The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression
Open accessAbstract
Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the adult population. OA is primarily caused by trauma induced by an external force or by age-related cartilage damage. Chondrocyte hypertrophy or chondrocyte senescence is thought to play a role in the initiation and progression of OA. Although chondrocyte hypertrophy and cell death are both crucial steps during the natural process of endochondral bone formation, the abnormal activation of these two processes after injury or during aging seems to accelerate the progression of OA. However, the exact mechanisms of OA progression and these two processes remain poorly understood. Chondrocyte senescence and hypertrophy during OA share various markers and processes. In this study, we reviewed the changes that occur during chondrocyte hypertrophy or senescence in OA and the attempts that were made to regulate them. Regulation of hypertrophic or senescent chondrocytes might be a potential therapeutic target to slow down or stop OA progression; thus, a better understanding of the processes is required for management.
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Cites
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Cited by
He, Y., Li, Z., Alexander, P. G., Ocasio-Nieves, B. D., Yocum, L., Lin, H., & Tuan, R. S. (2020) · Biology · doi:10.3390/biology9080194 · Cited by 380
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Plasma proteomics identifies CRTAC1 as a biomarker for osteoarthritis severity and progression
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Kirsch, V., Ramge, J.-M., Schoppa, A., Ignatius, A., & Riegger, J. (2022) · Cells · doi:10.3390/cells11071106 · Cited by 47
Metadata
- Authors
- Rim, Y. A., Nam, Y., & Ju, J. H.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-03-29
- Volume
- 21
- Issue
- 7
- Pages
- 2358
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W3014070799
- Cited by
- 382
- References
- 93
- FWCI
- 25.58
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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