The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Systematic Review of Therapeutic Physical Exercise in Patients with Amyotrophic Lateral Sclerosis over Time
Open accessPublished version of a preprint
Abstract
Background: the main objective of this study was to analyze the potential short-, medium- and long-term effects of a therapeutic physical exercise (TFE) programme on the functionality of amyotrophic lateral sclerosis (ALS) patients, measured with the Revised Amyotrophic Lateral Sclerosis Functional Scale (ALSFRS-R) scale. Methods: a systematic review of the PubMed, SCOPUS, Cochrane, Scientific Electronic Library Online (Scielo), Physiotherapy Evidence Database (PEDro), Cumulative Index of Nursing and Allied Health Literature (CINAHL) and Medical Literature Analysis and Retrieval System Online (MEDline) databases was carried out. The information was filtered using the following Medical Subjects Heading (MeSH) terms: “Amyotrophic lateral sclerosis”, “Physical Therapy”, and “Physical and Rehabilitation Medicine”. The internal validity of the selected documents was evaluated using the PEDro scale. The study included clinical trials published in the last 5 years in which one of the interventions was therapeutic physical exercise in patients with ALS, using the ALSFRS-R as the main outcome variable and functional variables as secondary variables. Results: 10 clinical trials were analyzed, with an internal validity of 5–7 points. The TFE groups showed significant short-, medium- and long-term differences, obtaining a mean difference of 5.8 points compared to the 7.6 points obtained by the control groups, at six months, measured with ALSFRS-R. In addition, the participants showed significant improvements in functional abilities in the short, medium and long terms. Conclusions: Therapeutic physical exercise could contribute to slowing down the deterioration of the musculature of patients with ALS, thus facilitating their performance in activities of daily living, based on the significant differences shown by these individuals in the short, medium and long term both in subjective perception, measured with ALSFRS-R, and functional capacities.
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“These beneficial changes underscore the importance of exercise in preventing and slowing the progression of ageing as well as neurodegenerative diseases.504–508”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [505]
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Cites
Reliability of the PEDro Scale for Rating Quality of Randomized Controlled Trials
Maher, C. G., Sherrington, C., Herbert, R. D., Moseley, A. M., & Elkins, M. (2003) · Physical Therapy · doi:10.1093/ptj/83.8.713 · Cited by 4,808 · cited 2×
“, 1 point per item), thus points were obtained based on compliance with the requirements of each particular item [8].”
MethodLatimer‐Cheung, A. E., Pilutti, L. A., Hicks, A. L., Ginis, K. A. M., Fenuta, A. M., MacKibbon, K. A., & Motl, R. W. (2013) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2013.04.020 · Cited by 619 · cited 1×
“studied patients with ALS—moderate intensity, twice per week and aerobic skills combined with strength exercise [21].”
BackgroundMultidisciplinary rehabilitation for adults with multiple sclerosis
Khan, F., Turner‐Stokes, L. F., Ng, L., Kilpatrick, T. J., & Amatya, B. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006036.pub2 · Cited by 314
Stroud, N. M., & MINAHAN, C. L. (2009) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-7-68 · Cited by 164 · cited 1×
“Although, as has been seen in the case of multiple sclerosis, the mechanisms related to fatigue and corticospinal function are altered by the abnormalities in the CNS causing these neurological diseases, the response to exercise and fatigue seems to be different from that in healthy subjects [31].”
Ferreira, G. D., Costa, A. C. C., Plentz, R. D. M., Coronel, C. C., & Sbruzzi, G. (2016) · Physiotherapy · doi:10.1016/j.physio.2016.01.002 · Cited by 114 · cited 1×
“This shows the importance of cardiovascular training in these patients, since the respiratory muscles in more advanced stages of the disease are severely affected [30].”
BackgroundLunetta, C., Lizio, A., Sansone, V., Cellotto, N. M., Maestri, E., Bettinelli, M., Gatti, V., Melazzini, M. G., Meola, G., & Corbo, M. (2015) · Journal of Neurology · doi:10.1007/s00415-015-7924-z · Cited by 98
A randomized controlled trial of resistance and endurance exercise in amyotrophic lateral sclerosis
Clawson, L., Cudkowicz, M., Krivickas, L. S., Brooks, B. R., Sanjak, M., Allred, P., Atassi, N., Swartz, A., Steinhorn, G., Uchil, A., et al. (2017) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2017.1404108 · Cited by 77
Physical therapy for individuals with amyotrophic lateral sclerosis: current insights
Bello-Haas, V. P. M. D. (2018) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s146949 · Cited by 77 · cited 1×
“This fact supports the theory that training must be balanced between muscle overwork and underwork [22].”
BackgroundExercise and amyotrophic lateral sclerosis
de Almeida, J. P. L., Silvestre, R., Pinto, A. C., & de Carvalho, M. A. (2012) · Neurological Sciences · doi:10.1007/s10072-011-0921-9 · Cited by 69 · cited 1×
“It is even inferred that these two aspects could influence factors such as appetite, sleep or mood [29].”
BackgroundMerico, A., Cavinato, M., Gregorio, C., Lacatena, A., Gioia, E., Piccione, F., & Angelini, C. I. (2018) · European Journal of Translational Myology · doi:10.4081/ejtm.2018.7278 · Cited by 68 · cited 7×
“However, in both of the aforementioned studies, the distance in the 6MWT was greater after 1 month [11,16].”
BackgroundResultInfluential
Cited by
Sorted by citations
Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances
Jiang, Q., Liu, J., Huang, S., Wang, X.-Y., Chen, X., Liu, G.-H., Ye, K., Song, W., Masters, C. L., Wang, J., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02145-7 · Cited by 165
Current State and Future Directions in the Therapy of ALS
Tzeplaeff, L., Wilfling, S., Requardt, M. V., & Herdick, M. L. (2023) · Cells · doi:10.3390/cells12111523 · Cited by 171
“Moderate active physical therapy has been shown to have a positive impact on the stabilization and maintenance of physical activity and ALSFRS-R levels when compared to passive therapy [16,65].”
BackgroundUnderstanding Amyotrophic Lateral Sclerosis: Pathophysiology, Diagnosis, and Therapeutic Advances
Rizea, R. E., Corlatescu, A.-D., Costin, H. P., Dumitru, A. V., & Ciurea, A. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25189966 · Cited by 76
“Finally, Riluzole appears to reduce gamma-aminobutyric acid (GABA) reuptake and enhance GABA receptors [110].”
BackgroundThe panoramic view of amyotrophic lateral sclerosis: A fatal intricate neurological disorder
Dhasmana, S., Dhasmana, A., Narula, A. S., Jaggi, M., Yallapu, M. M., & Chauhan, S. C. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120156 · Cited by 54
Convergent pathways of the gut microbiota–brain axis and neurodegenerative disorders
Gubert, C., Gasparotto, J., & Morais, L. H. (2022) · Gastroenterology report · doi:10.1093/gastro/goac017 · Cited by 40
“A more recent systematic review corroborated the effect of exercise on functional abilities in patients with MS in the short, medium and long terms [201].”
Metadata
- Authors
- Ortega-Hombrados, L., Molina-Torres, G., Galán-Mercant, A., Sánchez-Guerrero, E., González-Sánchez, M., & Ruiz-Muñoz, M.
- Affiliations
- Universidad de Cádiz (ES)
- Department of Nursing Sciences, Physiotherapy and Medicine, Faculty of Health Sciences, University of Almería, 04120 Almería, Spain
- Department of Physiotherapy, Faculty of Health Sciences, University of Málaga, 29071 Málaga, Spain
- Institute of Biomedicine of Málaga (IBIMA), 29010 Málaga, Spain
- ORCID
- Venue
- International Journal of Environmental Research and Public Health
- Publisher
- MDPI AG
- Published
- 2021-01-26
- Volume
- 18
- Issue
- 3
- Pages
- 1074
- ISSN
- 1660-4601 (ISSN-L)
- PMC
- PMC7908444
- OpenAlex
- W3124148958
- Cited by
- 62
- References
- 35
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 21 · 2023: 12 · 2022: 5 · 2021: 2
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Repositorio de Patentes de la Universidad de Almería (Universidad de Almería) (submittedVersion, cc-by-nc-nd)
- RODIN (Universidad de Cádiz) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Keywords
- amyotrophic lateral sclerosis, exercise therapy, ALSFRS-R, functional capacity, activities of daily living, long-term outcomes, rehabilitation
- MeSH terms
- Activities of Daily Living, Amyotrophic Lateral Sclerosis, Exercise Therapy, Humans, Exercise, Physical Therapy Modalities
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- Ortega-Hombrados, L., Molina-Torres, G., Galán-Mercant, A., Sánchez-Guerrero, E., González-Sánchez, M., & Ruiz-Muñoz, M. (2021). Systematic Review of Therapeutic Physical Exercise in Patients with Amyotrophic Lateral Sclerosis over Time. International Journal of Environmental Research and Public Health. https://doi.org/10.3390/ijerph18031074
