The DOI matches its Crossref record; 318 of the 318 references it cites were found in a registry or an index.
Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability
Open accessAbstract
Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles. We provide here a review on the recent knowledge accrued on the zinc-dependent HDAC protein family across different species, tissues, and human pathologies, specifically focusing on the role of HDAC inhibitors as anti-cancer agents. We will investigate the chemical specificity of different HDACs and discuss their role in the human interactome as members of chromatin-binding and regulatory complexes.
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Cites
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Histone deacetylases (HDACs): characterization of the classical HDAC family
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HDAC6 is a microtubule-associated deacetylase
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“Indeed, HDACs are predominantly located in the nucleus, but some have been observed in the cytoplasm as well (Table 1), such as HDAC6 [42].”
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Cited by
Epigenetics in hepatocellular carcinoma development and therapy: The tip of the iceberg
Fernández-Barrena, M. G., Arechederra, M., Colyn, L., Berasain, C., & Avila, M. A. (2020) · JHEP Reports · doi:10.1016/j.jhepr.2020.100167 · Cited by 126
Bahl, S., & Seto, E. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03599-4 · Cited by 82
Structure-Based Inhibitor Discovery of Class I Histone Deacetylases (HDACs)
Luo, Y., & Li, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228828 · Cited by 62
Metadata
- Authors
- Milazzo, G., Mercatelli, D., Di Muzio, G., Triboli, L., De Rosa, P., Perini, G., & Giorgi, F. M.
- Venue
- Genes
- Publisher
- MDPI AG
- Published
- 2020-05-15
- Volume
- 11
- Issue
- 5
- Pages
- 556
- ISSN
- 2073-4425 (ISSN-L)
- OpenAlex
- W3024404242
- Cited by
- 423
- References
- 318
- FWCI
- 12.31
- Type
- journal article
- Language
- en
- Open access
- gold
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- Milazzo, G., Mercatelli, D., Di Muzio, G., Triboli, L., De Rosa, P., Perini, G., & Giorgi, F. M. (2020). Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability. Genes. https://doi.org/10.3390/genes11050556
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