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Cited by 156DNA and Nucleic Acid ChemistryDNA Repair MechanismsGenomics and Chromatin Dynamics

Replication of G Quadruplex DNA

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Lerner, Leticia Koch, Sale, Julian E.·2019·Genes
DOI 10.3390/genes10020095PMC PMC6409989
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Abstract

A cursory look at any textbook image of DNA replication might suggest that the complex machine that is the replisome runs smoothly along the chromosomal DNA. However, many DNA sequences can adopt non-B form secondary structures and these have the potential to impede progression of the replisome. A picture is emerging in which the maintenance of processive DNA replication requires the action of a significant number of additional proteins beyond the core replisome to resolve secondary structures in the DNA template. By ensuring that DNA synthesis remains closely coupled to DNA unwinding by the replicative helicase, these factors prevent impediments to the replisome from causing genetic and epigenetic instability. This review considers the circumstances in which DNA forms secondary structures, the potential responses of the eukaryotic replisome to these impediments in the light of recent advances in our understanding of its structure and operation and the mechanisms cells deploy to remove secondary structure from the DNA. To illustrate the principles involved, we focus on one of the best understood DNA secondary structures, G quadruplexes (G4s), and on the helicases that promote their resolution.

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  • The application of G4-stabilizing ligands has been observed to activate DDRs and arrest cells in G2-phase, hinting at an increase in genomic instability due to aberrant G4 formation.

    “Moreover, the application of G4-stabilizing ligands has been observed to activate DDRs and arrest cells in G2-phase, hinting at an increase in genomic instability due to aberrant G4 formation (30).”

    From G-quadruplex-mediated genomic instability drives SNVs in cancer (2024) · cites this paper as [30]

    Section 4.2 reports genetic instability in budding yeast treated with a G4-stabilising ligand and interrupted DNA synthesis when G4s are stabilised with ligands in wild-type cells. It does not report that the ligands activate DNA damage responses or arrest cells in G2 phase (searched: DNA damage response, DDR, and G2-phase). The genomic-instability implication is supported, but those specific observed effects are not. (LLM, conf=0.86)

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Authors
Lerner, L. K., & Sale, J. E.
Affiliations
  • MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK
  • MRC Laboratory of Molecular Biology (GB)
Corresponding author
Sale, Julian E.
ORCID
Venue
Genes
Publisher
MDPI AG
Published
2019-01-29
Volume
10
Issue
2
Pages
95
ISSN
2073-4425 (ISSN-L)
DOI
10.3390/genes10020095
PMC
PMC6409989
OpenAlex
W2912285434
Cited by
156
References
222
Citations by year
2026: 9 · 2025: 13 · 2024: 19 · 2023: 26 · 2022: 15 · 2021: 35 · 2020: 29 · 2019: 9 · 2018: 1
FWCI
1.94
Type
journal article
Language
en
Open access
Licence
Locations
  • Genes (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Medical Research Council (U105178808)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
G-quadruplex, DNA replication, replisome, DNA secondary structure, non-B DNA structures, replicative helicase, DNA unwinding, genomic instability, epigenetic instability, eukaryotic DNA replication
MeSH terms
Animals, DNA Replication, DNA Helicases, Humans, Genomic Instability, Epigenesis, Genetic, G-Quadruplexes

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