Advanced glycation end products in foods and a practical guide to their reduction in the diet
Open accessAbstract
Modern diets are largely heat-processed and as a result contain high levels of advanced glycation end products (AGEs). Dietary advanced glycation end products (dAGEs) are known to contribute to increased oxidant stress and inflammation, which are linked to the recent epidemics of diabetes and cardiovascular disease. This report significantly expands the available dAGE database, validates the dAGE testing methodology, compares cooking procedures and inhibitory agents on new dAGE formation, and introduces practical approaches for reducing dAGE consumption in daily life. Based on the findings, dry heat promotes new dAGE formation by >10- to 100-fold above the uncooked state across food categories. Animal-derived foods that are high in fat and protein are generally AGE-rich and prone to new AGE formation during cooking. In contrast, carbohydrate-rich foods such as vegetables, fruits, whole grains, and milk contain relatively few AGEs, even after cooking. The formation of new dAGEs during cooking was prevented by the AGE inhibitory compound aminoguanidine and significantly reduced by cooking with moist heat, using shorter cooking times, cooking at lower temperatures, and by use of acidic ingredients such as lemon juice or vinegar. The new dAGE database provides a valuable instrument for estimating dAGE intake and for guiding food choices to reduce dAGE intake.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Highly cross-linked advanced glycation end products and melanoidins are predominantly excreted in faeces, while absorbed Maillard reaction products are generally rapidly excreted by the kidney with limited accumulation in tissues and organs.
“Highly cross-linked AGE and melanoidins were predominantly excreted in the faeces while absorbed MRP were in general rapidly excreted by the kidney, with limited accumulation in tissues and organs (465,528 -531) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [528]
Studies in experimental animals and human volunteers show that absorption of ingested Maillard reaction products is variable and dependent on the Maillard reaction product.
“Studies in experimental animals fed or injected with radiolabelled protein-bound AGE and human volunteers receiving diets enriched with MRP or specific AGE have shown that absorption of ingested MRP is variable and dependent on the MRP (464,465,527 -529) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [528]
Marinating food or meat with acidic ingredients such as lemon juice and vinegar decreases dietary AGEs produced during high-heat cooking by as much as 50%.
“Marinating food or meat with acidic ingredients such as lemon juice and vinegar can decrease the amounts of dietary AGEs produced during the high-heat cooking process by as much as 50%272.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [272]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works
Food, nutrition, physical activity, and the prevention of cancer: a global perspective
Marmot, M. G., Atinmo, T., Byers, T., Chen, J., Hirohata, T., Jackson, A., James, W., Kolonel, L. N., Kumanyika, S., Leitzmann, C., et al. (2008) · Choice Reviews Online · doi:10.5860/choice.45-5024 · Cited by 5,365 · see citing works
Gupta, A., & Uribarri, J. (2016) · Hormone Research in Paediatrics · doi:10.1159/000444053 · Cited by 4,019 · see citing works
Self-citationLichtenstein, A. H., Appel, L. J., Brands, M., Carnethon, M., Daniels, S., Franch, H. A., Franklin, B., Kris-Etherton, P., Harris, W. S., Howard, B., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.176158 · Cited by 2,705 · see citing works
Advanced glycation end-products: A review
Singh, R., Barden, A., Mori, T., & Beilin, L. (2001) · Diabetologia · doi:10.1007/s001250051591 · Cited by 2,597 · see citing works
Advanced Glycation End Products: Sparking the Development of Diabetic Vascular Injury
Goldin, A., Beckman, J. A., Schmidt, A. M., & Creager, M. A. (2006) · Circulation · doi:10.1161/circulationaha.106.621854 · Cited by 2,261 · see citing works
Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet
Shai, I., Schwarzfuchs, D., Henkin, Y., Shahar, D. R., Witkow, S., Greenberg, I., Golan, R., Fraser, D., Bolotin, A., Vardi, H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708681 · Cited by 2,143 · see citing works
Bantle (2008) · doi:10.2337/dc08-s061 · Cited by 1,795 · see citing works
Gardner, C., Kiazand, A., Alhassan, S., Kim, S., Stafford, R., Balise, R., Kraemer, H., & King, A. (2007) · Journal of the American Medical Association (JAMA) · doi:10.13016/ncvz-hfu9 · Cited by 1,052 · see citing works
Gardner, C. D., Kiazand, A., Alhassan, S., Kim, S., Stafford, R. S., Balise, R. R., Kraemer, H. C., & King, A. C. (2007) · JAMA · doi:10.1001/jama.297.9.969 · Cited by 1,051 · see citing works
Fu, M.-X., Requena, J. R., Jenkins, A. J., Lyons, T. J., Baynes, J. W., & Thorpe, S. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.9982 · Cited by 822 · see citing works
Protein Glycation, Diabetes, and Aging
Ulrich, P. C. (2001) · Recent Progress in Hormone Research · doi:10.1210/rp.56.1.1 · Cited by 810 · see citing works
Koschinsky, T., He, C.-J., Mitsuhashi, T., Bucala, R., Liu, C., Buenting, C., Heitmann, K., & Vlassara, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6474 · Cited by 792 · see citing works
Self-citationActivation of Receptor for Advanced Glycation End Products
Schmidt, A. M., Yan, S. D., Wautier, J., & Stern, D. M. (1999) · Circulation Research · doi:10.1161/01.res.84.5.489 · Cited by 792 · see citing works
Advanced glycoxidation end products in commonly consumed foods
Goldberg, T., Cai, W., Peppa, M., Dardaine, V., Baliga, B. S., Uribarri, J., & Vlassara, H. (2004) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2004.05.214 · Cited by 744 · see citing works
Self-citationVlassara, H., Cai, W., Crandall, J., Goldberg, T., Oberstein, R., Dardaine, V., Peppa, M., & Rayfield, E. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242407999 · Cited by 668 · see citing works
Self-citationLipid advanced glycosylation: pathway for lipid oxidation in vivo.
Bucala, R., Makita, Z., Koschinsky, T., Cerami, A., & Vlassara, H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6434 · Cited by 571 · see citing works
Self-citationUribarri, J., Cai, W., Peppa, M., Goodman, S., Ferrucci, L., Striker, G., & Vlassara, H. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.4.427 · Cited by 570 · see citing works
Self-citationLow-Carbohydrate-Diet Score and the Risk of Coronary Heart Disease in Women
Halton, T. L., Willett, W. C., Liu, S., Manson, J. E., Albert, C. M., Rexrode, K., & Hu, F. B. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055317 · Cited by 519 · see citing works
Nutritional and toxicological aspects of the Maillard browning reaction in foods
O'Brien, J., Morrissey, P. A., & Ames, J. M. (1989) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398909527499 · Cited by 477 · see citing works
Advanced glycation end products and the kidney
Bohlender, J. M., Franke, S., Stein, G., & Wolf, G. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00398.2004 · Cited by 386 · see citing works
Uribarri, J., Peppa, Μ., Cai, W., Goldberg, T., Lu, M. M., He, C., & Vlassara, H. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000051593.41395.b9 · Cited by 331 · see citing works
Self-citationDiabetes and Advanced Glycoxidation End Products
Huebschmann, A. G., Regensteiner, J. G., Vlassara, H., & Reusch, J. E. B. (2006) · Diabetes Care · doi:10.2337/dc05-2096 · Cited by 331 · see citing works
Self-citationThe AGE‐receptor in the pathogenesis of diabetic complications
Vlassara, H. (2001) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.233 · Cited by 301 · see citing works
Self-citationHofmann, S. M., Dong, H. H., Li, Z., Cai, W., Altomonte, J., Thung, S. N., Zeng, F., Fisher, E. A. A., & Vlassara, H. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2082 · Cited by 296 · see citing works
Self-citationAccumulation of α-oxoaldehydes during oxidative stress: a role in cytotoxicity
Abordo, E. A., Minhas, H. S., & Thornalley, P. J. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00132-x · Cited by 239 · see citing works
Cai, W., Gao, Q.-D., Zhu, L., Peppa, Μ., He, C., & Vlassara, H. (2002) · Molecular Medicine · doi:10.1007/bf03402014 · Cited by 235 · see citing works
Self-citationVlassara, H., Cai, W., Goodman, S., Pyzik, R., Yong, A., Chen, X., Zhu, L., Neade, T., Beeri, M. S., Silverman, J. M., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0089 · Cited by 226 · see citing works
Self-citationNonenzymatic glucosylation and glucose-dependent cross-linking of protein.
Eble, A. S., Thorpe, S. R., & Baynes, J. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44682-5 · Cited by 214 · see citing works
Insulin Resistance and Type 2 Diabetes in High-Fat–Fed Mice Are Linked to High Glycotoxin Intake
Sandu, O. A., Song, K., Cai, W., Zheng, F., Uribarri, J., & Vlassara, H. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2314 · Cited by 213 · see citing works
Self-citationPrevention of diabetic nephropathy in mice by a diet low in glycoxidation products
Zheng, F., He, C., Cai, W., Hattori, M., Steffes, M. W., & Vlassara, H. (2002) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.283 · Cited by 207 · see citing works
Self-citationResch, K. (2008) · PubMed · Cited by 203 · see citing works
Uribarri, J., Peppa, Μ., Cai, W., Goldberg, T., Lu, M. M., Baliga, S. K., Vassalotti, J. A., & Vlassara, H. (2003) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(03)00779-0 · Cited by 197 · see citing works
Self-citationHe, C., Sabol, J., Mitsuhashi, T., & Vlassara, H. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1308 · Cited by 191 · see citing works
Cai, W., He, C., Zhu, L., Xue, C., Zheng, F., Striker, G. E., & Vlassara, H. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080152 · Cited by 186 · see citing works
Self-citationDietary glycotoxins promote diabetic atherosclerosis in apolipoprotein E-deficient mice
Lin, R.-Y., Choudhury, R. P., Cai, W., Lu, M. M., Fallon, J. T., Fisher, E. A. A., & Vlassara, H. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00050-9 · Cited by 171 · see citing works
Self-citationRestricted-Carbohydrate Diets in Patients with Type 2 Diabetes: A Meta-Analysis
Kirk, J. K., Graves, D. E., Craven, T. E., Lipkin, E. W., Austin, M., & Margolis, K. L. (2008) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2007.10.003 · Cited by 171 · see citing works
Ahmed, N., Mirshekar-Syahkal, B., Kennish, L., Karachalias, N., Babaei‐Jadidi, R., & Thornalley, P. J. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500008 · Cited by 155 · see citing works
Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice
Peppa, M., Brem, H., Ehrlich, P., Zhang, J.-G., Cai, W., Li, Z., Croitoru, A., Thung, S., & Vlassara, H. (2003) · Diabetes · doi:10.2337/diabetes.52.11.2805 · Cited by 153 · see citing works
Fetal or Neonatal Low-Glycotoxin Environment Prevents Autoimmune Diabetes in NOD Mice
Peppa, Μ., He, C., Hattori, M., McEvoy, R. C., Zheng, F., & Vlassara, H. (2003) · Diabetes · doi:10.2337/diabetes.52.6.1441 · Cited by 129 · see citing works
Self-citationSwain, J. F., McCarron, P. B., Hamilton, E. F., Sacks, F. M., & Appel, L. J. (2008) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2007.10.040 · Cited by 112 · see citing works
Lin, R.-Y., Reis, E. D., Dore, A. T., Lu, M., Ghodsi, N., Fallon, J. T., Fisher, E. A., & Vlassara, H. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00008-4 · Cited by 109 · see citing works
Self-citationGlycoxidation and Diabetic Complications: Modern Lessons and a Warning?
Vlassara, H., & Uribarri, J. (2004) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/b:remd.0000032406.84813.f6 · Cited by 105 · see citing works
Self-citationAvailability of Foods in High Schools
Story, M. T., HAYES, M., & Kalina, B. (1996) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(96)00039-9 · Cited by 94 · see citing works
Miller, E. R., Erlinger, T. P., & Appel, L. J. (2006) · Current Atherosclerosis Reports · doi:10.1007/s11883-006-0020-1 · Cited by 90 · see citing works
de Souza, R. J., Swain, J. F., Appel, L. J., & Sacks, F. M. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.1.1 · Cited by 72 · see citing works
Wheeler, M. L., Daly, A. E., Evert, A. B., Franz, M. J., Geil, P., Holzmeister, L. A., Kulkarni, K. D., Loghmani, E. S., Ross, T. A., & Woolf, P. (2008) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.02.002 · Cited by 51 · see citing works
Levi, B., & Werman, M. J. (2003) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00254-1 · Cited by 45 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- [8]Eble AS Thorpe SR Baynes JW Nonenzymatic glycosylation and glucose-dependent cross-linking of proteins J Biol Chem 1983 258 9406 9412 6409904
- [28]Vlassara H Cai W Goodman S Pyzik R Yong A Zhu L Neade T Beeri M Silverman JM Ferrucci L Tansman L Striker GE Uribarri J Protection against loss of innate defenses in adulthood by low AGE intake: Role of a new anti-inflammatory AGE-receptor-1 J Clin Endocrinol Metab 2009 94 4483 4491 19820033 PMC2775660
- [36]Gardner CD Kiazand A Alhasan S Kim S Stafford RS Balise RR Kraemer H King A Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women JAMA 2007 297 969 977 17341711
- [44]American Diabetes Association position statement: Nutrition recommendations and interventions for Diabetes Diabetes Care 2008 31 suppl S61 S78 18165339
Cited by
Sorted by citations
Treatment of NAFLD with diet, physical activity and exercise
Romero-Gómez, M., Zelber-Sagi, S., & Trenell, M. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.05.016 · Cited by 1,347 · see citing works
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
Control of Maillard Reactions in Foods: Strategies and Chemical Mechanisms
Lund, M. N., & Ray, C. A. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b00882 · Cited by 871 · see citing works
Advanced glycation endproducts in food and their effects on health
Poulsen, M. W., Hedegaard, R. V., Andersen, J. M., de Courten, B., Bügel, S., Nielsen, J., Skibsted, L. H., & Dragsted, L. O. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.06.052 · Cited by 751 · see citing works
Advanced Glycation End Products (AGE) and Diabetes: Cause, Effect, or Both?
Vlassara, H., & Uribarri, J. (2014) · Current Diabetes Reports · doi:10.1007/s11892-013-0453-1 · Cited by 594 · see citing works
Self-citationPerrone, A., Giovino, A., Benny, J., & Martinelli, F. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3818196 · Cited by 459 · see citing works
Rungratanawanich, W., Qu, Y., Wang, X., Essa, M. M., & Song, B.-J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00561-7 · Cited by 411 · see citing works
Dietary Advanced Glycation End Products and Aging
Luevano-Contreras, C., & Chapman-Novakofski, K. (2010) · Nutrients · doi:10.3390/nu2121247 · Cited by 396 · see citing works
The western diet and lifestyle and diseases of civilization
Carrera-Bastos, P., Fontes, O'Keefe, Lindeberg, & Cordain (2011) · Research Reports in Clinical Cardiology · doi:10.2147/rrcc.s16919 · Cited by 342 · see citing works
Scheijen, J. L. J. M., Clevers, E., Engelen, L., Dagnelie, P. C., Brouns, F., Stehouwer, C. D. A., & Schalkwijk, C. G. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2015.06.049 · Cited by 343 · see citing works
Restriction of Advanced Glycation End Products Improves Insulin Resistance in Human Type 2 Diabetes
Uribarri, J., Cai, W., Ramdas, M., Goodman, S., Pyzik, R., Chen, X., Zhu, L., Striker, G. E., & Vlassara, H. (2011) · Diabetes Care · doi:10.2337/dc11-0091 · Cited by 320 · see citing works
Self-citationMediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing
Gantenbein, K. V., & Kanaka-Gantenbein, C. (2021) · Nutrients · doi:10.3390/nu13061951 · Cited by 288 · see citing works
AGE restriction in diabetes mellitus: a paradigm shift
Vlassara, H., & Striker, G. E. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.74 · Cited by 277 · see citing works
Self-citationLifestyle interventions in nonalcoholic fatty liver disease
Younossi, Z. M., Zelber-Sagi, S., Henry, L., & Gerber, L. H. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00800-4 · Cited by 281 · see citing works
The Role of Advanced Glycation End Products in Diabetic Vascular Complications
Rhee, S. Y., & Kim, Y. S. (2018) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2017.0105 · Cited by 274 · see citing works
Dietary advanced glycation end products and their relevance for human health
Nowotny, K., Schröter, D., Schreiner, M., & Grune, T. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.06.005 · Cited by 255 · see citing works
Meat consumption, diabetes, and its complications
Feskens, E. J. M., Sluik, D., & van Woudenbergh, G. J. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0365-0 · Cited by 248 · see citing works
Snelson, M., & Coughlan, M. (2019) · Nutrients · doi:10.3390/nu11020215 · Cited by 230 · see citing works
Qu, W., Yuan, X., Zhao, J., Zhang, Y., Hu, J., Wang, J., & Li, J. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700118 · Cited by 195 · see citing works
The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction
Sergi, D., Boulestin, H., Campbell, F. M., & Williams, L. M. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900934 · Cited by 194 · see citing works
Fernando, D. H., Forbes, J. M., Angus, P. W., & Herath, C. B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205037 · Cited by 184 · see citing works
Kim, Y., Keogh, J., & Clifton, P. (2015) · Metabolism · doi:10.1016/j.metabol.2015.03.008 · Cited by 181 · see citing works
Kumar Pasupulati, A., Chitra, P. S., & Reddy, G. B. (2016) · Biomolecular Concepts · doi:10.1515/bmc-2016-0021 · Cited by 163 · see citing works
Yacoub, R., Nugent, M., Cai, W., Nadkarni, G. N., Chaves, L. D., Abyad, S., Honan, A. M., Thomas, S. A., Zheng, W., Valiyaparambil, S. A., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0184789 · Cited by 139 · see citing works
Self-citationOverview of anti-inflammatory diets and their promising effects on non-communicable diseases
Yu, X., Pu, H., & Voss, M. (2024) · British Journal of Nutrition · doi:10.1017/s0007114524001405 · Cited by 134 · see citing works
Role of advanced glycation end products in carcinogenesis and their therapeutic implications
Schröter, D., & Höhn, A. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190130145549 · Cited by 126 · see citing works
Bettiga, A., Fiorio, F., Di Marco, F., Trevisani, F., Romani, A., Porrini, E., Salonia, A., Montorsi, F., & Vago, R. (2019) · Nutrients · doi:10.3390/nu11081748 · Cited by 127 · see citing works
Adipose Tissue Dysfunction in Polycystic Ovary Syndrome
Bril, F., Ezeh, U., Amiri, M., Hatoum, S., Pace, L., Chen, Y.-H., Bertrand, F., Gower, B., & Azziz, R. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad356 · Cited by 123 · see citing works
Turner, D. P. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0169 · Cited by 109 · see citing works
Nutrition and AGE‐ing: Focusing on Alzheimer’s Disease
Abate, G., Marziano, M., Rungratanawanich, W., Memo, M., & Uberti, D. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7039816 · Cited by 103 · see citing works
Environmental pollution and the risk of developing metabolic disorders: obesity and diabetes
Khalil, W. J., Akeblersane, M., Khan, A. S., Moin, A. S. M., & Butler, A. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108870 · Cited by 95 · see citing works
Dietary glycotoxins exacerbate progression of experimental fatty liver disease
Leung, C., Herath, C. B., Jia, Z., Goodwin, M., Mak, K. Y., Watt, M. J., Forbes, J. M., & Angus, P. W. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.11.033 · Cited by 88 · see citing works
Maternally Transmitted and Food-Derived Glycotoxins
Mericq, V., Piccardo, C., Cai, W., Chen, X., Zhu, L., Striker, G. E., Vlassara, H., & Uribarri, J. (2010) · Diabetes Care · doi:10.2337/dc10-1058 · Cited by 82 · see citing works
Self-citationDietary advanced glycation end-products aggravate non-alcoholic fatty liver disease
Leung, C., Herath, C. B., Jia, Z., Andrikopoulos, S., Brown, B. E., Davies, M. J., Rivera, L. R., Furness, J. B., Forbes, J. M., & Angus, P. W. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i35.8026 · Cited by 80 · see citing works
Chen, H., Virk, M. S., & Chen, F. (2016) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2016.1166187 · Cited by 65 · see citing works
Gutierrez‐Mariscal, F. M., Cardelo, M. P., de la Cruz, S., Alcala‐Diaz, J. F., Roncero‐Ramos, I., Guler, I., Vals‐Delgado, C., López‐Moreno, A., Luque, R. M., Delgado‐Lista, J., et al. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201901290 · Cited by 60 · see citing works
Poulsen, M. W., Bak, M. J., Andersen, J. M., Monošík, R., Giraudi-Futin, A. C., Holst, J. J., Nielsen, J., Lauritzen, L., Larsen, L. H., Bügel, S., et al. (2014) · European Journal of Nutrition · doi:10.1007/s00394-013-0574-y · Cited by 55 · see citing works
Baye, E., de Courten, M. P., Walker, K., Ranasinha, S., Earnest, A., Forbes, J. M., & de Courten, B. (2017) · Scientific Reports · doi:10.1038/s41598-017-04214-6 · Cited by 50 · see citing works
Lopez‐Moreno, J., Quintana‐Navarro, G. M., Camargo, A., Jimenez‐Lucena, R., Delgado‐Lista, J., Marin, C., Tinahones, F. J., Striker, G. E., Roche, H. M., Perez‐Martinez, P., et al. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201601029 · Cited by 41 · see citing works
Self-citationChen, Y., Filipov, N. M., & Guo, T. L. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700641 · Cited by 20 · see citing works
Plant Foods, Healthy Plant-Based Diets, and Type 2 Diabetes: A Review of the Evidence
del Carmen Fernández-Fígares Jiménez, M. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuad099 · Cited by 20 · see citing works
- Authors
- Uribarri, J., Woodruff, S., Goodman, S., Cai, W., Chen, X., Pyzik, R., Yong, A., Striker, G. E., & Vlassara, H.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Vlassara, Helen
- Venue
- Journal of the American Dietetic Association
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 110
- Issue
- 6
- Pages
- 911-916.e12
- ISSN
- 0002-8223 (ISSN-L)
- PMC
- PMC3704564
- OpenAlex
- W2037141143
- Cited by
- 1,289
- References
- 48
- Citations by year
- 2026: 86 · 2025: 96 · 2024: 99 · 2023: 115 · 2022: 103 · 2021: 129 · 2020: 104 · 2019: 98 · 2018: 75 · 2017: 96 · 2016: 80 · 2015: 71 · 2014: 42 · 2013: 45 · 2012: 23
- FWCI
- 18.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of the American Dietetic Association (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG-23188, AG-09453)
- National Institute of Research Resources (MO1-RR-00071)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- advanced glycation end products, dietary AGEs, food processing, cooking methods, dry heat cooking, AGE formation, aminoguanidine, AGE inhibitors, oxidative stress, inflammation, diabetes mellitus, cardiovascular disease, food choice
- MeSH terms
- Consumer Product Safety, Cooking, Diet, Food Analysis, Food Handling, Hot Temperature, Humans, Hydrogen-Ion Concentration, Databases, Factual, Glycation End Products, Advanced
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
