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6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice
Open accessAbstract
The anti-diabetic activity of ginger powder (Zingiber officinale) has been recently promoted, with the recommendation to be included as one of the dietary supplements for diabetic patients. However, previous studies presented different results, which may be caused by degradation and metabolic changes of ginger components, gingerols, shogaols and paradols. Therefore, we prepared 10 ginger active components, namely 6-, 8-, 10-paradols, 6-, 8-, 10-shogaols, 6-, 8-, 10-gingerols and zingerone, and evaluated their anti-hyperglycemic activity. Among the tested compounds, 6-paradol and 6-shogaol showed potent activity in stimulating glucose utilization by 3T3-L1 adipocytes and C2C12 myotubes. The effects were attributed to the increase in 5′ adenosine monophosphate-activated protein kinase (AMPK) phosphorylation in 3T3-L1 adipocytes. 6-Paradol, the major metabolite of 6-shogaol, was utilized in an in vivo assay and significantly reduced blood glucose, cholesterol and body weight in high-fat diet-fed mice.
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Cites
Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles
Chrubasik, S., Pittler, M. H., & Roufogalis, B. D. (2005) · Phytomedicine · doi:10.1016/j.phymed.2004.07.009 · Cited by 623
Cited by
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Mao, Q.-Q., Xu, X.-Y., Cao, S.-Y., Gan, R.-Y., Corke, H., Beta, T., & Li, H.-B. (2019) · Foods · doi:10.3390/foods8060185 · Cited by 1,418
Bioactive compounds in anti-diabetic plants: from herbal medicine to modern drug discovery
Tran, N., Pham, B., & Le, L. (2020) · Biology · doi:10.3390/biology9090252 · Cited by 553
Zhang, M., Zhao, R., Wang, D., Wang, L., Zhang, Q., Wei, S., Lu, F., Peng, W., & Wu, C. (2021) · Phytotherapy Research · doi:10.1002/ptr.6858 · Cited by 258
Sheikhhossein, F., Borazjani, M., Jafari, A., Askari, M., Vataniyan, E., Gholami, F., & Amini, M. R. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2021.07.010 · Cited by 24
Cannabis Roots: Therapeutic, Biotechnological and Environmental Aspects
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Metadata
- Authors
- Wei, C.-K., Tsai, Y.-H., Korinek, M., Hung, P.-H., El-Shazly, M., Cheng, Y.-B., Wu, Y.-C., Hsieh, T.-J., & Chang, F.-R.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2017-01-17
- Volume
- 18
- Issue
- 1
- Pages
- 168
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2574668764
- Cited by
- 168
- References
- 1
- FWCI
- 8.91
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wei, C.-K., Tsai, Y.-H., Korinek, M., Hung, P.-H., El-Shazly, M., Cheng, Y.-B., Wu, Y.-C., Hsieh, T.-J., & Chang, F.-R. (2017). 6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms18010168
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