The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Analgesic Mechanisms of Antidepressants for Neuropathic Pain
Open accessAbstract
Tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors are used to treat chronic pain, such as neuropathic pain. Why antidepressants are effective for treatment of neuropathic pain and the precise mechanisms underlying their effects, however, remain unclear. The inhibitory effects of these antidepressants for neuropathic pain manifest more quickly than their antidepressive effects, suggesting different modes of action. Recent studies of animal models of neuropathic pain revealed that noradrenaline is extremely important for the inhibition of neuropathic pain. First, increasing noradrenaline in the spinal cord by reuptake inhibition directly inhibits neuropathic pain through α2-adrenergic receptors. Second, increasing noradrenaline acts on the locus coeruleus and improves the function of an impaired descending noradrenergic inhibitory system. Serotonin and dopamine may reinforce the noradrenergic effects to inhibit neuropathic pain. The mechanisms of neuropathic pain inhibition by antidepressants based mainly on experimental findings from animal models of neuropathic pain are discussed in this review.
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Cites
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Cited by
A Comprehensive Algorithm for Management of Neuropathic Pain
Bates, D., Schultheis, B. C., Hanes, M. C., Jolly, S. M., Chakravarthy, K. V., Deer, T. R., Levy, R. M., & Hunter, C. W. (2019) · Pain Medicine · doi:10.1093/pm/pnz075 · Cited by 401
Guideline No. 445: Management of Chronic Pelvic Pain
Allaire, C., Yong, P. J., Bajzak, K., Jarrell, J., Lemos, N., Miller, C., Morin, M., Nasr-Esfahani, M., Singh, S. S., & Chen, I. (2024) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2023.102283 · Cited by 53
Metadata
- Authors
- Obata, H.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2017-11-21
- Volume
- 18
- Issue
- 11
- Pages
- 2483
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2768362509
- Cited by
- 398
- References
- 88
- FWCI
- 16.14
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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