The DOI matches its Crossref record; 150 of the 150 references it cites were found in a registry or an index.
Mesenchymal Stem Cells for Spinal Cord Injury: Current Options, Limitations, and Future of Cell Therapy
Open accessAbstract
Spinal cord injury (SCI) constitutes an inestimable public health issue. The most crucial phase in the pathophysiological process of SCI concerns the well-known secondary injury, which is the uncontrolled and destructive cascade occurring later with aberrant molecular signaling, inflammation, vascular changes, and secondary cellular dysfunctions. The use of mesenchymal stem cells (MSCs) represents one of the most important and promising tested strategies. Their appeal, among the other sources and types of stem cells, increased because of their ease of isolation/preservation and their properties. Nevertheless, encouraging promise from preclinical studies was followed by weak and conflicting results in clinical trials. In this review, the therapeutic role of MSCs is discussed, together with their properties, application, limitations, and future perspectives.
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Cites
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Cited by
Zhuang, W.-Z., Lin, Y.-H., Su, L.-J., Wu, M.-S., Jeng, H.-Y., Chang, H.-C., Huang, Y.-H., & Ling, T.-Y. (2021) · Journal of Biomedical Science · doi:10.1186/s12929-021-00725-7 · Cited by 258
Mesenchymal stem cell secretome for regenerative medicine: Where do we stand?
Trigo, C. M., Rodrigues, J. S., Camões, S. P., Solá, S., & Miranda, J. P. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2024.05.004 · Cited by 252
“Moreover, MSC-derived factors, such as and BDNF, FGF-2 GDNF, IGF, NGF and neurotrophin-3, revealed to be important growth factors for neuronal/glial cell population [120,214,222,224–226] (Fig.”
Xia, Y., Zhu, J., Yang, R., Wang, H., Li, Y., & Fu, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1141601 · Cited by 87
Influences of Xeno-Free Media on Mesenchymal Stem Cell Expansion for Clinical Application
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Epigenetic modifications of inflammation in spinal cord injury
Lu, Z.-J., Pan, Q.-L., & Lin, F.-X. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117306 · Cited by 14
Metadata
- Authors
- Cofano, F., Boido, M., Monticelli, M., Zenga, F., Ducati, A., Vercelli, A., & Garbossa, D.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2019-05-31
- Volume
- 20
- Issue
- 11
- Pages
- 2698
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2946906538
- Cited by
- 398
- References
- 150
- FWCI
- 25.98
- Type
- journal article
- Language
- en
- Open access
- gold
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- Cofano, F., Boido, M., Monticelli, M., Zenga, F., Ducati, A., Vercelli, A., & Garbossa, D. (2019). Mesenchymal Stem Cells for Spinal Cord Injury: Current Options, Limitations, and Future of Cell Therapy. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms20112698
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