M., & Frautschy, S. A. (2015) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.1044981 · Cited by 179 · see citing works

Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica

Wattanathorn, J., Mator, L., Muchimapura, S., Tong-un, T., Pasurivong, O., Piyawatkul, N., Yimtae, K., Sripanidkulchai, B., & Singkhoraard, J. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.11.038 · Cited by 179 · see citing works

Hesperidin ameliorates cognitive dysfunction, oxidative stress and apoptosis against aluminium chloride induced rat model of Alzheimer's disease

Thenmozhi, A. J., Raja, T. R. W., Manivasagam, T., Janakiraman, U., & Essa, M. M. (2016) · Nutritional Neuroscience · doi:10.1080/1028415x.2016.1144846 · Cited by 173 · see citing works

Resveratrol neuroprotection in stroke and traumatic CNS injury

Lopez, M. S., Dempsey, R. J., & Vemuganti, R. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.08.009 · Cited by 171 · see citing works

Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field

Barbosa, A. I., Coutinho, A. J., Lima, S. A. C., & Reis, S. (2019) · Marine Drugs · doi:10.3390/md17120654 · Cited by 166 · see citing works

In vitro–in vivo correlation: Perspectives on model development

Lü, Y., Kim, S., & Park, K. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.01.010 · Cited by 165 · see citing works

β-Caryophyllene, a phytocannabinoid attenuates oxidative stress, neuroinflammation, glial activation, and salvages dopaminergic neurons in a rat model of Parkinson disease

Ojha, S. K., Javed, H., Azimullah, S., & Haque, M. E. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2733-y · Cited by 165 · see citing works

Nanocarriers as a powerful vehicle to overcome blood-brain barrier in treating neurodegenerative diseases: Focus on recent advances

Niu, X.-Q., Chen, J.-J., & Gao, J.-Q. (2018) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2018.09.005 · Cited by 161 · see citing works

Development, characterization and nasal delivery of rosmarinic acid-loaded solid lipid nanoparticles for the effective management of Huntington’s disease

Bhatt, R., Singh, D., Prakash, A. K., & Mishra, N. (2014) · Drug Delivery · doi:10.3109/10717544.2014.880860 · Cited by 160 · see citing works

Natural Antioxidant Anthocyanins—A Hidden Therapeutic Candidate in Metabolic Disorders with Major Focus in Neurodegeneration

Ullah, R., Khan, M., Shah, S. A., Saeed, K. M., & Kim, M. O. (2019) · Nutrients · doi:10.3390/nu11061195 · Cited by 154 · see citing works

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

Hannan, M. A., Dash, R., Haque, M. N., Mohibbullah, M., Sohag, A. A. M., Rahman, M. A., Uddin, M. J., Alam, M., & Moon, I. S. (2020) · Marine Drugs · doi:10.3390/md18070347 · Cited by 152 · see citing works

Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus

Ali, T., Yoon, G. H., Shah, S. A., Lee, H. Y., & Kim, M. O. (2015) · Scientific Reports · doi:10.1038/srep11708 · Cited by 146 · see citing works

Natural product for the treatment of Alzheimer’s disease

Bui, T. T., & Nguyễn, T. H. (2017) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2016-0147 · Cited by 146 · see citing works

Resveratrol as a Therapeutic Agent for Alzheimer’s Disease

Ma, T., Tan, M., Yu, J., & Tan, L. (2014) · BioMed Research International · doi:10.1155/2014/350516 · Cited by 144 · see citing works

Species- and tissue-specific relationships between mitochondrial permeability transition and generation of ROS in brain and liver mitochondria of rats and mice

Panov, A., Dikalov, S., Shalbuyeva, N., Hemendinger, R., Greenamyre, J. T., & Rosenfeld, J. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00202.2006 · Cited by 141 · see citing works

Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study

Durrenberger, P. F., Fernando, F. S., Kashefi, S. N., Bonnert, T. P., Seilhean, D., Nait‐Oumesmar, B., Schmitt, A., Gebicke‐Haerter, P. J., Falkai, P., Grünblatt, E., et al. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1293-0 · Cited by 139 · see citing works

Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease.

Xu, S., Gao, Z., Weng, Z., Du, Z., Xu, W. A., Yang, J., Zhang, M. L., Tong, Z. H., Fang, Y., & Chai, X. S. (1995) · PubMed · Cited by 137 · see citing works

Quercetin in Food: Possible Mechanisms of Its Effect on Memory

Babaei, F., Mirzababaei, M., & Nassiri‐Asl, M. (2018) · Journal of Food Science · doi:10.1111/1750-3841.14317 · Cited by 137 · see citing works

Phyto-Therapeutic and Nanomedicinal Approaches to Cure Alzheimer’s Disease: Present Status and Future Opportunities

Ovais, M., Zia, N., Ahmad, I., Khalil, A. T., Raza, A., Ayaz, M., Sadiq, A., Ullah, F., & Shinwari, Z. K. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00284 · Cited by 137 · see citing works

Nutritional and Toxicological Importance of Macro, Trace, and Ultra-Trace Elements in Algae Food Products

Dawczynski, C., Schäfer, U., Leiterer, M., & Jahreis, G. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0721500 · Cited by 134 · see citing works

The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients

Boskabady, M. H., Javan, H., Sajady, M., et al. (2007) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2007.00509.x · Cited by 132 · see citing works

Flavonoid transport across RBE4 cells: A blood-brain barrier model

Faria, A., Pestana, D., Teixeira, D., Azevedo, J., de Freitas, V. A. P., Mateus, N. F. D. C. B., & Calhau, C. (2010) · Cellular & Molecular Biology Letters · doi:10.2478/s11658-010-0006-4 · Cited by 130 · see citing works

Protective effects of C-phycocyanin against kainic acid-induced neuronal damage in rat hippocampus

Rimbau, V., Camins, A., Romay, C., González, R., & Pallàs, M. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00792-2 · Cited by 130 · see citing works

Brain Iron Metabolism and CNS Diseases

Thirupathi, A., & Chang, Y. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9589-5_1 · Cited by 127 · see citing works

Roles of Phenolic Compounds in the Reduction of Risk Factors of Cardiovascular Diseases

Mariane Lutz, R., Eduardo Fuentes, Q., Ávila, F., Alarcón, M. A., & Palomo, I. F. (2019) · Molecules · doi:10.3390/molecules24020366 · Cited by 126 · see citing works

Gender Disparities in Health Care

Kent, J. A., Patel, V., & Varela, N. A. (2012) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.21336 · Cited by 122 · see citing works

Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases

Renaud, J., & Martinoli, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081883 · Cited by 122 · see citing works

Fucoidan Protects Dopaminergic Neurons by Enhancing the Mitochondrial Function in a Rotenone-induced Rat Model of Parkinson’s Disease

Zhang, L., Hao, J., Zheng, Y., Su, R., Liao, Y., Gong, X., Liu, L., & Wang, X. (2018) · Aging and Disease · doi:10.14336/ad.2017.0831 · Cited by 120 · see citing works

Protective Effects of Fucoidan on Aβ25–35 and d-Gal-Induced Neurotoxicity in PC12 Cells and d-Gal-Induced Cognitive Dysfunction in Mice

Wei, H., Gao, Z., Zheng, L., Zhang, C., Liu, Z., Yang, Y., Teng, H., Hou, L., Yin, Y., & Zou, X. (2017) · Marine Drugs · doi:10.3390/md15030077 · Cited by 119 · see citing works

Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection

Martínez‐Huélamo, M., Rodríguez-Morató, J., Boronat, A., & de la Torre, R. (2017) · Antioxidants · doi:10.3390/antiox6040073 · Cited by 118 · see citing works

Improvement of Main Cognitive Functions in Patients with Alzheimer’s Disease after Treatment with Coconut Oil Enriched Mediterranean Diet: A Pilot Study

de la Rubia Ortí, J. E., García-Pardo, M. P., Drehmer, E., Sancho Cantus, D., Julián Rochina, M., Aguilar, M. A., & Hu Yang, I. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-180184 · Cited by 116 · see citing works

Effects of turmeric on Alzheimer′s disease with behavioral and psychological symptoms of dementia

Hishikawa, N., Takahashi, Y., Amakusa, Y., Tanno, Y., Tuji, Y., Niwa, H., Murakami, N., & Krishna, U. (2012) · AYU (An International Quarterly Journal of Research in Ayurveda) · doi:10.4103/0974-8520.110524 · Cited by 115 · see citing works

Enhancement of flavonoid ability to cross the blood–brain barrier of rats by co-administration with α-tocopherol

Ferri, P., Angelino, D., Gennari, L., Benedetti, S., Ambrogini, P., Grande, P. D., & Ninfali, P. (2014) · Food & Function · doi:10.1039/c4fo00817k · Cited by 115 · see citing works

Neuroprotective effect of Tinospora cordifolia ethanol extract on 6-hydroxy dopamine induced Parkinsonism

Kosaraju, J., Chinni, S., Roy, P., Kannan, E., Antony, A., & Kumar, M. N. S. (2014) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.129312 · Cited by 113 · see citing works

Cell Death Mechanisms of Neurodegeneration

Fan, J., Dawson, T. M., & Dawson, V. L. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-57193-5_16 · Cited by 112 · see citing works

Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy

Saito, S., Yamamoto, Y., Maki, T., Hattori, Y., Ito, H., Mizuno, K., Harada-Shiba, M., Kalaria, R. N., Fukushima, M., Takahashi, R., et al. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0429-5 · Cited by 110 · see citing works

Exploring the efficacy of natural products in alleviating Alzheimer’s disease

Singh, A., Deshpande, P., & Gogia, N. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.253509 · Cited by 108 · see citing works

Hypericum perforatum extract attenuates behavioral, biochemical, and neurochemical abnormalities in Aluminum chloride-induced Alzheimer’s disease rats

Cao, Z., Wang, F., Xiu, C., Zhang, J., & Li, Y. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.05.022 · Cited by 106 · see citing works

Natural Products in Neurodegenerative Diseases: A Great Promise but an Ethical Challenge

Paolo, M. D., Papi, L., Gori, F., & Turillazzi, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205170 · Cited by 104 · see citing works

The acute effects of an extract of <i>Bacopa monniera</i> (Brahmi) on cognitive function in healthy normal subjects

Nathan, P. J., Clarke, J., Lloyd, J., Hutchison, C. W., Downey, L., & Stough, C. (2001) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.306 · Cited by 103 · see citing works

Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity

Ren, Z., Zhao, Y.-F., Cao, T., & Zhen, X.-C. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.42 · Cited by 101 · see citing works

Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MSn

Yang, P., Xu, F., Li, H., Wang, Y., Li, F., Shang, M., Liu, G., Wang, X., & Cai, S. (2016) · Molecules · doi:10.3390/molecules21091209 · Cited by 101 · see citing works

Effects of the hook of Uncaria rhynchophylla on neurotoxicity in the 6-hydroxydopamine model of Parkinson's disease

Shim, J. S., Kim, H. G., Ju, M. S., et al. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.08.023 · Cited by 100 · see citing works

A critical review on grape polyphenols for neuroprotection: Strategies to enhance bioefficacy

Zhao, D., Simon, J. E., & Wu, Q. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1546668 · Cited by 99 · see citing works

Insights into GABA A ergic system alteration in Huntington's disease

Hsu, Y., Chang, Y., & Chern, Y. (2018) · Open Biology · doi:10.1098/rsob.180165 · Cited by 97 · see citing works

Phytochemicals Having Neuroprotective Properties from Dietary Sources and Medicinal Herbs

Kumar, G. P., Anilakumar, K. R., & Naveen, S. (2015) · Pharmacognosy Journal · doi:10.5530/pj.2015.1.1 · Cited by 94 · see citing works

Uncaria rhynchophylla and its Major Constituents on Central Nervous System: A Review on Their Pharmacological Actions

Yang, W., Ip, S., Liu, L., Xian, Y., & Lin, Z. (2019) · Current Vascular Pharmacology · doi:10.2174/1570161117666190704092841 · Cited by 92 · see citing works

Role of Dietary Supplements in the Management of Parkinson’s Disease

Ciulla, M., Marinelli, L., Cacciatore, I., & Stefano, A. D. (2019) · Biomolecules · doi:10.3390/biom9070271 · Cited by 92 · see citing works

Neuroprotective Effect of Omega-3 Polyunsaturated Fatty Acids in the 6-OHDA Model of Parkinson’s Disease Is Mediated by a Reduction of Inducible Nitric Oxide Synthase

Mori, M. A., Delattre, A. M., Carabelli, B., Pudell, C., Bortolanza, M., Staziaki, P. V., Visentainer, J. V., Montanher, P. F., Del Bel, E. A., & Ferraz, A. C. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1290928 · Cited by 89 · see citing works

Neuroprotection: Targeting Multiple Pathways by Naturally Occurring Phytochemicals

Khan, A., Jahan, S., Imtiyaz, Z., Alshahrani, S., Makeen, H. A., Alshehri, B., Kumar, A., Arafah, A. M., & Rehman, M. U. (2020) · Biomedicines · doi:10.3390/biomedicines8080284 · Cited by 89 · see citing works

Exploring the multimodal role of phytochemicals in the modulation of cellular signaling pathways to combat age-related neurodegeneration

Uddin, M. S., Hossain, M. F., Mamun, A. A., Shah, M. A., Hasana, S., Bulbul, I. J., Sarwar, M. S., Mansouri, R. A., Ashraf, G. M., Rauf, A., et al. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.138313 · Cited by 88 · see citing works

Mitochondrial iPLA2 Activity Modulates the Release of Cytochrome c from Mitochondria and Influences the Permeability Transition

Gadd, M. E., Broekemeier, K. M., Crouser, E. D., Kumar, J., Graff, G., & Pfeiffer, D. R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510845200 · Cited by 87 · see citing works

Limelight on Alpha-Synuclein: Pathological and Mechanistic Implications in Neurodegeneration

Wales, P., Pinho, R., Lázaro, D. F., & Outeiro, T. F. (2013) · Journal of Parkinson s Disease · doi:10.3233/jpd-130216 · Cited by 86 · see citing works

The Role of Metal Binding in the Amyotrophic Lateral Sclerosis-Related Aggregation of Copper-Zinc Superoxide Dismutase

Sirangelo, I., & Iannuzzi, C. (2017) · Molecules · doi:10.3390/molecules22091429 · Cited by 85 · see citing works

Amphiphilic Nanocarrier Systems for Curcumin Delivery in Neurodegenerative Disorders

Rakotoarisoa, M., & Angelova, A. (2018) · Medicines · doi:10.3390/medicines5040126 · Cited by 84 · see citing works

Antioxidant and Photoprotective Activity of Apigenin and its Potassium Salt Derivative in Human Keratinocytes and Absorption in Caco-2 Cell Monolayers

Sánchez‐Marzo, N., Pérez-Sánchez, A., Ruiz-Torres, V., Martínez-Tébar, A., Castillo, J., Herranz‐López, M., & Barrajón‐Catalán, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092148 · Cited by 84 · see citing works

Bioassay-Guided Isolation of Neuroprotective Compounds fromUncaria rhynchophyllaagainst Beta-Amyloid-Induced Neurotoxicity

Xian, Y., Lin, Z.-X., Mao, Q., Hu, Z. J., Zhao, M., Che, C., & Ip, S. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/802625 · Cited by 82 · see citing works

Benefits of hesperidin in central nervous system disorders: a review

Kim, J., Wie, M., Ahn, M., Tanaka, A., Matsuda, H., & Shin, T. (2019) · Anatomy & Cell Biology · doi:10.5115/acb.19.119 · Cited by 77 · see citing works

High dose genistein aglycone therapy is safe in patients with mucopolysaccharidoses involving the central nervous system

Kim, K. H., Dodsworth, C., Paras, A., et al. (2013) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2013.06.012 · Cited by 75 · see citing works

Metal-deficient SOD1 in amyotrophic lateral sclerosis

Hilton, J. B. W., White, A. R., & Crouch, P. J. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1273-3 · Cited by 75 · see citing works

Neuroprotective Effects of Anthraquinones from Rhubarb in Central Nervous System Diseases

Li, X., Chu, S., Liu, Y., & Chen, N. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/3790728 · Cited by 74 · see citing works

Improved delivery of poorly soluble compounds using nanoparticle technology: a review

Kalepu, S., & Nekkanti, V. (2016) · Drug Delivery and Translational Research · doi:10.1007/s13346-016-0283-1 · Cited by 72 · see citing works

Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease

Leonoudakis, D., Rane, A., Angeli, S., Lithgow, G. J., Andersen, J. K., & Chinta, S. J. (2017) · Mediators of Inflammation · doi:10.1155/2017/8302636 · Cited by 72 · see citing works

Functional effect of Saffron supplementation and risk genotypes in early age-related macular degeneration: a preliminary report

Marangoni, D., Falsini, B., Piccardi, M., Ambrosio, L., Minnella, A. M., Savastano, M. C., Bisti, S., Maccarone, R., Fadda, A., Mello, E., et al. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-228 · Cited by 70 · see citing works

Natural Compounds and Neuroprotection: Mechanisms of Action and Novel Delivery Systems.

Bagli, E., GOUSSIA, A. C., Moschos, M. M., Agnantis, N. J., & Kitsos, G. (2016) · PubMed · Cited by 70 · see citing works

Neuroprotective effects of seaweeds against 6-hydroxidopamine-induced cell death on an in vitro human neuroblastoma model

Silva, J., Alves, C., Pintéus, S., Mendes, S., & Pedrosa, R. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2103-2 · Cited by 70 · see citing works

Nutraceuticals and amyloid neurodegenerative diseases: a focus on natural phenols

Rigacci, S., & Stefani, M. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.986101 · Cited by 69 · see citing works

Neuroprotective strategies against calpain-mediated neurodegeneration

Yıldız, A., Korulu, Ş., & Karabay, A. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s78226 · Cited by 67 · see citing works

Dietary Polyphenols for Treatment of Alzheimer’s Disease– Future Research and Development

Malar, D. S., & Devi, K. P. (2014) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201015666140813122703 · Cited by 67 · see citing works

Recent Advances in Self-Assembled Nanoparticles for Drug Delivery

Varma, L. T., Singh, N., Gorain, B., Choudhury, H., Tambuwala, M. M., Kesharwani, P., & Shukla, R. (2020) · Current Drug Delivery · doi:10.2174/1567201817666200210122340 · Cited by 67 · see citing works

Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum–to–mitochondria Ca 2+ transfer for survival

Cárdenas, C., Lovy, A., Silva-Pavez, E., Urra, F. A., Mizzoni, C., Ahumada-Castro, U., Bustos, G., Jaña, F., Cruz, P., Farías, P., et al. (2020) · Science Signaling · doi:10.1126/scisignal.aay1212 · Cited by 66 · see citing works

Diet and Brain Health: Which Role for Polyphenols?

Castelli, V., Grassi, D., Bocale, R., d'Angelo, M., Antonosante, A., Cimini, A., Ferri, C., & Desideri, G. (2017) · Current pharmaceutical design · doi:10.2174/1381612824666171213100449 · Cited by 64 · see citing works

Hesperidin potentiates the neuroprotective effects of diazepam and gabapentin against pentylenetetrazole-induced convulsions in mice: Possible behavioral, biochemical and mitochondrial alterations

Kumar, A., Lalitha, S., & Mishra, J. (2014) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.132180 · Cited by 62 · see citing works

The blood-brain barrier is disrupted in a mouse model of infantile neuronal ceroid lipofuscinosis: amelioration by resveratrol

Saha, A., Sarkar, C., SINGH, S. P., Zhang, Z., Munasinghe, J., Peng, S., Chandra, G., Kong, E., & Mukherjee, A. B. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds038 · Cited by 62 · see citing works

Resveratrol promotes neuroprotection and attenuates oxidative and nitrosative stress in the small intestine in diabetic rats

Ferreira, P. E. B., Beraldi, E. J., Borges, S. C., Natali, M. R. M., & Buttow, N. C. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.030 · Cited by 62 · see citing works

Marine-Derived Natural Compounds for the Treatment of Parkinson’s Disease

Huang, C., Zhang, Z., & Cui, W. (2019) · Marine Drugs · doi:10.3390/md17040221 · Cited by 62 · see citing works

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic AdvancesPreprint

Hannan, M. A., Dash, R., Haque, M. N., et al. (2020) · Preprints.org · doi:10.20944/preprints202005.0342.v1 · Cited by 60 · see citing works

Interactions between Phytochemicals from Traditional Chinese Medicines and Human Cytochrome P450 Enzymes

Wu, J., Ai, C., Liu, Y., Zhang, Y., Jiang, M., Fan, X., Ai-ping, L., & Yang, L. (2012) · Current Drug Metabolism · doi:10.2174/1389200211209050599 · Cited by 59 · see citing works

Natural Products as Potential Anti-Alzheimer Agents

Panda, S. S., & Jhanji, N. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190618113613 · Cited by 58 · see citing works

Protective effects of a polysaccharide from Spirulina platensis on dopaminergic neurons in an MPTP-induced Parkinson′s disease model in C57BL/6J mice

Zhang, F., Xie, J.-X., Lu, J., & Zhang, J.-G. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.152387 · Cited by 57 · see citing works

Uncaria rhynchophylla Ameliorates Parkinson’s Disease by Inhibiting HSP90 Expression: Insights from Quantitative Proteomics

Lan, Y., Zhou, J., Liu, J., et al. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000490837 · Cited by 56 · see citing works

Natural Products and Neuroprotection

Angeloni, C., & Vauzour, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225570 · Cited by 56 · see citing works

Redox Effects of Molecular Hydrogen and Its Therapeutic Efficacy in the Treatment of Neurodegenerative Diseases

Rahman, M. H., Bajgai, J., Fadriquela, A., Sharma, S., Thi, T. T., Akter, R., Goh, S. H., Kim, C.-S., & Lee, K. (2021) · Processes · doi:10.3390/pr9020308 · Cited by 56 · see citing works

Alteration of the nuclear pore complex in Ca2+-mediated cell death

Bano, D., Dinsdale, D. D., Cabrera‐Socorro, A., Maida, S., Lambacher, N. J., McColl, B. W., Ferrando‐May, E., Hengartner, M. O., & Nicotera, P. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.112 · Cited by 55 · see citing works

The Role of Natural Antioxidants in the Prevention of Dementia—Where Do We Stand and Future Perspectives

Jurcău, A. (2021) · Nutrients · doi:10.3390/nu13020282 · Cited by 55 · see citing works

Ameliorative effects of Matricaria chamomilla L. hydroalcoholic extract on scopolamine-induced memory impairment in rats: A behavioral and molecular study

Ioniță, R., Postu, P. A., Mihăşan, M., Gorgan, L., Hăncianu, M., Cioancă, O., & Hriţcu, L. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.04.049 · Cited by 54 · see citing works

A Novel Quinolyl‐Substituted Analogue of Resveratrol Inhibits LPS‐Induced Inflammatory Responses in Microglial Cells by Blocking the NF‐κB/MAPK Signaling Pathways

Hou, Y., Zhang, Y., Mi, Y., Wang, J., Zhang, H., Xu, J., Yang, Y., Liu, J., Ding, L., Yang, J., et al. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201801380 · Cited by 54 · see citing works

Polyphenols Nanoencapsulation for Therapeutic Applications

Salle, A. D. (2016) · Journal of Biomolecular Research & Therapeutics · doi:10.4172/2167-7956.1000139 · Cited by 53 · see citing works

The flavonoid apigenin delays forgetting of passive avoidance conditioning in rats

Popović, M., Caballero‐Bleda, M., Benavente-García, O., & Castillo, J. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113512040 · Cited by 51 · see citing works

2,3,5,4 ′‐Tetrahydroxystilbene‐2‐O‐beta‐D‐glucoside Reverses Stress‐Induced Depression via Inflammatory and Oxidative Stress Pathways

Jiang, C.-Y., Qin, X., Yuan, M.-M., Lu, G.-J., & Cheng, Y. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9501427 · Cited by 51 · see citing works

<i>Spirulina maxima</i>pretreatment partially protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity

Chamorro, G., Pérez-Albiter, M., Serrano-García, N., Mares-Sámano, J. J., & Rojas, P. (2006) · Nutritional Neuroscience · doi:10.1080/10284150600929748 · Cited by 50 · see citing works

Spirulina maxima Extract Prevents Neurotoxicity via Promoting Activation of BDNF/CREB Signaling Pathways in Neuronal Cells and Mice

Koh, E.-J., Seo, Y.-J., Choi, J., Lee, H. Y., Kang, D.-H., Kim, K.-J., & Lee, B.-Y. (2017) · Molecules · doi:10.3390/molecules22081363 · Cited by 49 · see citing works

The antioxidant and neurochemical activity of Apium graveolens L. and its ameliorative effect on MPTP-induced Parkinson-like symptoms in mice

Chonpathompikunlert, P., Boonruamkaew, P., Sukketsiri, W., Hutamekalin, P., & Sroyraya, M. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2166-0 · Cited by 49 · see citing works

Gender disparities in health care

Friedman, E. H. (1991) · JAMA · doi:10.1001/jama.266.21.2984b · Cited by 49 · see citing works

Spirulina maxima Extract Ameliorates Learning and Memory Impairments via Inhibiting GSK-3β Phosphorylation Induced by Intracerebroventricular Injection of Amyloid-β 1–42 in Mice

Koh, E.-J., Kim, K.-J., Song, J.-H., Choi, J., Lee, H., Kang, D.-H., Heo, H., & Lee, B.-Y. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112401 · Cited by 48 · see citing works

Resveratrol alleviates lipopolysaccharide-induced inflammation in PC-12 cells and in rat model

Zhang, G., Liu, Y., Xu, L., Sha, C., Zhang, H., & Xu, W. (2019) · BMC Biotechnology · doi:10.1186/s12896-019-0502-1 · Cited by 48 · see citing works

Hesperidin inhibits glutamate release and exerts neuroprotection against excitotoxicity induced by kainic acid in the hippocampus of rats.

Chang, C.-Y., Lin, T.-Y., Lu, C.-W., Huang, S.-K., Wang, Y.-C., Chou, S. P., & Wang, S.-J. (2015) · Neurotoxicology · doi:10.1016/j.neuro.2015.08.014 · Cited by 47 · see citing works

Huntingtin gene repeat size variations affect risk of lifetime depression

Gardiner, S. L., van Belzen, M. J., Boogaard, M. W., van Roon‐Mom, W., Rozing, M. P., van Hemert, A. M., Smit, J. H., Beekman, A. T. F., van Grootheest, G., Schoevers, R. A., et al. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0042-1 · Cited by 47 · see citing works

The neuroprotective effects of hydro-alcoholic extract of olive (Olea europaea L.) leaf on rotenone-induced Parkinson’s disease in rat

Sarbishegi, M., Gorgich, E. A. C., Khajavi, O., Komeili, G., & Salimi, S. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0131-0 · Cited by 46 · see citing works

Behavioral, axonal, and proteomic alterations following repeated mild traumatic brain injury: Novel insights using a clinically relevant rat model

Pham, L., Wright, D. K., O’Brien, W. T., Bain, J., Huang, C., Sun, M., Casillas-Espinosa, P. M., Shah, A. D., Schittenhelm, R. B., Sobey, C. G., et al. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105151 · Cited by 44 · see citing works

Genistein protects against Aβ25–35 induced apoptosis of PC12 cells through JNK signaling and modulation of Bcl-2 family messengers

You, F., Li, Q., Jin, G., et al. (2017) · BMC Neuroscience · doi:10.1186/s12868-016-0329-9 · Cited by 43 · see citing works

Efficacy of Natural Compounds in Neurodegenerative Disorders

Srivastava, P., & Yadav, R. S. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-28383-8_7 · Cited by 41 · see citing works

Resveratrol Intervenes Cholesterol- and Isoprenoid-Mediated Amyloidogenic Processing of AβPP in Familial Alzheimer’s Disease

Sathya, M., Ponnusamy, M., Palanisamy, P., Kandasamy, M., Jayachandran, K. S., & Anusuyadevi, M. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161034 · Cited by 41 · see citing works

Taxifolin prevents β-amyloid-induced impairments of synaptic formation and deficits of memory via the inhibition of cytosolic phospholipase A2/prostaglandin E2 content

Wang, Y., Wang, Q., Bao, X., Ding, Y., Shentu, J., Cui, W., Chen, X., Wei, X., & Xu, S. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0207-5 · Cited by 41 · see citing works

Safflower yellow attenuates learning and memory deficits in amyloid β-induced Alzheimer’s disease rats by inhibiting neuroglia cell activation and inflammatory signaling pathways

Zhang, L., Zhou, Z., Zhai, W., Pang, J., Mo, Y., Yang, G., Qu, Z., & Hu, Y. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00398-0 · Cited by 41 · see citing works

Phytochemical constituents from Uncaria rhynchophylla in human carboxylesterase 2 inhibition: Kinetics and interaction mechanism merged with docking simulations

Wang, Y., Dong, P., Liang, J., et al. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.10.006 · Cited by 39 · see citing works

Brain‐targeted co‐delivery of β‐amyloid converting enzyme 1 shRNA and epigallocatechin‐3‐gallate by multifunctional nanocarriers for Alzheimer's disease treatment

Lv, L., Yang, F., Li, H., & Yuan, J. (2020) · IUBMB Life · doi:10.1002/iub.2330 · Cited by 39 · see citing works

Antioxidant-Rich Fraction of Urtica dioica Mediated Rescue of Striatal Mito-Oxidative Damage in MPTP-Induced Behavioral, Cellular, and Neurochemical Alterations in Rats

Bisht, R., Joshi, B. C., Kalia, A. N., & Prakash, A. K. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0084-z · Cited by 37 · see citing works

Herbal Medicine Formulas for Parkinson's Disease: A Systematic Review and Meta-Analysis of Randomized Double-Blind Placebo-Controlled Clinical Trials

Shan, C.-S., Zhang, H., Xu, Q., Shi, Y., Wang, Y., Li, Y., Lin, Y., & Zheng, G. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00349 · Cited by 37 · see citing works

Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP5+, Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme

Yulyana, Y., Tovmasyan, A. G., Ho, I. A. W., et al. (2015) · Stem Cell Reviews and Reports · doi:10.1007/s12015-015-9628-2 · Cited by 36 · see citing works

The time course of action of two neuroprotectants, dietary saffron and photobiomodulation, assessed in the rat retina.

Marco, F. D., Romeo, S., Nandasena, C., Purushothuman, S., Adams, C., Bisti, S., & Stone, J. (2013) · Europe PMC (PubMed Central) · Cited by 33 · see citing works

Conformational deviation of Thrombin binding G-quadruplex aptamer (TBA) in presence of divalent cation Sr2+: A classical molecular dynamics simulation study

Pal, S., & Paul, S. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.09.102 · Cited by 33 · see citing works

Flavonoids and Polyphenolic Compounds as Potential Talented Agents for the Treatment of Alzheimer’s Disease and their Antioxidant Activities

Akter, R., Chowdhury, M. A. R., & Rahman, M. H. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666201102102810 · Cited by 33 · see citing works

&lt;p&gt;Therapeutic Effects of &lt;em&gt;Spirulina platensis&lt;/em&gt; Against Adolescent Stress-Induced Oxidative Stress, Brain-Derived Neurotrophic Factor Alterations and Morphological Remodeling in the Amygdala of Adult Female Rats&lt;/p&gt;

Moradi-Kor, N., Ghanbari, A., Rashidipour, H., Bandegi, A. R., Yousefi, B., Barati, M., Kokhaei, P., & Rashidy-Pour, A. (2020) · Journal of Experimental Pharmacology · doi:10.2147/jep.s237378 · Cited by 32 · see citing works

The Blood-Brain Barrier Permeability of Six Indole Alkaloids from Uncariae Ramulus Cum Uncis in the MDCK-pHaMDR Cell Monolayer Model

Zhang, Y., Yang, Y., Xu, W., & Yang, X.-W. (2017) · Molecules · doi:10.3390/molecules22111944 · Cited by 31 · see citing works

Effect of Fermented Spirulina maxima Extract on Cognitive‐Enhancing Activities in Mice with Scopolamine‐Induced Dementia

Choi, W. Y., Kang, D. H., & Lee, H.-Y. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/7218504 · Cited by 30 · see citing works

A Study for Therapeutic Treatment against Parkinson’s Disease via Chou’s 5-steps Rule

Lan, J., Liu, Z., Liao, C., Merkler, D. J., Han, Q., & Li, J. (2019) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026619666191019111528 · Cited by 29 · see citing works

Transport and metabolic profiling studies of amentoflavone in Caco-2 cells by UHPLC-ESI-MS/MS and UHPLC-ESI-Q-TOF-MS/MS

Wang, B., Lu, Y., Wang, R., et al. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2020.113441 · Cited by 26 · see citing works

Evidence on Integrating Pharmacokinetics to Find Truly Therapeutic Agent for Alzheimer’s Disease: Comparative Pharmacokinetics and Disposition Kinetics Profiles of Stereoisomers Isorhynchophylline and Rhynchophylline in Rats

Zhang, C., Wu, X., Xian, Y., et al. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/4016323 · Cited by 25 · see citing works

On the Right Track to Treat Movement Disorders: Promising Therapeutic Approaches for Parkinson’s and Huntington’s Disease

Troncoso-Escudero, P., Sepúlveda, D., Pérez-Arancibia, R., Parra, A. V., Arcos, J., Grunenwald, F., & Vidal, R. L. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.571185 · Cited by 25 · see citing works

Prospective Function of Different Antioxidant Containing Natural Products in the Treatment of Neurodegenerative Diseases

Rahman, M. H., Akter, R., & Kamal, M. A. (2020) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527319666200722153611 · Cited by 24 · see citing works

Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes

Piccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73 · see citing works

Neuroprotective effects of the survival promoting peptide Y-P30

Schneeberg, J., Riek‐Burchardt, M., Braun, H., Landgraf, P., Kreutz, M. R., & Reymann, K. G. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.05.029 · Cited by 8 · see citing works

Neuroprotective Properties of Chitosan and Its Derivatives

Pangestuti, R., & Kim, S. (2010) · Marine Drugs · doi:10.3390/md8072117 · Cited by 173 · see citing works

POTENTIAL NEUROPROTECTIVE EFFECTS OF HERBAL COMPOUNDS

Baibado, J. T., & Cheung, H. (2015) · International Journal of Pharmaceutical and Biological Science Archive

Review paper Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?

Pluta, R., Bogucka-Kocka, A., Ułamek-Kozioł, M., Furmaga-Jabłońska, W., Januszewski, S., Brzozowska, J., Jabłoński, M., & Kocki, J. (2015) · Folia Neuropathologica · doi:10.5114/fn.2015.52405 · Cited by 34 · see citing works

Exosomes: Mediators of Neurodegeneration, Neuroprotection and Therapeutics

Kalani, A., Tyagi, A. A., & Tyagi, N. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8544-1 · Cited by 333 · see citing works