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Cited by 553Natural Antidiabetic Agents StudiesMedicinal Plant ResearchBioactive natural compounds

Bioactive compounds in anti-diabetic plants: from herbal medicine to modern drug discovery

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Tran, Ngan, Pham, Bao, Le, Ly·2020·Biology
DOI 10.3390/biology9090252PMC PMC7563488
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Abstract

Natural products, including organisms (plants, animals, or microorganisms) have been shown to possess health benefits for animals and humans. According to the estimation of the World Health Organization, in developing countries, 80% of the population has still depended on traditional medicines or folk medicines which are mostly prepared from the plant for prevention or treatment diseases. Traditional medicine from plant extracts has proved to be more affordable, clinically effective and relatively less adverse effects than modern drugs. Literature shows that the attention on the application of phytochemical constituents of medicinal plants in the pharmaceutical industry has increased significantly. Plant-derived secondary metabolites are small molecules or macromolecules biosynthesized in plants including steroids, alkaloids, phenolic, lignans, carbohydrates and glycosides, etc. that possess a diversity of biological properties beneficial to humans, such as their antiallergic, anticancer, antimicrobial, anti-inflammatory, antidiabetic and antioxidant activities Diabetes mellitus is a chronic disease result of metabolic disorders in pancreas β-cells that have hyperglycemia. Hyperglycemia can be caused by a deficiency of insulin production by pancreatic (Type 1 diabetes mellitus) or insufficiency of insulin production in the face of insulin resistance (Type 2 diabetes mellitus). The current medications of diabetes mellitus focus on controlling and lowering blood glucose levels in the vessel to a normal level. However, most modern drugs have many side effects causing some serious medical problems during a period of treating. Therefore, traditional medicines have been used for a long time and play an important role as alternative medicines. Moreover, during the past few years, some of the new bioactive drugs isolated from plants showed antidiabetic activity with more efficacy than oral hypoglycemic agents used in clinical therapy. Traditional medicine performed a good clinical practice and is showing a bright future in the therapy of diabetes mellitus. World Health Organization has pointed out this prevention of diabetes and its complications is not only a major challenge for the future, but essential if health for all is to be attained. Therefore, this paper briefly reviews active compounds, and pharmacological effects of some popular plants which have been widely used in diabetic treatment. Morphological data from V-herb database of each species was also included for plant identification.

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  • Flavonoids are part of the class of nutraceuticals that have been demonstrated to improve insulin sensitivity, manage hyperglycemia in diabetics, and govern metabolism.

    “Flavonoids are part of the class of nutraceuticals that have been demonstrated to improve insulin sensitivity, manage hyperglycemia in diabetics, and govern metabolism.”

    From A critical review on diabetes mellitus type 1 and type 2 management approaches: from lifestyle modification to current and novel targets and therapeutic agents. (2024) · cites this paper as [134]

    Section 2, “Management of Diabetes Mellitus” (page unavailable), lists flavonoids among plant components with antidiabetic activity. Section 3.4 reports a blood-glucose-lowering effect associated with flavonoids and other phenolic compounds in hyperglycemic rats. The cited paper does not establish that flavonoids as a nutraceutical class improve insulin sensitivity, manage hyperglycemia in people with diabetes, or govern metabolism. (LLM, conf=0.85)

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Sorted by citations

Authors
Tran, N., Pham, B., & Le, L.
Affiliations
  • Vietnam National University Ho Chi Minh City (VN)
  • Saigon University (VN)
Corresponding author
Le, Ly
ORCID
Venue
Biology
Publisher
MDPI AG
Published
2020-08-28
Volume
9
Issue
9
Pages
252
ISSN
2079-7737 (ISSN-L)
DOI
10.3390/biology9090252
PMC
PMC7563488
OpenAlex
W3082557756
Cited by
553
References
2
Citations by year
2026: 74 · 2025: 127 · 2024: 148 · 2023: 105 · 2022: 66 · 2021: 31 · 2020: 2
FWCI
7.84
Type
journal article
Language
en
Open access
Licence
Locations
  • Biology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Quỹ Đổi mới sáng tạo Vingroup (VINIF.2019.DA13)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
Keywords
antidiabetic plants, diabetes mellitus, phytochemicals, medicinal plants, traditional medicine, secondary metabolites, plant-derived drugs, type 1 diabetes, type 2 diabetes, hyperglycemia, insulin resistance, herbal medicine, plant identification

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