The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Chelation in Metal Intoxication
Open accessAbstract
Chelation therapy is the preferred medical treatment for reducing the toxic effects of metals. Chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. 2,3-Dimercaprol has long been the mainstay of chelation therapy for lead or arsenic poisoning, however its serious side effects have led researchers to develop less toxic analogues. Hydrophilic chelators like meso-2,3-dimercaptosuccinic acid effectively promote renal metal excretion, but their ability to access intracellular metals is weak. Newer strategies to address these drawbacks like combination therapy (use of structurally different chelating agents) or co-administration of antioxidants have been reported recently. In this review we provide an update of the existing chelating agents and the various strategies available for the treatment of heavy metals and metalloid intoxications.
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Cites
Oxidative mechanisms in the toxicity of metal ions
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P HYTOCHELATINS AND M ETALLOTHIONEINS : Roles in Heavy Metal Detoxification and Homeostasis
Cobbett, C., & Goldsbrough, P. (2002) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.53.100301.135154 · Cited by 2,518
Toxic Metals and Oxidative Stress Part I: Mechanisms Involved in Me-tal induced Oxidative Damage
Nuran Ercal, B. S. P., Hande Gurer-Orhan, B. S. P., & Nukhet Aykin-Burns, B. S. P. (2001) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026013394831 · Cited by 1,944
Brain iron pathways and their relevance to Parkinson's disease
Berg, D., Gerlach, M., Youdim, M. B. H., Double, K. L., Zecca, L., Riederer, P., & Becker, G. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00608.x · Cited by 362
Cited by
The effects of cadmium toxicity
Genchi, G., Sinicropi, M. S., Lauria, G., Carocci, A., & Catalano, A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17113782 · Cited by 2,722
Ullah, H., Noreen, S., Fozia, Rehman, A., Waseem, A., Zubair, S., Adnan, M., & Ahmad, I. (2017) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2013.09.021 · Cited by 172
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Collagen Prolyl 4-Hydroxylase as a Therapeutic Target: Miniperspective
Vasta, J. D., & Raines, R. T. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00822 · Cited by 82
Metadata
- Authors
- Flora, S. J. S., & Pachauri, V.
- Venue
- International Journal of Environmental Research and Public Health
- Publisher
- MDPI AG
- Published
- 2010-06-28
- Volume
- 7
- Issue
- 7
- Pages
- 2745-2788
- ISSN
- 1660-4601 (ISSN-L)
- OpenAlex
- W2166447472
- Cited by
- 1,005
- References
- 4
- FWCI
- 16.25
- Type
- journal article
- Language
- en
- Open access
- gold
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