Cited by 406RNA Research and SplicingRNA regulation and diseaseRNA and protein synthesis mechanisms

Dynamic integration of splicing within gene regulatory pathways

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Braunschweig, Ulrich, Gueroussov, Serge, Plocik, Alex M., Graveley, Brenton R., Blencowe, Benjamin J.·2013·Cell

Abstract

Precursor mRNA splicing is one of the most highly regulated processes in metazoan species. In addition to generating vast repertoires of RNAs and proteins, splicing has a profound impact on other gene regulatory layers, including mRNA transcription, turnover, transport, and translation. Conversely, factors regulating chromatin and transcription complexes impact the splicing process. This extensive crosstalk between gene regulatory layers takes advantage of dynamic spatial, physical, and temporal organizational properties of the cell nucleus, and further emphasizes the importance of developing a multidimensional understanding of splicing control.

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Crossref · 10.1016/j.cell.2013.02.034

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  • Alternative splicing expands the functional and regulatory capacity of metazoan genomes.

    “Alternative splicing (AS) – the process by which different pairs of splice sites are selected in precursor mRNA to generate multiple mRNA and protein products – is responsible for greatly expanding the functional and regulatory capacity of metazoan genomes (Braunschweig et al., 2013; Chen and Manley, 2009; Kalsotra and Cooper, 2011).”

    From A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains (2014) · cites this paper as Braunschweig et al., 2013

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Authors
Braunschweig, U., Gueroussov, S., Plocik, A. M., Graveley, B. R., & Blencowe, B. J.
Affiliations
  • University of Toronto (CA)
  • UConn Health (US)
Corresponding author
  • Graveley, Brenton R.
  • Blencowe, Benjamin J.
Venue
Cell
Publisher
Elsevier BV
Published
2013-03
Volume
152
Issue
6
Pages
1252-1269
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2051604556
Cited by
406
References
182
Citations by year
2026: 7 · 2025: 13 · 2024: 20 · 2023: 18 · 2022: 27 · 2021: 24 · 2020: 32 · 2019: 34 · 2018: 29 · 2017: 30 · 2016: 36 · 2015: 57 · 2014: 53 · 2013: 25
FWCI
5.36
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Canadian Institutes of Health Research
  • National Human Genome Research Institute (U54HG006994, U54HG007005)
  • National Institute of General Medical Sciences (R01GM095296, F32GM105264, R01GM067842)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords
pre-mRNA splicing, gene expression regulation, transcription, mRNA turnover, mRNA transport, translation (biology), chromatin regulation, nuclear organization, splicing regulation, RNA processing
MeSH terms
Animals, Cell Nucleus, Chromatin, Humans, RNA Splicing, Transcription, Genetic, Alternative Splicing, Regulatory Sequences, Ribonucleic Acid, Gene Regulatory Networks

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