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Mechanism of Action of IL-7 and Its Potential Applications and Limitations in Cancer Immunotherapy
Open accessAbstract
Interleukin-7 (IL-7) is a non-hematopoietic cell-derived cytokine with a central role in the adaptive immune system. It promotes lymphocyte development in the thymus and maintains survival of naive and memory T cell homeostasis in the periphery. Moreover, it is important for the organogenesis of lymph nodes (LN) and for the maintenance of activated T cells recruited into the secondary lymphoid organs (SLOs). The immune capacity of cancer patients is suppressed that is characterized by lower T cell counts, less effector immune cells infiltration, higher levels of exhausted effector cells and higher levels of immunosuppressive cytokines, such as transforming growth factor β (TGF-β). Recombinant human IL-7 (rhIL-7) is an ideal solution for the immune reconstitution of lymphopenia patients by promoting peripheral T cell expansion. Furthermore, it can antagonize the immunosuppressive network. In animal models, IL-7 has been proven to prolong the survival of tumor-bearing hosts. In this review, we will focus on the mechanism of action and applications of IL-7 in cancer immunotherapy and the potential restrictions for its usage.
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“IL-7R down-regulation guarantees an efficient use of the limited amount of IL-7 to naïve T cells that need it, driving their proliferation and preserving their phenotype (160).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [160]
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Metadata
- Authors
- Gao, J., Zhao, L., Wan, Y., & Zhu, B.
- Affiliations
- Army Medical University (CN)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Wan, Yisong
- Zhu, Bo
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2015-05-06
- Volume
- 16
- Issue
- 5
- Pages
- 10267-10280
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC4463645
- OpenAlex
- W1595607998
- Cited by
- 122
- References
- 80
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 8 · 2023: 12 · 2022: 15 · 2021: 15 · 2020: 15 · 2019: 16 · 2018: 8 · 2017: 13 · 2016: 9 · 2015: 2
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UNC Libraries
- Funders
- National Natural Science Foundation of China (81222031, 81071772, 81070018)
- Chongqing Science and Technology Commission
- National Key Research and Development Program of China
- National Institute of Allergy and Infectious Diseases (R01AI097392)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- IL-7, cancer immunotherapy, T cell homeostasis, lymphocyte development, secondary lymphoid organs, T cell exhaustion, immunosuppression, TGF-beta, lymphopenia, immune reconstitution
- MeSH terms
- Animals, Humans, Immunotherapy, Neoplasms, T-Lymphocytes, Signal Transduction, Interleukin-7
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