The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
The CCL20-CCR6 Axis in Cancer Progression
Open accessAbstract
Chemokines, which are basic proteins that exert their effects via G protein-coupled receptors and a subset of the cytokine family, are mediators deeply involved in leukocyte migration during an inflammatory reaction. Chemokine (C-C motif) ligand 20 (CCL20), also known as macrophage inflammatory protein (MIP)-3α, liver activation regulated chemokine (LARC), and Exodus-1, is a small protein that is physiologically expressed in the liver, colon, and skin, is involved in tissue inflammation and homeostasis, and has a specific receptor C-C chemokine receptor 6 (CCR6). The CCL20-CCR6 axis has long been known to be involved in inflammatory and infectious diseases, such as rheumatoid arthritis and human immunodeficiency virus infections. Recently, however, reports have shown that the CCL20-CCR6 axis is associated with several cancers, including hepatocellular carcinoma, colorectal cancer, breast cancer, pancreatic cancer, cervical cancer, and kidney cancer. The CCL20-CCR6 axis promotes cancer progression directly by enhancing migration and proliferation of cancer cells and indirectly by remodeling the tumor microenvironment through immune cell control. The present article reviewed the role of the CCL20-CCR6 axis in cancer progression and its potential as a therapeutic target.
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Cites
1 retracted
lncRNA‑u50535 promotes the progression of lung cancer by activating CCL20/ERK signaling
Wei, W., Zhao, X., Zhu, J., Zhang, L., Chen, Y., Zhang, B., Li, Y., Wang, M., Zhang, Z., & Wang, C. (2019) · Oncology Reports · doi:10.3892/or.2019.7302 · Cited by 19
RetractedSiegel, R. L., Miller, K. D., & Jemal, A. (2020) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21590 · Cited by 20,444
Understanding the tumor immune microenvironment (TIME) for effective therapy
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Regulatory T Cells and Immune Tolerance
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Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma
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Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
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“However, cytokines have been found to be significantly upregulated in many cancers, promoting cancer growth and progression within the tumor microenvironment (TME) [1,2].”
BackgroundPapillomaviruses and cancer: from basic studies to clinical application
zur Hausen, H. (2002) · Nature Reviews Cancer · doi:10.1038/nrc798 · Cited by 4,024
Clonal heterogeneity and tumor evolution: past, present, and the future
McGranahan, N., & Swanton, C. (2017) · Cell · doi:10.1016/j.cell.2017.01.018 · Cited by 2,840
Metadata
- Authors
- Kadomoto, S., Izumi, K., & Mizokami, A.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-07-22
- Volume
- 21
- Issue
- 15
- Pages
- 5186
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W3043853060
- Cited by
- 267
- References
- 107
- FWCI
- 10.27
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kadomoto, S., Izumi, K., & Mizokami, A. (2020). The CCL20-CCR6 Axis in Cancer Progression. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms21155186
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
