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Sertraline, an Antidepressant, Induces Apoptosis in Hepatic Cells Through the Mitogen-Activated Protein Kinase Pathway

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Human Hepatic Cytochrome P450-Specific Metabolism of the Organophosphorus Pesticides Methyl Parathion and Diazinon

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Mechanism study of goldenseal-associated DNA damage

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The Role of Autophagy in Usnic Acid-Induced Toxicity in Hepatic Cells

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Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract

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The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity

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Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury

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Upgrading cytochrome P450 activity in HepG2 cells co-transfected with adenoviral vectors for drug hepatotoxicity assessment

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Contribution of Carboxylesterase and Cytochrome P450 to the Bioactivation and Detoxification of Isocarbophos and Its Enantiomers in Human Liver Microsomes

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The role of hepatic cytochrome P450s in the cytotoxicity of sertraline

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Advantages of Human Hepatocyte-Derived Transformants Expressing a Series of Human Cytochrome P450 Isoforms for Genotoxicity Examination

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DNA damage‐induced apoptosis and mitogen‐activated protein kinase pathway contribute to the toxicity of dronedarone in hepatic cells

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Brivanib Exhibits Potential for Pharmacokinetic Drug–Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes

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Mechanism-Based Inactivation of Human Cytochrome P450 2B6 by Chlorpyrifos

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Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme

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Human Liver Microsomes Atropselectively Metabolize 2,2′,3,4′,6-Pentachlorobiphenyl (PCB 91) to a 1,2-Shift Product as the Major Metabolite

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Calcium Contributes to the Cytotoxic Interaction Between Diclofenac and Cytokines

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Chinese Herbal Medicine Hepatotoxicity: The Evaluation and Recognization Based on Large-scale Evidence Database

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Use of Liver-Derived Cell Lines for the Study of Drug-Induced Liver Injury

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Atropselective Oxidation of 2,2′,3,3′,4,6′-Hexachlorobiphenyl (PCB 132) to Hydroxylated Metabolites by Human Liver Microsomes and Its Implications for PCB 132 Neurotoxicity

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The role of hepatic cytochrome P450s in the cytotoxicity of dronedarone

Chen, S., Wu, Q., Ning, B., Bryant, M., & Guo, L. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2196-x · Cited by 12 · see citing works

Determination of the human cytochrome P450 monooxygenase catalyzing the enantioselective oxidation of 2,2′,3,5′,6-pentachlorobiphenyl (PCB 95) and 2,2′,3,4,4′,5′,6-heptachlorobiphenyl (PCB 183)

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Roles of CYP3A4, CYP3A5 and CYP2C8 drug-metabolizing enzymes in cellular cytostatic resistance

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Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays

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In vitro localization of modified zinc oxide nanoparticles showing selective anticancer effects against colorectal carcinoma using biophysical techniques

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Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s

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The Performance of HepG2 and HepaRG Systems through the Glass of Acetaminophen-Induced Toxicity

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Vascularized liver-on-a-chip model to investigate nicotine-induced dysfunction

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Unveiling the therapeutic potential of anthocyanin/cisplatin-loaded chitosan nanoparticles against breast and liver cancers

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Metabolism and liver toxicity of cannabidiol

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Dabrafenib inhibits ABCG2 and cytochrome P450 isoenzymes; potential implications for combination anticancer therapy

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Advancing hepatotoxicity assessment: current advances and future directions

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The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib

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Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System

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Nutrient environment improves drug metabolic activity in human iPSC-derived hepatocytes and HepG2

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Moringa oleifera Lam Leaf Extract Stimulates NRF2 and Attenuates ARV-Induced Toxicity in Human Liver Cells (HepG2)

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Study of the roles of cytochrome P450 (CYPs) in the metabolism and cytotoxicity of perhexiline

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Application of HepaRG cells for genotoxicity assessment: a review

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Microphysiological systems as an emerging in vitro approach for the evaluation of drug absorption, distribution, metabolism, and excretion and toxicity

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Investigation of cannabidiol-induced cytotoxicity in human hepatic cells

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A Review on New Frontiers in Drug-Drug Interaction Predictions and Safety Evaluations with In Vitro Cellular Models

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Novel emerging cell and organoid systems for the study of drug metabolism and toxicity in humans

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Therapeutic Intervention of Opuntia Ficus Indica (L.) Fruit and Seed Powder against CCl4-Induced Acute Liver Injury in Wistar Rats

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Mixed Ru(II)–Ir(III) Complexes as Photoactive Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4

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Ir(III)-Based Agents for Monitoring the Cytochrome P450 3A4 Active Site Occupancy

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The HepG2 Cell Line as a Model for Studying Metabolic Dysfunction-Associated Steatotic Liver Disease

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Metabolic flux analysis of bile acid biosynthesis acidic pathway in HepG2 cells reveals CYP8B1 inhibition of azole antifungals

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Safety of ferrite nanoparticles for biomedical applications: Cyto- and genotoxic effects of MxFe3-xO4 (M = Fe, Zn, Mn) in an Advanced 3D human hepatic in vitro model

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Ruthenium Complex Suppresses Proliferation of Residual Hepatocellular Carcinoma after Incomplete Radiofrequency Ablation Therapy

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Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing

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7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells

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A Network-based Transcriptomic Landscape of HepG2 cells to Uncover Causal Gene Cytotoxicity Interactions Underlying Drug-Induced Liver InjuryPreprint

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Plumbagin and Plumbago indica Differentially Modulated Cytochrome P450 and Transporter Profiles in BeWo and HepG2 Cells

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Virus adsorbent systems based on Amazon holocellulose and nanomaterials

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2‐Ethyl‐Hexyldiphenyl Phosphate ( EHDPP ) Induces Cytotoxicity by Activation of Autophagy Process in HepG2 Cells

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Early prediction of potential hepatotoxic metabolites to aid lead selection in drug discovery

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Drug-Metabolizing Enzymes in Human Keratinocytes and In Vitro Detection of Cytochrome P450-Mediated Phenolic Lamotrigine Metabolite

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In Vitro Three-Dimensional Human Liver Model for Drug-Induced Liver and Bile Duct Injury Prediction

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