The DOI matches its Crossref record; 168 of the 169 references it cites were found in a registry or an index.
Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging
Open accessAbstract
Autophagy is emerging as a core regulator of Central Nervous System (CNS) aging and neurodegeneration. In the brain, it has mostly been studied in neurons, where the delivery of toxic molecules and organelles to the lysosome by autophagy is crucial for neuronal health and survival. However, we propose that the (dys)regulation of autophagy in microglia also affects innate immune functions such as phagocytosis and inflammation, which in turn contribute to the pathophysiology of aging and neurodegenerative diseases. Herein, we first describe the basic concepts of autophagy and its regulation, discuss key aspects for its accurate monitoring at the experimental level, and summarize the evidence linking autophagy impairment to CNS senescence and disease. We focus on acute, chronic, and autoimmunity-mediated neurodegeneration, including ischemia/stroke, Alzheimer’s, Parkinson’s, and Huntington’s diseases, and multiple sclerosis. Next, we describe the actual and potential impact of autophagy on microglial phagocytic and inflammatory function. Thus, we provide evidence of how autophagy may affect microglial phagocytosis of apoptotic cells, amyloid-β, synaptic material, and myelin debris, and regulate the progression of age-associated neurodegenerative diseases. We also discuss data linking autophagy to the regulation of the microglial inflammatory phenotype, which is known to contribute to age-related brain dysfunction. Overall, we update the current knowledge of autophagy and microglia, and highlight as yet unexplored mechanisms whereby autophagy in microglia may contribute to CNS disease and senescence.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Autophagy and phagocytosis share key morphological and mechanistic features [428].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [428]
In the citing paper
“For instance, both pathways rely on vesicular structures to deliver contents to lysosomes for degradation.”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [428]
In the citing paper
“Microglia actively clear apoptotic cells, myelin and synaptic debris, axonal fragments and protein deposits from the CNS through phagocytosis [428–430].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [428]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2 retracted
Martinez, J., Almendinger, J., Oberst, A., Ness, R., Dillon, C. P., Fitzgerald, P., Hengartner, M. O., & Green, D. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113421108 · Cited by 655 · cited 4×
“Thus, upon Toll-like receptor (TLR)- or T cell immunoglobulin mucin protein 4 (TIM4)-stimulated phagocytosis of bacteria [99] or apoptotic cells [97] by macrophages, LC3 is recruited to the single-membrane phagosome depending on the activity of autophagy enzymes BECN-1, ATG-5, and ATG-7 [97,99] but not the recruitment…”
BackgroundResultInfluentialRetractedMartinez, J., Cunha, L. D., Park, S., Yang, M., Lu, Q., Orchard, R., Li, Q.-Z., Yan, M., Janke, L., Guy, C., et al. (2016) · Nature · doi:10.1038/nature17950 · Cited by 381
RetractedLópez-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023
Autophagy: Renovation of Cells and Tissues
Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,615
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226
Kalia, L. V., & Lang, A. E. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61393-3 · Cited by 6,184
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358
Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214
Flagged first, then by citations
1 of the 169 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Monti, 2016, Inflammaging and omics in human longevity, Mech. Ageing Dev., 6374, 30261
Cited by
Sorted by citations
Items 201–300 of 318
Wang, Y., Zhou, K., Li, T., Xu, Y., Xie, C., Sun, Y., Rodríguez, J., Zhang, S., Song, J., Wang, X., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00241 · Cited by 13
Omp31 of Brucella Inhibits NF-κB p65 Signaling Pathway by Inducing Autophagy in BV-2 Microglia
Wang, Z., Wang, Y., Wang, Y., Li, H., Li, H., Xie, P., & Wang, Z. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03429-4 · Cited by 13
Gao, X., Yu, M., Sun, W., Han, Y., Yang, J., Lu, X., Jin, C., Wu, S., & Cai, Y. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112632 · Cited by 14
TSPO Ligands Protect against Neuronal Damage Mediated by LPS‐Induced BV‐2 Microglia Activation
Ma, B., Liu, Y., Xiao, Z., Zhang, R., Zhang, Z., Zhang, Z., Liu, J., Juan, Z., Sun, X., Sun, L., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5896699 · Cited by 15
Neuroimmune dynamics and cytokines in traumatic brain injury
Davis, A. C., & Godbout, J. P. (2025) · Trends in Immunology · doi:10.1016/j.it.2025.09.009 · Cited by 13
Fritze, J., Muralidharan, C., Stamp, E., & Ahlenius, H. (2024) · Developmental Neurobiology · doi:10.1002/dneu.22939 · Cited by 12
Le, L., Eliseeva, S. I., Plunk, E. C., Kara-Pabani, K., Li, H., Yarovinsky, F., & Majewska, A. K. (2025) · Cell Reports · doi:10.1016/j.celrep.2024.115176 · Cited by 13
Endocannabinoid Signaling for GABAergic-Microglia (Mis)Communication in the Brain Aging
Carrera, J., Tomberlin, J., Kurtz, J., Karakaya, E., Bostancıklıoğlu, M., & Albayram, Ö. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.606808 · Cited by 12
Microglial autophagy in cerebrovascular diseases
Chen, M., Zhang, H., Chu, Y., Tang, Y., Pang, X., Qin, C., & Tian, D. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1023679 · Cited by 11
Короленко, Т. А., Johnston, T. P., & Větvička, V. (2020) · Molecules · doi:10.3390/molecules25215052 · Cited by 13
Oskuye, Z. Z., Mehri, K., Khalilpour, J., Nemati, S., Hosseini, L., Bafadam, S., Abdollahzade, N., & Badalzadeh, R. (2025) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2025.101629 · Cited by 11
Arya, J. K., Kumar, R., Tripathi, S. S., & Rizvi, S. I. (2022) · Biogerontology · doi:10.1007/s10522-022-09988-5 · Cited by 11
Autophagy in Intracerebral Hemorrhage: From Mechanism to Regulation
Zheng, J., Zou, W., & Yu, X. (2023) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2205134 · Cited by 11
Li, Z., Cui, X., Lv, H., Liu, J., Di, W., Jiang, F., Liu, Y., & Cheng, X. (2020) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2020.104475 · Cited by 11
Latella, D., Formica, C., Ielo, A., Grioli, P., Marra, A., Costanzo, D., Merlo, M., Pappalardo, S. M., Corallo, F., Marino, S., et al. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1402894 · Cited by 10
Role of Autophagy in HIV-1 and Drug Abuse-Mediated Neuroinflammaging
Sil, S., Thangaraj, A., Oladapo, A., Hu, G., Kutchy, N. A., Liao, K., Buch, S. J., & Periyasamy, P. (2022) · Viruses · doi:10.3390/v15010044 · Cited by 10
Extracellular vesicles promote autophagy in human microglia through lipid raft‐dependent mechanisms
Romenskaja-Avgul, D., Jonavičė, U., & Pivoriūnas, A. (2024) · FEBS Journal · doi:10.1111/febs.17192 · Cited by 10
The fate of neuronal synapse homeostasis in aging, infection, and inflammation
Tacke, C., Landgraf, P., Dieterich, D. C., & Kröger, A. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00466.2024 · Cited by 9
Bridging the Gap: The Neuro-immune Axis as a Key Player in Neurodegenerative Disorders
Liu, T., Wu, H., & Wei, J. (2025) · Neuroscience Bulletin · doi:10.1007/s12264-025-01439-8 · Cited by 9
Barrella, L., Ramírez-Ponce, M. P., Vázquez‐Román, V., Millán-Huang, M. S., y Aibar, M. D. M., Flores-Cordero, J. A., & Alés, E. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106170 · Cited by 9
Borim, P. A., Mimura, L. A. N., Zorzella-Pezavento, S. F. G., Polonio, C. M., Peron, J. P. S., Sartori, A., & Fraga‐Silva, T. F. D. C. (2022) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2021.0206 · Cited by 9
Niu, C., Zhu, M., Zhang, J., Zhang, C., & Tian, W. (2022) · The Chinese Journal of Physiology · doi:10.4103/cjp.cjp_108_21 · Cited by 9
Autophagy as an Anti-senescent in Aging Neurocytes
Marzoog, B. A. (2023) · Current Molecular Medicine · doi:10.2174/1566524023666230120102718 · Cited by 9
Chen, K., Padilla, C. G., Kiselyov, K. I., & Kozai, T. D. Y. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122316 · Cited by 9
Yao, C., Liu, X., Tang, Y., Wang, C., Duan, C., Liu, X., Chen, M., Zhou, Y., Tang, E., Xiang, Y., et al. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-24292-y · Cited by 10
Sirtuins in Brain and Neurodegenerative Disease
Szegő, É. M., Outeiro, T. F., & Kazantsev, A. G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813499-3.00013-7 · Cited by 9
Zhou, C., Qiu, S., Wang, F.-M., Liu, Y.-C., Hu, W. M., Yang, M.-L., Liu, W., & Li, H. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1449452 · Cited by 8
Sha, Z., Dong, S., Nie, M., Liu, T., Wu, C., Lv, C., Liu, M., Jiang, W., Yuan, J., Yu, Q., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07501-7 · Cited by 8
A neuroimmune cerebral assembloid model to study the pathophysiology of familial Alzheimer’s disease
Becerra-Calixto, A., Banerjee, A., Fan, H., Tan, C., Lee, E., McCullough, L. D., & Lee, J. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03544-x · Cited by 10
Ma, C., Wei, X., Wang, F., Zhang, T., Jiang, Y., Meng, Z., & Zhang, Z. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137223 · Cited by 8
Role of the P2 × 7 receptor in neurodegenerative diseases and its pharmacological properties
Hu, Z., Luo, Y., Zhu, J., Jiang, D., Luo, Z., Wu, L., Jin, L., Peng, S., & Hu, J. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01161-w · Cited by 8
Fan, Z., Zhang, X., Zhao, S., Zhong, S., Li, Z., Yan, Y., Zhang, B., & Chen, Y. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae031 · Cited by 8
Saccà, S. C., Cutolo, C. A., & Rossi, T. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_14 · Cited by 8
Chen, X., Zhou, X., Lan, C., Fu, H.-J., Li, Z.-C., Chen, M.-Y., Wen, Y.-P., Yu, L., Qin, D., Wu, J., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05242-4 · Cited by 7
Mitochondria at the heart of aging: structure, function, and failure
Marei, H. E. S. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08047-8 · Cited by 7
Yang, Z., Zhou, L., Meng, Q., Shi, H., & Li, Y.-H. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.285004 · Cited by 7
Dietary zinc inadequacy affects neurotrophic factors and proteostasis in the rat brain
Savitikadi, P., Palika, R., Pullakhandam, R., Reddy, G. B., & Reddy, S. S. (2023) · Nutrition Research · doi:10.1016/j.nutres.2023.06.002 · Cited by 7
The Cl− transporter ClC-7 is essential for phagocytic clearance by microglia
Iyer, H., & Talbot, W. S. (2024) · Journal of Cell Science · doi:10.1242/jcs.261616 · Cited by 9
Dominguez‐Martín, H., Gavilán, E., Parrado, C., Burguillos, M. Á., Daza, P., & Ruano, D. (2024) · Cells · doi:10.3390/cells13242069 · Cited by 7
Effect of pyrroloquinoline quinone on lipopolysaccharide-induced autophagy in HAPI microglia cells
Gao, S., Zhou, Q., Jin, H., Shi, N., Wang, X., Zhang, L., & Yan, M. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-730 · Cited by 7
Cai, D., Luo, Z., Su, J., Gan, H., Wang, Z., Liu, X., Li, S., Wu, J., Chen, J., Ma, R., et al. (2022) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b21-00781 · Cited by 7
Non-Communicable Neurological Disorders and Neuroinflammation
Ballerini, C., NJAMNSHI, A. K., Juliano, S. L., Kalaria, R. N., Furlan, R., & Akinyemi, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.834424 · Cited by 7
Kim, K. H., Cho, Y., Lee, J., Jeong, H., Lee, Y., Kim, S. I., Kim, C., Lee, H., & Nam, K. T. (2019) · Scientific Reports · doi:10.1038/s41598-019-47676-6 · Cited by 7
Liu, Z., & Jia, J. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04361-8 · Cited by 6
The role of autophagy in brain health and disease: Insights into exosome and autophagy interactions
Wang, H., Lv, C., Feng, L., Guo, J., Zhao, S., & Jiang, P. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e38959 · Cited by 7
Bano, N., Khan, S., Ahamad, S., Dar, N. J., Alanazi, H. H., Nazir, A., & Bhat, S. A. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00617 · Cited by 6
Rihani, S. B. A., Elfakhri, K. H., Ebrahim, H. Y., Al-Ghraiybah, N. F., Alkhalifa, A. E., Sayed, K. A. E., & Kaddoumi, A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00326 · Cited by 5
Jaffa, A. A., Jaffa, M. A., Moussa, M., Ahmed, I. A., Karam, M., Aldeen, K. S., Sayegh, R. A., El‐Achkar, G. A., Nasrallah, L., Yehya, Y., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.743059 · Cited by 5
p27kip1 Modulates the Morphology and Phagocytic Activity of Microglia
Beeken, J., Kessels, S., Rigo, J., Alpizar, Y. A., Nguyen, L., & Brône, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810432 · Cited by 5
Vásquez-Carrasco, E., Branco, B. H. M., Hernandez-Martinez, J., Sandoval, C., & Valdés‐Badilla, P. (2025) · Journal of the American Geriatrics Society · doi:10.1111/jgs.70154 · Cited by 5
Zou, X., Shi, M., Xiao, X., Lv, X., Yang, M., Tian, M., Xie, B., Wang, L., Wang, J., & Qin, D. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1775841 · Cited by 4
Guo, H., Shen, X., Liang, X., & Li, L.-Z. (2022) · Bioengineered · doi:10.1080/21655979.2022.2084273 · Cited by 4
RetractedEmmerich, K. B., White, D. T., Kambhampati, S. P., Casado, G. L., Tian-ming Fu, B., Sahoo, A., Saxena, M. T., Betzig, E., Kannan, R. M., & Mumm, J. S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.05.238352 · Cited by 4
Xiang, C., Raghunathan, V., Qiu, Y., Mehta, M. N., Demirs, J. T., Grosskreutz, C. L., Wilson, C. W., & Prasanna, G. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01880-2 · Cited by 3
Non-cell autonomous autophagy in amyotrophic lateral sclerosis: A new promising target?
Rosso, F., Magdalena, R., Torazza, C., Bacchetti, F., Milanese, M., Poletti, A., Bonanno, G., Cristofani, R., & Bonifacino, T. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107203 · Cited by 5
Targeting inflammaging in Alzheimer’s disease: molecular pathways and emerging pharmacotherapies
Alotaibi, M. O., Al‐kuraishy, H. M., Fahad, E. H., Abdelaziz, A. M., & Batiha, G. E. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02281-8 · Cited by 3
Studying Autophagy in Microglia: Overcoming the Obstacles
Plaza‐Zabala, A., & Sierra, A. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3437-0_3 · Cited by 3
Self-citationPerera, N. D., Silva, S. D., Tomas, D., Cuic, B., & Turner, B. J. (2025) · Glia · doi:10.1002/glia.70045 · Cited by 3
Ding, R., Hu, N., Zhang, X., Jiang, F., Feng, Y., Li, Z., Tang, S., Li, W., Shi, H., & Si, Y. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.08.008 · Cited by 2
Targeting neurodegenerative diseases with bioactive oligosaccharides: Mechanisms and prospects
Ni, Q., Zhang, S., Jia, G., Wang, Y., Guo, Y., & Liu, Y. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115560 · Cited by 2
Akash, A., Ahamed, M., Porel, P., & Aran, K. R. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149949 · Cited by 2
From knowledge landscapes to network mechanisms: charting regulated cell death pathways in ALS
Zhang, J., Zhao, Z., Xiang, T., Teng, D., Wan, H., Zhang, Q., & Liu, X. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1742805 · Cited by 2
Testicular aging revisited: Current understanding of mechanisms and emerging interventions
Jiang, F., Wang, X., Wang, N., Niu, D., & Xi, H. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103111 · Cited by 2
Zou, M., Zhao, T., Wu, W., Zhang, J. Y., Pan, P., Yan, J., Li, Q., & Zhou, Y. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03946-5 · Cited by 1
Resolvin D1 Induces mTOR-independent and ATG5-dependent Autophagy in BV-2 Microglial Cells
Pan, S., Hu, L., Wang, H., Li, R.-T., He, Y.-J., Shang, Y., Dai, Z.-L., Chen, L., & Xiong, W. (2023) · Current Medical Science · doi:10.1007/s11596-023-2787-5 · Cited by 2
Neuroprotection in Perimenopausal Women
Russu, M. C., & Antonescu, A. C. (2018) · InTech eBooks · doi:10.5772/intechopen.74330 · Cited by 3
Autophagy in the Immunosuppressive Perivascular Microenvironment of Glioblastoma
Molina, M. L., García‐Bernal, D., Martı́nez, S., & Valdor, R. (2020) · Vide Leaf, Hyderabad eBooks · doi:10.37247/pacr.1.2020.18 · Cited by 2
Autophagy–Actin Crosstalk: Implications for Cellular Homeostasis and Disease
Fierti, A. O., Rozsa, R. G., Potu, A., Tajammal, A., & Li, H. (2026) · Cells · doi:10.3390/cells15080665 · Cited by 1
Zhang, S.-M., Tang, W.-C., Liu, F.-F., Bai, Q.-Q., Guo, Y., Bai, X.-Z., Wang, Y. J., Xw, M., Pan, S.-J., Yang, Y.-H., et al. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1803309 · Cited by 1
Safety, Stability Concerns, and Regulatory Aspects of Nanocarriers for Brain Delivery
Jitendra, N. N., Alam, M. I., Mazahir, F., & Yadav, A. K. (2024) · Springer eBooks · doi:10.1007/978-981-97-2859-6_13 · Cited by 1
Jiang, H., Jiang, L., Xia, T., Yu, J., Bu, Y., Shen, H., Zhu, L., Lin, C., Wang, Y., Chen, Y., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102734 · Cited by 1
BEYİN YAŞLANMASINDA MOLEKÜLER MEKANİZMALAR
ÖZDEK, E., & Han, S. (2022) · Ankara Universitesi Eczacilik Fakultesi Dergisi · doi:10.33483/jfpau.1099963 · Cited by 1
Weis, S., Sonnberger, M., Dunzinger, A., Voglmayr, E., Aichholzer, M., Kleiser, R., & Strasser, P. (2019) · Springer eBooks · doi:10.1007/978-3-7091-1544-2_31 · Cited by 1
Genomic Tools Used in Molecular Clinical Aging Research
García-Venzor, A., & Mandujano-Tinoco, E. A. (2020) · Springer eBooks · doi:10.1007/978-3-030-40955-5_5 · Cited by 1
Regulation of autophagy by TDP-43
Tomar, A. K., & Yadav, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820066-7.00005-9 · Cited by 1
Harry, G. J. (2022) · Advances in neurotoxicology · doi:10.1016/bs.ant.2022.06.001 · Cited by 2
Delirium in Head Trauma: Looking for a Culprit
Villani, E. R., Franza, L., & Cianci, R. (2022) · Reviews on Recent Clinical Trials · doi:10.2174/1574887117666220811090608 · Cited by 1
di Domenico, A. (2017) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 1
Cellina, M. I., & Orsi, M. (2018) · Neuroimmunology and Neuroinflammation · doi:10.20517/2347-8659.2018.15
A is for Autophagy and Alzheimer's
Dow, C. T., & Szepieniec, J. (2018) · OBM Geriatrics · doi:10.21926/obm.geriatr.1804020
Colasanti, T., Vomero, M., Barbati, C., Finucci, A., Conti, F., Alessandri, C., & Valesini, G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814307-0.00016-5
Microglial Mitophagy and Neurodegenerative Disorders
Oyindamola, E. A., Agyemang, M. K., Owusu-Sarfo, J., Yeboah, K. O., & Osafo, N. (2020) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-7998-1317-0.ch004
Mammalian target of rapamycin complexes
Querfurth, H. W., & Lee, H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815868-5.00022-0
Russell, A. E. (2019) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.3947
Ji, M. J., Huang, Z., Zhang, G., Sun, Q., Zhang, H., Wei, M., Xie, J., Chen, L., & Guan, H. (2022) · Research Square · doi:10.21203/rs.3.rs-1516632/v1
Dietary Polyphenols and its Molecular Mechanism in the Management of Breast Cancer
Rai, G., & Shekhar, S. K. (2022) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9781681089522112010012
Aged-Related Physiological Changes: CNS Function
Miot, S., Chancel, R., & Blain, H. (2022) · Lessons from the ICU · doi:10.1007/978-3-030-94133-8_3
Chen, H., Li, Q., Yu, H., Pan, Z., Zhang, B., Yan, N., Zhang, Y., Li, G., Lv, S., & Lv, M. (2023) · Research Square · doi:10.21203/rs.3.rs-3356908/v1
Murthy, M. K., Khandayataray, P., Samal, D., Pattanayak, R., & Mohanty, C. S. (2023) · Methods in molecular biology · doi:10.1007/7651_2023_508
Neuropathic pain in HIV and the role of the autophagy pathway
Rodriguez, M., Pokharel, M. D., Owens, F., McLaughlin, J. P., & El‐Hage, N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99744-7.00031-6
Recent Advances in Anti-Fungal Finishing for Natural Textiles
Roy, R., Kaur, A., & Dalvi, L. A. (2024) · Advances in chemical and materials engineering book series · doi:10.4018/979-8-3693-5473-5.ch013
Identification of Distinct Topological Structures From High-Dimensional DataPreprint
Xu, B., & Braun, R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.26.672446
Microglial activation and lysosomal dysfunction in hemorrhagic stroke
Lee, C.-H., Pang, C., Wang, M.-J., Hu, W.-F., Huang, H., Tsai, S., & Liew, H. (2025) · Tzu Chi Medical Journal · doi:10.4103/tcmj.tcmj_213_25
Xie, Y., Yu, L., Cheng, Z., Peng, Y., Cao, Z., Chen, B., Duan, Y., & Wang, Y. (2022) · Figshare · doi:10.6084/m9.figshare.19817856
Kang, C., Sang, Q., Liu, D., Wang, L., Li, J., & Liu, X. (2024) · Figshare · doi:10.6084/m9.figshare.26720427
Kang, C., Sang, Q., Liu, D., Wang, L., Li, J., & Liu, X. (2024) · Figshare · doi:10.6084/m9.figshare.26720430
Kaganovich, A., Horan-Portelance, L., Landeck, N., Acri, D. J., Ding, J., Langston, R. G., & Cookson, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.18.695199
Spanou, S., Vogiatzoglou, A. P., Papanikolaou, S., Maria, P., Pandi, I., Makatounakis, T., Deligianni, E., Tzanos, D., Nikolaou, C., Poirazi, P., et al. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-04088-4
Metadata
- Authors
- Plaza-Zabala, A., Sierra-Torre, V., & Sierra, A.
- Affiliations
- Achucarro Basque Center for Neuroscience, 48170 Zamudio, Spain
- Ikerbasque (ES)
- Corresponding author
- Sierra, Amanda
- ORCID
- Sierra, Amanda
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2017-03-09
- Volume
- 18
- Issue
- 3
- Pages
- 598
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC5372614
- OpenAlex
- W2594094135
- Cited by
- 323
- References
- 169
- Citations by year
- 2026: 23 · 2025: 24 · 2024: 25 · 2023: 42 · 2022: 37 · 2021: 55 · 2020: 38 · 2019: 39 · 2018: 32 · 2017: 8
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Spanish Ministry of Economy and Competitiveness (BFU2015-66689, RYC-2013-12817)
- BBVA Foundation Grant for Researchers and Cultural Creators
- Basque Government (PI_2016_1_0011)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- autophagy, microglia, neurodegeneration, brain aging, microglial phagocytosis, neuroinflammation, Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, amyloid-beta clearance, myelin debris, autophagy regulation, autophagy monitoring
- MeSH terms
- Aging, Animals, Autophagy, Central Nervous System, Humans, Microglia, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
