The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hepatotoxicity by Drugs: The Most Common Implicated Agents
Abstract
Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. Information on the documented hepatotoxicity of drugs has recently been made available by a website that can be accessed in the public domain: LiverTox (http://livertox.nlm.nih.gov). According to critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one case report of convincing reports of liver injury. Only 48 drugs had more than 50 case reports of DILI. Amoxicillin-clavulanate is the most commonly implicated agent leading to DILI in the prospective series. In a recent prospective study, liver injury due to amoxicillin-clavulanate was found to occur in approximately one out of 2300 users. Drugs with the highest risk of DILI in this study were azathioprine and infliximab.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The LiverTox database is known for inclusion of liver injury cases lacking robust CAMs and is therefore disputed.
“Critical is also the data source of used cases, which were partially retrieved from the USA’s National Institutes of Health LiverTox database,67 known for inclusion of liver injury cases lacking robust CAMs and being therefore disputed.69–71”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [69]
Cases were also derived from the LiverTox database, with its published problems in assessing a correct causality in liver injury cases.
“Cases were also derived from the LiverTox database,67 with its published problems in assessing a correct causality in liver injury cases.69–71”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [69]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Björnsson, E. S., Bergmann, O. M., Björnsson, H. K., Kvaran, R. B., & Olafsson, S. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.006 · Cited by 865
Flagged first, then by citations
Research works printed but not linked: 20
- Bjornsson, 2015, Discrepancies in liver disease labeling in the package inserts of commonly prescribed medications, Gastroenterology, 148, 269, 10.1053/j.gastro.2014.12.007 · DOI
- Andrade, 2009, Rechallenge in drug-induced liver injury: The attractive hazard, Expert Opin. Drug Saf., 8, 709, 10.1517/14740330903397378 · DOI · Paper page
- Papay, 2009, Drug-induced liver injury following positive drug rechallenge, Regul. Toxicol. Pharmacol., 54, 84, 10.1016/j.yrtph.2009.03.003 · DOI
- Sciff, E.R., Sorrell, M.F., and Maddrey, W.C. (1999). Diseases of the Liver, Schiff’s Lippincott-Raven Publishers. [8th ed.].
- Agarwal, 2010, Important elements for the diagnosis of drug-induced liver injury, Clin. Gastroenterol. Hepatol., 8, 463, 10.1016/j.cgh.2010.02.008 · DOI
- Björnsson, E.S., and Hoofnagle, J.H. (2015). Categorization of drugs implicated in causing liver injury: Critical assessment based upon published case reports. Hepatology. · DOI · Paper page
- Danan, G., and Teschke, R. (2016). RUCAM in drug and herb induced liver injury: The update. Int. J. Mol. Sci., 17. · DOI · Paper page
- Senior, 2014, Evolution of the Food and Drug Administration approach to liver safety assessment for new drugs: Current status and challenges, Drug Saf., 37, S9, 10.1007/s40264-014-0182-7 · DOI
- Andrade, 2005, Drug-induced liver injury: An analysis of 461 incidences submitted to the Spanish registry over a 10-year period, Gastroenterology, 129, 512, 10.1016/j.gastro.2005.05.006 · DOI
- Chalasani, 2008, Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States, Gastroenterology, 135, 1924, 10.1053/j.gastro.2008.09.011 · DOI
- Olsson, 2005, Outcome and prognostic markers in severe drug-induced liver disease, Hepatology, 42, 481, 10.1002/hep.20800 · DOI · Paper page
- Devarbhavi, 2010, Single-center experience with drug-induced liver injury from India: Causes, outcome, prognosis, and predictors of mortality, Am. J. Gastroenterol., 105, 2396, 10.1038/ajg.2010.287 · DOI · Paper page
- Leaf, 1997, Severe hepatitis in three AIDS patients treated with indinavir, Lancet, 349, 924, 10.1016/S0140-6736(05)62700-6 · DOI
- Vergis, 1998, Indinavir-associated hepatitis in patients with advanced HIV infection, Int. J. STD AIDS, 9, 53, 10.1258/0956462981920883 · DOI
- Pavel, 2007, Severe liver toxicity in postexposure prophylaxis for HIV infection with a zidovudine, lamivudine and fosamprenavir/ritonavir regimen, AIDS, 21, 268, 10.1097/QAD.0b013e328011aa35 · DOI
- Chalasani, 2015, Features and outcomes of 889 patients with drug-induced liver injury: The DILIN prospective study, Gastroenterology, 148, 1340, 10.1053/j.gastro.2015.03.006 · DOI · Paper page
- Suzuki, 2010, Unified list of drugs causing hepatotoxicity and the reporting frequency of liver events in the WHO vigibaset: International collaborative work, Drug Saf., 33, 503, 10.2165/11535340-000000000-00000 · DOI
- 1993, The increased risk of hospitalizations for acute liver injury in a population with exposure to multiple drugs, Epidemiology, 4, 496, 10.1097/00001648-199311000-00004 · DOI
- Jick, 1997, A review of epidemiologic research on drug-induced acute liver injury using the general practice research data base in the United Kingdom, Pharmacotherapy, 17, 721, 10.1002/j.1875-9114.1997.tb03747.x · DOI
- Montero, 2004, Acute and clinically relevant drug-induced liver injury: A population based case-control study, Br. J. Clin. Pharmacol., 58, 71, 10.1111/j.1365-2125.2004.02133.x · DOI
Cited by
Sorted by citations
Baudy, A. R., Otieno, M. A., Hewitt, P., Gan, J., Roth, A., Keller, D., Sura, R., Van Vleet, T. R., & Proctor, W. R. (2020) · Lab on a Chip · doi:10.1039/c9lc00768g · Cited by 150
Chen, S., Wu, Q., Li, X., Li, D., Mei, N., Ning, B., Puig, M., Ren, Z., Tolleson, W. H., & Guo, L. (2021) · Journal of Environmental Science and Health, Part C · doi:10.1080/26896583.2021.1880242 · Cited by 44
Teschke, R., Zhu, Y., & Jing, J. (2020) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2020.00009 · Cited by 41
Metadata
- Authors
- Björnsson, E.
- Affiliations
- Department of Internal Medicine, Division of Gastroenterology and Hepatology, The National University Hospital of Iceland and The Faculty of Medicine, The University of Iceland, 108 Reykjavik, Iceland
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2016-02-06
- Volume
- 17
- Issue
- 2
- Pages
- 224
- ISSN
- 1422-0067
- PMC
- PMC4783956
- Cited by
- 254
- References
- 1
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
