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Cited by 319Tissue Engineering and Regenerative Medicine3D Printing in Biomedical ResearchBone Tissue Engineering Materials

Tissue-Engineered Grafts from Human Decellularized Extracellular Matrices: A Systematic Review and Future Perspectives

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Porzionato, Andrea, Stocco, Elena, Barbon, Silvia, Grandi, Francesca, Macchi, Veronica, De Caro, Raffaele·2018·International Journal of Molecular Sciences
DOI 10.3390/ijms19124117PMC PMC6321114
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Abstract

Tissue engineering and regenerative medicine involve many different artificial and biologic materials, frequently integrated in composite scaffolds, which can be repopulated with various cell types. One of the most promising scaffolds is decellularized allogeneic extracellular matrix (ECM) then recellularized by autologous or stem cells, in order to develop fully personalized clinical approaches. Decellularization protocols have to efficiently remove immunogenic cellular materials, maintaining the nonimmunogenic ECM, which is endowed with specific inductive/differentiating actions due to its architecture and bioactive factors. In the present paper, we review the available literature about the development of grafts from decellularized human tissues/organs. Human tissues may be obtained not only from surgery but also from cadavers, suggesting possible development of Human Tissue BioBanks from body donation programs. Many human tissues/organs have been decellularized for tissue engineering purposes, such as cartilage, bone, skeletal muscle, tendons, adipose tissue, heart, vessels, lung, dental pulp, intestine, liver, pancreas, kidney, gonads, uterus, childbirth products, cornea, and peripheral nerves. In vitro recellularizations have been reported with various cell types and procedures (seeding, injection, and perfusion). Conversely, studies about in vivo behaviour are poorly represented. Actually, the future challenge will be the development of human grafts to be implanted fully restored in all their structural/functional aspects.

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Authors
Porzionato, A., Stocco, E., Barbon, S., Grandi, F., Macchi, V., & De Caro, R.
Affiliations
  • University of Padua (IT)
  • Ospedale di Bolzano (IT)
  • Department of Neuroscience, Section of Human Anatomy, University of Padova, Via A. Gabelli 65, 35121 Padova, Italy
Corresponding author
Stocco, Elena
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2018-12-18
Volume
19
Issue
12
Pages
4117
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms19124117
PMC
PMC6321114
OpenAlex
W2904444744
Cited by
319
References
367
Citations by year
2026: 15 · 2025: 31 · 2024: 45 · 2023: 40 · 2022: 62 · 2021: 51 · 2020: 53 · 2019: 20 · 2018: 1 · 2016: 1
FWCI
6.95
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion, cc-by)
Funders
Regione del Veneto
Topics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords
decellularized extracellular matrix, tissue-engineered grafts, recellularization, decellularization protocols, body donation, stem cell seeding, cartilage, bone, cornea, peripheral nerves, organ regeneration
MeSH terms
Extracellular Matrix, Humans, Stem Cells, Transplants, Tissue Engineering, Stem Cell Transplantation, Tissue Scaffolds, Precision Medicine

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