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Cited by 8Connective tissue disorders researchMusculoskeletal pain and rehabilitationFibromyalgia and Chronic Fatigue Syndrome Research

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Generalized Joint Hypermobility and Anxiety in Adolescents and Young Adults, the Impact on Physical and Psychosocial Functioning

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de Vries, Janneke, Verbunt, Jeanine, Stubbe, Janine, Visser, Bart, Ramaekers, Stephan, Calders, Patrick, Engelbert, Raoul·2021·Healthcare
DOI 10.3390/healthcare9050525PMC PMC8146775
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Abstract

The purpose of this study was to study the association between the presence of generalized joint hypermobility (GJH) and anxiety within a non-clinical high performing group of adolescents and young adults. Second, to study the impact of GJH and/or anxiety on physical and psychosocial functioning, 168 adolescents and young adults (mean (SD) age 20 (2.9)) were screened. Joint (hyper)mobility, anxiety, and physical and psychosocial functioning were measured. In 48.8% of all high performing adolescents and young adults, GJH was present, whereas 60% had symptoms of anxiety. Linear models controlled for confounders showed that adolescents and young adults with GJH and anxiety had decreased workload (ß (95%CI) −0.43 (−0.8 to −0.08), p-value 0.02), increased fatigue (ß (95%CI) 12.97 (6.3–19.5), p-value < 0.01), and a higher level of pain catastrophizing (ß (95%CI) 4.5 (0.5–8.6), p-value 0.03). Adolescents and young adults with only anxiety had increased fatigue (ß (95%CI) 11 (4.9–19.5). In adolescents and young adults with GJH alone, no impact on physical and psychosocial functioning was found. Adolescents and young adults with the combination of GJH and anxiety were significantly more impaired, showing decreased physical and psychosocial functioning with decreased workload, increased fatigue, and pain catastrophizing. Presence of GJH alone had no negative impact on physical and psychosocial functioning. This study confirms the association between GJH and anxiety, but especially emphasizes the disabling role of anxiety. Screening for anxiety is relevant in adolescents and young adults with GJH and might influence tailored interventions.

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References 35 · Cited by 8

Research works printed but not linked: 28

  1. Briggs, 2009, Injury and joint hypermobility syndrome in ballet dancers—A 5-year follow-up, Rheumatology, 48, 1613, 10.1093/rheumatology/kep175 · DOI
  2. McCormack, 2004, Joint laxity and the benign joint hypermobility syndrome in student and professional ballet dancers, J. Rheumatol., 31, 173
  3. Bergeron, 2015, International Olympic Committee consensus statement on youth athletic development, Br. J. Sports Med., 49, 843, 10.1136/bjsports-2015-094962 · DOI
  4. Remvig, 2011, Need for a consensus on the methods by which to measure joint mobility and the definition of norms for hypermobility that reflect age, gender and ethnic-dependent variation: Is revision of criteria for joint hypermobility syndrome and Ehlers-Danlos syndrome hypermobility type indicated?, Rheumatology, 50, 1169, 10.1093/rheumatology/ker140 · DOI · Paper page
  5. Beighton, 1998, Ehlers-Danlos syndromes: Revised nosology, Villefranche, 1997, Am. J. Med. Genet., 77, 31, 10.1002/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O · DOI · Paper page
  6. Scheper, 2017, The natural history of children with joint hypermobility syndrome and Ehlers–Danlos hypermobility type: A longitudinal cohort study, Rheumatology, 56, 2073, 10.1093/rheumatology/kex148 · DOI · Paper page
  7. Bulbena, 2017, Psychiatric and psychological aspects in the Ehlers-Danlos syndromes, Am. J. Med. Genet. Part C Semin. Med. Genet., 175, 237, 10.1002/ajmg.c.31544 · DOI · Paper page
  8. Beesdo, 2009, Anxiety and Anxiety Disorders in Children and Adolescents: Developmental Issues and Implications for DSM-V, Psychiatr. Clin. N. Am., 32, 483, 10.1016/j.psc.2009.06.002 · DOI · Paper page
  9. (2021, April 29). Teaching the Hypermobile Dancer. Available online: https://www.semanticscholar.org/paper/Teaching-the-Hypermobile-Dancer-McCormack/da84141e69bb14f6c572920d28a916e7bed94506.
  10. Liederbach, 2012, Assessing and Reporting Dancer Capacities, Risk Factors, and Injuries: Recommendations from the IADMS Standard Measures Consensus Initiative, J. Dance Med. Sci., 16, 139, 10.1177/1089313X1201600401 · DOI
  11. Engelbert, 2006, Exercise Tolerance in Children and Adolescents With Musculoskeletal Pain in Joint Hypermobility and Joint Hypomobility Syndrome, Pediatrics, 118, e690, 10.1542/peds.2005-2219 · DOI
  12. Koblbauer, I.F.H., Lambrecht, Y., Van Der Hulst, M.L.M., Neeter, C., Engelbert, R.H.H., Poolman, R.W., and Scholtes, V.A. (2011). Reliability of maximal isometric knee strength testing with modified hand-held dynamometry in patients awaiting total knee arthroplasty: Useful in research and individual patient settings? A reliability study. BMC Musculoskelet. Disord., 12. · DOI
  13. Bongers, 2013, The Steep Ramp Test in Dutch White Children and Adolescents: Age- and Sex-Related Normative Values, Phys. Ther., 93, 1530, 10.2522/ptj.20120508 · DOI
  14. Schep, 2007, Exercise Testing and Training in a Cancer Rehabilitation Program: The Advantage of the Steep Ramp Test, Arch. Phys. Med. Rehabil., 88, 610, 10.1016/j.apmr.2007.02.013 · DOI
  15. Bjelland, 2002, The validity of the Hospital Anxiety and Depression Scale, J. Psychosom. Res., 52, 69, 10.1016/S0022-3999(01)00296-3 · DOI · Paper page
  16. Beurskens, 2000, Measurement of prolonged fatigue in the working population: Determination of a cutoff point for the checklist individual strength, J. Occup. Health Psychol., 5, 411, 10.1037/1076-8998.5.4.411 · DOI
  17. Engelbert, 2007, Alexithymia in adolescents with chronic fatigue syndrome, J. Psychosom. Res., 63, 377, 10.1016/j.jpsychores.2007.07.009 · DOI
  18. Vercoulen, 1999, Checklist Individuele Spankracht (CIS), Gedragstherapie, 32, 131
  19. Roelofs, 2003, The pain vigilance and awareness questionnaire (PVAQ): Further psychometric evaluation in fibromyalgia and other chronic pain syndromes, Pain, 101, 299, 10.1016/S0304-3959(02)00338-X · DOI · Paper page
  20. Hulzebos, 2018, Reference values for maximum work rate in apparently healthy Dutch/Flemish adults: Data from the LowLands fitness registry, Acta Cardiol., 74, 223
  21. Lench, 2010, Trait anxiety and achievement goals as predictors of self-reported health in dancers, J. Dance Med. Sci., 14, 163, 10.1177/1089313X1001400405 · DOI
  22. Grahame, 1991, The hypermobility syndrome (Reply), Ann. Rheum. Dis., 50, 201, 10.1136/ard.50.3.201-a · DOI
  23. Kleef, 2009, Motor Performance in Children with Generalized Hypermobility: The Influence of Muscle Strength and Exercise Capacity, Pediatr. Phys. Ther., 21, 194, 10.1097/PEP.0b013e3181a3ac5f · DOI
  24. Ginsburg, 2006, Somatic Symptoms in Children and Adolescents With Anxiety Disorders, J. Am. Acad. Child Adolesc. Psychiatry, 45, 1179, 10.1097/01.chi.0000231974.43966.6e · DOI · Paper page
  25. Crawley, 2013, Somatic complaints in anxious youth, Child Psychiatry Hum. Dev., 45, 398, 10.1007/s10578-013-0410-x · DOI
  26. Gouttebarge, 2017, The prevalence and risk indicators of symptoms of common mental disorders among current and former Dutch elite athletes, J. Sports Sci., 35, 2148, 10.1080/02640414.2016.1258485 · DOI
  27. Vlaeyen, 2000, Fear-avoidance and its consequences in chronic musculoskeletal pain: A state of the art, Pain, 85, 317, 10.1016/S0304-3959(99)00242-0 · DOI · Paper page
  28. Spinhoven, 1997, A validation study of the Hospital Anxiety and Depression Scale (HADS) in different groups of Dutch subjects, Psychol. Med., 27, 363, 10.1017/S0033291796004382 · DOI · Paper page

Metadata

Authors
de Vries, J., Verbunt, J., Stubbe, J., Visser, B., Ramaekers, S., Calders, P., & Engelbert, R.
Affiliations
  • Amsterdam University Medical Centers (NL)
  • Maastricht University Medical Centre (NL)
  • Codarts Rotterdam (NL)
  • Amsterdam University of Applied Sciences (NL)
  • Ghent University (BE)
  • Emma Kinderziekenhuis (NL)
Corresponding author
  • de Vries, Janneke
  • Engelbert, Raoul
ORCID
Venue
Healthcare
Publisher
MDPI AG
Published
2021-04-29
Volume
9
Issue
5
Pages
525
ISSN
2227-9032 (ISSN-L)
DOI
10.3390/healthcare9050525
PMC
PMC8146775
OpenAlex
W3158842291
Cited by
8
References
35
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 2
FWCI
0.57
Type
journal article
Language
en
Open access
Licence
Locations
  • Healthcare (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, cc-by)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, cc-by)
  • Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
  • Research Publications (Maastricht University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Pure Amsterdam UMC (submittedVersion, cc-by)
  • Research Publications (Maastricht University) (submittedVersion, other-oa)
Funders
Dutch Research Council (0.23.003.138)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Keywords
generalized joint hypermobility, anxiety, adolescents, young adults, physical function, psychosocial functioning, fatigue, pain catastrophizing, workload, anxiety screening

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