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Nanoliposomes from Agro-Resources as Promising Delivery Systems for Chondrocytes
Open accessAbstract
Investigations in cartilage biology have been hampered by the limited capacity of chondrocytes, especially in rats and humans, to be efficiently transfected. Liposomes are a promising delivery system due to their lipid bilayer structure similar to a biological membrane. Here we used natural rapeseed lecithin, which contains a high level of mono- and poly-unsaturated fatty acids, to evaluate the cytocompatibility of these phospholipids as future potential carriers of biomolecules in joint regenerative medicine. Results show that appropriate concentrations of nanoliposome rapeseed lecithin under 500 µg/mL were safe for chondrocytes and did not induce any alterations of their phenotype. Altogether, these results sustain that they could represent a novel natural carrier to deliver active substances into cartilage cells.
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Liposomes offer better biocompatibility and safety than polymeric and metal-based nanoparticles due to their resemblance to biomembranes.
“Indeed, they offer better biocompatibility and safety than polymeric and metal-based nanoparticles due to their resemblance to biomembranes [204,205].”
From Alzheimer's Disease: Treatment Strategies and Their Limitations. (2022) · cites this paper as [205]
The Introduction describes liposomes as having a lipid bilayer similar to a biological membrane and says they can safely deliver drugs. Results and Discussion §2.5 reports low cytotoxicity for the tested rapeseed nanoliposomes at several concentrations in rat chondrocytes. The paper does not establish that liposomes are safer or more biocompatible than polymeric or metal-based nanoparticles. (LLM, conf=0.88)
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Metadata
- Authors
- Bianchi, A., Velot, É., Kempf, H., Elkhoury, K., Sanchez-Gonzalez, L., Linder, M., Kahn, C., & Arab-Tehrany, E.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Laboratoire d'Ingénierie des Biomolécules (FR)
- Laboratoire d’ingénierie des Biomolécules, Université de Lorraine, F-54505 Vandœuvre-Lès-Nancy, France
- Corresponding author
- Bianchi, Arnaud
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-05-13
- Volume
- 21
- Issue
- 10
- Pages
- 3436
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC7279141
- OpenAlex
- W3024260651
- Cited by
- 23
- References
- 46
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2022: 4 · 2021: 5 · 2020: 5
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Université de Lorraine
- Centre National de la Recherche Scientifique
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- nanoliposomes, rapeseed lecithin, chondrocytes, cartilage regeneration, gene delivery, cytocompatibility, unsaturated fatty acids
- MeSH terms
- Animals, Cartilage, Articular, Cell Membrane, Humans, Liposomes, Phospholipids, Drug Delivery Systems, Chondrocytes, Brassica napus, Regenerative Medicine, Rats, Nanoparticles, Lecithins
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