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Cited by 459

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Maternal–Fetal Nutrient Transport in Pregnancy Pathologies: The Role of the Placenta

Open access
Brett, Kendra, Ferraro, Zachary, Yockell-Lelievre, Julien, Gruslin, Andrée, Adamo, Kristi·2014·International Journal of Molecular Sciences
DOI 10.3390/ijms150916153
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Abstract

Appropriate in utero growth is essential for offspring development and is a critical contributor to long-term health. Fetal growth is largely dictated by the availability of nutrients in maternal circulation and the ability of these nutrients to be transported into fetal circulation via the placenta. Substrate flux across placental gradients is dependent on the accessibility and activity of nutrient-specific transporters. Changes in the expression and activity of these transporters is implicated in cases of restricted and excessive fetal growth, and may represent a control mechanism by which fetal growth rate attempts to match availability of nutrients in maternal circulation. This review provides an overview of placenta nutrient transport with an emphasis on macro-nutrient transporters. It highlights the changes in expression and activity of these transporters associated with common pregnancy pathologies, including intrauterine growth restriction, macrosomia, diabetes and obesity, as well as the potential impact of maternal diet. Molecular signaling pathways linking maternal nutrient availability and placenta nutrient transport are discussed. How sexual dimorphism affects fetal growth strategies and the placenta’s response to an altered intrauterine environment is considered. Further knowledge in this area may be the first step in the development of targeted interventions to help optimize fetal growth.

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Metadata

Authors
Brett, K., Ferraro, Z., Yockell-Lelievre, J., Gruslin, A., & Adamo, K.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2014-09-12
Volume
15
Issue
9
Pages
16153-16185
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms150916153
OpenAlex
W2121636881
Cited by
459
References
28
FWCI
26.05
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Maternal–Fetal Nutrient Transport in Pregnancy Pathologies: The Role of the Placenta. https://app.cochat.ai/papers/10.3390/ijms150916153
The paper
Brett, K., Ferraro, Z., Yockell-Lelievre, J., Gruslin, A., & Adamo, K. (2014). Maternal–Fetal Nutrient Transport in Pregnancy Pathologies: The Role of the Placenta. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms150916153

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.