The DOI matches its Crossref record; 179 of the 179 references it cites were found in a registry or an index.
Actions of Brain-Derived Neurotrophin Factor in the Neurogenesis and Neuronal Function, and Its Involvement in the Pathophysiology of Brain Diseases
Open accessAbstract
It is well known that brain-derived neurotrophic factor, BDNF, has an important role in a variety of neuronal aspects, such as differentiation, maturation, and synaptic function in the central nervous system (CNS). BDNF stimulates mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK), phosphoinositide-3kinase (PI3K), and phospholipase C (PLC)-gamma pathways via activation of tropomyosin receptor kinase B (TrkB), a high affinity receptor for BDNF. Evidence has shown significant contributions of these signaling pathways in neurogenesis and synaptic plasticity in in vivo and in vitro experiments. Importantly, it has been demonstrated that dysfunction of the BDNF/TrkB system is involved in the onset of brain diseases, including neurodegenerative and psychiatric disorders. In this review, we discuss actions of BDNF and related signaling molecules on CNS neurons, and their contributions to the pathophysiology of brain diseases.
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2 retracted
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Polyphenols and neuroprotection: therapeutic implications for cognitive decline
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“stress, an important factor contributing to the emergence of depression (Numakawa et al., 2018; Warner-Schmidt and Duman, 2006).”
Background
Metadata
- Authors
- Numakawa, T., Odaka, H., & Adachi, N.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-11-19
- Volume
- 19
- Issue
- 11
- Pages
- 3650
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2901734506
- Cited by
- 353
- References
- 179
- FWCI
- 12.89
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Actions of Brain-Derived Neurotrophin Factor in the Neurogenesis and Neuronal Function, and Its Involvement in the Pathophysiology of Brain Diseases. https://app.cochat.ai/papers/10.3390/ijms19113650
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- Numakawa, T., Odaka, H., & Adachi, N. (2018). Actions of Brain-Derived Neurotrophin Factor in the Neurogenesis and Neuronal Function, and Its Involvement in the Pathophysiology of Brain Diseases. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms19113650
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
