Dynamic integration of splicing within gene regulatory pathways
Open accessAbstract
Precursor mRNA splicing is one of the most highly regulated processes in metazoan species. In addition to generating vast repertoires of RNAs and proteins, splicing has a profound impact on other gene regulatory layers, including mRNA transcription, turnover, transport, and translation. Conversely, factors regulating chromatin and transcription complexes impact the splicing process. This extensive crosstalk between gene regulatory layers takes advantage of dynamic spatial, physical, and temporal organizational properties of the cell nucleus, and further emphasizes the importance of developing a multidimensional understanding of splicing control.
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Alternative splicing expands the functional and regulatory capacity of metazoan genomes.
“Alternative splicing (AS) – the process by which different pairs of splice sites are selected in precursor mRNA to generate multiple mRNA and protein products – is responsible for greatly expanding the functional and regulatory capacity of metazoan genomes (Braunschweig et al., 2013; Chen and Manley, 2009; Kalsotra and Cooper, 2011).”
From A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains (2014) · cites this paper as Braunschweig et al., 2013
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ParaspecklesPreprint
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Argonaute proteins couple chromatin silencing to alternative splicing
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Mechanisms and Regulation of Alternative Pre-mRNA Splicing
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Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development
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Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration
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- Authors
- Braunschweig, U., Gueroussov, S., Plocik, A. M., Graveley, B. R., & Blencowe, B. J.
- Affiliations
- University of Toronto (CA)
- UConn Health (US)
- Corresponding author
- Graveley, Brenton R.
- Blencowe, Benjamin J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 152
- Issue
- 6
- Pages
- 1252-1269
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3642998
- OpenAlex
- W2051604556
- Cited by
- 406
- References
- 182
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 20 · 2023: 18 · 2022: 27 · 2021: 24 · 2020: 32 · 2019: 34 · 2018: 29 · 2017: 30 · 2016: 36 · 2015: 57 · 2014: 53 · 2013: 25
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Canadian Institutes of Health Research
- National Human Genome Research Institute (U54HG006994, U54HG007005)
- National Institute of General Medical Sciences (R01GM095296, F32GM105264, R01GM067842)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- pre-mRNA splicing, gene expression regulation, transcription, mRNA turnover, mRNA transport, translation (biology), chromatin regulation, nuclear organization, splicing regulation, RNA processing
- MeSH terms
- Animals, Cell Nucleus, Chromatin, Humans, RNA Splicing, Transcription, Genetic, Alternative Splicing, Regulatory Sequences, Ribonucleic Acid, Gene Regulatory Networks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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