Cited by 122T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

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Mechanism of Action of IL-7 and Its Potential Applications and Limitations in Cancer Immunotherapy

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Gao, Jianbao, Zhao, Lintao, Wan, Yisong, Zhu, Bo·2015·International Journal of Molecular Sciences

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Abstract

Interleukin-7 (IL-7) is a non-hematopoietic cell-derived cytokine with a central role in the adaptive immune system. It promotes lymphocyte development in the thymus and maintains survival of naive and memory T cell homeostasis in the periphery. Moreover, it is important for the organogenesis of lymph nodes (LN) and for the maintenance of activated T cells recruited into the secondary lymphoid organs (SLOs). The immune capacity of cancer patients is suppressed that is characterized by lower T cell counts, less effector immune cells infiltration, higher levels of exhausted effector cells and higher levels of immunosuppressive cytokines, such as transforming growth factor β (TGF-β). Recombinant human IL-7 (rhIL-7) is an ideal solution for the immune reconstitution of lymphopenia patients by promoting peripheral T cell expansion. Furthermore, it can antagonize the immunosuppressive network. In animal models, IL-7 has been proven to prolong the survival of tumor-bearing hosts. In this review, we will focus on the mechanism of action and applications of IL-7 in cancer immunotherapy and the potential restrictions for its usage.

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Figure 1 Effects of IL-7 in cancer immunotherapy. IL-7 can maintain the survival of CTLs and memory T cells. It promotes immune reconstitution both from the thymus-independent homeostatic expansion of peripheral T cells and thymopoiesis. It enhances the efficacy of tumor regression by enhancing effector cells infiltration, such as CTL, NK, NKT and Th17 with an upregulated killing capability. It also antagonizes the immunosuppressive network.CC BY · PubMed Central

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Authors: Gao, J., Zhao, L., Wan, Y., & Zhu, B.
Affiliations: Army Medical University (CN)
University of North Carolina at Chapel Hill (US)
Corresponding author: Wan, Yisong
Zhu, Bo
ORCID: Gao, Jianbao
Zhao, Lintao
Wan, Yisong
Zhu, Bo
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2015-05-06
Volume: 16
Issue: 5
Pages: 10267-10280
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms160510267
PMC: PMC4463645
OpenAlex: W1595607998
Cited by: 122
References: 80
Citations by year: 2026: 4 · 2025: 4 · 2024: 8 · 2023: 12 · 2022: 15 · 2021: 15 · 2020: 15 · 2019: 16 · 2018: 8 · 2017: 13 · 2016: 9 · 2015: 2
FWCI: 1.00
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
UNC Libraries
Funders: National Natural Science Foundation of China (81222031, 81071772, 81070018)
Chongqing Science and Technology Commission
National Key Research and Development Program of China
National Institute of Allergy and Infectious Diseases (R01AI097392)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: IL-7, cancer immunotherapy, T cell homeostasis, lymphocyte development, secondary lymphoid organs, T cell exhaustion, immunosuppression, TGF-beta, lymphopenia, immune reconstitution
MeSH terms: Animals, Humans, Immunotherapy, Neoplasms, T-Lymphocytes, Signal Transduction, Interleukin-7

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Mechanism of Action of IL-7 and Its Potential Applications and Limitations in Cancer Immunotherapy

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