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Cited by 3,995

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

Open access
Domingos da Silveira da Luz, Anna Claudia, Pereira Dias, Gisele, do Nascimento Bevilaqua, Mário Cesar, Cocks, Graham, Gardino, Patricia Franca, Thuret, Sandrine, Nardi, Antonio Egidio·2013·Neuropsychobiology
DOI 10.1159/000353269
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Abstract

Background/Aims: Anxious responses are evolutionarily adaptive, but excessive fear can become disabling and lead to anxiety disorders. Translational models of anxiety might be useful sources for understanding the neurobiology of fear and anxiety and can contribute to future proposals of therapeutic intervention for the disorders studied. Brain-derived neurotrophic factor (BDNF), which is known for its importance on neuroplasticity and contextual memory, has emerged as a relevant element for emotional memory. Recent studies show that the Val 66 Met BDNF polymorphism correlates with various psychiatric disorders, including anxiety, but there are several differences between experimental and clinical studies. Methods: In this work, we review the literature focused on the BDNF Val 66 Met polymorphism and anxiety, and discuss biological findings from animal models to clinical studies. Results: As occurs with other psychiatric disorders, anxiety correlates with anatomical, behavioral and physiological changes related to the BDNF polymorphism. In animal studies, it has been shown that a significant decrease in regulated secretion from both BDNF Val/Met and BDNF Met/Met neurons represented a significant decrease in available BDNF. Conclusion: These studies suggest that developing pharmacological strategies facilitating the release of BDNF from synapses or prolongation of the half-life of secreted BDNF may improve the therapeutic responses of humans expressing the BDNF polymorphism.

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Metadata

Authors
Domingos da Silveira da Luz, A. C., Pereira Dias, G., do Nascimento Bevilaqua, M. C., Cocks, G., Gardino, P. F., Thuret, S., & Nardi, A. E.
Venue
Neuropsychobiology
Publisher
S. Karger AG
Published
2013
Volume
68
Issue
3
Pages
129-138
ISSN
  • 0302-282X (ISSN-L)
  • 1423-0224
DOI
10.1159/000353269
OpenAlex
W2000209446
Cited by
3,995
References
41
FWCI
128.30
Type
journal article
Language
en
Open access
green
Licence

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CoChat. (2026). Citation check: Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice. https://app.cochat.ai/papers/10.1159/000353269
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Domingos da Silveira da Luz, A. C., Pereira Dias, G., do Nascimento Bevilaqua, M. C., Cocks, G., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013). Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice. Neuropsychobiology. https://doi.org/10.1159/000353269

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