The DOI matches its Crossref record; 174 of the 174 references it cites were found in a registry or an index.
Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer
Open accessAbstract
Non-small-cell lung cancer (NSCLC) constitutes 85% of all lung cancers, and is the leading cause of cancer-related death worldwide. The poor prognosis and resistance to both radiation and chemotherapy warrant further investigation into the molecular mechanisms of NSCLC and the development of new, more efficacious therapeutics. The processes of autophagy and apoptosis, which induce degradation of proteins and organelles or cell death upon cellular stress, are crucial in the pathophysiology of NSCLC. The close interplay between autophagy and apoptosis through shared signaling pathways complicates our understanding of how NSCLC pathophysiology is regulated. The apoptotic effect of autophagy is controversial as both inhibitory and stimulatory effects have been reported in NSCLC. In addition, crosstalk of proteins regulating both autophagy and apoptosis exists. Here, we review the recent advances of the relationship between autophagy and apoptosis in NSCLC, aiming to provide few insights into the discovery of novel pathogenic factors and the development of new cancer therapeutics.
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1 retracted
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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
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Cited by
Cheng, Y., Luo, W., Li, Z., Cao, M., Zhu, Z., Han, C., Dai, X., Zhang, W., Wang, J., Yao, H., et al. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0017oc · Cited by 70
Autophagy dark genes: Can we find them with machine learning?
Ranjbar, M., Yang, J. J., Kumar, P., Byrd, D. R., Bearer, E. L., & Oprea, T. I. (2023) · Natural Sciences · doi:10.1002/ntls.20220067 · Cited by 7
Metadata
- Authors
- Liu, G., Pei, F., Yang, F., Li, L., Amin, A., Liu, S., Buchan, J., & Cho, W.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2017-02-10
- Volume
- 18
- Issue
- 2
- Pages
- 367
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2587125658
- Cited by
- 425
- References
- 174
- FWCI
- 24.67
- Type
- journal article
- Language
- en
- Open access
- gold
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- Liu, G., Pei, F., Yang, F., Li, L., Amin, A., Liu, S., Buchan, J., & Cho, W. (2017). Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms18020367
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
