TGF-β Signaling in Cellular Senescence and Aging-Related Pathology

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Items 201–300 of 394

1. NFATc1 Regulation of Dexamethasone-Induced TGFB2 Expression Is Cell Cycle Dependent in Trabecular Meshwork Cells
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2. The Metformin Immunoregulatory Actions in Tumor Suppression and Normal Tissues Protection
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3. Latent-Transforming Growth Factor β-Binding Protein 1/Transforming Growth Factor β1 Complex Drives Antitumoral Effects upon ERK5 Targeting in Melanoma
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4. MicroRNA mediated suppression of airway lactoperoxidase by TGF-β1 and cigarette smoke promotes airway inflammation
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5. Urolithin A Ameliorates the TGF Beta-Dependent Impairment of Podocytes Exposed to High Glucose
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6. Memantine/Rosuvastatin Therapy Abrogates Cognitive and Hippocampal Injury in an Experimental Model of Alzheimer's Disease in Rats: Role of TGF-β1/Smad Signaling Pathway and Amyloid-β Clearance
   Esraa F. Zidan, Nesrine S. El-Mezayen, Safaa H. El‐Rewini, Elham A. Afify, Mennatallah A. Ali · 2024 · Journal of Neuroimmune Pharmacology
7. SARS-CoV-2 leverages airway epithelial protective mechanism for viral infection
   Allison Marie Greaney, Micha Sam Brickman Raredon, Maria P. Kochugaeva, Laura E. Niklason, Andre Levchenko · 2023 · iScience
8. PPP3R1 Promotes MSCs Senescence by Inducing Plasma Membrane Depolarization and Increasing Ca2+ Influx
   Molin Li, Weimin Gong, Jie Chen, Yining Zhang, Yufei Ma, Xiaolin Tu · 2023 · International Journal of Molecular Sciences
9. Matrisome Transcriptome Dynamics during Tissue Aging
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10. Restoration of angiogenic capacity in senescent endothelial cells by a pharmacological reprogramming approach
    Katrin Kalies, Kai Knöpp, Susanne Koch, Claudia Pilowski, Leonie Wurmbrand, Daniel Sedding · 2025 · PLoS ONE
11. Red blood cell Rpl13a small noncoding nucleolar RNAs guides 2ʹ-O-methylation on peroxidasin messenger RNA promoting venous thrombosis in aging
    Waseem Chauhan, Sudharshan SJ, Shirin Ferdowsi, Akib Sohel, Rahima Zennadi · 2025 · Journal of Thrombosis and Haemostasis
12. Pyrroloquinoline Quinone Reprograms the Single‐Cell Landscape of Immune Aging in Hematopoietic Immune System
    Xiuxing Liu, Chun Zhang, Jianjie Lv, Yidan Liu, Chenyang Gu, Yuehan Gao, Wen Ding, Hui Chen, Nanwei Xu, Hongbin Yin et al. · 2025 · Aging Cell
13. Dysfunctional pericellular hyaluronan deposition contributes to attenuated CD44/EGFR co-localization and impaired myofibroblast differentiation in chronic wound fibroblasts
    Nathaniel Glyn Morris, Emma Louise Woods, Jordanna Dally, Adam C. Midgley, Robert Steadman, Ryan Moseley · 2025 · Experimental Cell Research
14. Cyclin-Dependent Kinase 1 Inhibition Potentiates the Proliferation of Tonsil-Derived Mesenchymal Stem Cells by Delaying Cellular Senescence
    Da Hyeon Choi, Kyeong Eun Lee, Yoon Shin Park · 2022 · Stem Cells International
15. Radiation and Diabetic Retinopathy: A Dark Synergy
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16. mTORC2: A neglected player in aging regulation
    Weitong Xu, Honghan Chen, Hengyi Xiao · 2024 · Journal of Cellular Physiology
17. Effects of Replicative Senescence of Human Chorionic MSCs on their EV-miRNA Profile
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18. Cardiomyocyte engineering: The meeting point of transcription factors, signaling networks, metabolism and function
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19. Emerging Roles of Signal Transduction Pathways in Neurodegenerative Diseases. Hunting New Possible Therapeutic Molecular Targets
    Vincenza Rita Lo Vasco · 2023 · OBM Geriatrics
20. Morphofunctional Changes in Brain and Peripheral Blood in Adult and Aged Wistar Rats with AlCl3-Induced Neurodegeneration
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21. miRNAs in cerebrospinal fluid associated with Alzheimer's disease: A systematic review and pathway analysis using a data mining and machine learning approach
    Jéssica Diniz Pereira, Lívia Cristina Ribeiro Teixeira, Izabela Mamede, Michelle Teodoro Alves, Paulo Caramelli, Marcelo R. Luizon, Adriano Veloso, Karina Braga Gomes · 2024 · Journal of Neurochemistry
22. p38 Mitogen-Activated Protein Kinase Inhibition of Mesenchymal Transdifferentiated Tumor Cells in Head and Neck Squamous Cell Carcinoma
    Julia Ingruber, Maria do Carmo Greier, Andrea Ladányi, József Dudás · 2023 · Biomedicines
23. Survey of transcriptome analyses of hippocampal neurogenesis with focus on adult dentate gyrus stem cells
    Laura Micheli, Maurizia Caruso, Giorgio D’Andrea, Daniel Volpe, Manuela Ceccarelli, Felice Tirone · 2025 · Frontiers in Cell and Developmental Biology
24. Cellular senescence—from solid organs to vascularized composite allotransplants
    Leonard Knoedler, Andreas Schroeter, Jasper Iske, Jillian Dean, Sam Boroumand, Thomas Schaschinger, Tobias Niederegger, Samuel A. Knoedler, Adriana Christine Panayi, Max Heiland et al. · 2025 · GeroScience
25. Comprehensive analysis of the TGF-β signaling pathway: molecular mechanisms, disease drivers, and frontiers in clinical translation
    Yiting Zhang, Haixia Tang, Ze Zhou, Jiabao Liao, Xiaoyu Zhou, Xin Chu, Mengqiu Shao, Caiyan Zhang, Lijuan Jiang · 2026 · Frontiers in Immunology
26. Simvastatin attenuates aluminium chloride-induced neurobehavioral impairments through activation of TGF-β1/ SMAD2 and GSK3β/β-catenin signalling pathways
    Mangreed M. Atef, Yasser M. Mostafa, Amal A.M. Ahmed, Norhan Mohamed El-Sayed · 2023 · Environmental Toxicology and Pharmacology
27. Anti-photoaging Properties of Asiaticoside in Ultraviolet A-irradiated Human Dermal Fibroblasts by Activating the PI3K-AKT Pathway and Inhibiting the NF-κB Pathway
    Jia Huang, Yiyi Gong, Ke Liu, Jun Chen, Xiaobo Zhou · 2023 · Exploratory Research and Hypothesis in Medicine
28. Potential Player of Platelet in the Pathogenesis of Cardiotoxicity: Molecular Insight and Future Perspective
    Arash Amin, Ahmad Mohajerian, Sara Rashki Ghalenoo, Mehdi Mohamadinia, Shana Ahadi, Tooba Sohbatzadeh, Mahboubeh Pazoki, Afshin Hasanvand, Ferdos Faghihkhorasani, Zeinab Habibi · 2024 · Cardiovascular Toxicology
29. Plant‐Derived Treatments for Different Types of Muscle Atrophy
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30. Rpl13a snoRNAs-regulated NADPH oxidase 1-dependent ROS generation: A novel RBC pathway mediating complement C3a deposition and triggering thrombosis in aging and venous blood clotting disorders
    Waseem Chauhan, Shirin Ferdowsi, Sudharshan SJ, Rahima Zennadi · 2025 · Free Radical Biology and Medicine
31. Ligand-specific regulation of a binary enhancer code dictating cellular senescence
    Thomas Suter, Meyer J. Friedman, Cagdas Tazearslan, Daria Merkurjev, Kenny Ohgi, Dario Meluzzi, Michael G. Rosenfeld, Yousin Suh · 2025 · Proceedings of the National Academy of Sciences
32. Testis Molecular Pathways in CAIS Unveil Testosterone/Estradiol on Germ Cell Tumor Risk in Non-Obstructive Azoospermia
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33. Serum-Induced Proliferation of Human Cardiac Stem Cells Is Modulated via TGFβRI/II and SMAD2/3
    Kazuko E. Schmidt, Anna L. Höving, Sina Kiani Zahrani, Katerina Trevlopoulou, Barbara Kaltschmidt, Cornelius Knabbe, Christian Kaltschmidt · 2024 · International Journal of Molecular Sciences
34. Proteomic pipeline to identify age-related compositional and structural changes of the human dentin extracellular matrix
    Mariana Cavalcante dos Reis, Fred Lee, Ana K. Bedran‐Russo, Alexandra Naba · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
35. Age-related Differences in T-cell Subsets and Markers of Subclinical Inflammation in Aging Are Independently Associated With Type 2 Diabetes in the Health and Retirement Study
    Sithara Vivek, Eileen M. Crimmins, Anna E. Prizment, Helen C.S. Meier, Ramya Ramasubramanian, Helene Barcelo, Jessica D. Faul, Bharat Thyagarajan · 2023 · Canadian Journal of Diabetes
36. Pan-cancer characterization of cellular senescence reveals its inter-tumor heterogeneity associated with the tumor microenvironment and prognosis
    Kang Li, Chen Guo, Rufeng Li, Yufei Yao, Min Qiang, Yuanyuan Chen, Kangsheng Tu, Yungang Xu · 2024 · Computers in Biology and Medicine
37. Involvement of TGF-β, mTOR, and inflammatory mediators in aging alterations during myxomatous mitral valve disease in a canine model
    Arkadiusz Grzeczka, Szymon Graczyk, Paweł Kordowitzki · 2025 · GeroScience
38. Aging-related changes of miR-23b-3p expression in extracellular vesicles from mesenchymal stromal cells affect TGFBR3 signaling
    Maki Itokazu, Toshiyuki Takehara, Kensuke Toriumi, Natsumi Iwawaki, Tatsufumi Mori, Yuta Ondoera, Yuji Higashimoto, Koji Goto, Hidekazu Yamada, Takeshi Teramura · 2025 · Scientific Reports
39. Pathophysiological mechanisms linking osteoarthritis and neurodegenerative disease risk
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40. Circulating microRNAs miR-21-5p, miR-23a-3p and miR-26a-5p reflect clinical and molecular features of aging
    Rossella La Grotta, Paolina Crocco, Serena Dato, Giuseppe Passarino, Giuseppina Rose · 2025 · Scientific Reports
41. Repurposing niclosamide to mitigate inflammaging: a review of multi-target mechanisms in cellular senescence and age-related decline
    Ayman Ali Mohammed Alameen, Hayder M. Al‐kuraishy, Ahmed M Abdelaziz, Gaber El‐Saber Batiha · 2026 · Inflammation Research
42. Early Development of Cardiac Fibrosis in Young Old‐Father Offspring
    Anis Ismail, Youakim Saliba, Nassim Farès · 2022 · Oxidative Medicine and Cellular Longevity
43. Functional Characterization of Transforming Growth Factor-β Signaling in Dasatinib Resistance and Pre-BCR+ Acute Lymphoblastic Leukemia
    Gila Mostufi-Zadeh-Haghighi, Pia Veratti, Kyra Zodel, Gabriele Greve, Miguel Waterhouse, Robert Zeiser, Michael L. Cleary, Michael Lübbert, Jesús Duque‐Afonso · 2023 · Cancers
44. Effect of cellular senescence on the response of human peritoneal mesothelial cells to TGF-β
    Edyta Kawka, Rebecca Herzog, Marcin Ruciński, Agnieszka Malińska, Markus Unterwurzacher, Juan Manuel Sacnun, Anja Wagner, Katarzyna Kowalska, Karol Jopek, Agata Kucz-Chrostowska et al. · 2024 · Scientific Reports
45. TGFβ ‐mediated inhibition of hypodermal adipocyte progenitor differentiation promotes wound‐induced skin fibrosis
    Meimei Yin, Lixiang Sun, Shuai Wu, Jinhang Ma, Wenlu Zhang, Xiaoxuan Ji, Zhichong Tang, Xiaowei Zhang, Yichun Yang, Xinyuan Zhang et al. · 2024 · Cell Proliferation
46. FunlncModel: integrating multi-omic features from upstream and downstream regulatory networks into a machine learning framework to identify functional lncRNAs
    Yanyu Li, Fengcui Qian, Guorui Zhang, Xuecang Li, Li‐Wei Zhou, Zhengmin Yu, Wei Liu, Qiuyu Wang, Chunquan Li · 2024 · Briefings in Bioinformatics
47. Radiotherapy and inflammaging: the influence of prostate cancer radiotherapy on systemic inflammation
    Katarzyna Paal, Bettina Stranz, Eva-Maria Thurner, Tobias Niedrist, Wilfried Renner, Tanja Langsenlehner · 2024 · World Journal of Urology
48. RNA-seq analysis of phagocytic cells from murine epididymal white adipose tissue shows immunosenescence and age-related phosphorus metabolism
    Martin C. Nwadiugwu · 2022 · Human Cell
49. Liver sinusoidal cells in aging
    Jordi Gracia‐Sancho · 2024 · Elsevier eBooks
50. Plasma Proteomics of Genetic Brain Arteriosclerosis and Dementia Syndrome Identifies Signatures of Fibrosis, Angiogenesis, and Metabolic Alterations
    Jonah N. Keller, Hannah Radabaugh, Nikolaos Karvelas, Stephen Fitzsimons, Scott Treiman, Maria F. Palafox, Lisa McDonnell, Yakeel T. Quiroz, Francisco Javier Lopera, Debarag Banerjee et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
51. Changes in Gene Expression Patterns in Young and Senescent Fibroblasts in Glycated Three-Dimensional Collagen Matrices
    Zulfiya G. Guvatova, Evelina R. Kudasheva, Yuri M. Efremov, Peter S. Timashev, Maria Fedorova, Elena A. Pudova, Anastasiya V. Snezhkina, Anna V. Kudryavtseva, Anastasiya A. Kobelyatskaya, Alexey Moskalev · 2025 · International Journal of Molecular Sciences
52. In Old Mice, Exercise Induces Inflammation and Fibrosis Unless Alk5‐Inhibitor and Oxytocin Are Used
    Joana Marie C. Cruz, Hayden Yeung, Rana Alzalzalee, Qile Yang, Hannaneh Kabir, Samantha Annaliese McDonough, Xiaoyue Mei, Michael J. Conboy, Irina M. Conboy · 2025 · Journal of Cellular Physiology
53. Ferroptosis and cellular senescence -Related Genes in Cervical Cancer: Mechanistic Insights from Multi-Omics and Clinical Sample Analysis
    Yongjin Luo, Lihua Tang, Zhonghong Zeng, DinhHuyen Trang, Dan Mo, Yihua Yang · 2025 · Translational Oncology
54. Lysyl oxidase-like 2 inhibition alleviates subretinal fibrosis in neovascular age-related macular degeneration model
    Xiaowei Yang, Anping Ma, Yuan Liu, Zhi-Cheng He, Jianfeng Yu, Shu Su, Jia Chen, Aimin Sang · 2025 · Experimental Eye Research
55. Aging-related epigenetic instability in lncRNAs and miRNAs mediates the development of hypertension
    M Chandhru, Karthikeyan Ramamurthy, Gokul Sudhakaran, Ki Choon Choi, Mariadhas Valan Arasu, Jesu Arockiaraj · 2025 · European Journal of Pharmacology
56. Angiopoietin-like 8 governs osteoblast-adipocyte lineage commitment during skeletal aging
    Yaming Guo, Zeqing Zhang, Junyu He, Peiqiong Luo, Zhihan Wang, Yurong Zhu, Xiaoyu Meng, Limeng Pan, Ranran Kan, Yuxi Xiang et al. · 2025 · JCI Insight
57. From basic biology to engineered therapies: the keratinocyte stem cell playbook
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58. Amelioration of premature aging in Werner syndrome stem cells by targeting SHIP/AKT pathway
    Hei-Yin Tam, Jiaxing Liu, Tsz-Ching Yiu, Adrian On-Wah Leung, Chang Li, Shen Gu, Owen M. Rennert, Boxian Huang, Hoi‐Hung Cheung · 2025 · Cell & Bioscience
59. Oxy210 Inhibits Hepatic Expression of Senescence-Associated, Pro-Fibrotic, and Pro-Inflammatory Genes in Mice During Development of MASH and in Hepatocytes In Vitro
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60. Dual SMAD inhibition enhances the longevity of human epididymis epithelial cells
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61. Assessment of the association of myofibroblasts and structural components of the extracellular matrix with histopathological parameters of actinic cheilitis and lower lip squamous cell carcinoma
    Farah Essguí Orellana Martinez, Thâmara Manoela Marinho Bezerra, Ana Paula Negreiros Nunes Alves, Isabelle Joyce Lima Silva Fernandes, Fabrício Bitú Sousa, Paulo Goberlânio de Barros Silva, Mário Rogério Lima Mota · 2024 · Journal of Oral Pathology and Medicine
62. Circulating microRNA profile of long‐lived Okinawans identifies novel potential targets for optimizing lifespan and health span
    Sarah A. Noureddine, Augusto Schneider, Sydney Strader, Xiang Zhu, Joseph M. Dhahbi, Richard Allsopp, D. Craig Willcox, Timothy A. Donlon, Michio Shimabukuro, Moritake Higa et al. · 2024 · Aging Cell
63. A Preliminary Study on Factors That Drive Patient Variability in Human Subcutaneous Adipose Tissues
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64. Exploration of common molecular mechanisms of psoriatic arthritis and aging based on integrated bioinformatics and single-cell RNA-seq analysis
    Shuang Liu, Peng Pu, Qing Xiang, Xiangling Pu · 2025 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
65. Uric Acid Promotes Human Umbilical Vein Endothelial Cell Senescence In Vitro
    Katarzyna Lewandowska, Justyna Mikuła‐Pietrasik, Krzysztof Książek, Andrzej Tykarski, Paweł Uruski · 2025 · Metabolites
66. Deconstructing replicative senescence heterogeneity of human mesenchymal stem cells at single cell resolution reveals therapeutically targetable senescent cell sub-populations
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67. The Multifaceted Phenotype of Senescent HL-60/S4 Macrophages
    Ada L. Olins, David B. Mark Welch, Dominik Saul, Igor A. Prudovsky, Donald E. Olins · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
68. Long-term supplementation with EPA and DHA changes the fatty acid profile of rat tissues, upregulates NRF2 expression and downregulates TGFβ expression
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69. Identification of diagnostic genes and the miRNA‒mRNA‒TF regulatory network in human oocyte aging via machine learning methods
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70. In Search of New Pharmacological Targets: Beyond Carnosine’s Antioxidant, Anti-Inflammatory, and Anti-Aggregation Activities
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71. Prenatal Stress Increases the Risk of the FPR2-related Dysfunction in the Brain's Resolution of Inflammation: A Study on the Humanized APPNL-F/NL-F Mouse Model of Alzheimer's Disease
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72. Network insights into childhood obesity: unveiling methylated-differentially expressed genes and pathways through integrative bioinformatics analysis
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73. Unraveling the aging-reversal potency of stem cell-derived extracellular vesicles in a rat model of premature cardiac senescence
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74. Lipopolysaccharide-Activated Macrophages Suppress Cellular Senescence and Promote Rejuvenation in Human Dermal Fibroblasts
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75. Molecular time machines unleashed: small-molecule-driven reprogramming to reverse the senescence
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76. P16 + Cells Drive Adverse Postischemic Cardiac Remodeling Through CCL8-Mediated Recruitment of Cytotoxic Lymphocytes
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77. Anshen Bunao syrup as a potential anti-aging agent: mechanistic insights and pharmacological evidence
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78. Gli2 and Gli3 synergistically mediate HH-TGF-β crosstalk in mesenchymal progenitor cells to orchestrate tooth root morphogenesis
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79. Endothelial cell senescence shapes T cell activity in late-stage of chronic obstructive pulmonary disease
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80. Cellular senescence in skeletal muscle: myogenic and nonmyogenic cell populations, mechanisms, and therapeutic opportunities
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81. Cellular senescence: from pathogenic mechanisms to precision anti-aging interventions
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82. Recent advances in methotrexate pharmacology and potential therapeutic uses in age-related cardiometabolic and neurodegenerative diseases
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83. Decoding vascular aging: implications for atherosclerosis progression and clinical intervention
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84. Signaling Pathways in Neurodegeneration
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85. Deciphering the CREB-NR2B axis: Unraveling the crosstalk of insulin and TGF-β signalling in ameliorating postoperative cognitive dysfunction
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86. Cytoplasm or Supernatant: Where Is the Treasury of the Bioactive Antiaging Factor from Mesenchymal Stem Cells?
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87. A tumour-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer
    Estela González‐Gualda, David Macías, Samir Morsli, Jose‐Ezequiel Martín, Hui‐Ling Ou, Mary Denholm, Ioana Olan, Reuben J. Hoffmann, Mark A. Dane, Dimitris Veroutis et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
88. Ensemble of Time-Evolving SASP Gene Sets Identifies IGFBP7 and CDKN1A as a Potential Marker Pair for Senescent Fibroblast Subpopulations Across Tissues
    Kim, Hyunsoo, Kummerfeld, Erich, Niedernhofer, Laura J., Aliferis, Constantin, Robbins, Paul D., Wang, Jinhua · 2026 · International Journal of Molecular Sciences
89. Progress in human embryonic stem cell research and aging
    Anjali P. Patni, Joel P. Joseph, Dannie Macrin, Arikketh Devi · 2021 · Elsevier eBooks
90. Cord Blood as a Trophic-Growth Additive for Culture Work
    A. G. Goncharov, Valeria V. Shupletsova, Н. Д. Газатова, Olga Borisovna Melashchenko, Kristina Alekseevna Yurova, Larisa Sergeevna Litvinova · 2024 · Cell and Tissue Biology
91. Integrative bioinformatic approach reveals novel melatonin-related biomarkers for Alzheimer’s disease
    Huaxiong Zhang, Dilmurat Hamit, Qing Li, Xiao Hu, San-feng Li, Fu Xu, Mingyuan Wang, Guo-qing Bao, Hongyan Li · 2025 · Scientific Reports
92. Escape from TGF ‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells
    Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Çakıroğlu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Öztürk et al. · 2025 · Molecular Oncology
93. 3D Spheroid Cultures for Salivary Gland Tissue Engineering: Effects of Fibroblast on Epithelial Cell Function
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94. Matrix viscoelasticity drives cell cluster formation to counteract cellular senescence
    Xinying Wang, Limin Song, Jingwen Zhao, Yiling Xiong, Rongrong Jin, Jing Hui He · 2025 · Journal of Materials Chemistry B
95. Dehydroacteoside rejuvenates senescence via TVP23C-CDRT4 regulation
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96. Extracellular matrix-associated molecules of senescent cells induce a senescence phenotype in proliferative cells via TGF-β signaling pathway
    Rita Sá Ferreira, Helena Isabel Reis Aires, Catarina Rebelo, João F. Passos, Alessandro Ori‬‬, Patrícia R. Pitrez, Lino Ferreira · 2026 · Biomaterials
97. Exploring the uncharted role of cell senescence in rare diseases
    Piera Selvaggio, Esi Taci, Alessandra Barassi, Valentina Massa, Cristina Gervasini, Elena A. Lesma, Clara Bernardelli, Elisabetta Di Fede · 2025 · Orphanet Journal of Rare Diseases
98. Development of a Machine Learning-Based Predictive Model for Anastomotic Leakage Following Gastric Cancer Surgery
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