Cited by 611Traditional and Medicinal Uses of AnnonaceaePhytochemical Studies and BioactivitiesMedicinal Plant Research

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Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities

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Moghadamtousi, Soheil, Fadaeinasab, Mehran, Nikzad, Sonia, Mohan, Gokula, Ali, Hapipah, Kadir, Habsah·2015·International Journal of Molecular Sciences

DOI 10.3390/ijms160715625PMC PMC4519917

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Abstract

Annona muricata is a member of the Annonaceae family and is a fruit tree with a long history of traditional use. A. muricata, also known as soursop, graviola and guanabana, is an evergreen plant that is mostly distributed in tropical and subtropical regions of the world. The fruits of A. muricata are extensively used to prepare syrups, candies, beverages, ice creams and shakes. A wide array of ethnomedicinal activities is contributed to different parts of A. muricata, and indigenous communities in Africa and South America extensively use this plant in their folk medicine. Numerous investigations have substantiated these activities, including anticancer, anticonvulsant, anti-arthritic, antiparasitic, antimalarial, hepatoprotective and antidiabetic activities. Phytochemical studies reveal that annonaceous acetogenins are the major constituents of A. muricata. More than 100 annonaceous acetogenins have been isolated from leaves, barks, seeds, roots and fruits of A. muricata. In view of the immense studies on A. muricata, this review strives to unite available information regarding its phytochemistry, traditional uses and biological activities.

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Authors: Moghadamtousi, S., Fadaeinasab, M., Nikzad, S., Mohan, G., Ali, H., & Kadir, H.
Affiliations: University of Malaya (MY)
Corresponding author: Kadir, Habsah
ORCID: Fadaeinasab, Mehran
Kadir, Habsah
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2015-07-10
Volume: 16
Issue: 7
Pages: 15625-15658
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms160715625
PMC: PMC4519917
OpenAlex: W1589548587
Cited by: 577
References: 151
Citations by year: 2026: 39 · 2025: 50 · 2024: 65 · 2023: 73 · 2022: 71 · 2021: 80 · 2020: 60 · 2019: 66 · 2018: 39 · 2017: 24 · 2016: 9 · 2015: 1
FWCI: 2.31
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Traditional and Medicinal Uses of Annonaceae
Physical Sciences › Chemistry › Organic Chemistry › Phytochemical Studies and Bioactivities
Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords: Annona muricata, Annonaceae, acetogenins, traditional medicine, ethnomedicine, anticancer activity, anticonvulsant activity, anti-arthritic activity, antiparasitic activity, antimalarial activity, hepatoprotection, antidiabetic activity, phytochemistry, medicinal plants
MeSH terms: Anti-Infective Agents, Anti-Inflammatory Agents, Antineoplastic Agents, Phytogenic, Antioxidants, Central Nervous System, Central Nervous System Agents, Hypoglycemic Agents, Oils, Volatile, Apoptosis, Annona, Acetogenins

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Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities

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