mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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The Hallmarks of Aging

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mTOR Signaling in Growth Control and Disease

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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DNA methylation age of human tissues and cell types

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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A Randomized Comparison of a Sirolimus-Eluting Stent with a Standard Stent for Coronary Revascularization

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

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Cellular senescence: from physiology to pathology

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Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

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The role of senescent cells in ageing

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International Journal of Molecular Medicine

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Autophagy and Aging

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An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

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Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

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Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle.

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High performance plasma amyloid-β biomarkers for Alzheimer's disease

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Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

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mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex

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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

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Programmed cell senescence during mammalian embryonic development

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

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Regulation of 4E-BP1 phosphorylation: a novel two-step mechanismPreprint

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Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

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mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent <i>in vivo</i> antitumor activity

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Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

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Cellular Senescence in Aging Primates

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The mTOR‐regulated phosphoproteome reveals a mechanism of mTORC1‐mediated inhibition of growth factor signaling

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Autophagy mediates the mitotic senescence transition

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mTOR kinase structure, mechanism and regulation

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Influence of TOR kinase on lifespan in C. elegans

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Cellular senescence drives age-dependent hepatic steatosis

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Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

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Feedback between p21 and reactive oxygen production is necessary for cell senescence

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SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

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Sorting out the roles of PPAR  in energy metabolism and vascular homeostasis

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Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

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Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

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mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

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The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

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Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

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Mitochondria are required for pro-ageing features of the senescent phenotype

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AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity

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mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

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mTOR inhibition improves immune function in the elderly

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Phase 1 clinical study of an embryonic stem cell–derived retinal pigment epithelium patch in age-related macular degeneration

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Mitochondrial dysfunction in Parkinson's disease

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Rapamycin slows aging in mice

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Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer’s disease

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Activation of mTORC2 by Association with the Ribosome

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mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

Sengupta, S., Peterson, T. R., Laplante, M., Oh, S., & Sabatini, D. M. (2010) · Nature · doi:10.1038/nature09584 · Cited by 646 · see citing works

The Regulation of AMPK β1, TSC2, and PTEN Expression by p53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways

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Autophagy is a protective mechanism in normal cartilage, and its aging‐related loss is linked with cell death and osteoarthritis

Caramés, B., Taniguchi, N., Otsuki, S., Blanco, F. J., & Lotz, M. (2010) · Arthritis &amp; Rheumatism · doi:10.1002/art.27305 · Cited by 632 · see citing works

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

Fernández, Á. F., Sebti, S., Wei, Y., Zou, Z., Shi, M., McMillan, K. L., He, C., Ting, T., Liu, Y., Chiang, W.-C., et al. (2018) · Nature · doi:10.1038/s41586-018-0162-7 · Cited by 630 · see citing works

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

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Nephropathy in Patients with Type 2 Diabetes

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Frailty and sarcopenia: The potential role of an aged immune system

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The mechanistic target of rapamycin: the grand conducTOR of metabolism and aging

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mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

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Selective Glycogen Synthase Kinase 3 Inhibitors Potentiate Insulin Activation of Glucose Transport and Utilization In Vitro and In Vivo

Ring, D. B., Johnson, K. W., Henriksen, E. J., Nuss, J. M., Goff, D., Kinnick, T. R., Ma, S. T., Reeder, J. W., Samuels, I., Slabiak, T., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.3.588 · Cited by 532 · see citing works

Inhibition of mTOR Signaling With Rapamycin Regresses Established Cardiac Hypertrophy Induced by Pressure Overload

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Autophagy and aging: keeping that old broom working

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Hypoxia-inducible Factor 1α Is Regulated by the Mammalian Target of Rapamycin (mTOR) via an mTOR Signaling Motif

Land, S. C., & Tee, A. R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611782200 · Cited by 507 · see citing works

Senescent Human Fibroblasts Increase the Early Growth of Xenograft Tumors via Matrix Metalloproteinase Secretion

Liu, D., & Hornsby, P. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3452 · Cited by 499 · see citing works

TORC1 inhibition enhances immune function and reduces infections in the elderly

Mannick, J. B., Morris, M., Hockey, H.-U. P., Roma, G., Beibel, M., Kulmatycki, K., Watkins, M., Shavlakadze, T., Zhou, W., Quinn, D., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aaq1564 · Cited by 496 · see citing works

Rapamycin Attenuates Load-Induced Cardiac Hypertrophy in Mice

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A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations

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Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

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mTORC1 and mTORC2 in cancer and the tumor microenvironment

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Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise

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A diverse array of cancer-associated mTOR mutations are hyperactivating and can predict rapamycin sensitivity

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p53-Dependent apoptosis pathways

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mTORC2 Promotes Tumorigenesis via Lipid Synthesis

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Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

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Quantitative identification of senescent cells in aging and disease

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A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs

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The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential

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Reinstating Aberrant mTORC1 Activity in Huntington’s Disease Mice Improves Disease Phenotypes

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Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration

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The mTOR–S6K pathway links growth signalling to DNA damage response by targeting RNF168

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S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response

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Combination of Rapamycin and Resveratrol for Treatment of Bladder Cancer

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Ribosomopathies: Old Concepts, New Controversies

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Metformin and Aging: A Review

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Senescent Cells: A Therapeutic Target in Cardiovascular Diseases

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mTORC1 and mTORC2 Differentially Regulate Cell Fate Programs to Coordinate Osteoblastic Differentiation in Mesenchymal Stromal Cells

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Aging and Options to Halt Declining Immunity to Virus Infections

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Intercellular Transfer of Mitochondria between Senescent Cells through Cytoskeleton‐Supported Intercellular Bridges Requires mTOR and CDC42 Signalling

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The Post-amyloid Era in Alzheimer's Disease: Trust Your Gut Feeling

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The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19

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The central role of DNA damage in immunosenescence

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Crosstalk Between Senescent Bone Cells and the Bone Tissue Microenvironment Influences Bone Fragility During Chronological Age and in Diabetes

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Rapamycin/metformin co‐treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice

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Senotherapeutics in Cancer and HIV

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Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan

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