The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A Review of Curcumin and Its Derivatives as Anticancer Agents
Open accessAbstract
Cancer is the second leading cause of death in the world and one of the major public health problems. Despite the great advances in cancer therapy, the incidence and mortality rates of cancer remain high. Therefore, the quest for more efficient and less toxic cancer treatment strategies is still at the forefront of current research. Curcumin, the active ingredient of the Curcuma longa plant, has received great attention over the past two decades as an antioxidant, anti-inflammatory, and anticancer agent. In this review, a summary of the medicinal chemistry and pharmacology of curcumin and its derivatives in regard to anticancer activity, their main mechanisms of action, and cellular targets has been provided based on the literature data from the experimental and clinical evaluation of curcumin in cancer cell lines, animal models, and human subjects. In addition, the recent advances in the drug delivery systems for curcumin delivery to cancer cells have been highlighted.
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Cites
Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233
Apoptosis in cancer: from pathogenesis to treatment
Wong, R. S. (2011) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-30-87 · Cited by 2,836
Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cancer
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Cited by
The biology of ergothioneine, an antioxidant nutraceutical
Borodina, I., Kenny, L. C., McCarthy, C. M., Paramasivan, K., Pretorius, E., Roberts, T. J., van der Hoek, S. A., & Kell, D. B. (2020) · Nutrition Research Reviews · doi:10.1017/s0954422419000301 · Cited by 296
“In a similar vein, and although outwith our scope here, we note the potential of other antioxidant natural products such as curcumin (281 – 286) .”
BackgroundThe Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145
Single- versus Dual-Targeted Nanoparticles with Folic Acid and Biotin for Anticancer Drug Delivery
Jurczyk, M., Jelonek, K., Musiał-Kulik, M., Beberok, A., Wrześniok, D., & Kasperczyk, J. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13030326 · Cited by 133
Hasan, M., Elkhoury, K., Kahn, C. J. F., Arab-Tehrany, E., & Linder, M. (2019) · Molecules · doi:10.3390/molecules24102023 · Cited by 133
Ali, S. A., Helmy, H. I., & Gaber, M. H. (2026) · Scientific Reports · doi:10.1038/s41598-026-36607-x · Cited by 4
Metadata
- Authors
- Tomeh, M. A., Hadianamrei, R., & Zhao, X.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2019-02-27
- Volume
- 20
- Issue
- 5
- Pages
- 1033
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2916045508
- Cited by
- 949
- References
- 3
- FWCI
- 31.13
- Type
- journal article
- Language
- en
- Open access
- gold
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