Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities

Moghadamtousi, Soheil; Fadaeinasab, Mehran; Nikzad, Sonia; Mohan, Gokula; Ali, Hapipah; Kadir, Habsah

doi:10.3390/ijms160715625

Cited by 611Traditional and Medicinal Uses of AnnonaceaePhytochemical Studies and BioactivitiesMedicinal Plant Research

Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities

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Moghadamtousi, Soheil, Fadaeinasab, Mehran, Nikzad, Sonia, Mohan, Gokula, Ali, Hapipah, Kadir, Habsah·2015·International Journal of Molecular Sciences

DOI 10.3390/ijms160715625PMC PMC4519917

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Abstract

Annona muricata is a member of the Annonaceae family and is a fruit tree with a long history of traditional use. A. muricata, also known as soursop, graviola and guanabana, is an evergreen plant that is mostly distributed in tropical and subtropical regions of the world. The fruits of A. muricata are extensively used to prepare syrups, candies, beverages, ice creams and shakes. A wide array of ethnomedicinal activities is contributed to different parts of A. muricata, and indigenous communities in Africa and South America extensively use this plant in their folk medicine. Numerous investigations have substantiated these activities, including anticancer, anticonvulsant, anti-arthritic, antiparasitic, antimalarial, hepatoprotective and antidiabetic activities. Phytochemical studies reveal that annonaceous acetogenins are the major constituents of A. muricata. More than 100 annonaceous acetogenins have been isolated from leaves, barks, seeds, roots and fruits of A. muricata. In view of the immense studies on A. muricata, this review strives to unite available information regarding its phytochemistry, traditional uses and biological activities.

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A. muricata caused a significant increase in Hsp70, which is crucial for healing due to its role in cell proliferation.
“Heat-shock proteins (Hsp70) expressed during the inflammatory phase are crucial for healing due to their role in cell proliferation, and A. muricata caused a significant increase in Hsp70 [2].”
From Annona muricata: Comprehensive Review on the Ethnomedicinal, Phytochemistry, and Pharmacological Aspects Focusing on Antidiabetic Properties (2023) · cites this paper as [2]
Section 5.13 (Wound Healing Activity; page not provided) reports that topical A. muricata leaf extract promoted healing of excisional wounds in rats and up-regulated Hsp70 during healing. It does not say that the Hsp70 increase was statistically significant or that Hsp70 is crucial to healing because of a role in cell proliferation. (LLM, conf=0.86)
Experimental — accuracy not yet measured
A. muricata exhibits hypotensive action, which can reduce blood pressure by blocking calcium ion channels rather than engaging endothelium- and nitric-oxide-dependent mechanisms.
“A. muricata exhibits hypotensive action, which can reduce blood pressure by blocking calcium ion channels rather than engaging endothelium- and nitric-oxide-dependent mechanisms.”
From Annona muricata: Comprehensive Review on the Ethnomedicinal, Phytochemistry, and Pharmacological Aspects Focusing on Antidiabetic Properties (2023) · cites this paper as [2]
Section 5.7, “Antihypertensive Activity” (page not provided), reports that an aqueous A. muricata leaf extract lowered blood pressure in normotensive rats and suggests a mechanism involving Ca²⁺ antagonism. It does not establish calcium-channel blockade or say that endothelium- and nitric-oxide-dependent mechanisms are excluded. The claim also presents the suggested mechanism more definitively than the review does. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Oral administration of A. muricata ethanolic leaf extracts (10, 30, 100, and 300 mg/kg) significantly reduced carrageenan-induced paw edema.
“Oral administration of A. muricata ethanolic leaf extracts (10, 30, 100, and 300 mg/kg) significantly reduced carrageenan-induced paw edema, demonstrating the plant’s anti-inflammatory properties.”
From Annona muricata: Comprehensive Review on the Ethnomedicinal, Phytochemistry, and Pharmacological Aspects Focusing on Antidiabetic Properties (2023) · cites this paper as [2]
The same extract, administered orally to mice, significantly reduced abdominal contortions generated by acetic acid (0.6% v/v), displaying a potent anti-nociceptive effect.
“The same extract, administered orally to mice, significantly reduced abdominal contortions generated by acetic acid (0.6% v/v), displaying a potent anti-nociceptive effect [2].”
From Annona muricata: Comprehensive Review on the Ethnomedicinal, Phytochemistry, and Pharmacological Aspects Focusing on Antidiabetic Properties (2023) · cites this paper as [2]
This plant showed a compromising wound-healing activity, especially from the leaf and bark extract.
“This plant showed a compromising wound-healing activity, especially from the leaf and bark extract [2].”
From Annona muricata: Comprehensive Review on the Ethnomedicinal, Phytochemistry, and Pharmacological Aspects Focusing on Antidiabetic Properties (2023) · cites this paper as [2]

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Muricatetrocins A and B and Gigantetrocin B: Three New Cytotoxic Monotetrahydrofuran‐Ring Acetogenins from Annona muricata
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Two acetogenins from Annona muricata seeds
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Acetogenins in Annona muricata L. (annonaceae) leaves are potent molluscicides
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Enhanced extraction yields and mobile phase separations by solvent mixtures for the analysis of metabolites in Annona muricata L. leaves
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Additional Bioactive Acetogenins, Annomutacin and (2,4-trans and cis)-10R-Annonacin-A-ones, from the Leaves of Annona muricata
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Volatile Components ofAnnona muricataL.
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Evaluation of hepatoprotective effect of aqueous extract of Annona muricata (Linn.) leaf against carbon tetrachloride and acetaminophen-induced liver damage
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Synergistic larvicidal effect and morphological alterations induced by ethanolic extracts of Annona muricata and Piper nigrum against the dengue fever vector Aedes aegypti
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Bioactive Single-Ring Acetogenins from Seed Extracts ofAnnona muricata
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Three new megastigmanes from the leaves of Annona muricata
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Cohibins A and B, acetogenins from roots of Annona muricata
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Murisolin: A New Cytotoxic Mono-tetrahydrofuran-g-lactone from Annona muricata
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Annomuricatin C, a novel cyclohexapeptide from the seeds of Annona muricata
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Protective Effects Of Annona Muricata Linn. (Annonaceae) Leaf Aqueous Extract On Serum Lipid Profiles And Oxidative Stress In Hepatocytes Of Streptozotocin-Treated Diabetic Rats
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Epoxymurins A and B, two biogenetic precursors of annonaceous acetogenins from annona muricata
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Mosquito larvicidal and cytotoxic activities of 3 Annona species and isolation of active principles
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Anti Hyperlipidemic Activities Of Annona Muricata (Linn)
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Murihexocins A and B, two novel mono-THF acetogenins with six hydroxyls, from Annona muricata (Annonaceae)
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Actividad insecticida de extractos de semilla de Annona muricata (Anonaceae) sobre Sitophilus zeamais (Coleoptera: Curculionidae)
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Evaluation of Jatropha curcas and Annona muricata Seed Crude Extracts Against Sitophilus zeamais Infesting Stored Rice
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Wound Healing Activity of Annona muricata extract
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Chemical Compositions, Anti-Inflammatory, Antiproliferative and Radical-Scavenging Activities of Actinidia callosa var. ephippioides
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Thermal diffusivity of soursop (Annona muricata L.) pulp
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Cyclopeptide from the seeds of Annona muricata
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Anti Hyperglycemic Activities Of Annona Muricata (Linn)
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Isolation and structure elucidation of sabadelin, an acetogenin from roots of Annona muricata
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Murihexol, a linear acetogenin from Annona muricata
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Cohibins C and D, Two Important Metabolites in the Biogenesis of Acetogenins from Annona muricata and Annona nutans
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Annonaa muricata Linn Leaf Induce Apoptosis in Cancer Cause Virus
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Isolation of Montecristin, a Key Metabolite in Biogenesis of Acetogenins from Annona muricata and Its Structure Elucidation by Using Tandem Mass Spectrometry
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Alkaloids from Annona muricata leaves
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Evaluation of Anticancer Activity of Annona muricata in 1, 2-Dimethyl Hydrazine Induced Colon Cancer
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Anti-inflammatory and anti-nociceptive activities of the ethanolic extract of Annona muricata leaf
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Annonaceous Acetogenins of the Seeds fromAnnona Muricata
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Induction of Apoptosis in Myelogenous Leukemic K562 Cells by Ethanolic Leaf Extract of Annona muricata
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Annona muricata L.
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Anti-arthritic activities of Annona muricata L. leaves extract on complete Freund's adjuvant (CFA) – induced arthritis in rats
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Toxicity, Anti-Lipid Peroxidation, Invitro and Invivo Evaluation of Antioxidant Activity of Annona Muricata Ethanol Stem Bark Extract
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Effect of Annooa muricata and Polyalthia cerasoides on Brain Neurotransimitters and Enzyme Monoamine Oxidase Following Cold Immobilization Stress
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Coronin from Roots of Annona muricata, a Putative Intermediate in Acetogenin Biosynthesis (1)
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ChemInform Abstract: Acetogenins from Annonaceae, Inhibitors of Mitochondrial Complex I
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Insecticidal Activity of Annona Muricata (Anonaceae) Seed Extracts On Sitophilus Zeamais (Coleoptera: Curculionidae)
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Actividad citotóxica in Vitro de la mezcla de Annona muricata y Krameria Lappacea sobre células cancerosas de glándula mamaria, pulmón y sistema nervioso central
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Antioxidative and Antimutagenic Activities of Healthy Herbal Drinks from Chinese Medicinal Herbs
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ANNOMURICATIN A,A NEW CYCLOPEPTIDE FROM THE SEEDS OF ANNONA MURICATA
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Effects Of Annona Muricata (Linn) On The Morphology Of Pancreatic Islet Cells Of Experimentally-Induced Diabetic Wistar Rats
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Muricatenol, a Linear Acetogenin from Annona muricata (Annonaceae)
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Effects of ethanol extract of Annona muricata on pentylenetetrazol‐induced convulsive seizures in mice
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The medicinal and poisonous plants of southern and eastern Africa: being an account of their medicinal and other uses, chemical composition, pharmacological effects aod toricotogy in man and annimal.
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Efficacy of seed extracts of Annona squamosa and Annona muricata(Annonaceae) for the control of Aedes albopictus and Culex quinquefasciatus(Culicidae)
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Anticancer therapeutic efficacy of biogenic Am-ZnO nanoparticles on 2D and 3D tumor models
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Ethnobotanical Documentation of Medicinal Plants Used by the Indigenous Panay Bukidnon in Lambunao, Iloilo, Philippines
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Annonaceae: Breaking the Wall of Inflammation
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Annona muricata: An alternate mosquito control agent with special reference to inhibition of detoxifying enzymes in Aedes aegypti
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Annona cherimola Seed Extract Activates Extrinsic and Intrinsic Apoptotic Pathways in Leukemic Cells
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A review of Cameroonian medicinal plants with potentials for the management of the COVID-19 pandemic
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A review of adsorbents for removal of yellow tartrazine dye from water and wastewater
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Biodiesel Production from a Novel Nonedible Feedstock, Soursop (Annona muricata L.) Seed Oil
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Neuroprotective effect of Annona muricata-derived polysaccharides in neuronal HT22 cell damage induced by hydrogen peroxide
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Antifungal Annona muricata L. (soursop) extract targets the cell envelope of multi-drug resistant Candida albicans
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Acetogenins from Annonaceae plants: potent antitumor and neurotoxic compounds
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Current Situation and Perspectives of Fruit Annonaceae in Mexico: Biological and Agronomic Importance and Bioactive Properties
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Evaluation of Annona muricata extract against Staphylococcus aureus isolate and in-silico activity of bioactive compounds against Capsular protein (Cap5O)
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Ethnomedicinal plant species commonly used to manage arthritis in North-West Nigeria
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Evaluation of wound healing activity of ethanol extract of Annona reticulata L. leaf both in vitro and in diabetic mice model
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Folate-modified Annonaceous acetogenins nanosuspensions and their improved antitumor efficacy
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Ethanol Extracts from Thai Plants have Anti-Plasmodium and Anti-Toxoplasma Activities In Vitro
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Ethnobotanical Survey of Medicinal Plants Used in Breast Cancer Treatment by Traditional Health Practitioners in Central Uganda
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Acetogenins from Annona muricata as potential inhibitors of antiapoptotic proteins: a molecular modeling study
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Soursop fruit extract mitigates scopolamine-induced amnesia and oxidative stress via activating cholinergic and Nrf2/HO-1 pathways
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Tropical foods as functional foods for metabolic syndrome
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Biological Activity of Selected Compounds from Annona muricata Seed as Antibreast Cancer Agents: Theoretical Study
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Salicylic acid relieves the effect of saline stress on soursop morphysiology
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Revealing the potency of Annona muricata leaves extract as FOXO1 inhibitor for diabetes mellitus treatment through computational study
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Cytotoxic and Bactericidal Effect of Silver Nanoparticles Obtained by Green Synthesis Method Using Annona muricata Aqueous Extract and Functionalized with 5-Fluorouracil
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Health Benefits Of Annona Muricata - A Review
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Authors: Moghadamtousi, S., Fadaeinasab, M., Nikzad, S., Mohan, G., Ali, H., & Kadir, H.
Affiliations: University of Malaya (MY)
Corresponding author: Kadir, Habsah
ORCID: Fadaeinasab, Mehran
Kadir, Habsah
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2015-07-10
Volume: 16
Issue: 7
Pages: 15625-15658
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms160715625
PMC: PMC4519917
OpenAlex: W1589548587
Cited by: 577
References: 151
Citations by year: 2026: 39 · 2025: 50 · 2024: 65 · 2023: 73 · 2022: 71 · 2021: 80 · 2020: 60 · 2019: 66 · 2018: 39 · 2017: 24 · 2016: 9 · 2015: 1
FWCI: 2.31
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Traditional and Medicinal Uses of Annonaceae
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords: Annona muricata, Annonaceae, acetogenins, traditional medicine, ethnomedicine, anticancer activity, anticonvulsant activity, anti-arthritic activity, antiparasitic activity, antimalarial activity, hepatoprotection, antidiabetic activity, phytochemistry, medicinal plants
MeSH terms: Anti-Infective Agents, Anti-Inflammatory Agents, Antineoplastic Agents, Phytogenic, Antioxidants, Central Nervous System, Central Nervous System Agents, Hypoglycemic Agents, Oils, Volatile, Apoptosis, Annona, Acetogenins

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Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities

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