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Role of microRNAs in vascular diseases, inflammation, and angiogenesis

Urbich, C., Kuehbacher, A., Dimmeler, S.·2008·Cardiovascular Research
DOI 10.1093/cvr/cvn156
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Abstract

The integrity of the endothelial monolayer is fundamental for the homoeostasis of the vascular system. Functional endothelial cells are also required for the growth of new blood vessels during neovascularization. Although multiple growth factors have been shown to regulate angiogenesis and vascular development, little is known about the complex upstream regulation of gene expression and translation. MicroRNAs (miRNAs) are an emerging class of highly conserved, non-coding small RNAs that regulate gene expression on the post-transcriptional level by inhibiting the translation of protein from mRNA or by promoting the degradation of mRNA. More than 500 human miRNAs have been identified so far, and increasing evidence indicates that miRNAs have distinct expression profiles and play crucial roles in various physiological and pathological processes such as cardiogenesis, haematopoietic lineage differentiation, and oncogenesis. Meanwhile, a few specific miRNAs that regulate endothelial cell functions and angiogenesis have been described. Let7-f, miR-27b, and mir-130a were identified as pro-angiogenic miRNAs. In contrast, miR-221 and miR-222 inhibit endothelial cell migration, proliferation, and angiogenesis in vitro by targeting the stem cell factor receptor c-kit and indirectly regulating endothelial nitric oxide synthase expression. Moreover, some miRNAs are involved in tumour angiogenesis such as the miR-17-92 cluster and miR-378. Early studies also indicate the contribution of sp…

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Crossref · 10.1093/cvr/cvn156

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  • miRNAs play a critical role in post-transcriptional gene regulation in several biological processes of the central nervous system and in the pathogenesis of different disorders.

    “An increasing body of literature supports the critical role of miRNAs in post-transcriptional gene regulation in several biological processes of the central nervous system (CNS), as well as in the pathogenesis of different disorders (including developmental, neurodegenerative, vascular and neuroinflammatory disorders), and in oncogenesis [10]–[12].”

    From MicroRNA-146a: A Key Regulator of Astrocyte-Mediated Inflammatory Response (2012) · cites this paper as [12]

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Authors
Urbich, C., Kuehbacher, A., & Dimmeler, S.
Venue
Cardiovascular Research
Publisher
Oxford University Press (OUP)
Published
2008-07-02
Volume
79
Issue
4
Pages
581-588
ISSN
0008-6363
DOI
10.1093/cvr/cvn156
Cited by
762
References
5
Language
en

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