The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.
TGF-β Signaling in Cellular Senescence and Aging-Related Pathology
Open accessAbstract
Aging is broadly defined as the functional decline that occurs in all body systems. The accumulation of senescent cells is considered a hallmark of aging and thought to contribute to the aging pathologies. Transforming growth factor-β (TGF-β) is a pleiotropic cytokine that regulates a myriad of cellular processes and has important roles in embryonic development, physiological tissue homeostasis, and various pathological conditions. TGF-β exerts potent growth inhibitory activities in various cell types, and multiple growth regulatory mechanisms have reportedly been linked to the phenotypes of cellular senescence and stem cell aging in previous studies. In addition, accumulated evidence has indicated a multifaceted association between TGF-β signaling and aging-associated disorders, including Alzheimer’s disease, muscle atrophy, and obesity. The findings regarding these diseases suggest that the impairment of TGF-β signaling in certain cell types and the upregulation of TGF-β ligands contribute to cell degeneration, tissue fibrosis, inflammation, decreased regeneration capacity, and metabolic malfunction. While the biological roles of TGF-β depend highly on cell types and cellular contexts, aging-associated changes are an important additional context which warrants further investigation to better understand the involvement in various diseases and develop therapeutic options. The present review summarizes the relationships between TGF-β signaling and cellular senescence, stem cell aging, and aging-related diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Moreover, TGF-β participates in multiple signaling pathways and has broad, context-dependent effects [14].”
From Ensemble of Time-Evolving SASP Gene Sets Identifies IGFBP7 and CDKN1A as a Potential Marker Pair for Senescent Fibroblast Subpopulations Across Tissues (2026) · cites this paper as [14]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 55,044
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670
Wound repair and regeneration: Mechanisms, signaling, and translation
Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562
Mitochondrial free radical generation, oxidative stress, and aging
Cadenas, E., & Davies, K. J. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00317-8 · Cited by 3,010
Senolytics improve physical function and increase lifespan in old age
Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287
Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087
Conserved cell types with divergent features in human versus mouse cortex
Hodge, R. D., Bakken, T. E., Miller, J. A., Smith, K. A., Barkan, E. R., Graybuck, L. T., Close, J. L., Long, B., Johansen, N., Penn, O., et al. (2019) · Nature · doi:10.1038/s41586-019-1506-7 · Cited by 1,775
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 394
Salminen, A. (2023) · Biogerontology · doi:10.1007/s10522-023-10072-9 · Cited by 27
de Cavanagh, E. M. V., Inserra, F., & Ferder, L. (2024) · Physiological Reports · doi:10.14814/phy2.16094 · Cited by 25
ATOH8 binds SMAD3 to induce cellular senescence and prevent Ras-driven malignant transformation
Liu, X., Li, X., Wang, S., Liu, Q., Feng, X., Wang, W., Huang, Z., Huang, Y., Wu, J., Cai, M., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2208927120 · Cited by 27
Li, J., Niu, C., Ai, H., Li, X., Zhang, L., Yan, L., Wang, S., Gao, F., Mei, X., Yu, C., et al. (2024) · Advanced Science · doi:10.1002/advs.202305893 · Cited by 25
WWOX and Its Binding Proteins in Neurodegeneration
Hsu, C.-Y., Lee, K., Sun, T.-Y., Sze, C., Huang, S., Hsu, L., & Chang, N. (2021) · Cells · doi:10.3390/cells10071781 · Cited by 26
Integrin β3 Induction Promotes Tubular Cell Senescence and Kidney Fibrosis
Shen, L., Jiang, S., Zhang, Q., Jin, B. R., Lv, D., Li, W., Zhao, M., Jiang, C., Dai, C., & Liu, Z. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.733831 · Cited by 27
Circulating α-Klotho Counteracts Transforming Growth Factor-β–Induced Sarcopenia
Ohsawa, Y., Ohtsubo, H., Munekane, A., Ohkubo, K., Murakami, T., Fujino, M., Nishimatsu, S., Hagiwara, H., Nishimura, H., Kaneko, R., et al. (2023) · American Journal Of Pathology · doi:10.1016/j.ajpath.2023.01.009 · Cited by 24
Liu, J., Macnaughtan, J., Kerbert, A. J. C., Portlock, T., González, J. M., Jin, Y., Clasen, F., Habtesion, A., Ji, H., Jin, Q., et al. (2024) · Gut · doi:10.1136/gutjnl-2023-330699 · Cited by 23
Zhong, W., Chen, W., Liu, Y., Zhang, J., Lu, Y., Wan, X., Qiao, Y., Huang, H., Zeng, Z., Li, W., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202200406rr · Cited by 23
Research progress on interferon and cellular senescence
Wang, D., Chen, K., Wang, Z., Wu, H., & Li, Y. (2024) · The FASEB Journal · doi:10.1096/fj.202400808rr · Cited by 23
Yokozeki, Y., Kawakubo, A., Miyagi, M., Kuroda, A., Sekiguchi, H., Inoue, G., Takaso, M., & Uchida, K. (2021) · BioMed Research International · doi:10.1155/2021/7988320 · Cited by 21
Sammad, A., Luo, H., Hu, L., Zhao, S., Gong, J., Umer, S., Khan, A. A., Zhu, H., & Wang, Y. (2022) · Biology · doi:10.3390/biology11060839 · Cited by 22
Antisenescence Therapy Improves Function in a Human Model of Cardiac Fibrosis-on-a-Chip
Mourad, O., Mastikhina, O., Khan, S. T., Sun, X., Hatkar, R., Williams, K., & Nunes, S. S. (2023) · ACS Materials Au · doi:10.1021/acsmaterialsau.3c00009 · Cited by 23
Protein-Bound Uremic Toxins in Senescence and Kidney Fibrosis
Yang, Y., Mihajlovic, M., & Masereeuw, R. (2023) · Biomedicines · doi:10.3390/biomedicines11092408 · Cited by 21
Microglial Transforming Growth Factor-β Signaling in Alzheimer’s Disease
Vidovic, N., & Spittau, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063090 · Cited by 22
Peng, X., Li, P., Zhang, Y., Zhang, Q., & Liang, W. (2025) · Genome Medicine · doi:10.1186/s13073-025-01520-x · Cited by 22
Hypoperfusion is a potential inducer of immunosuppressive network in Alzheimer's disease
Salminen, A. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104919 · Cited by 20
dos Santos, T. M., Júnior, O. V. R., Alves, V. S., Coutinho‐Silva, R., Savio, L. E. B., & Wyse, Â. T. D. S. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119386 · Cited by 20
Thompson, E. L., Hu, J., & Niedernhofer, L. J. (2021) · Cancers · doi:10.3390/cancers13092241 · Cited by 19
Guo, G., Watterson, S., Zhang, S., Bjourson, A. J., McGilligan, V., Peace, A. J., & Singh, T. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101363 · Cited by 22
Algeciras, L., Palanca, A., Maestro, D., RuizdelRio, J., & Villar, A. V. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.06.003 · Cited by 20
Evolution and Diversity of TGF-β Pathways are Linked with Novel Developmental and Behavioral Traits
Lo, W., Roca, M., Dardiry, M., Mackie, M., Eberhardt, G., Witte, H., Hong, R. L., Sommer, R. J., & Lightfoot, J. W. (2022) · Molecular Biology and Evolution · doi:10.1093/molbev/msac252 · Cited by 17
Jo, M. K., Moon, C. M., Jeon, H.-J., Han, Y., Lee, E. S., Kwon, J.-H., Yang, K., Ahn, Y., Kim, S., Jung, S.-A., et al. (2023) · Inflammation and Regeneration · doi:10.1186/s41232-023-00282-6 · Cited by 22
Chang, H., Chen, I.-L., Wang, Y., Chang, M., Tsai, Y., Lan, W.-C., Wang, T., Yeung, S., & Jeng, J. (2020) · Aging · doi:10.18632/aging.103848 · Cited by 20
Salminen, A. (2024) · Biogerontology · doi:10.1007/s10522-024-10114-w · Cited by 22
Combining stem cell rejuvenation and senescence targeting to synergistically extend lifespan
Kaur, P., Otgonbaatar, A., Ramamoorthy, A., Chua, E. H. Z., Harmston, N., Gruber, J., & Tolwinski, N. S. (2022) · Aging · doi:10.18632/aging.204347 · Cited by 20
Papaspyropoulos, A., Hazapis, O. G., Altulea, A., Polyzou, A., Verginis, P., Evangelou, K., Fousteri, M. I., Papantonis, A., Demaria, M., & Gorgoulis, V. G. (2023) · Aging Cell · doi:10.1111/acel.13893 · Cited by 18
Mazzella, M., Walker, K., Cormier, C., Kapanowski, M., Ishmakej, A., Saifee, A., Govind, Y., & Chaudhry, G. R. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03533-y · Cited by 18
Oishi, H., Doi, S., Nakashima, A., Ike, T., Maeoka, Y., Sasaki, K., Doi, T., & Masaki, T. (2021) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00609.2020 · Cited by 19
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2025) · Biogerontology · doi:10.1007/s10522-025-10268-1 · Cited by 21
González‐Gualda, E., Reinius, M., Macías, D., Morsli, S., Ge, J., Olan, I., Martín, J. E., Ou, H., Hartono, M., Puerto-Camacho, M. P., et al. (2026) · Nature Aging · doi:10.1038/s43587-025-01054-2 · Cited by 19
Zhang, X., Hou, X., Liu, T., Zhongsheng, Z., Jiang, J., & Wu, X. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1010562 · Cited by 19
Senescence-associated exosomes transfer miRNA-induced fibrosis to neighboring cells
Lee, A. H., Ghosh, D., Koh, I. L., & Dawson, M. (2023) · Aging · doi:10.18632/aging.204539 · Cited by 20
Thamarath, S. S., Tee, C. A., Neo, S. H., Yang, D., Othman, R. B., Boyer, L. A., & Han, J. (2023) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szad014 · Cited by 19
Imran, S. A. M., Yazid, M. D., Idrus, R. B. H., Maarof, M., Nordin, A., Razali, R. A., & Lokanathan, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083888 · Cited by 18
Kandhaya‐Pillai, R., Hou, D., Zhang, J., Yang, X., Compoginis, G., Mori, T., Tchkonia, T., Martin, G. M., Hisama, F. M., Kirkland, J. L., et al. (2021) · GeroScience · doi:10.1007/s11357-020-00318-6 · Cited by 19
Nonninger, T. J., Mak, J., Gerisch, B., Ramponi, V., Kawamura, K., Ripa, R., Schilling, K., Latza, C., Kölschbach, J., Serrano, M., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00911-4 · Cited by 24
Chiu, Y., Spierings, J., van Laar, J. M., Vries-Bouwstra, J. K. D., van Dijk, M. R., & Goldschmeding, R. (2022) · Clinical and Experimental Rheumatology · doi:10.55563/clinexprheumatol/i49d3o · Cited by 18
Structure, unique biological properties, and mechanisms of action of transforming growth factor β
Zelisko, N., Lesyk, R., & Stoika, R. S. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107611 · Cited by 18
A Deep-Learning Proteomic-Scale Approach for Drug Design
Overhoff, B., Falls, Z., Mangione, W., & Samudrala, R. (2021) · Pharmaceuticals · doi:10.3390/ph14121277 · Cited by 16
The Impact of Klotho in Cancer: From Development and Progression to Therapeutic Potential
Ortega, M. A., Boaru, D. L., León-Oliva, D. D., Castro-Martinez, P. D., Minaya‐Bravo, A., Casanova-Martín, C., Barrena-Blázquez, S., Montero, C. G., Fraile‐Μartinez, O., López-González, L., et al. (2025) · Genes · doi:10.3390/genes16020128 · Cited by 18
Obesity and type 2 diabetes mellitus: insights from skeletal muscle extracellular matrix remodeling
Wu, L., & Coletta, D. K. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00154.2024 · Cited by 17
Vázquez-Villaseñor, I., Smith, C. I., Thang, Y. J. R., Heath, P. R., Wharton, S. B., Blackburn, D. J., Ridger, V. C., & Simpson, J. E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115913 · Cited by 16
Li, T., Lu, L., & Meng, Y. (2022) · Current Molecular Medicine · doi:10.2174/1566524023666221025104629 · Cited by 16
Potent New Targets for Autophagy Enhancement to Delay Neuronal Ageing
Szinyákovics, J., Keresztes, F., Kiss, E. A., Falcsik, G., Vellai, T., & Kovács, T. (2023) · Cells · doi:10.3390/cells12131753 · Cited by 16
Dole, N. S., Betancourt-Torres, A., Kaya, S., Obata, Y., Schurman, C. A., Yoon, J., Yee, C. S., Khanal, V., Luna, C. A., Carroll, M. D., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.175103 · Cited by 16
Janus, P., Kuś, P., Jaksik, R., Vydra, N., Toma-Jonik, A., Gramatyka, M., Kurpas, M. K., Kimmel, M., & Widłak, W. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01821-5 · Cited by 16
Salminen, A. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102926 · Cited by 15
Global research trends in atherosclerosis: A bibliometric and visualized study
Tian, W., Zhang, T., Wang, X., Zhang, J., Ju, J., & Xu, H. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.956482 · Cited by 18
LEF1 isoforms regulate cellular senescence and aging
Jia, M., Sayed, K., Kapetanaki, M. G., Dion, W. A., Rosas, L., Irfan, S., Valenzi, E., Mora, A. L., Lafyatis, R., Rojas, M. M., et al. (2023) · Aging Cell · doi:10.1111/acel.14024 · Cited by 16
Zhou, L., Wang, N., Feng, W., Liu, X., Wu, Q., Chen, J., Jiao, X., Ning, X., Qi, Z., Xu, Z., et al. (2024) · Glia · doi:10.1002/glia.24606 · Cited by 14
FBLN1 promotes chondrocyte proliferation by increasing phosphorylation of Smad2
Xu, G., Geng, X., Yang, F., & Zhang, Y. (2021) · Journal of Orthopaedic Science · doi:10.1016/j.jos.2020.12.006 · Cited by 15
Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline
Rojas-Vázquez, S., Blasco-Chamarro, L., López-Fabuel, I., Martínez-Máñez, R., & Fariñas, I. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.666881 · Cited by 15
Typhoid toxin hijacks Wnt5a to establish host senescence and Salmonella infection
ElGhazaly, M., Collins, M. O., Ibler, A. E., & Humphreys, D. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113181 · Cited by 13
miR-30c-1 encourages human corneal endothelial cells to regenerate through ameliorating senescence
Bae, Y., Hwang, J. S., & Shin, Y. J. (2021) · Aging · doi:10.18632/aging.202719 · Cited by 14
Multi-target regulatory mechanism of Yang Xin Tang − a traditional Chinese medicine against dementia
Lo, T. Y., Chan, A. S. L., Cheung, S. T., Yung, L. Y., Leung, M. M. H., & Wong, Y. H. (2023) · Chinese Medicine · doi:10.1186/s13020-023-00813-w · Cited by 16
Identification and analysis of key genes in adipose tissue for human obesity based on bioinformatics
Hua, Y., Xie, D., Zhang, Y., Wang, M., Wen, W., & Sun, J. M. (2023) · Gene · doi:10.1016/j.gene.2023.147755 · Cited by 13
Paine, P. T., Rechsteiner, C., Morandini, F., Desdín-Micó, G., Mrabti, C., Parras, A., Haghani, A., Brooke, R., Horvath, S., Seluanov, A., et al. (2024) · Frontiers in Aging · doi:10.3389/fragi.2023.1323194 · Cited by 13
English, J., Dhanikonda, S., Tanaka, K. E., Koba, W. R., Eichenbaum, G. M., Yang, W., & Guha, C. (2024) · JCI Insight · doi:10.1172/jci.insight.181330 · Cited by 13
Healthy Aging Metabolomic and Proteomic Signatures Across Multiple Physiological Compartments
Moaddel, R., Candia, J., Ubaida‐Mohien, C., Tanaka, T., Moore, A. Z., Zhu, M., Fantoni, G., Church, S. J., D'Agostino, J., Fan, J., et al. (2025) · Aging Cell · doi:10.1111/acel.70014 · Cited by 15
Possible Role of Activin in the Adiponectin Paradox-Induced Progress of Alzheimer’s Disease
Hashimoto, M., Ho, G. J., Sugama, S., Takenouchi, T., Waragai, M., Sugino, H., Inoue, S., & Masliah, E. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210206 · Cited by 12
Ponnusamy, S., Amin, M., Bhat, A. G., Garczynski, S., Rahman, S. U., Rasam, S. S., Govindool, S. R., Khan, I., & Arany, P. R. (2026) · Cells · doi:10.3390/cells15010088 · Cited by 12
Huang, Y., Ge, M.-X., Li, Y.-H., Li, J.-L., Yu, Q., Xiao, F.-H., Ao, H.-S., Yang, L.-Q., Li, J., He, Y., et al. (2022) · Aging and disease · doi:10.14336/ad.2022.1217 · Cited by 12
Matrix disequilibrium in Alzheimer’s disease and conditions that increase Alzheimer’s disease risk
Amontree, M., Deasy, S., Turner, R. S., & Conant, K. E. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1188065 · Cited by 13
Chen, B. H., Lu, X. Q., Liang, X. H., & Wang, P. (2023) · Scientific Reports · doi:10.1038/s41598-023-43411-4 · Cited by 13
The dichotomic role of cytokines in aging
Silva, R. C. M. C. (2024) · Biogerontology · doi:10.1007/s10522-024-10152-4 · Cited by 16
TGFβ1 Induces Senescence and Attenuated VEGF Production in Retinal Pericytes
Avramović, D., Archaimbault, S. A., Kemble, A. M., Gruener, S., Lazendic, M., & Westenskow, P. D. (2022) · Biomedicines · doi:10.3390/biomedicines10061404 · Cited by 12
Early-onset Exfoliation Syndrome: A Literature Synthesis
Mayro, E. L., Ritch, R. H., & Pasquale, L. R. (2021) · Journal of Glaucoma · doi:10.1097/ijg.0000000000001784 · Cited by 12
Mo, F., Tsai, C., Zheng, R., Cheng, C., Heslop, H. E., Brenner, M. K., Mamonkin, M., & Watanabe, N. (2024) · Cytotherapy · doi:10.1016/j.jcyt.2024.03.006 · Cited by 12
Increased vascular smooth muscle cell senescence in aneurysmal Fibulin-4 mutant mice
Stefens, S. J. M., van Vliet, N., IJpma, A. S., Burger, J. E., Li, Y., van Heijningen, P. M., Lindeman, J. H. N., Majoor‐Krakauer, D. F., Verhagen, H. J. M., Kanaar, R., et al. (2024) · npj Aging · doi:10.1038/s41514-024-00154-4 · Cited by 10
Podocyte senescence: from molecular mechanisms to therapeutics
Zhao, Q., Huang, Y., Fu, N., Cui, C., Peng, X., Kang, H., Xiao, J., & Ke, G. (2024) · Renal Failure · doi:10.1080/0886022x.2024.2398712 · Cited by 12
Charoenphannathon, J. S., Wong, P. D., Royce, S. G., Jaffar, J., Westall, G. P., Wang, C., Bourke, J. E., & Samuel, C. S. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118370 · Cited by 13
Wang, E., Liao, Z., Wang, L., Liao, Y., Xu, X., Liu, P., Wang, X., Hou, J., Jiang, H., Wu, X., et al. (2021) · Parasitology · doi:10.1017/s0031182021000287 · Cited by 11
Okamura, K., Suzuki, T., & Nohara, K. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115259 · Cited by 11
Spatio-temporal correlates of gene expression and cortical morphology across lifespan and aging
Qiu, A., Zhang, H., Kennedy, B. K., & Lee, A. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117426 · Cited by 10
Stinchfield, M. J., Weasner, B. P., Weasner, B. M., Zhitomersky, D., Kumar, J. P., O’Connor, M. B., & Newfeld, S. J. (2023) · Genetics · doi:10.1093/genetics/iyad201 · Cited by 10
SenMayo transcriptomic senescence panel highlights glial cells in the ageing mouse and human retina
Suresh, S., Karthik, G., Ouyang, J. F., Chrysostomou, V., Tang, S. A., Petretto, E. G., Crowston, J. G., & Bell, K. C. (2024) · npj Aging · doi:10.1038/s41514-024-00187-9 · Cited by 10
Sun, K., Kang, Z., Chen, Y., Yu, Y., Han, L., Shi, Y., Chen, L., Shi, J., Chen, Y., & Sun, J. (2025) · Advanced Science · doi:10.1002/advs.202412908 · Cited by 10
A Guide in Synthetic Biology: Designing Genetic Circuits and Their Applications in Stem Cells
Elnaggar, K. S., Gamal, O., Hesham, N., Ayman, S., Mohamed, N., Moataz, A., Elzayat, E. M., & Hassan, N. (2025) · SynBio · doi:10.3390/synbio3030011 · Cited by 10
Sánchez‐Sánchez, J. L., Ader, I., Jeanson, Y., Planat‐Benard, V., Vellas, B. J., Casteilla, L., & Barreto, P. D. S. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac226 · Cited by 10
Petrocelli, J. J., Liu, J., Yee, E. M., Ferrara, P. J., Bourrant, P., de Hart, N. M. M. P., Tatum, S. M., Holland, W. J., Funai, K., & Drummond, M. J. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00261.2023 · Cited by 10
Non-Intrinsic, Systemic Mechanisms of Cellular Senescence
Schwartz, R. E., & Conboy, I. M. (2023) · Cells · doi:10.3390/cells12242769 · Cited by 10
Tuz-Sasik, M. U., Karoglu-Eravsar, E. T., Kinali, M., Ergul, A. A., & Adams, M. M. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.04.003 · Cited by 10
Traumatic MicroRNAs: Deconvolving the Signal After Severe Traumatic Brain Injury
Cente, M., Matyasova, K., Csicsatkova, N., Tomikova, A., Porubska, S., Niu, Y., Majdan, M., Filipcik, P., & Jurisica, I. (2022) · Cellular and molecular neurobiology · doi:10.1007/s10571-022-01254-z · Cited by 9
Jin, W. Z., Jiang, S., Liu, X., He, Y., Li, T., Ma, J., Chen, Z., Lu, X., Liu, X., Shou, W., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54338-3 · Cited by 9
Aging and lung diseases: Unraveling mechanisms and therapeutic targets
Zhou, Y., Chen, G., Li, X., Li, X., Lin, Z., Liu, L., Pu, D., Chen, J., Chen, Y., Lin, Z., et al. (2025) · Chinese Medical Journal - Pulmonary and Critical Care Medicine · doi:10.1016/j.pccm.2025.11.005 · Cited by 10
Lu, Y., Li, J., & Hu, T. (2022) · Computational and Mathematical Methods in Medicine · doi:10.1155/2022/2701748 · Cited by 9
RetractedLee, S. J., Kim, S., Jo, D. H., Park, K., & Kim, J. H. (2021) · The FASEB Journal · doi:10.1096/fj.202001939rr · Cited by 9
Wu, R.-D., Zhang, X., Zhang, X., Sun, L., Xia, T., & Zhang, L. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1287133 · Cited by 9
Synergistic ROS Reduction Through the Co-Inhibition of BRAF and p38 MAPK Ameliorates Senescence
Kuk, M. U., Kim, D., Lee, Y. H., Yoon, J. H., Park, J. H., Lee, Y. J., So, B., Kim, M., Kwon, H. W., Byun, Y., et al. (2024) · Antioxidants · doi:10.3390/antiox13121465 · Cited by 8
Dworak, H., Rozmaric, T., Grillari, J., & Ogrodnik, M. B. (2025) · FEBS Letters · doi:10.1002/1873-3468.70037 · Cited by 8
Wang, D., & Guan, H. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156115 · Cited by 9
Merino, A. M., Hoogduijn, M. J., Molina‐Molina, M., Arias‐Salgado, E. G., Korevaar, S. S., Baan, C. C., & Montes‐Worboys, A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248415 · Cited by 8
Sex Differences in Progression of Diabetic Cardiomyopathy in OVE26 Type 1 Diabetic Mice
Tang, X., Jiang, S., Zhang, J., Zhou, S., & Zheng, Y. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6961348 · Cited by 8
Could senescence phenotypes strike the balance to promote tumor dormancy?
Chiu, F.-Y., Kvadas, R. M., Mheidly, Z., Shahbandi, A., & Jackson, J. G. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10089-z · Cited by 8
Beyond acute infection: molecular mechanisms underpinning cardiovascular complications in long COVID
Mostafa, R. H., & Moustafa, A. A. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1268571 · Cited by 11
Mobasheri, A., Choi, H., & Martı́n-Vasallo, P. (2020) · Biology · doi:10.3390/biology9100330 · Cited by 8
Menopause mysteries: the exosome-inflammation connection
Sultania, A., Brahadeeswaran, S., Kolasseri, A. E., Jayanthi, S., & Tamizhselvi, R. (2025) · Journal of Ovarian Research · doi:10.1186/s13048-025-01591-9 · Cited by 7
Zheng, M., Yuan, G., Han, J., Li, J., Jiang, Y., Li, Z., & Yao, Y. (2025) · Immunologic Research · doi:10.1007/s12026-025-09646-1 · Cited by 8
He, Z., Li, Z., Chen, Q., Xiong, S., He, Z., Hu, J., Ma, Z., Zhang, Q., He, J., Ye, L., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315349 · Cited by 7
Metadata
- Authors
- Tominaga, K., & Suzuki, H. I.
- Affiliations
- Massachusetts Institute of Technology (US)
- Koch Institute for Integrative Cancer Research At MIT (US)
- Corresponding author
- Suzuki, Hiroshi I.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2019-10-10
- Volume
- 20
- Issue
- 20
- Pages
- 5002
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC6834140
- OpenAlex
- W2979971613
- Cited by
- 393
- References
- 139
- Citations by year
- 2026: 54 · 2025: 84 · 2024: 82 · 2023: 56 · 2022: 51 · 2021: 47 · 2020: 19
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Grant-in-Aid for JSPS postdoc Fellows (NA)
- the Osamu Hayaishi Memorial Scholarship for Study Abroad (NA)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- TGF-beta signaling, cellular senescence, aging, stem cell aging, age-related diseases, Alzheimer's disease, muscle atrophy, obesity, fibrosis, inflammation, tissue regeneration, metabolic dysfunction
- MeSH terms
- Aging, Alzheimer Disease, Fibrosis, Hematopoietic Stem Cells, Homeostasis, Inflammation, Ligands, Muscular Atrophy, Obesity, Stem Cells, Signal Transduction, Transforming Growth Factor beta, Cellular Senescence, Cell Proliferation, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
