CoChat
Sign Up
Cited by 202RNA and protein synthesis mechanismsRNA Research and SplicingPI3K/AKT/mTOR signaling in cancer

IRES Trans-Acting Factors, Key Actors of the Stress Response

Open access
Godet, Anne-Claire, David, Florian, Hantelys, Fransky, Tatin, Florence, Lacazette, Eric, Garmy-Susini, Barbara, Prats, Anne-Catherine·2019·International Journal of Molecular Sciences
DOI 10.3390/ijms20040924PMC PMC6412753

Published version of a preprint

Open this paper in CoChat — free accountOpen PDF

Abstract

The cellular stress response corresponds to the molecular changes that a cell undergoes in response to various environmental stimuli. It induces drastic changes in the regulation of gene expression at transcriptional and posttranscriptional levels. Actually, translation is strongly affected with a blockade of the classical cap-dependent mechanism, whereas alternative mechanisms are activated to support the translation of specific mRNAs. A major mechanism involved in stress-activated translation is the internal ribosome entry site (IRES)-driven initiation. IRESs, first discovered in viral mRNAs, are present in cellular mRNAs coding for master regulators of cell responses, whose expression must be tightly controlled. IRESs allow the translation of these mRNAs in response to different stresses, including DNA damage, amino-acid starvation, hypoxia or endoplasmic reticulum stress, as well as to physiological stimuli such as cell differentiation or synapse network formation. Most IRESs are regulated by IRES trans-acting factor (ITAFs), exerting their action by at least nine different mechanisms. This review presents the history of viral and cellular IRES discovery as well as an update of the reported ITAFs regulating cellular mRNA translation and of their different mechanisms of action. The impact of ITAFs on the coordinated expression of mRNA families and consequences in cell physiology and diseases are also highlighted.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/ijms20040924

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 209

  1. [1]Kozak M. Inability of circular mRNA to attach to eukaryotic ribosomes Nature 1979 280 82 85 10.1038/280082a0 15305588 · DOI
  2. [2]Kozak M. The scanning model for translation: An update J. Cell Biol. 1989 108 229 241 10.1083/jcb.108.2.229 2645293 PMC2115416 · DOI
  3. [3]Jang S.K. Krausslich H.G. Nicklin M.J. Duke G.M. Palmenberg A.C. Wimmer E. A segment of the 5′ nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation J. Virol. 1988 62 2636 2643 2839690 PMC253694
  4. [4]Pelletier J. Sonenberg N. Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA Nature 1988 334 320 325 10.1038/334320a0 2839775 · DOI
  5. [5]Balvay L. Lopez Lastra M. Sargueil B. Darlix J.L. Ohlmann T. Translational control of retroviruses Nat. Rev. Microbiol. 2007 5 128 140 10.1038/nrmicro1599 17224922 PMC7096986 · DOI
  6. [6]Berlioz C. Darlix J.L. An internal ribosomal entry mechanism promotes translation of murine leukemia virus gag polyprotein precursors J. Virol. 1995 69 2214 2222 7884868 PMC188890
  7. [7]Jackson R.J. The current status of vertebrate cellular mRNA IRESs Cold Spring Harb. Perspect. Biol. 2013 5 a011569 10.1101/cshperspect.a011569 23378589 PMC3552511 · DOI
  8. [8]Kwan T. Thompson S.R. Noncanonical Translation Initiation in Eukaryotes Cold Spring Harb. Perspect. Biol. 2018 10.1101/cshperspect.a032672 PMC6442200 29959190 · DOI
  9. [9]Tsukiyama-Kohara K. Iizuka N. Kohara M. Nomoto A. Internal ribosome entry site within hepatitis C virus RNA J. Virol. 1992 66 1476 1483 1310759 PMC240872
  10. [10]Vagner S. Waysbort A. Marenda M. Gensac M.C. Amalric F. Prats A.C. Alternative translation initiation of the Moloney murine leukemia virus mRNA controlled by internal ribosome entry involving the p57/PTB splicing factor J. Biol. Chem. 1995 270 20376 20383 10.1074/jbc.270.35.20376 7657611 · DOI
  11. [11]Wang C. Sarnow P. Siddiqui A. Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism J. Virol. 1993 67 3338 3344 8388503 PMC237677
  12. [12]Wilson J.E. Pestova T.V. Hellen C.U. Sarnow P. Initiation of protein synthesis from the A site of the ribosome Cell 2000 102 511 520 10.1016/S0092-8674(00)00055-6 10966112 · DOI
  13. [13]Macejak D.G. Sarnow P. Internal initiation of translation mediated by the 5′ leader of a cellular mRNA Nature 1991 353 90 94 10.1038/353090a0 1652694 · DOI
  14. [14]Vagner S. Gensac M.C. Maret A. Bayard F. Amalric F. Prats H. Prats A.C. Alternative translation of human fibroblast growth factor 2 mRNA occurs by internal entry of ribosomes Mol. Cell Biol. 1995 15 35 44 10.1128/MCB.15.1.35 7799942 PMC231905 · DOI
  15. [15]Lee K.M. Chen C.J. Shih S.R. Regulation Mechanisms of Viral IRES-Driven Translation Trends Microbiol. 2017 25 547 562 10.1016/j.tim.2017.01.010 28242053 · DOI
  16. [16]Thompson S.R. So you want to know if your message has an IRES? Wires RNA 2012 3 697 705 22733589 PMC3419317
  17. [17]Wang C. Sarnow P. Siddiqui A. A conserved helical element is essential for internal initiation of translation of hepatitis C virus RNA J. Virol. 1994 68 7301 7307 7933114 PMC237171
  18. [18]Lu H.H. Wimmer E. Poliovirus chimeras replicating under the translational control of genetic elements of hepatitis C virus reveal unusual properties of the internal ribosomal entry site of hepatitis C virus Proc. Natl. Acad. Sci. USA 1996 93 1412 1417 10.1073/pnas.93.4.1412 8643645 PMC39952 · DOI
  19. [19]Reynolds J.E. Kaminski A. Carroll A.R. Clarke B.E. Rowlands D.J. Jackson R.J. Internal initiation of translation of hepatitis C virus RNA: The ribosome entry site is at the authentic initiation codon RNA 1996 2 867 878 8809014 PMC1369422
  20. [20]Wang C. Le S.Y. Ali N. Siddiqui A. An RNA pseudoknot is an essential structural element of the internal ribosome entry site located within the hepatitis C virus 5′ noncoding region RNA 1995 1 526 537 7489514 PMC1482419
  21. [21]Hellen C.U. Witherell G.W. Schmid M. Shin S.H. Pestova T.V. Gil A. Wimmer E. A cytoplasmic 57-kDa protein that is required for translation of picornavirus RNA by internal ribosomal entry is identical to the nuclear pyrimidine tract-binding protein Proc. Natl. Acad. Sci. USA 1993 90 7642 7646 10.1073/pnas.90.16.7642 8395052 PMC47198 · DOI
  22. [22]Jang S.K. Wimmer E. Cap-independent translation of encephalomyocarditis virus RNA: Structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein Genes Dev. 1990 4 1560 1572 10.1101/gad.4.9.1560 2174810 · DOI
  23. [23]Luz N. Beck E. Interaction of a cellular 57-kilodalton protein with the internal translation initiation site of foot-and-mouth disease virus J. Virol. 1991 65 6486 6494 1658355 PMC250694
  24. [24]Meerovitch K. Pelletier J. Sonenberg N. A cellular protein that binds to the 5′-noncoding region of poliovirus RNA: Implications for internal translation initiation Genes Dev. 1989 3 1026 1034 10.1101/gad.3.7.1026 2550319 · DOI
  25. [25]Bonneau A.M. Sonenberg N. Involvement of the 24-kDa cap-binding protein in regulation of protein synthesis in mitosis J. Biol. Chem. 1987 262 11134 11139 3038908
  26. [26]Huang J.T. Schneider R.J. Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein Cell 1991 65 271 280 10.1016/0092-8674(91)90161-Q 1849798 · DOI
  27. [27]Lindquist S. Varying patterns of protein synthesis in Drosophila during heat shock: Implications for regulation Dev. Biol. 1980 77 463 479 10.1016/0012-1606(80)90488-1 7399133 · DOI
  28. [28]Huez I. Creancier L. Audigier S. Gensac M.C. Prats A.C. Prats H. Two independent internal ribosome entry sites are involved in translation initiation of vascular endothelial growth factor mRNA Mol. Cell Biol. 1998 18 6178 6190 10.1128/MCB.18.11.6178 9774635 PMC109205 · DOI
  29. [29]Morfoisse F. Kuchnio A. Frainay C. Gomez-Brouchet A. Delisle M.B. Marzi S. Helfer A.C. Hantelys F. Pujol F. Guillermet-Guibert J. Hypoxia induces VEGF-C expression in metastatic tumor cells via a HIF-1alpha-independent translation-mediated mechanism Cell Rep. 2014 6 155 167 10.1016/j.celrep.2013.12.011 24388748 · DOI
  30. [30]Morfoisse F. Tatin F. Hantelys F. Adoue A. Helfer A.C. Cassant-Sourdy S. Pujol F. Gomez-Brouchet A. Ligat L. Lopez F. Nucleolin Promotes Heat Shock-Associated Translation of VEGF-D to Promote Tumor Lymphangiogenesis Cancer Res. 2016 76 4394 4405 10.1158/0008-5472.CAN-15-3140 27280395 · DOI
  31. [31]Nanbru C. Lafon I. Audigier S. Gensac M.C. Vagner S. Huez G. Prats A.C. Alternative translation of the proto-oncogene c-myc by an internal ribosome entry site J. Biol. Chem. 1997 272 32061 32066 10.1074/jbc.272.51.32061 9405401 · DOI
  32. [32]Oh S.K. Scott M.P. Sarnow P. Homeotic gene Antennapedia mRNA contains 5′-noncoding sequences that confer translational initiation by internal ribosome binding Genes Dev. 1992 6 1643 1653 10.1101/gad.6.9.1643 1355457 · DOI
  33. [33]Prats A.C. Prats H. Translational control of gene expression: Role of IRESs and consequences for cell transformation and angiogenesis Prog. Nucleic Acid Res. Mol. Biol. 2002 72 367 413 12206457
  34. [34]Stoneley M. Paulin F.E. Le Quesne J.P. Chappell S.A. Willis A.E. C-Myc 5′ untranslated region contains an internal ribosome entry segment Oncogene 1998 16 423 428 10.1038/sj.onc.1201763 9467968 · DOI
  35. [35]Braunstein S. Karpisheva K. Pola C. Goldberg J. Hochman T. Yee H. Cangiarella J. Arju R. Formenti S.C. Schneider R.J. A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer Mol. Cell 2007 28 501 512 10.1016/j.molcel.2007.10.019 17996713 · DOI
  36. [36]Bellodi C. Kopmar N. Ruggero D. Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenita Embo J. 2010 29 1865 1876 10.1038/emboj.2010.83 20453831 PMC2885924 · DOI
  37. [37]Bonnal S. Pileur F. Orsini C. Parker F. Pujol F. Prats A.C. Vagner S. Heterogeneous nuclear ribonucleoprotein A1 is a novel internal ribosome entry site trans-acting factor that modulates alternative initiation of translation of the fibroblast growth factor 2 mRNA J. Biol. Chem. 2005 280 4144 4153 10.1074/jbc.M411492200 15525641 · DOI
  38. [38]Martineau Y. Le Bec C. Monbrun L. Allo V. Chiu I.M. Danos O. Moine H. Prats H. Prats A.C. Internal ribosome entry site structural motifs conserved among mammalian fibroblast growth factor 1 alternatively spliced mRNAs Mol. Cell Biol. 2004 24 7622 7635 10.1128/MCB.24.17.7622-7635.2004 15314170 PMC507008 · DOI
  39. [39]Karginov T.A. Pastor D.P.H. Semler B.L. Gomez C.M. Mammalian Polycistronic mRNAs and Disease Trends Genet. 2017 33 129 142 10.1016/j.tig.2016.11.007 28012572 PMC5285393 · DOI
  40. [40]Arnaud E. Touriol C. Boutonnet C. Gensac M.C. Vagner S. Prats H. Prats A.C. A new 34-kilodalton isoform of human fibroblast growth factor 2 is cap dependently synthesized by using a non-AUG start codon and behaves as a survival factor Mol. Cell Biol. 1999 19 505 514 10.1128/MCB.19.1.505 9858574 PMC83908 · DOI
  41. [41]Huez I. Bornes S. Bresson D. Creancier L. Prats H. New vascular endothelial growth factor isoform generated by internal ribosome entry site-driven CUG translation initiation Mol. Endocrinol. 2001 15 2197 2210 10.1210/mend.15.12.0738 11731620 · DOI
  42. [42]Prats H. Kaghad M. Prats A.C. Klagsbrun M. Lelias J.M. Liauzun P. Chalon P. Tauber J.P. Amalric F. Smith J.A. High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons Proc. Natl. Acad. Sci. USA 1989 86 1836 1840 10.1073/pnas.86.6.1836 2538817 PMC286799 · DOI
  43. [43]Nanbru C. Prats A.C. Droogmans L. Defrance P. Huez G. Kruys V. Translation of the human c-myc P0 tricistronic mRNA involves two independent internal ribosome entry sites Oncogene 2001 20 4270 4280 10.1038/sj.onc.1204548 11464293 · DOI
  44. [44]Xiong Z. Liu E. Yan Y. Silver R.T. Yang F. Chen I.H. Chen Y. Verstovsek S. Wang H. Prchal J. An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions J. Immunol. 2006 177 4907 4916 10.4049/jimmunol.177.7.4907 16982933 PMC3902139 · DOI
  45. [45]Hui D. Kumar K.N. Mach J.R. Srinivasan A. Pal R. Bao X. Agbas A. Hofner G. Wanner K.T. Michaelis E.K. A rat brain bicistronic gene with an internal ribosome entry site codes for a phencyclidine-binding protein with cytotoxic activity J. Biol. Chem. 2009 284 2245 2257 10.1074/jbc.M807063200 19028684 PMC2629087 · DOI
  46. [46]Bahar Halpern K. Veprik A. Rubins N. Naaman O. Walker M.D. GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins J. Biol. Chem. 2012 287 20154 20163 10.1074/jbc.M112.358887 22493486 PMC3370198 · DOI
  47. [47]Holcik M. Lefebvre C. Yeh C.L. Chow T. Korneluk R.G. A new internal-ribosome-entry-site motif potentiates XIAP-mediated cytoprotection Nat. Cell Biol. 1999 1 190 192 10.1038/11109 10559907 · DOI
  48. [48]Coldwell M.J. Mitchell S.A. Stoneley M. MacFarlane M. Willis A.E. Initiation of Apaf-1 translation by internal ribosome entry Oncogene 2000 19 899 905 10.1038/sj.onc.1203407 10702798 · DOI
  49. [49]Ray P.S. Grover R. Das S. Two internal ribosome entry sites mediate the translation of p53 isoforms Embo Rep. 2006 7 404 410 10.1038/sj.embor.7400623 16440000 PMC1456917 · DOI
  50. [50]Stoneley M. Chappell S.A. Jopling C.L. Dickens M. MacFarlane M. Willis A.E. c-Myc protein synthesis is initiated from the internal ribosome entry segment during apoptosis Mol. Cell Biol. 2000 20 1162 1169 10.1128/MCB.20.4.1162-1169.2000 10648601 PMC85234 · DOI
  51. [51]Yang D.Q. Halaby M.J. Zhang Y. The identification of an internal ribosomal entry site in the 5′-untranslated region of p53 mRNA provides a novel mechanism for the regulation of its translation following DNA damage Oncogene 2006 25 4613 4619 10.1038/sj.onc.1209483 16607284 · DOI
  52. [52]Holcik M. Sonenberg N. Translational control in stress and apoptosis Nat. Rev. Mol. Cell Biol. 2005 6 318 327 10.1038/nrm1618 15803138 · DOI
  53. [53]Creancier L. Morello D. Mercier P. Prats A.C. Fibroblast growth factor 2 internal ribosome entry site (IRES) activity ex vivo and in transgenic mice reveals a stringent tissue-specific regulation J. Cell Biol. 2000 150 275 281 10.1083/jcb.150.1.275 10893274 PMC2185555 · DOI
  54. [54]Audigier S. Guiramand J. Prado-Lourenco L. Conte C. Gonzalez-Herrera I.G. Cohen-Solal C. Recasens M. Prats A.C. Potent activation of FGF-2 IRES-dependent mechanism of translation during brain development RNA 2008 14 1852 1864 10.1261/rna.790608 18676616 PMC2525950 · DOI
  55. [55]Gonzalez-Herrera I.G. Prado-Lourenco L. Pileur F. Conte C. Morin A. Cabon F. Prats H. Vagner S. Bayard F. Audigier S. Testosterone regulates FGF-2 expression during testis maturation by an IRES-dependent translational mechanism Faseb J. 2006 20 476 478 10.1096/fj.04-3314fje 16423876 · DOI
  56. [56]Conte C. Ainaoui N. Delluc-Clavieres A. Khoury M.P. Azar R. Pujol F. Martineau Y. Pyronnet S. Prats A.C. Fibroblast growth factor 1 induced during myogenesis by a transcription-translation coupling mechanism Nucleic Acids Res. 2009 37 5267 5278 10.1093/nar/gkp550 19561198 PMC2760804 · DOI
  57. [57]Creancier L. Mercier P. Prats A.C. Morello D. c-myc Internal ribosome entry site activity is developmentally controlled and subjected to a strong translational repression in adult transgenic mice Mol. Cell Biol. 2001 21 1833 1840 10.1128/MCB.21.5.1833-1840.2001 11238920 PMC86749 · DOI
  58. [58]Xue S. Tian S. Fujii K. Kladwang W. Das R. Barna M. RNA regulons in Hox 5′ UTRs confer ribosome specificity to gene regulation Nature 2015 517 33 38 10.1038/nature14010 25409156 PMC4353651 · DOI
  59. [59]Weingarten-Gabbay S. Elias-Kirma S. Nir R. Gritsenko A.A. Stern-Ginossar N. Yakhini Z. Weinberger A. Segal E. Systematic discovery of cap-independent translation sequences in human and viral genomes Science 2016 351 aad4939 10.1126/science.aad4939 26816383 · DOI · Paper page
  60. [60]Chappell S.A. LeQuesne J.P.C. Paulin F.E.M. deSchoolmeester M.L. Stoneley M. Soutar R.L. Ralston S.H. Helfrich M.H. Willis A.E. A mutation in the c-myc-IRES leads to enhanced internal ribosome entry in multiple myeloma: A novel mechanism of oncogene de-regulation Oncogene 2000 19 4437 4440 10.1038/sj.onc.1203791 10980620 · DOI
  61. [61]Hudder A. Werner R. Analysis of a Charcot-Marie-Tooth disease mutation reveals an essential internal ribosome entry site element in the connexin-32 gene J. Biol. Chem. 2000 275 34586 34591 10.1074/jbc.M005199200 10931843 · DOI
  62. [62]Lambrechts D. Storkebaum E. Morimoto M. Del-Favero J. Desmet F. Marklund S.L. Wyns S. Thijs V. Andersson J. van Marion I. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death Nat. Genet. 2003 34 383 394 10.1038/ng1211 12847526 · DOI
  63. [63]Marcel V. Ghayad S.E. Belin S. Therizols G. Morel A.P. Solano-Gonzalez E. Vendrell J.A. Hacot S. Mertani H.C. Albaret M.A. p53 acts as a safeguard of translational control by regulating fibrillarin and rRNA methylation in cancer Cancer Cell 2013 24 318 330 10.1016/j.ccr.2013.08.013 24029231 PMC7106277 · DOI
  64. [64]Ryoo H.D. Vasudevan D. Two distinct nodes of translational inhibition in the Integrated Stress Response Bmb Rep. 2017 50 539 545 10.5483/BMBRep.2017.50.11.157 28803610 PMC5720466 · DOI
  65. [65]Hinnebusch A.G. Translational regulation of GCN4 and the general amino acid control of yeast Annu. Rev. Microbiol. 2005 59 407 450 10.1146/annurev.micro.59.031805.133833 16153175 · DOI
  66. [66]Fernandez J. Yaman I. Sarnow P. Snider M.D. Hatzoglou M. Regulation of internal ribosomal entry site-mediated translation by phosphorylation of the translation initiation factor eIF2 alpha J. Biol. Chem. 2002 277 19198 19205 10.1074/jbc.M201052200 11877448 · DOI
  67. [67]Kang M.J. Vasudevan D. Kang K. Kim K. Park J.E. Zhang N. Zeng X.M. Neubert T.A. Marr M.T. Ryoo H.D. 4E-BP is a target of the GCN2 ATF4 pathway during Drosophila development and aging J. Cell Biol. 2017 216 115 129 10.1083/jcb.201511073 27979906 PMC5223598 · DOI
  68. [68]Thakor N. Holcik M. IRES-mediated translation of cellular messenger RNA operates in eIF2 alpha-independent manner during stress Nucleic Acids Res 2012 40 541 552 10.1093/nar/gkr701 21917851 PMC3258125 · DOI
  69. [69]Holcik M. Could the elF2 alpha-Independent Translation Be the Achilles Heel of Cancer? Front. Oncol. 2015 5 264 10.3389/fonc.2015.00264 26636041 PMC4659918 · DOI
  70. [70]Bornes S. Prado-Lourenco L. Bastide A. Zanibellato C. Iacovoni J.S. Lacazette E. Prats A.C. Touriol C. Prats H. Translational induction of VEGF internal ribosome entry site elements during the early response to ischemic stress Circ. Res. 2007 100 305 308 10.1161/01.RES.0000258873.08041.c9 17255526 · DOI
  71. [71]Conte C. Riant E. Toutain C. Pujol F. Arnal J.F. Lenfant F. Prats A.C. FGF2 translationally induced by hypoxia is involved in negative and positive feedback loops with HIF-1alpha PLoS ONE 2008 3 e3078 10.1371/journal.pone.0003078 18728783 PMC2518102 · DOI
  72. [72]Hantelys FGodet A.C. Tatin F. Renaud-Gabardos E. Pujol F.A.I. Ligat L. Henras A. Lacazette E. Parini A. Garmy-Susini A. aPAC Vasohibin1, a new IRES trans-acting factor for sequential induction of angiogenic factors in hypoxia BioRxiv 2019 10.1101/260364 · DOI
  73. [73]Renaud-Gabardos E. Tatin F. Hantelys F. Lebas B. Calise D. Kunduzova O. Masri B. Pujol F. Sicard P. Valet P. Therapeutic Benefit and Gene Network Regulation by Combined Gene Transfer of Apelin, FGF2, and SERCA2a into Ischemic Heart Mol. Ther. 2018 26 902 916 10.1016/j.ymthe.2017.11.007 29249393 PMC5910659 · DOI
  74. [74]Yang Y. Wang C.F. Zhao K.L. Zhang G. Wang D.C. Mei Y.D. TRMP, a p53-inducible long noncoding RNA, regulates G1/S cell cycle progression by modulating IRES-dependent p27 translation Cell Death Dis. 2018 9 886 10.1038/s41419-018-0884-3 30166522 PMC6117267 · DOI
  75. [75]Masaki T. Arend K.C. Li Y. Yamane D. McGivern D.R. Kato T. Wakita T. Moorman N.J. Lemon S.M. miR-122 stimulates hepatitis C virus RNA synthesis by altering the balance of viral RNAs engaged in replication versus translation Cell Host Microbe 2015 17 217 228 10.1016/j.chom.2014.12.014 25662750 PMC4326553 · DOI
  76. [76]Sharathchandra A. Lal R. Khan D. Das S. Annexin A2 and PSF proteins interact with p53 IRES and regulate translation of p53 mRNA RNA Biol. 2012 9 1429 1439 10.4161/rna.22707 23131771 · DOI
  77. [77]Fox J.T. Shin W.K. Caudill M.A. Stover P.J. A UV-responsive internal ribosome entry site enhances serine hydroxymethyltransferase 1 expression for DNA damage repair J. Biol. Chem. 2009 284 31097 31108 10.1074/jbc.M109.015800 19734144 PMC2781509 · DOI
  78. [78]Zheng Y. Miskimins W.K. CUG-binding protein represses translation of p27Kip1 mRNA through its internal ribosomal entry site RNA Biol. 2011 8 365 371 10.4161/rna.8.3.14804 21508681 PMC3218506 · DOI
  79. [79]Hanson P.J. Ye X. Qiu Y. Zhang H.M. Hemida M.G. Wang F. Lim T. Gu A. Cho B. Kim H. Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES-containing genes Cell Death Differ. 2016 23 828 840 10.1038/cdd.2015.145 26586572 PMC4832101 · DOI
  80. [80]Henis-Korenblit S. Shani G. Sines T. Marash L. Shohat G. Kimchi A. The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins Proc. Natl. Acad. Sci. USA 2002 99 5400 5405 10.1073/pnas.082102499 11943866 PMC122781 · DOI
  81. [81]Henis-Korenblit S. Strumpf N.L. Goldstaub D. Kimchi A. A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation Mol. Cell Biol. 2000 20 496 506 10.1128/MCB.20.2.496-506.2000 10611228 PMC85113 · DOI
  82. [82]Lewis S.M. Holcik M. For IRES trans-acting factors, it is all about location Oncogene 2008 27 1033 1035 10.1038/sj.onc.1210777 17767196 · DOI
  83. [83]Liberman N. Gandin V. Svitkin Y.V. David M. Virgili G. Jaramillo M. Holcik M. Nagar B. Kimchi A. Sonenberg N. DAP5 associates with eIF2beta and eIF4AI to promote Internal Ribosome Entry Site driven translation Nucleic Acids Res. 2015 43 3764 3775 10.1093/nar/gkv205 25779044 PMC4402527 · DOI
  84. [84]Liberman N. Marash L. Kimchi A. The translation initiation factor DAP5 is a regulator of cell survival during mitosis Cell Cycle 2009 8 204 209 10.4161/cc.8.2.7384 19158497 · DOI
  85. [85]Marash L. Liberman N. Henis-Korenblit S. Sivan G. Reem E. Elroy-Stein O. Kimchi A. DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosis Mol Cell. 2008 30 447 459 10.1016/j.molcel.2008.03.018 18450493 · DOI
  86. [86]Nevins T.A. Harder Z.M. Korneluk R.G. Holcik M. Distinct regulation of internal ribosome entry site-mediated translation following cellular stress is mediated by apoptotic fragments of eIF4G translation initiation factor family members eIF4GI and p97/DAP5/NAT1 J. Biol. Chem. 2003 278 3572 3579 10.1074/jbc.M206781200 12458215 · DOI
  87. [87]Warnakulasuriyarachchi D. Cerquozzi S. Cheung H.H. Holcik M. Translational induction of the inhibitor of apoptosis protein HIAP2 during endoplasmic reticulum stress attenuates cell death and is mediated via an inducible internal ribosome entry site element J. Biol. Chem. 2004 279 17148 17157 10.1074/jbc.M308737200 14960583 · DOI
  88. [88]Weingarten-Gabbay S. Khan D. Liberman N. Yoffe Y. Bialik S. Das S. Oren M. Kimchi A. The translation initiation factor DAP5 promotes IRES-driven translation of p53 mRNA Oncogene 2014 33 611 618 10.1038/onc.2012.626 23318444 · DOI
  89. [89]Lampe S. Kunze M. Scholz A. Brauss T.F. Winslow S. Simm S. Keller M. Heidler J. Wittig I. Brune B. Identification of the TXNIP IRES and characterization of the impact of regulatory IRES trans-acting factors Biochim. Biophys. Acta Gene Regul. Mech. 2018 1861 147 157 10.1016/j.bbagrm.2018.01.010 29378331 · DOI
  90. [90]Tsai B.P. Wang X. Huang L. Waterman M.L. Quantitative profiling of in vivo-assembled RNA-protein complexes using a novel integrated proteomic approach Mol. Cell Proteomics 2011 10 M110 007385 10.1074/mcp.M110.007385 PMC3069349 21285413 · DOI
  91. [91]Cobbold L.C. Spriggs K.A. Haines S.J. Dobbyn H.C. Hayes C. de Moor C.H. Lilley K.S. Bushell M. Willis A.E. Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs Mol. Cell Biol. 2008 28 40 49 10.1128/MCB.01298-07 17967896 PMC2223313 · DOI
  92. [92]Woeller C.F. Fox J.T. Perry C. Stover P.J. A ferritin-responsive internal ribosome entry site regulates folate metabolism J. Biol. Chem. 2007 282 29927 29935 10.1074/jbc.M706264200 17702748 · DOI
  93. [93]Malbert-Colas L. Ponnuswamy A. Olivares-Illana V. Tournillon A.S. Naski N. Fahraeus R. HDMX folds the nascent p53 mRNA following activation by the ATM kinase Mol. Cell 2014 54 500 511 10.1016/j.molcel.2014.02.035 24813712 · DOI
  94. [94]Cammas A. Pileur F. Bonnal S. Lewis S.M. Leveque N. Holcik M. Vagner S. Cytoplasmic relocalization of heterogeneous nuclear ribonucleoprotein A1 controls translation initiation of specific mRNAs Mol. Biol. Cell 2007 18 5048 5059 10.1091/mbc.e07-06-0603 17898077 PMC2096577 · DOI
  95. [95]Jo O.D. Martin J. Bernath A. Masri J. Lichtenstein A. Gera J. Heterogeneous nuclear ribonucleoprotein A1 regulates cyclin D1 and c-myc internal ribosome entry site function through Akt signaling. (vol 283, pg 23274, 2008) J. Biol. Chem. 2008 283 31268 10.1074/jbc.M801185200 PMC2516998 18562319 · DOI
  96. [96]Kim H.J. Lee H.R. Seo J.Y. Ryu H.G. Lee K.H. Kim D.Y. Kim K.T. Heterogeneous nuclear ribonucleoprotein A1 regulates rhythmic synthesis of mouse Nfil3 protein via IRES-mediated translation Sci. Rep. 2017 7 42882 10.1038/srep42882 28220845 PMC5318856 · DOI
  97. [97]Kunze M.M. Benz F. Brauss T.F. Lampe S. Weigand J.E. Braun J. Richter F.M. Wittig I. Brune B. Schmid T. sST2 translation is regulated by FGF2 via an hnRNP A1-mediated IRES-dependent mechanism Biochim. Biophys. Acta 2016 1859 848 859 10.1016/j.bbagrm.2016.05.005 27168114 · DOI
  98. [98]Lewis S.M. Veyrier A. Hosszu Ungureanu N. Bonnal S. Vagner S. Holcik M. Subcellular relocalization of a trans-acting factor regulates XIAP IRES-dependent translation Mol. Biol. Cell 2007 18 1302 1311 10.1091/mbc.e06-06-0515 17287399 PMC1838995 · DOI
  99. [99]Roy R. Durie D. Li H. Liu B.Q. Skehel J.M. Mauri F. Cuorvo L.V. Barbareschi M. Guo L. Holcik M. hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling Nucleic Acids Res. 2014 42 12483 12497 10.1093/nar/gku953 25324306 PMC4227786 · DOI
  100. [100]Shi Y. Frost P.J. Hoang B.Q. Benavides A. Sharma S. Gera J.F. Lichtenstein A.K. IL-6-induced stimulation of c-myc translation in multiple myeloma cells is mediated by myc internal ribosome entry site function and the RNA-binding protein, hnRNP A1 Cancer Res. 2008 68 10215 10222 10.1158/0008-5472.CAN-08-1066 19074889 PMC2701383 · DOI
  101. [101]Shi Y. Yang Y. Hoang B. Bardeleben C. Holmes B. Gera J. Lichtenstein A. Therapeutic potential of targeting IRES-dependent c-myc translation in multiple myeloma cells during ER stress Oncogene 2016 35 1015 1024 10.1038/onc.2015.156 25961916 PMC5104155 · DOI
  102. [102]Siculella L. Tocci R. Rochira A. Testini M. Gnoni A. Damiano F. Lipid accumulation stimulates the cap-independent translation of SREBP-1a mRNA by promoting hnRNP A1 binding to its 5′-UTR in a cellular model of hepatic steatosis Biochim. Biophys. Acta 2016 1861 471 481 10.1016/j.bbalip.2016.02.003 26869449 · DOI
  103. [103]Christian K.J. Lang M.A. Raffalli-Mathieu F. Interaction of heterogeneous nuclear ribonucleoprotein C1/C2 with a novel cis-regulatory element within p53 mRNA as a response to cytostatic drug treatment Mol. Pharm. 2008 73 1558 1567 10.1124/mol.107.042507 18296503 · DOI
  104. [104]Holcik M. Gordon B.W. Korneluk R.G. The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2 Mol. Cell Biol. 2003 23 280 288 10.1128/MCB.23.1.280-288.2003 12482981 PMC140676 · DOI
  105. [105]Kim J.H. Paek K.Y. Choi K. Kim T.D. Hahm B. Kim K.T. Jang S.K. Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner Mol. Cell Biol. 2003 23 708 720 10.1128/MCB.23.2.708-720.2003 12509468 PMC151538 · DOI
  106. [106]Meng Z. Jackson N.L. Choi H. King P.H. Emanuel P.D. Blume S.W. Alterations in RNA-binding activities of IRES-regulatory proteins as a mechanism for physiological variability and pathological dysregulation of IGF-IR translational control in human breast tumor cells J. Cell Physiol. 2008 217 172 183 10.1002/jcp.21486 18452152 · DOI
  107. [107]Schepens B. Tinton S.A. Bruynooghe Y. Parthoens E. Haegman M. Beyaert R. Cornelis S. A role for hnRNP C1/C2 and Unr in internal initiation of translation during mitosis Embo J. 2007 26 158 169 10.1038/sj.emboj.7601468 17159903 PMC1782369 · DOI
  108. [108]Omnus D.J. Mehrtens S. Ritter B. Resch K. Yamada M. Frank R. Nourbakhsh M. Reboll M.R. JKTBP1 is involved in stabilization and IRES-dependent translation of NRF mRNAs by binding to 5′ and 3′ untranslated regions J. Mol. Biol. 2011 407 492 504 10.1016/j.jmb.2011.01.050 21300069 · DOI
  109. [109]Reboll M.R. Oumard A. Gazdag A.C. Renger I. Ritter B. Schwarzer M. Hauser H. Wood M. Yamada M. Resch K. NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt RNA element RNA 2007 13 1328 1340 10.1261/rna.545407 17592041 PMC1924892 · DOI
  110. [110]Dobbyn H.C. Hill K. Hamilton T.L. Spriggs K.A. Pickering B.M. Coldwell M.J. de Moor C.H. Bushell M. Willis A.E. Regulation of BAG-1 IRES-mediated translation following chemotoxic stress Oncogene 2008 27 1167 1174 10.1038/sj.onc.1210723 17700523 PMC2570717 · DOI
  111. [111]Evans J.R. Mitchell S.A. Spriggs K.A. Ostrowski J. Bomsztyk K. Ostarek D. Willis A.E. Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo Oncogene 2003 22 8012 8020 10.1038/sj.onc.1206645 12970749 · DOI
  112. [112]Pickering B.M. Mitchell S.A. Evans J.R. Willis A.E. Polypyrimidine tract binding protein and poly r(C) binding protein 1 interact with the BAG-1 IRES and stimulate its activity in vitro and in vivo Nucleic Acids Res. 2003 31 639 646 10.1093/nar/gkg146 12527772 PMC140511 · DOI
  113. [113]Notari M. Neviani P. Santhanam R. Blaser B.W. Chang J.S. Galietta A. Willis A.E. Roy D.C. Caligiuri M.A. Marcucci G. A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation Blood 2006 107 2507 2516 10.1182/blood-2005-09-3732 16293596 PMC1895740 · DOI
  114. [114]Majumder M. Yaman I. Gaccioli F. Zeenko V.V. Wang C. Caprara M.G. Venema R.C. Komar A.A. Snider M.D. Hatzoglou M. The hnRNA-binding proteins hnRNP L and PTB are required for efficient translation of the Cat-1 arginine/lysine transporter mRNA during amino acid starvation Mol. Cell Biol. 2009 29 2899 2912 10.1128/MCB.01774-08 19273590 PMC2682027 · DOI
  115. [115]Peddigari S. Li P.W. Rabe J.L. Martin S.L. hnRNPL and nucleolin bind LINE-1 RNA and function as host factors to modulate retrotransposition Nucleic Acids Res. 2013 41 575 585 10.1093/nar/gks1075 23161687 PMC3592465 · DOI
  116. [116]Seo J.Y. Kim D.Y. Kim S.H. Kim H.J. Ryu H.G. Lee J. Lee K.H. Kim K.T. Heterogeneous nuclear ribonucleoprotein (hnRNP) L promotes DNA damage-induced cell apoptosis by enhancing the translation of p53 Oncotarget 2017 8 51108 51122 10.18632/oncotarget.17003 28881634 PMC5584235 · DOI
  117. [117]Ainaoui N. Hantelys F. Renaud-Gabardos E. Bunel M. Lopez F. Pujol F. Planes R. Bahraoui E. Pichereaux C. Burlet-Schiltz O. Promoter-Dependent Translation Controlled by p54nrb and hnRNPM during Myoblast Differentiation PLoS ONE 2015 10 e0136466 10.1371/journal.pone.0136466 26332123 PMC4558007 · DOI
  118. [118]Cho S. Park S.M. Kim T.D. Kim J.H. Kim K.T. Jang S.K. BiP internal ribosomal entry site activity is controlled by heat-induced interaction of NSAP1 Mol. Cell Biol. 2007 27 368 383 10.1128/MCB.00814-06 17074807 PMC1800651 · DOI
  119. [119]Choi J.H. Kim S.H. Jeong Y.H. Kim S.W. Min K.T. Kim K.T. hnRNP Q regulates IRES-mediated fmr1 translation in neurons Mol. Cell Biol. 2018 10.1128/MCB.00371-18 PMC6362317 30478144 · DOI
  120. [120]Kim D.Y. Kim W. Lee K.H. Kim S.H. Lee H.R. Kim H.J. Jung Y. Choi J.H. Kim K.T. hnRNP Q regulates translation of p53 in normal and stress conditions Cell Death Differ. 2013 20 226 234 10.1038/cdd.2012.109 22935615 PMC3554343 · DOI
  121. [121]Kim D.Y. Woo K.C. Lee K.H. Kim T.D. Kim K.T. hnRNP Q and PTB modulate the circadian oscillation of mouse Rev-erb alpha via IRES-mediated translation Nucleic Acids Res. 2010 38 7068 7078 10.1093/nar/gkq569 20576698 PMC2978350 · DOI
  122. [122]Kim T.D. Woo K.C. Cho S. Ha D.C. Jang S.K. Kim K.T. Rhythmic control of AANAT translation by hnRNP Q in circadian melatonin production Genes Dev. 2007 21 797 810 10.1101/gad.1519507 17403780 PMC1838531 · DOI
  123. [123]Lee K.H. Woo K.C. Kim D.Y. Kim T.D. Shin J. Park S.M. Jang S.K. Kim K.T. Rhythmic interaction between Period1 mRNA and hnRNP Q leads to circadian time-dependent translation Mol. Cell Biol. 2012 32 717 728 10.1128/MCB.06177-11 22124155 PMC3266596 · DOI
  124. [124]Lee H.R. Kim T.D. Kim H.J. Jung Y. Lee D. Lee K.H. Kim D.Y. Woo K.C. Kim K.T. Heterogeneous ribonucleoprotein R regulates arylalkylamine N-acetyltransferase synthesis via internal ribosomal entry site-mediated translation in a circadian manner J. Pineal Res. 2015 59 518 529 10.1111/jpi.12284 26444903 · DOI
  125. [125]Badawi A. Biyanee A. Nasrullah U. Winslow S. Schmid T. Pfeilschifter J. Eberhardt W. Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells Oncotarget 2018 9 18367 18385 10.18632/oncotarget.24840 29719611 PMC5915078 · DOI
  126. [126]Durie D. Hatzoglou M. Chakraborty P. Holcik M. HuR controls mitochondrial morphology through the regulation of BclxL translation Translation 2013 1 e23980 10.4161/trla.23980 25328858 PMC4199323 · DOI
  127. [127]Durie D. Lewis S.M. Liwak U. Kisilewicz M. Gorospe M. Holcik M. RNA-binding protein HuR mediates cytoprotection through stimulation of XIAP translation Oncogene 2011 30 1460 1469 10.1038/onc.2010.527 21102524 PMC3514411 · DOI
  128. [128]Kullmann M. Gopfert U. Siewe B. Hengst L. ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5′UTR Genes Dev. 2002 16 3087 3099 10.1101/gad.248902 12464637 PMC187493 · DOI · Paper page
  129. [129]Meng Z. King P.H. Nabors L.B. Jackson N.L. Chen C.Y. Emanuel P.D. Blume S.W. The ELAV RNA-stability factor HuR binds the 5′-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation Nucleic Acids Res. 2005 33 2962 2979 10.1093/nar/gki603 15914670 PMC1140080 · DOI
  130. [130]Yeh C.H. Hung L.Y. Hsu C. Le S.Y. Lee P.T. Liao W.L. Lin Y.T. Chang W.C. Tseng J.T. RNA-binding protein HuR interacts with thrombomodulin 5′untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatment Mol. Biol. Cell 2008 19 3812 3822 10.1091/mbc.e07-09-0962 18579691 PMC2526687 · DOI
  131. [131]Gao W. Li Q. Zhu R. Jin J. La Autoantigen Induces Ribosome Binding Protein 1 (RRBP1) Expression through Internal Ribosome Entry Site (IRES)-Mediated Translation during Cellular Stress Condition Int. J. Mol. Sci. 2016 17 1174 10.3390/ijms17071174 27447629 PMC4964545 · DOI
  132. [132]Holcik M. Korneluk R.G. Functional characterization of the X-linked inhibitor of apoptosis (XIAP) internal ribosome entry site element: Role of La autoantigen in XIAP translation Mol. Cell Biol. 2000 20 4648 4657 10.1128/MCB.20.13.4648-4657.2000 10848591 PMC85872 · DOI
  133. [133]Kim Y.K. Back S.H. Rho J. Lee S.H. Jang S.K. La autoantigen enhances translation of BiP mRNA Nucleic Acids Res. 2001 29 5009 5016 10.1093/nar/29.24.5009 11812831 PMC97601 · DOI
  134. [134]Gu L. Zhu N. Zhang H. Durden D.L. Feng Y. Zhou M. Regulation of XIAP translation and induction by MDM2 following irradiation Cancer Cell 2009 15 363 375 10.1016/j.ccr.2009.03.002 19411066 PMC2696306 · DOI
  135. [135]Faye M.D. Graber T.E. Liu P. Thakor N. Baird S.D. Durie D. Holcik M. Nucleotide composition of cellular internal ribosome entry sites defines dependence on NF45 and predicts a posttranscriptional mitotic regulon Mol. Cell Biol. 2013 33 307 318 10.1128/MCB.00546-12 23129811 PMC3554113 · DOI
  136. [136]Spriggs K.A. Cobbold L.C. Ridley S.H. Coldwell M. Bottley A. Bushell M. Willis A.E. Siddle K. The human insulin receptor mRNA contains a functional internal ribosome entry segment Nucleic Acids Res. 2009 37 5881 5893 10.1093/nar/gkp623 19654240 PMC2761284 · DOI
  137. [137]Chen J. Guo K. Kastan M.B. Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA J. Biol. Chem. 2012 287 16467 16476 10.1074/jbc.M112.349274 22433872 PMC3351294 · DOI
  138. [138]Takagi M. Absalon M.J. McLure K.G. Kastan M.B. Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin Cell 2005 123 49 63 10.1016/j.cell.2005.07.034 16213212 · DOI
  139. [139]Shen W. Liang X.H. Sun H. De Hoyos C.L. Crooke S.T. Depletion of NEAT1 lncRNA attenuates nucleolar stress by releasing sequestered P54nrb and PSF to facilitate c-Myc translation PLoS ONE 2017 12 e0173494 10.1371/journal.pone.0173494 28288210 PMC5348036 · DOI
  140. [141]Olson C.M. Donovan M.R. Spellberg M.J. Marr M.T. 2nd The insulin receptor cellular IRES confers resistance to eIF4A inhibition Elife 2013 2 e00542 10.7554/eLife.00542 23878722 PMC3713452 · DOI
  141. [144]Cho S. Kim J.H. Back S.H. Jang S.K. Polypyrimidine tract-binding protein enhances the internal ribosomal entry site-dependent translation of p27Kip1 mRNA and modulates transition from G1 to S phase Mol. Cell Biol. 2005 25 1283 1297 10.1128/MCB.25.4.1283-1297.2005 15684381 PMC548013 · DOI
  142. [145]Cobbold L.C. Wilson L.A. Sawicka K. King H.A. Kondrashov A.V. Spriggs K.A. Bushell M. Willis A.E. Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1 Oncogene 2010 29 2884 2891 10.1038/onc.2010.31 20190818 · DOI
  143. [146]Cornelis S. Tinton S.A. Schepens B. Bruynooghe Y. Beyaert R. UNR translation can be driven by an IRES element that is negatively regulated by polypyrimidine tract binding protein Nucleic Acids Res. 2005 33 3095 3108 10.1093/nar/gki611 15928332 PMC1142345 · DOI
  144. [147]Dhar D. Venkataramana M. Ponnuswamy A. Das S. Role of polypyrimidine tract binding protein in mediating internal initiation of translation of interferon regulatory factor 2 RNA PLoS ONE 2009 4 e7049 10.1371/journal.pone.0007049 19756143 PMC2737629 · DOI
  145. [148]Grover R. Ray P.S. Das S. Polypyrimidine tract binding protein regulates IRES-mediated translation of p53 isoforms Cell Cycle 2008 7 2189 2198 10.4161/cc.7.14.6271 18635961 · DOI
  146. [149]Ismail R. Ul Hussain M. The up regulation of phosphofructokinase1 (PFK1) protein during chemically induced hypoxia is mediated by the hypoxia-responsive internal ribosome entry site (IRES) element, present in its 5′untranslated region Biochimie 2017 139 38 45 10.1016/j.biochi.2017.05.012 28545955 · DOI
  147. [150]Kim Y.K. Hahm B. Jang S.K. Polypyrimidine tract-binding protein inhibits translation of bip mRNA J. Mol. Biol. 2000 304 119 133 10.1006/jmbi.2000.4179 11080450 · DOI
  148. [151]Mitchell S.A. Spriggs K.A. Coldwell M.J. Jackson R.J. Willis A.E. The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr Mol. Cell 2003 11 757 771 10.1016/S1097-2765(03)00093-5 12667457 · DOI
  149. [152]Romanelli M.G. Diani E. Lievens P.M.J. New Insights into Functional Roles of the Polypyrimidine Tract-Binding Protein Int. J. Mol. Sci. 2013 14 22906 22932 10.3390/ijms141122906 24264039 PMC3856098 · DOI
  150. [153]Schepens B. Tinton S.A. Bruynooghe Y. Beyaert R. Cornelis S. The polypyrimidine tract-binding protein stimulates HIF-1alpha IRES-mediated translation during hypoxia Nucleic Acids Res. 2005 33 6884 6894 10.1093/nar/gki1000 16396835 PMC1310900 · DOI
  151. [154]Yang B. Hu P. Lin X. Han W. Zhu L. Tan X. Ye F. Wang G. Wu F. Yin B. PTBP1 induces ADAR1 p110 isoform expression through IRES-like dependent translation control and influences cell proliferation in gliomas Cell Mol. Life Sci. 2015 72 4383 4397 10.1007/s00018-015-1938-7 26047657 PMC11114032 · DOI
  152. [155]Halaby M.J. Harris B.R. Miskimins W.K. Cleary M.P. Yang D.Q. Deregulation of Internal Ribosome Entry Site-Mediated p53 Translation in Cancer Cells with Defective p53 Response to DNA Damage Mol. Cell Biol. 2015 35 4006 4017 10.1128/MCB.00365-15 26391949 PMC4628062 · DOI
  153. [156]Khan D. Chattopadhyay S. Das S. Influence of metabolic stress on translation of p53 isoforms Mol. Cell Oncol. 2016 3 e1039689 10.1080/23723556.2015.1039689 27308557 PMC4845197 · DOI
  154. [157]Bisio A. Latorre E. Andreotti V. Bressac-de Paillerets B. Harland M. Scarra G.B. Ghiorzo P. Spitale R.C. Provenzani A. Inga A. The 5′-untranslated region of p16INK4a melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding Oncotarget 2015 6 39980 39994 10.18632/oncotarget.5387 26498684 PMC4741874 · DOI
  155. [158]Marr M.T. 2nd D’Alessio J.A. Puig O. Tjian R. IRES-mediated functional coupling of transcription and translation amplifies insulin receptor feedback Genes Dev. 2007 21 175 183 10.1101/gad.1506407 17234883 PMC1770900 · DOI
  156. [159]Li M. Pehar M. Liu Y. Bhattacharyya A. Zhang S.C. O’Riordan K.J. Burger C. D’Adamio L. Puglielli L. The amyloid precursor protein (APP) intracellular domain regulates translation of p44, a short isoform of p53, through an IRES-dependent mechanism Neurobiol. Aging 2015 36 2725 2736 10.1016/j.neurobiolaging.2015.06.021 26174856 PMC4562799 · DOI
  157. [160]Miura P. Coriati A. Belanger G. De Repentigny Y. Lee J. Kothary R. Holcik M. Jasmin B.J. The utrophin A 5′-UTR drives cap-independent translation exclusively in skeletal muscles of transgenic mice and interacts with eEF1A2 Hum. Mol. Genet. 2010 19 1211 1220 10.1093/hmg/ddp591 20053670 · DOI
  158. [161]Spriggs K.A. Cobbold L.C. Jopling C.L. Cooper R.E. Wilson L.A. Stoneley M. Coldwell M.J. Poncet D. Shen Y.C. Morley S.J. Canonical initiation factor requirements of the Myc family of internal ribosome entry segments Mol. Cell Biol. 2009 29 1565 1574 10.1128/MCB.01283-08 19124605 PMC2648239 · DOI
  159. [162]Thakor N. Smith M.D. Roberts L. Faye M.D. Patel H. Wieden H.J. Cate J.H.D. Holcik M. Cellular mRNA recruits the ribosome via eIF3-PABP bridge to initiate internal translation RNA Biol. 2017 14 553 567 10.1080/15476286.2015.1137419 26828225 PMC5449081 · DOI
  160. [163]Morrison J.K. Friday A.J. Henderson M.A. Hao E. Keiper B.D. Induction of cap-independent BiP (hsp-3) and Bcl-2 (ced-9) translation in response to eIF4G (IFG-1) depletion in C. elegans Translation 2014 2 e28935 10.4161/trla.28935 26779406 PMC4705828 · DOI
  161. [164]Horos R. Ijspeert H. Pospisilova D. Sendtner R. Andrieu-Soler C. Taskesen E. Nieradka A. Cmejla R. Sendtner M. Touw I.P. Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts Blood 2012 119 262 272 10.1182/blood-2011-06-358200 22058113 · DOI
  162. [165]Hertz M.I. Landry D.M. Willis A.E. Luo G.X. Thompson S.R. Ribosomal Protein S25 Dependency Reveals a Common Mechanism for Diverse Internal Ribosome Entry Sites and Ribosome Shunting Mol. Cell Biol. 2013 33 1016 1026 10.1128/MCB.00879-12 23275440 PMC3623076 · DOI
  163. [166]Shi Z. Fujii K. Kovary K.M. Genuth N.R. Rost H.L. Teruel M.N. Barna M. Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide Mol. Cell 2017 67 71 83 e77 10.1016/j.molcel.2017.05.021 28625553 PMC5548184 · DOI
  164. [167]Zhang C. Zhang M. Wu Q. Peng J. Ruan Y. Gu J. Hepsin inhibits CDK11p58 IRES activity by suppressing unr expression and eIF-2alpha phosphorylation in prostate cancer Cell Signal 2015 27 789 797 10.1016/j.cellsig.2014.12.020 25576733 · DOI
  165. [168]Lin W. Wadlington N.L. Chen L. Zhuang X. Brorson J.R. Kang U.J. Loss of PINK1 attenuates HIF-1alpha induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia J. Neurosci. 2014 34 3079 3089 10.1523/JNEUROSCI.2286-13.2014 24553947 PMC3931509 · DOI
  166. [169]Vaklavas C. Zinn K.R. Samuel S.L. Meng Z. Grizzle W.E. Choi H. Blume S.W. Translational control of the undifferentiated phenotype in ERpositive breast tumor cells: Cytoplasmic localization of ERalpha and impact of IRES inhibition Oncol. Rep. 2018 39 2482 2498 29620220 PMC5983923
  167. [170]Kampen K.R. Sulima S.O. Verbelen B. Girardi T. Vereecke S. Rinaldi G. Verbeeck J. Op de Beeck J. Uyttebroeck A. Meijerink J.P.P. The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL Leukemia 2018 10.1038/s41375-018-0176-z PMC6169730 29930300 · DOI
  168. [171]Kolupaeva V.G. Hellen C.U. Shatsky I.N. Structural analysis of the interaction of the pyrimidine tract-binding protein with the internal ribosomal entry site of encephalomyocarditis virus and foot-and-mouth disease virus RNAs RNA 1996 2 1199 1212 8972770 PMC1369448
  169. [172]Kafasla P. Morgner N. Poyry T.A. Curry S. Robinson C.V. Jackson R.J. Polypyrimidine tract binding protein stabilizes the encephalomyocarditis virus IRES structure via binding multiple sites in a unique orientation Mol. Cell 2009 34 556 568 10.1016/j.molcel.2009.04.015 19524536 · DOI
  170. [173]Carvajal F. Vallejos M. Walters B. Contreras N. Hertz M.I. Olivares E. Caceres C.J. Pino K. Letelier A. Thompson S.R. Structural domains within the HIV-1 mRNA and the ribosomal protein S25 influence cap-independent translation initiation Febs J. 2016 283 2508 2527 10.1111/febs.13756 27191820 PMC4935617 · DOI
  171. [174]Olivares E. Landry D.M. Caceres C.J. Pino K. Rossi F. Navarrete C. Huidobro-Toro J.P. Thompson S.R. Lopez-Lastra M. The 5′ Untranslated Region of the Human T-Cell Lymphotropic Virus Type 1 mRNA Enables Cap-Independent Translation Initiation J. Virol. 2014 88 5936 5955 10.1128/JVI.00279-14 24623421 PMC4093887 · DOI
  172. [175]Ji B. Harris B.R.E. Liu Y.H. Deng Y.B. Gradilone S.A. Cleary M.P. Liu J.H. Yang D.Q. Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics Int. J. Mol. Sci. 2017 18 E93 10.3390/ijms18010093 28054974 PMC5297727 · DOI
  173. [176]Johnson A.G. Grosely R. Petrov A.N. Puglisi J.D. Dynamics of IRES-mediated translation Philos. Trans. R. Soc. Lond. B Biol. Sci. 2017 372 20160177 10.1098/rstb.2016.0177 28138065 PMC5311923 · DOI
  174. [177]Boehringer D. Thermann R. Ostareck-Lederer A. Lewis J.D. Stark H. Structure of the hepatitis C virus IRES bound to the human 80S ribosome: Remodeling of the HCV IRES Structure 2005 13 1695 1706 10.1016/j.str.2005.08.008 16271893 · DOI
  175. [178]Spahn C.M. Kieft J.S. Grassucci R.A. Penczek P.A. Zhou K. Doudna J.A. Frank J. Hepatitis C virus IRES RNA-induced changes in the conformation of the 40s ribosomal subunit Science 2001 291 1959 1962 10.1126/science.1058409 11239155 · DOI
  176. [179]Fernandez I.S. Bai X.C. Murshudov G. Scheres S.H. Ramakrishnan V. Initiation of translation by cricket paralysis virus IRES requires its translocation in the ribosome Cell 2014 157 823 831 10.1016/j.cell.2014.04.015 24792965 PMC4017093 · DOI
  177. [180]Hashem Y. des Georges A. Dhote V. Langlois R. Liao H.Y. Grassucci R.A. Pestova T.V. Hellen C.U. Frank J. Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit Nature 2013 503 539 543 10.1038/nature12658 24185006 PMC4106463 · DOI
  178. [181]Quade N. Boehringer D. Leibundgut M. van den Heuvel J. Ban N. Cryo-EM structure of Hepatitis C virus IRES bound to the human ribosome at 3.9-A resolution Nat. Commun. 2015 6 7646 10.1038/ncomms8646 26155016 PMC4510694 · DOI
  179. [182]Yamamoto H. Collier M. Loerke J. Ismer J. Schmidt A. Hilal T. Sprink T. Yamamoto K. Mielke T. Burger J. Molecular architecture of the ribosome-bound Hepatitis C Virus internal ribosomal entry site RNA Embo J. 2015 34 3042 3058 10.15252/embj.201592469 26604301 PMC4687786 · DOI
  180. [183]Damiano F. Rochira A. Tocci R. Alemanno S. Gnoni A. Siculella L. hnRNP A1 mediates the activation of the IRES-dependent SREBP-1a mRNA translation in response to endoplasmic reticulum stress Biochem. J. 2013 449 543 553 10.1042/BJ20120906 23106379 · DOI
  181. [184]Lin J.C. Hsu M. Tarn W.Y. Cell stress modulates the function of splicing regulatory protein RBM4 in translation control Proc. Natl. Acad. Sci. USA 2007 104 2235 2240 10.1073/pnas.0611015104 17284590 PMC1893002 · DOI
  182. [185]Gao G. Dhar S. Bedford M.T. PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1 Nucleic Acids Res. 2017 45 4359 4369 10.1093/nar/gkw1367 28115626 PMC5416833 · DOI
  183. [186]Dorrello N.V. Peschiaroli A. Guardavaccaro D. Colburn N.H. Sherman N.E. Pagano M. S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth Science 2006 314 467 471 10.1126/science.1130276 17053147 · DOI · Paper page
  184. [187]Suk F.M. Lin S.Y. Lin R.J. Hsine Y.H. Liao Y.J. Fang S.U. Liang Y.C. Bortezomib inhibits Burkitt’s lymphoma cell proliferation by downregulating sumoylated hnRNP K and c-Myc expression Oncotarget 2015 6 25988 26001 10.18632/oncotarget.4620 26317903 PMC4694880 · DOI
  185. [188]Lu J. Gao F.H. Role and molecular mechanism of heterogeneous nuclear ribonucleoprotein K in tumor development and progression Biomed. Rep. 2016 4 657 663 10.3892/br.2016.642 27284403 PMC4887935 · DOI
  186. [189]Pickering B.M. Mitchell S.A. Spriggs K.A. Stoneley M. Willis A.E. Bag-1 internal ribosome entry segment activity is promoted by structural changes mediated by poly(rC) binding protein 1 and recruitment of polypyrimidine tract binding protein 1 Mol. Cell Biol. 2004 24 5595 5605 10.1128/MCB.24.12.5595-5605.2004 15169918 PMC419896 · DOI
  187. [190]Braunschweig U. Gueroussov S. Plocik A.M. Graveley B.R. Blencowe B.J. Dynamic integration of splicing within gene regulatory pathways Cell 2013 152 1252 1269 10.1016/j.cell.2013.02.034 23498935 PMC3642998 · DOI · Paper page
  188. [191]Pestova T.V. Shatsky I.N. Hellen C.U. Functional dissection of eukaryotic initiation factor 4F: The 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes Mol. Cell Biol. 1996 16 6870 6878 10.1128/MCB.16.12.6870 8943342 PMC231690 · DOI
  189. [192]Pestova T.V. Hellen C.U. Shatsky I.N. Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry Mol. Cell Biol. 1996 16 6859 6869 10.1128/MCB.16.12.6859 8943341 PMC231689 · DOI
  190. [193]Sizova D.V. Kolupaeva V.G. Pestova T.V. Shatsky I.N. Hellen C.U. Specific interaction of eukaryotic translation initiation factor 3 with the 5′ nontranslated regions of hepatitis C virus and classical swine fever virus RNAs J. Virol. 1998 72 4775 4782 9573242 PMC110013
  191. [194]Pestova T.V. de Breyne S. Pisarev A.V. Abaeva I.S. Hellen C.U. eIF2-dependent and eIF2-independent modes of initiation on the CSFV IRES: A common role of domain II Embo J. 2008 27 1060 1072 10.1038/emboj.2008.49 18337746 PMC2323255 · DOI
  192. [195]Balagopal V. Parker R. Polysomes, P bodies and stress granules: States and fates of eukaryotic mRNAs Curr. Opin. Cell Biol. 2009 21 403 408 10.1016/j.ceb.2009.03.005 19394210 PMC2740377 · DOI
  193. [196]Borghese F. Michiels T. The leader protein of cardioviruses inhibits stress granule assembly J. Virol. 2011 85 9614 9622 10.1128/JVI.00480-11 21752908 PMC3165746 · DOI
  194. [197]Guil S. Long J.C. Caceres J.F. hnRNP A1 relocalization to the stress granules reflects a role in the stress response Mol. Cell Biol. 2006 26 5744 5758 10.1128/MCB.00224-06 16847328 PMC1592774 · DOI
  195. [198]Galan A. Lozano G. Pineiro D. Martinez-Salas E. G3BP1 interacts directly with the FMDV IRES and negatively regulates translation Febs J. 2017 284 3202 3217 10.1111/febs.14184 28755480 · DOI
  196. [199]Fujimura K. Katahira J. Kano F. Yoneda Y. Murata M. Selective localization of PCBP2 to cytoplasmic processing bodies Biochim. Biophys. Acta 2009 1793 878 887 10.1016/j.bbamcr.2009.02.002 19230839 · DOI
  197. [200]Fierro-Monti I. Mohammed S. Matthiesen R. Santoro R. Burns J.S. Williams D.J. Proud C.G. Kassem M. Jensen O.N. Roepstorff P. Quantitative proteomics identifies Gemin5, a scaffolding protein involved in ribonucleoprotein assembly, as a novel partner for eukaryotic initiation factor 4E J. Proteome Res. 2006 5 1367 1378 10.1021/pr0504539 16739988 · DOI
  198. [201]Pacheco A. Lopez de Quinto S. Ramajo J. Fernandez N. Martinez-Salas E. A novel role for Gemin5 in mRNA translation Nucleic Acids Res. 2009 37 582 590 10.1093/nar/gkn979 19066202 PMC2632916 · DOI
  199. [202]Majzoub K. Hafirassou M.L. Meignin C. Goto A. Marzi S. Fedorova A. Verdier Y. Vinh J. Hoffmann J.A. Martin F. RACK1 controls IRES-mediated translation of viruses Cell 2014 159 1086 1095 10.1016/j.cell.2014.10.041 25416947 PMC4243054 · DOI
  200. [203]Yu Y. Ji H. Doudna J.A. Leary J.A. Mass spectrometric analysis of the human 40S ribosomal subunit: Native and HCV IRES-bound complexes Protein Sci. 2005 14 1438 1446 10.1110/ps.041293005 15883184 PMC2253395 · DOI

200 of 209 shown

Cited by

Sorted by citations

Authors
Godet, A.-C., David, F., Hantelys, F., Tatin, F., Lacazette, E., Garmy-Susini, B., & Prats, A.-C.
Affiliations
  • Inserm (FR)
  • UMR 1048-I2MC, Inserm, Université de Toulouse, UT3, 31432 Toulouse cedex 4, France
Corresponding author
Prats, Anne-Catherine
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2019-02-20
Volume
20
Issue
4
Pages
924
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms20040924
PMC
PMC6412753
OpenAlex
W2909535269
Cited by
202
References
3
Citations by year
2026: 20 · 2025: 27 · 2024: 32 · 2023: 31 · 2022: 35 · 2021: 26 · 2020: 19 · 2019: 11 · 2018: 1
FWCI
2.03
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Preprints.org (acceptedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords
IRES trans-acting factors, internal ribosome entry site, cellular stress response, cap-independent translation, translation initiation, post-transcriptional regulation, DNA damage response, amino acid starvation, hypoxia, endoplasmic reticulum stress, cell differentiation, synaptogenesis
MeSH terms
Internal Ribosome Entry Sites, Animals, Biological Transport, Carrier Proteins, Humans, Protein Binding, Ribosomes, RNA, Messenger, RNA, Viral, Stress, Physiological, Protein Biosynthesis, Trans-Activators, Response Elements

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review