mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases
Walters, Hannah E., Cox, Lynne S.·2018·International Journal of Molecular Sciences
Cites (234)
Items 201–230 of 230
- Muscle wasting associated with the long-term use of mTOR inhibitorsBishal Gyawali, Tomoya Shimokata, Kazunori Honda, Chihiro Nakayama Kondoh, Naomi Hayashi, Yasushi Yoshino, Naoto Sassa, Yasuyuki Nakano, Momokazu Gotoh, Yukio Ando · 2016 · Molecular and Clinical Oncology
- mTORC2 Is Required for Rit-Mediated Oxidative Stress ResistanceWeikang Cai, Douglas Andres · 2014 · PLoS ONE
- mTOR Activity Under HypoxiaDouangsone D. Vadysirisack, Leif William Ellisen · 2011 · Methods in molecular biology
- M(o)TOR of pseudo-hypoxic state in aging: Rapamycin to the rescueOlga V. Leontieva, Mikhail V. Blagosklonny · 2014 · Cell Cycle
- Quantitative Nuclear Proteomics Identifies mTOR Regulation of DNA Damage ResponseSricharan Bandhakavi, Young Mi Kim, Seung‐Hyun Ro, Hongwei Xie, Getiria Onsongo, Chang Jun, Do‐Hyung Kim, Timothy J. Griffin · 2009 · Molecular & Cellular Proteomics
- Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survivalLaura J. Smithson, David H. Gutmann · 2016 · Genes & Development
- Rapamycin and the transcription factor C/EBPβ as a switch in osteoclast differentiation: implications for lytic bone diseasesJeske J. Smink, Achim Leutz · 2009 · Journal of Molecular Medicine
- Interventions for preventing the progression of autosomal dominant polycystic kidney diseaseDavide Bolignano, Suetonia C. Palmer, Marinella Ruospo, Carmine Zoccali, Jonathan C. Craig, Giovanni FM Strippoli · 2015 · Cochrane Database of Systematic Reviews
- Efficacy of the oral mTORC1 inhibitor everolimus in relapsed or refractory indolent lymphomaN. Nora Bennani, Betsy R LaPlant, Stephen Maxted Ansell, Thomas Matthew Habermann, David James Inwards, Ivana N. Micallef, Patrick B. Johnston, Luis F. Porrata, Joseph P. Colgan, Svetomir N. Markovic et al. · 2017 · American Journal of Hematology
- Metformin reduces glucose intolerance caused by rapamycin treatment in genetically heterogeneous female miceR. Weiss, Elizabeth Fernández, Yuhong Liu, Randy Strong, Adam B. Salmon · 2018 · Aging
- Simultaneous induction and blockade of autophagy by a single agentKarolina Staniak, Magdalena Dudkowska, Anna M. Zawadzka, Mikolaj B. Ogrodnik, Andrzej Antoni Szczepankiewicz, Zbigniew Czarnocki, Ewa Sikora · 2018 · Cell Death and Disease
- Function of erbB receptors and DNA-PKcs on phosphorylation of cytoplasmic and nuclear Akt at S473 induced by erbB1 ligand and ionizing radiationMahmoud Toulany, Tim-Andre Schickfluß, Kazi Riaz Fattah, Kyung Jong Lee, Benjamin P.C. Chen, Birgit Fehrenbacher, Martin Schaller, David J. Chen, H. Peter Rodemann · 2011 · Radiotherapy and Oncology
- Livers with Constitutive mTORC1 Activity Resist Steatosis Independent of Feedback Suppression of AktHeidi L. Kenerson, Savitha Subramanian, Rebecca L. McIntyre, Machiko Kazami, Raymond S. W. Yeung · 2015 · PLoS ONE
- mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated agingKoji Takayama, Yohei Kawakami, Mitra Lavasani, Xiaodong Mu, James H. Cummins, Takashi Yurube, Ryosuke Kuroda, Masahiro Kurosaka, Freddie H. Fu, Paul D. Robbins et al. · 2016 · Journal of Orthopaedic Research®
- Treatments to slow progression of autosomal dominant polycystic kidney disease: systematic review and meta‐analysis of randomized trialsThida Maung Myint, Gopi K. Rangan, Angela Claire Webster · 2014 · Nephrology
- A phase I–II study on the combination of rapamycin and short course radiotherapy in rectal cancerJeroen Buijsen, Jørgen van den Bogaard, Barry Jutten, Eric H J Belgers, Meindert Nico Sosef, Jeroen W. A. Leijtens, Geerard L. Beets, Rob L. H. Jansen, Robert G. Riedl, Ruud Clarijs et al. · 2015 · Radiotherapy and Oncology
- Everolimus: a new hope for patients with breast cancerMehmet Alı Nahıt Şendur, Nurullah Zengin, Sercan Aksoy, Kadri Altundağ · 2013 · Current Medical Research and Opinion
- Rapamycin-enhanced mitomycin C-induced apoptotic death is mediated through the S6K1–Bad–Bak pathway in peritoneal carcinomatosisSong, X, Dilly, A-K, Kim, S-Y, Choudry, H A, Lee, Y J · 2014 · Cell Death & Disease
- Functional Proteomics Identifies Acinus L as a Direct Insulin- and Amino Acid-Dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) SubstrateJennifer Schwarz, Heike Wiese, Regine C. Tölle, Mostafa Zarei, Jörn Dengjel, Bettina Warscheid, Kathrin Thedieck · 2015 · Molecular & Cellular Proteomics
- Sirolimus for Treatment of Autosomal-Dominant Polycystic Kidney Disease: A Meta-Analysis of Randomized Controlled TrialsY.-M. Liu, Y.Q. Shao, Qiang He · 2014 · Transplantation Proceedings
- Profile of everolimus in the treatment of tuberous sclerosis complex: an evidence-based review of its place in therapyDavid Neal Franz, Jamie K. Capal · 2016 · Neuropsychiatric Disease and Treatment
- Author Correction: Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in miceÁlvaro F. Fernández, Salwa Sebti, Yongjie Wei, Zhongju Zou, Mingjun Shi, Kathryn L. McMillan, Congcong He, Tabitha C. Ting, Yang Liu, Wei‐Chung Chiang et al. · 2018 · Nature
- Bromodomain-containing protein 2 induces insulin resistance via the mTOR/Akt signaling pathway and an inflammatory response in adipose tissueRuixin Sun, Yi Wu, Weihua Hou, Zujun Sun, Yu-Xiong Wang, Huanhuan Wei, Wei Mo, Min Yu · 2016 · Cellular Signalling
- mTOR inhibition in autosomal-dominant polycystic kidney disease (ADPKD): the question remains openMeg Jardine, Thaminda Liyanage, Erin Buxton, Vlado Perkovic · 2012 · Nephrology Dialysis Transplantation
- LMO3 promotes gastric cancer cell invasion and proliferation through Akt-mTOR and Akt-GSK3β signalingYan-Song Qiu, Ningning Jiang, Yan Zhou, Kuai-Yun Yu, Hongyan Gong, Guangjun Liao · 2018 · International Journal of Molecular Medicine
- mTORC2: actin on your memorySheena A. Josselyn, Paul W. Frankland · 2013 · Nature Neuroscience
- Rapamycin reduces kidney volume and delays the loss of renal function in a patient with autosomal-dominant polycystic kidney diseaseRamón Peces, Carlos Peces, V. Perez-Duenas, Emilio Cuesta-López, Sebastián Azorín, Rafael Selgas · 2009 · Clinical Kidney Journal
- Rapamycin selectively reduces the association of transcripts containing complex 5′ UTRs with ribosomes in C4‐2B prostate cancer cellsLynn M. Opdenaker, Mary C. Farach‐Carson · 2009 · Journal of Cellular Biochemistry
- Everolimus vs. rapamycin for treating diabetic nephropathy in diabetic mouse modelLan Cheng, Jingli Chen, Xiaolu Mao · 2011 · Journal of Huazhong University of Science and Technology [Medical Sciences]
- Corrigendum to “Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms” [Mol. Cell. Endocrinol. 440 15 January 2017 57–68]S.C. Chen, Rebecca A. Brooks, Jessica Houskeeper, Shaun Bremner, John Dunlop, Benoı̂t Viollet, Pamela J. Logan, Ian P. Salt, S. Faisal Ahmed, Stephen J. Yarwood · 2017 · Molecular and Cellular Endocrinology